• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 2007.04a
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• pp.341-344
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• 2007

본 논문에서는 계층적 공정 경쟁 개념을 병렬 유전자 알고리즘에 적용하여 계층적 공정 경쟁 기반 병렬유전자 알고리즘 (Hierarchical Fair Competition Genetic Algorithm: HFCGA)을 구현하였을 뿐만 아니라 실수코딩 유전자 알고리즘(Real-Coded Genetic Algorithm: RCGA)에서 좋은 성능을 갖는 산술교배(Arithmetic crossover), 수정된 단순교배(modified simple crossover) 그리고 UNDX(unimodal normal distribution crossover)등의 다양한 교배연산자들을 적용, 분석함으로써 개선된 병렬 유전자 알고리즘을 제안하였다. UNDX연산자는 다수의 부모(multiple parents)를 이용하여 부모들의 기하학적 중심(geometric center)에 근접하게 정규분포를 이루며 생성된다. 본 논문은 UNDX를 이용한 HFCGA모델을 구현하고 함수파라미터 최적화 문제에 많이 쓰이는 함수들에 적용시킴으로써 그 성능의 우수성을 증명 한다.

• Journal of Pharmaceutical Investigation
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• v.34 no.5
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• pp.379-383
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• 2004

Statistical interpretations in a bioequivalence trial are considered and studied when the missing observations occurred in $2\;{\times}\;2$ crossover experiment. Patel (1985) suggested the approximate test procedures for carryover effect and drug effect in $2\;{\times}\;2$ crossover design when some of data are missing in the second period. A modified Patel method is newly proposed to the bioequivalence trial and it is compared with the current method through the simulation study.

• Korean Journal of English Language and Linguistics
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• v.1 no.1
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• pp.101-117
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• 2001

In English, whether or not wh-movement creates weak crossover effects depends upon the type of wh-phrases that cross over. A bare interrogative like who shows a typical weak crossover effect whereas which N type (e.g. which girl) and partitive type (e.g. which of these girls) wh-phrases would show mere weaker and weakest crossover effects, respectively. Previous approaches to English crossover phenomena that resort to a binary notion of specificity or D-linking cannot account for the three-way contrast the three different types of wh-phrases show. To overcome this problem, I argue in this paper that specificity should be a non-binary set-theoretic notion and propose the following subset principle and optimal binding relation: Between two lexical nominal expressions A and B, A is regarded as more specific than B iff the denotation of A comes from a more narrowly defined non-singleton set than B. Between two lexical nominal expressions A and B, if A locally binds B, then the non-singleton set from which the denotation of A comes should be a subset of the set from which the denotation of B comes (i.e. B cannot be more specific than A). The smaller the subset (i.e. the wider the specificity gap between binder and binder), the more optimal the local binding relation is. A locally binds B iff A is coindexed with B, and A c-commands B, and there is no such C that does not bind A but binds B. Finally, I show that partitivity functions to carve out a smaller subset and thus make partitive wh-phrases more specific than simple which N type wh-phrases.

• Bulletin of the Korean Chemical Society
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• v.35 no.9
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• pp.2835-2838
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• 2014

• Korean Journal of Microbiology
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• v.49 no.1
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• pp.1-7
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• 2013

During meiosis, genetic recombinants are formed by homologous recombination accompanying with the programmed double-strand breaks (DSBs) and strand exchanges between homologous chromosomes. The mechanism is generated by recombination intermediates such as single-end invasions (SEIs) and double-Holliday junctions (dHJs), and followed by crossover (CO) or non-crossover (NCO) products. Our study was focused on the analysis of meiotic recombination intermediates (DSBs, SEIs, and dHJs) and final recombination products (CO and NCO). We identified these meiotic recombination intermediates using DNA physical analysis under HIS4LEU2 "hot spot" system in budding yeast, Saccharomyces cerevisiae. For DNA physical analysis, when the hot spot locus is recognized by restriction enzyme from synchronous meiotic cells, the fragmented DNA that are forming recombination intermediates can be detected and quantified through Southern hybridization analysis. Our study suggests that this system can analyze the structural change of recombination intermediates during DSB-SEI transition, double-Holiday junctions and crossover/non-crossover products in meiosis.

• The Korean Journal of Applied Statistics
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• v.26 no.4
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• pp.675-686
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• 2013

The Korea Food and Drug Administration(KFDA) recommends the use of a $2{\times}2$ crossover design to assess the bioequivalence of generic drugs. However, a standard $2{\times}2$ crossover design for bioequivalence trials is often considered problematic due to ethical and economic issues as highly variable drugs are usually required by large numbers of subjects when designing the trial. To overcome this problem a $2{\times}4$ crossover design has been a recommended option as per US regulations; in addition, a $2{\times}3$ crossover design has also recently drawn special attention as an efficient alternative. The current KFDA regulation requires an ANOVA table for every bioequivalence study; however, ANOVA tables of $2{\times}4$ and $2{\times}3$ crossover designs have never been published in the literature. This study shows the derivation of tables of analysis of variance for a $2{\times}4$ cross-over design and a $2{\times}3$ cross-over design. We also suggest a sample size formulas for $2{\times}2$, $2{\times}4$ and $2{\times}3$ crossover designs to provide information on the selection of efficient designs for highly variable drugs.

• Asia Marketing Journal
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• v.11 no.3
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• pp.151-165
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• 2009

The objective of this case study is to analyze how effectively KIA SOUL, which is a leading Crossover Utility Vehicle (CUV) brand, has created a new market space through innovative product strategy. Up until now, most car manufacturers have focused only on the traditional product market segments missing out on the opportunity of the crossover segment market. KIA SOUL found a new market space by identifying the high crossover utility demand and filling the gap between the current product category values and the emerging crossover product category values. This case study illustrates that an innovative product strategy can be effectively employed to create a new market space in the saturated car manufacturing industry. The case summarizes that the innovative product strategy of KIA SOUL is comprised of four primary pillars: design innovation, market frontier in CUV, the first company to launch customizing service brand-TUON, and functional innovation. The KIA SOUL case study provides valuable insights and implications for many other companies that are planning to find "blue oceans" for their own business.

• The Korean Journal of Applied Statistics
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• v.24 no.6
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• pp.1095-1102
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• 2011

The classical two-period, two-sequence crossover design is no longer sufficient to assess various demands in a bioequivalence study. For instance, to estimate the within-subject and between-subject variances of test and reference formulations separately, it is necessary to use a replicate design in which each subject receives at least the reference formulation in two periods. Several designs were studied to satisfy the demands. It is provided a unified Bayesian approach applicable to those study designs. The benefit of the method in the bioequivalence study is discussed.

• Journal of Korea Entertainment Industry Association
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• v.14 no.6
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• pp.151-160
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• 2020

In the past, musicians followed strict patterns written by composers when playing classical music. However, since the development of postmodernism, which puts an emphasis on unique individualities and various ways of thinking, following the strict patterns of classical music unquestioningly became less significant. Classical music was thought to be difficult to follow and enjoy for most people. Thus, musicians have found ways to keep the dignity of classical music but added familiarity in order to popularize arias in operas. They created classical crossover music and this type of music enabled people to enjoy easy access to classical music. However, not many studies focus on arrangement methods of changing classical music into crossover music. The goal of this study is to research on arrangement methods of crossover music based on the findings from precedent researches on operas. This study focused on analyzing musical structure including chords, rhythms and compositions of musical instruments. According to the analysis, original classical songs and popera, which is a type of crossover music, share similarities in terms of rhythms and chords. However, there are differences when it comes to compositions of musical instruments. In case of a jazz version, it uses AfroCuban rhythm as well as Bolero rhythm which is a part of ballad and jazz acoustic instruments are mainly used. Also, in order to reduce the feeling of classical music and to differentiate the jazz version from the original version, a lot of tension is used in voicing. This study can be helpful for any researches related to arrangements of classical crossover music.

• The Korean Journal of Applied Statistics
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• v.18 no.1
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• pp.159-171
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• 2005

The US Food and Drug Administration(FDA) recommends that population bioequivalence and individual bioequivalence would be assessed to address the prescribability and switchability between a brand-name drug and its new formulation or generic copy in its 2001 guidance document. The test for population bioequivalence in the latest FDA guidance is recommended in 2 x 4 crossover design, but it turns out to be very conservative. Recently Lee, Shao & Chow(2002), Chow, Shao & Wang(2003) and McNally, Iyer & Mathew(2002) proposed new statistical methods for assessing population bioequivalence between drugs to correct the biasness of current FDA method. Since 2 x 2 crossover experiment is most welcomed design in bioequivalence testing, we adopt their methods to 2 x 2 crossover designs and compare their methodologies with FDA one through the simulation study.