• Journal of Ocean Engineering and Technology
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• v.18 no.2
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• pp.77-82
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• 2004

The purpose of this study is to develop a nesting algorithm, using a genetic algorithm to optimize nesting order, and modified No Fit Polygon(NFP) methodology to place parts with the order generated from the previous genetic algorithm. Various genetic algorithm techniques, which have thus far been applied to the Travelling Salesman Problem, were tested. The partially mapped crossover method, the inversion method for mutation, the elitist strategy, and the linear scaling method of fitness value were selected to optimize the nesting order. A modified NFP methodology, with improved searching capability for non-convex polygon, was applied repeatedly to the placement of parts according to the order generated from previous genetic algorithm. Modified NFP, combined with the genetic algorithms that have been proven in TSP, were applied to the nesting problem. For two example cases, the combined nesting algorithm, proposed in this study, shows better results than that from previous studies.

• Journal of Korean Clinical Health Science
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• v.8 no.1
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• pp.1355-1361
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• 2020

Purpose: This study was conducted to investigate the effect of flipped-learning method on dental hygiene practice satisfaction. Methods: The study was a patient-group crossover design involving 53 third-year students at D's Department of Dental Hygiene. The study tools used self-questionnair and the analysis program used SPSS Ver 25.0. Results: Class satisfaction increased to 3.85 in the first semester and 4.23 in the second semester (p <0.05). Satisfaction with the flip learning method was 4.26, and most answered yes. In addition, it showed a positive effect on class satisfaction (p <0.01). As a result, it can be seen that the flip-learning learning method has a positive effect on the learners' learning motivation, academic achievement, and class satisfaction. Conclusions: it is considered that the flip learning method for hands-on classes should be expanded for the purpose of fostering job competency and high quality clinical practice experts.

• Journal of International Academy of Physical Therapy Research
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• v.11 no.2
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• pp.2060-2064
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• 2020

Background: Recently, the kinesiology taping (KT) method was reported to be effective in improving walking ability in foot drop patients after stroke, but the clinical basis is still unclear. Objectives: The KT method was compared with ankle-foot orthotics (AFO) to investigate gait ability in foot drop patients after stroke. Design: Crossover study design. Methods: In this study, 11 stroke patients with foot drop participated. Walking ability of all subjects for both conditions (KT and AFO) was measured using the GAITRite system. The order of application of the two conditions was determined randomly by drawing lots. Wilcoxon signed-rank test was used to compare walking ability between the two conditions. The level of statistical significance was set at P<.05. Results: There were no significant differences between the KT and AFO methods in terms of velocity, cadence, step length, and stride length (P>.05, all). Conclusion: This study recommends KT as an alternative to the AFO, since KT provides evidence of preventing of foot drops and improving gait ability in stroke patient.

• Journal of International Academy of Physical Therapy Research
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• v.10 no.4
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• pp.1868-1872
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• 2019

Background: Lower trapezius muscle function is important for the prevention and treatment of shoulder injuries. However, scapular posterior tilt movement has been overlooked in lower trapezius strengthening exercise programs. Objective: To examine the effects of prone arm lifting with scapular posterior tilt (PALSPT) on trapezius muscles. Design: Crossover study Methods: 17 healthy males were recruited for participation in this study. Participants performed backward rocking diagonal arm lifting (BRDAL) and PALSPT. To train participants in scapular posterior tilt movements for PALSPT, visual biofeedback of scapular movements was provided using a motion sensor. Electromyography (EMG) activities of the middle and lower trapezius were recorded using a surface EMG system. Differences in middle and lower trapezius muscle activity between BRDAL and PALSPT exercises were analyzed. Results: Lower trapezius muscle activity was significantly greater during PALSPT than during BRDAL (p=.006). Although greater EMG activity was observed in the middle trapezius during PALSPT than during BRDAL, this difference was not significant (p=.055). Conclusions: The results of the present study indicate that scapular posterior tilt movements must be considered in lower trapezius muscle strengthening programs.

• The Korean Journal of Emergency Medical Services
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• v.19 no.2
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• pp.29-38
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• 2015

Purpose: The purpose of this study was to improve airway management ability by comparing the speed, angle of the neck, and confidence and ease of supraglottic airway laryngopharyngeal tube (SALT) and endotracheal intubation via direct laryngoscopy. Methods: The subjects of this experimental research study with a randomized crossover design were 44 emergency medicine technician - paramedics working in the fire department of 'J' - do. SPSS version 19.0 was used in the statistical analysis. Results: Speed and angle of the neck (p<.001), as well as confidence and ease (p<.001), showed significant differences between endotracheal intubation with a SALT and endotracheal intubation via direct laryngoscopy. Conclusion: If endotracheal intubation via direct laryngoscopy is difficult to use or in trauma patients, using a SALT is safe and enables fast intubation. Moreover, in order to improve the efficiency of advanced airway management, the application of SALT should be introduced in the domestic scene.

• Journal of Pharmaceutical Investigation
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• v.35 no.5
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• pp.323-328
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• 2005

The purpose of the present study was to evaluate the bioequivalence of two torasemide tablets, Torem tablet (Roche Korea Co., Ltd., Korea, reference drug) and Boryung Torsemide tablet (Boryung Pharmaceutical Co., Ltd., Korea, test drug), according to the guidelines of Korea Food and Drug Administration (KFDA). After adding an internal standard (furosemide) to human serum, serum samples were extracted using 5 mL of ethyl acetate. Compounds were analyzed by reverse-phase HPLC method with UV detection. This method showed linear response over the concentration range of 0.05 ug/mL with correlation coefficient of 0.999. The lower limit of quantitation using 0.5 mL of serum was 0.05 ug/mL which was sensitive enough for pharmacokinetic studies. Twenty-eight healthy male Korean volunteers received each medicine at the torasemide dose of 20 mg in a $2{\times}2$ crossover study. There was a one-week washout period between the doses. Serum concentrations of torasemide were monitored by an HPLC-UV for over a period of 12 hr after the administration. $AUC_{t}$(the area under the serum concentration-time curve from time zero to 12 hr) was calculated by the linear trapezoidal rule method. $C_{max}$ (maximum serum drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the serum concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_{t}$ and $C_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_{t}$ ratio and the $C_{max}$ ratio for Boryung Torsemide/Torem were log 0.97-10g 1.03 and log 0.93log 1.12, respectively. These values were within the acceptable bioequivalence intervals of log 0.80-log 1.25. Thus, the criteria of the KFDA guidelines for the bioequivalence was satisfied, indicating Boryung Torsemide tablet and Torem tablet are bioequivalent.

• Journal of Pharmaceutical Investigation
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• v.40 no.2
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• pp.109-115
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• 2010

The purpose of the present study was to evaluate the bioequivalence of two choline alphoscerate soft capsules, Gliatilin soft capsule (Daewoong Pharmaceuticals Co., Ltd.) and Cholicerin soft capsule (Sam Chun Dang Pharm. Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). Serum concentrations of choline after oral administration of choline alphoscerate were determined using a validated LC/MS/MS method. This method showed linear response over the concentration range of 0.5-20 ${\mu}g$/mL with correlation coefficient of 0.9999. The lower limit of quantitation using 100 ${\mu}L$ of serum was 0.5 ${\mu}g$/mL which was sensitive enough for pharmacokinetic studies. Thirty six healthy male Korean volunteers received each medicine at the choline alphoscerate dose of 1200 mg in a $2{\times}2$ crossover study. There was a one-week washout period between the doses. Blood samples were taken at predetermined time intervals up to 8 hr. $AUC_t$ (the area under the serum concentration-time curve from time 0 to 8 hr) was calculated by the linear trapezoidal rule method. $C_{max}$ (the maximum serum drug concentration) and $T_{max}$ (the time to reach $C_{max}$) were compiled from the serum concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t$ and $C_{max}$. No significant sequence effect was found for all of the bioavailability parameters, indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for Cholicerin/Gliatilin were log0.9998-log1.1172 and log0.9938-1.0944, respectively. These values were within the acceptable bioequivalence intervals of log0.80-log1.25. Thus, the criteria of the KFDA guidelines for the bioequivalence was satisfied, indicating Cholicerin soft capsule and Gliatilin soft capsule are bioequivalent.

• Journal of Environmental Health Sciences
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• v.32 no.3
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• pp.222-226
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• 2006

Smoking of tobacco cigarettes is associated with a rise in blood pressure together with increase in heart rate. This study was aimed to examine the acute effect of tobacco and non-tobacco cigarette smoking on the blood pressure and heart rate by randomized crossover study. In the results, systolic/diastolic blood pressure and heart rate changes after smoking were significantly different between male and female group. Blood pressure and heart rate were elevated after smoking, but statistical significance for the difference was identified only in the female group. Because Non-tobacco smoke made from leaves of E. ulmoides has no nicotine, its effect on blood pressure and heart rate was negligible. Remarkable difference of heart rate changes in women was observed between tobacco cigarette smoking group and non-tobacco cigarette smoking group.

• Proceedings of the Korean Institute of Interior Design Conference
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• 2006.05a
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• pp.97-98
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• 2006

This study proposes a method of generating steel house shop drawing in an automated design method, reducing construction manpower and period. With one hour fire-resistant approval code, reflecting work ability and efficiency, steel-framed house market is expected to extend from one or two story house to multi-purpose facilities up to four story height. More models have been constructed in this system than the first appearance of fire-resistant approval in Korea in 1997 Also, cost estimation of components such as frame walls, roof trusses and floors is obtained with shop drawings. Also, the lack of suppliers of steel framed house shop drawing and unstandardized drawing method get constructors have difficulty in understanding its design. In steel framed house industry, shop drawings are essential part in building and constructing framework and they have major effects on construction deadlines and expenses. By exploring method of shop drawing automation, this study aims to optimize work flow with a standardized drawing method. The proposed system can be applied to manufacturing automation in domestic industry of factory-built panelizing method in the near future.

• Proceedings of the Korean Environmental Health Society Conference
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• 2003.06a
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• pp.166-170
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• 2003

Smoking of tobacco cigarettes is associated with a rise in blood pressure together with an increase in heart beat rate. This study examined the acute effect of tobacco and non-tobacco cigarette smoking on the blood pressure and heart beat rate by randomized crossover study involved 39 volunteers. In the results, systolic blood pressure and heart beat rate changes after smoking were significantly different in non-tobacco cigarette smoking group from in tobacco cigarette smoking group.