• Advances in environmental research
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• v.1 no.1
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• pp.57-68
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• 2012

Recent studies showed that air pollution is a risk factor for hospitalization for chronic obstructive pulmonary disease (COPD). However, there is limited evidence to suggest which subpopulations are at higher risk from air pollution. This study was undertaken to examine the modifying effect of specific secondary diagnosis (including hypertension, diabetes, pneumonia, congestive heart failure) on the relationship between hospital admissions for COPD and ambient air pollutants concentrations. Hospital admissions for COPD and ambient air pollution data for Taipei were obtained for the period from 1999-2009. The relative risk of hospital admissions for COPD was estimated using a case-crossover approach. None of the secondary diagnosis we examined showed much evidence of effect modification.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.22 no.52
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• pp.275-284
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• 1999

The TTP(TimeTabling Problem) for a university which should be made every term is very difficult problem to schedule because each component must satisfy all fixed constraints. This TTP, therefore, is solved by several heuristic methods. In this paper, applying PPEP(Parallel Population Evolution Programs) for the TTP, we try to find the approximated optimal solution by maintaining independence of each subpopulation and by searching the wide feasible solution. In addition, we present the problem to be appeared when used PMX(Partially mapped crossover)operator for the long chromosomes and then propose GBX (Gene_Based crossover)operator which can complement it. Finally, experimental results are presented comparing EP(Evolution Programs) and PPEP, then GBX which has the random genes and the selected genes on a real TTP.

• Industrial Engineering and Management Systems
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• v.10 no.4
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• pp.247-254
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• 2011

In this paper, we study a single-machine scheduling problem with deteriorating processing time of jobs and multiple rate-modifying activities which reset deteriorated processing time to the original processing time. In this situation, the objective function is to minimize total completion time. First, we formulate an integer programming model. Since the model is difficult to solve as the size of real problem being very large, we design an improved genetic algorithm called adaptive genetic algorithm (AGA) with spontaneously adjusting crossover and mutation rate depending upon the status of current population. Finally, we conduct some computational experiments to evaluate the performance of AGA with the conventional GAs with various combinations of crossover and mutation rates.

• Journal of Ginseng Research
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• v.42 no.2
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• pp.144-148
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• 2018

Background: Panax ginseng is a well-known immune modulator, and there is concern that its immune-enhancing effects may negatively affect patients with rheumatoid arthritis (RA) by worsening symptoms or increasing the risk of adverse effects from other drugs. In this randomized, crossover clinical trial, we evaluated the impact of Korean Red Ginseng (KRG) on disease activity and safety in RA patients. Methods: A total of 80 female RA patients were randomly assigned to either the KRG (2 g/d, n = 40) treatment or placebo (n = 40) groups for 8 wk, followed by crossover to the other treatment group for an additional 8 wk. The primary outcome was the disease flare rate, defined as worsening disease activity according to the disease activity score 28 joints-erythrocyte sedimentation rate (DAS28-ESR). The secondary outcomes were development of adverse events (AEs) and patient reported outcomes. Outcomes were evaluated at baseline and 8 wk and 16 wk. The outcomes were compared using the Chi-square test. Results: Of the 80 patients, 70 completed the full study. Their mean age was 51.9 yr, and most exhibited low disease activity (mean DAS28-ESR $3.5{\pm}1.0$) at enrollment. After intervention, the flare rate was 3.7% in each group. During KRG treatment, 10 AEs were reported, while five AEs were developed with placebo; however, this difference was not statistically significant (p = 0.16). Gastrointestinal- and nervous system-related symptoms were frequent in the KRG group. Conclusion: KRG is not significantly associated with either disease flare rate or the rate of AE development in RA patients.

• Journal of Preventive Medicine and Public Health
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• v.45 no.4
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• pp.219-226
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• 2012

Objectives: To evaluate the risk of fractures related with zolpidem in elderly insomnia patients. Methods: Health claims data on the entire South Korean elderly population from January 2005 to June 2006 were extracted from the Health Insurance Review and Assessment Service database. We applied a case-crossover design. Cases were defined as insomnia patients who had a fracture diagnosis. We set the hazard period of 1 day length prior to the fracture date and four control periods of the same length at 5, 10, 15, and 20 weeks prior to the fracture date. Time independent confounding factors such as age, gender, lifestyle, cognitive function level, mobility, socioeconomic status, residential environment, and comorbidity could be controlled using the case-crossover design. Time dependent confounding factors, especially co-medication of patients during the study period, were adjusted by conditional logistic regression analysis. The odds ratios and their 95% confidence intervals (CIs) were estimated for the risk of fracture related to zolpidem. Results: One thousand five hundred and eight cases of fracture were detected in insomnia patients during the study period. In our data, the use of zolpidem increased the risk of fracture significantly (adjusted odds ratio [aOR], 1.72; 95% CI, 1.37 to 2.16). However, the association between benzodiazepine hypnotics and the risk of fracture was not statistically significant (aOR, 1.00; 95% CI, 0.83 to 1.21). Likewise, the results were not statistically significant in stratified analysis with each benzodiazepine generic subgroup. Conclusions: Zolpidem could increase the risk of fracture in elderly insomnia patients. Therefore zolpidem should be prescribed carefully and the elderly should be provided with sufficient patient education.

• Steel and Composite Structures
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• v.24 no.1
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• pp.113-128
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• 2017

This paper highlights a study undertaken on the free vibration of a precast steel-concrete composite slab panel for track support. The steel-concrete composite slab track is an evolvement from the slab track, a form of ballastless track which is becoming increasingly attractive to asset owners as they seek to reduce lifecycle costs and deal with increasing rail traffic speeds. The slender nature of the slab panel due to its reduced depth of construction makes it susceptible to vibration problems. The aim of the study is driven by the need to address the limited research available to date on the dynamic behaviour of steel-concrete composite slab panels for track support. Free vibration analysis of the track slab has been carried out using ABAQUS. Both eigenfrequencies and eigenmodes have been extracted using the Lanczos method. The fundamental natural frequencies of the slab panel have been identified together with corresponding mode shapes. To investigate the sensitivity of the natural frequencies and mode shapes, parametric studies have been established, considering concrete strength and mass and steel's modulus of elasticity. This study is the world first to observe crossover phenomena that result in the inversion of the natural orders without interaction. It also reveals that replacement of the steel with aluminium or carbon fibre sheeting can only marginally reduce the natural frequencies of the slab panel.

• Journal of Korean Academy of Nursing
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• v.49 no.1
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• pp.92-103
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• 2019

Purpose: This study aimed to compare the effects of simulation integrated with problem based learning (S-PBL) according to the sequences of problem-based learning (PBL) and high fidelity simulation training (HFS) on knowledge, clinical performance, clinical judgment, self-confidence, and satisfaction in fourth-grade nursing students. Methods: In this randomized crossover design study, four S-PBLs on medical-surgical nursing were applied alternatively to two randomly-assigned groups of 26 senior nursing students for 8 weeks. The collected data were analyzed using an independent t-test. Results: The method of administering PBL prior to HFS led to significantly higher scores on knowledge (t=2.28, p=.025) as compared to the method of administering HFS prior to PBL. However, the latter method led to significantly higher scores on clinical performance (t=-6.49, p<.001) and clinical judgment (t=-4.71, p<.001) as compared to the method of administering PBL prior to HFS. There were no differences in the effect of the two methods on self-confidence (t=1.53, p=.128) and satisfaction (t=1.28, p=.202). Conclusion: The integration sequences of S-PBL was associated with different learning outcomes. Therefore, when implementing S-PBL, it is necessary to consider the educational goal to executes an appropriate sequence of integration.

• Journal of International Academy of Physical Therapy Research
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• v.12 no.1
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• pp.2272-2278
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• 2021

Background: Vibration stimulation has emerged as a treatment tool to help reduce spasticity during physical therapy. Spasticity includes problems of reduced range of motion (ROM) and stiffness. However, the benefits of vibration rolling (VR) on interventions for stroke patients are unclear. Objectives: This study aimed to investigate the effect of VR intervention on the ankle ROM and ankle stiffness in stroke patients. Design: A randomized crossover study. Methods: Seven stroke patients completed two test sessions (one VR and one non-VR [NVR]) in a randomized order, with 48 hours of rest between each session. Participants completed intervention and its measurements on the same day. The measurements included ankle dorsiflexion and plantarflexion ROM and stiffness of ankle muscles, including the tibialis anterior, medial, and lateral gastrocnemius muscle. Results: After VR, ankle dorsiflexion ROM, lateral gastrocnemius stiffness, and medial gastrocnemius stiffness improved significantly (all P<.05). After NVR, only the lateral gastrocnemius stiffness improved significantly (P<.05). Furthermore, in the cases of changed values for ankle dorsiflexion ROM and lateral gastrocnemius stiffness were compared within groups, VR showed a more significant difference than NVR (P<.05) Conclusion: VR improved ankle ROM and muscle stiffness. Therefore, we suggest that practitioners need to consider VR as an intervention to improve dorsiflexion ROM and gastrocnemius stiffness in stroke patients.

• Transactions of the Korean hydrogen and new energy society
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• v.22 no.3
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• pp.292-298
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• 2011

This study examines the effects of the ambient temperature (AT), methanol feeding temperature (MFT), methanol concentration (MC) and methanol flow rate (MFR) on the performance and cell temperature (CT) of a 5-stacked direct methanol fuel cell (DMFC). The AT, MFT, MC, and MFR are varied from $-10^{\circ}C$ to $+40^{\circ}C$, $50^{\circ}C$ to $90^{\circ}C$, 0.5M to 3.0M and 11.7 mL $min^{-1}$ to 46.8 mL $min^{-1}$, respectively. The performance of the DMFC under various operating conditions is analyzed from the I-V polarization curve, and the methanol crossover is estimated by gas chromatography (GC). The performance of the DMFC improves significantly with increasing AT. The open circuit voltage (OCV) decreases with increasing MC due to the enhanced likelihood of methanol crossover. The cell performance is improved significantly when the MFR is increased from 11.7 mL $min^{-1}$ to 28.08 mL $min^{-1}$. The change in cell performance is marginal with further increases in MFR. The CT increases significantly with increasing AT. The effect of the MFT and MFR is moderate, and the effect of MC is marginal on the CT of the DMFC.

• Journal of Preventive Medicine and Public Health
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• v.34 no.3
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• pp.253-261
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• 2001

Objectives : To evaluate the hypothesis that air pollution could increase emergency room visits for respiratory diseases, and if so, to quantify the strength of association between those. Methods : We compiled daily records of hospital emergency room visits for respiratory diseases in Seoul, from November 1. 1955 to October 31. 1996, by using medical utilization data of unscheduled visits. In addition, air quality and weather data for the same period was collected. And a case-crossover design was applied by adopting conditional logistic regression analysis to determine the relationship between air pollutants and emergency room visits for respiratory diseases. In particular, the control periods were chosen by a bidirectional paired matching technique 7, 14, and 21 days before and after the case periods. Results : Only ozone was associated with the increased number of emergency room visits for respiratory diseases. The relative risk according to a 30ppb increase of ozone concentration (24hr mean, lagged 1day) was 1.91(95% confidence interval = 1.78-2.05). Conclusion : There was a statistically significant association between the ambient ozone and daily emergency room visits for respiratory diseases.