• Proceedings of the IEEK Conference
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• 2000.06a
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• pp.123-126
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• 2000

In this paper, we are proposed to pushing window input buffer A.T.M Switch that is not use memory read and write of general window police. Pushing window switch is superior to general window switch in performance but is large to general window switch in cross point number. Max throughput and Cell occupying probability results are verified by analysis an simulation. The evaluation of performance is max throughput and cell loss probability and mean queue length.

• Proceedings of the Korea Institute of Applied Superconductivity and Cryogenics Conference
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• 2003.10a
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• pp.146-149
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• 2003

In this Work, we have studied about an RSFQ 2$\times$2 crossbar switch. The circuit was designed, simulated, and laid out for mask fabrication The switch cell was composed of a splitter a confluence buffer, and a switch core. An RSFQ 2$\times$2 crossbar switch was composed of 4 switch cells, a switch control input to select the cross and bar, data input, and data outputs. When a pulse was input to the switch control input to select the cross or bar the route of the input data was determined, and the data was output at the proper output port. We simulated and optimized the switch-element circuit and 2$\times$2 crossbar switch, by using Xic and Julia. We also performed the mask layout of the circuit by using Xic and Lmeter.

• Proceedings of the IEEK Conference
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• 2001.06b
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• pp.369-372
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• 2001

This paper presents the design of high-speed virtual output queue(VOQ) management scheme for high performance cell/packet switch, which has a serial cross bar structure. The proposed VOQ management scheme has been designed for wire-speed routing with a pipelined buffer management. It provides the tolerance of requests and grants data transmission latency between the VOQ manager and central arbiter using a new request control method that is based on a high-speed shifter. The designed VOQ manager has been implemented in a field programmable gate array chip with a 77MHz operating frequency, a 900-pin fine ball grid array package, and 16$\times$16 switch size.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.36 no.2B
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• pp.120-130
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• 2011

Recently the multicast based contents transmission is rapidly increasing due to the various multimedia services and the importance of switching technology to handle it is increasing as a consequence. Though the CICQ architecture has advantages that reduction of HoL blocking probability and simple scheduling using cross point buffer, it has disadvantage that the processing rate of multicast traffic can be significantly degraded corresponds to the traffic load increment. Several schemes have been proposed to solve this problem however they still can't provide enough processing ratio for multicast traffic. Therefore this paper proposes the BA cell assignment scheme and the VT scheme, and the processing rate of multicast traffic can be guaranteed by reducing the HoL blocking probability of multicast traffic and reservation of cross point buffer. Also simulation results verify that using the proposed scheme, the QoS of multicast service can be improved.

• Tuberculosis and Respiratory Diseases
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• v.76 no.1
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• pp.1-7
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• 2014

Maintenance therapy has emerged as a novel therapeutic paradigm for advanced non-small-cell lung cancer (NSCLC). Maintenance therapy that aims to sustain a clinically favorable state after first-line chemotherapy has two strategies. Switch maintenance therapy entails switching to a new and non-cross-resistant agent in an alternating or sequential manner, on completion of first-line chemotherapy. Continuous maintenance therapy keeps ongoing administration of a component of the current regimen after four to six cycles of chemotherapy, if there is a stable disease, or better response. Both maintenance therapies can be continued, until disease progression. The potential evidence regarding maintenance therapy includes providing the opportunity to receive additional treatment, through sustaining tumor shrinkage, and delayed emergence of tumor-related symptom. Thus far, debates over the parameters used to predict the effectiveness of maintenance therapy, financial burden, and uncertainty of improving the quality of life exist. Despite many debates, maintenance therapy, which is currently recommended, has been disclosed to be beneficial.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.12 no.3
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• pp.312-320
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• 2019

In this paper, we design a 512Kb eFlash IP using 110nm eFlash cells. We proposed eFlash core circuit such as row driver circuit (CG/SL driver circuit), write BL driver circuit (write BL switch circuit and PBL switch select circuit), read BL switch circuit, and read BL S/A circuit which satisfy eFlash cell program, erase and read operation. In addition, instead of using a cross-coupled NMOS transistor as a conventional unit charge pump circuit, we propose a circuit boosting the gate of the 12V NMOS precharging transistor whose body is GND, so that the precharging node of the VPP unit charge pump is normally precharged to the voltage of VIN and thus the pumping current is increased in the VPP (boosted voltage) voltage generator circuit supplying the VPP voltage of 9.5V in the program mode and that of 11.5V in the erase mode. A 12V native NMOS pumping capacitor with a bigger pumping current and a smaller layout area than a PMOS pumping capacitor was used as the pumping capacitor. On the other hand, the layout area of the 512Kb eFlash memory IP designed based on the 110nm eFlash process is $933.22{\mu}m{\times}925{\mu}m(=0.8632mm^2)$.

• Tuberculosis and Respiratory Diseases
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• v.58 no.1
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• pp.31-42
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• 2005

Background : Peroxiredoxins (Prxs) are a relatively newly recognized, novel family of peroxidases that reduce $H_2O_2$ and alkylhydroperoxide into water and alcohol, respectively. There are 6 known isoforms of Prxs present in human cells. Normally, Prxs exist in a head-to-tail homodimeric state in a reduced form. However, in the presence of excess $H_2O_2$, it can be oxidized on its catalytically active cysteine site into inactive oxidized forms. This study surveyed the types of the Prx isoforms present in the pulmonary epithelial, macrophage, endothelial, and other cell lines and observed their response to oxidative stress. Methods : This study examined the effect of exogenous, excess $H_2O_2$ on the Prxs of established cell lines originating from the pulmonary epithelium, macrophages, and other cell lines, which are known to be exposed to high oxygen partial pressures or are believed to be subject to frequent oxidative stress, using non-reducing SDS polyacrylamide electrophoresis (PAGE) and 2 dimensional electrophoresis. Result : The addition of excess $H_2O_2$ to the culture media of the various cell-lines caused the immediate inactivation of Prxs, as evidenced by their inability to form dimers by a disulfide cross linkage. This was detected as a subsequent shift to its monomeric forms on the non-reducing SDS PAGE. These findings were further confirmed by 2 dimensional electrophoresis and immunoblot analysis by a shift toward a more acidic isoelectric point (pI). However, the subsequent reappearance of the dimeric Prxs with a comparable, corresponding decrease in the monomeric bands was noted on the non-reducing SDS PAGE as early as 30 minutes after the $H_2O_2$ treatment suggesting regeneration after oxidation. The regenerated dimers can again be converted to the inactivated form by a repeated $H_2O_2$ treatment, indicating that the protein is still catalytically active. The recovery of Prxs to the original dimeric state was not inhibited by a pre-treatment with cycloheximide, nor by a pretreatment with inhibitors of protein synthesis, which suggests that the reappearance of dimers occurs via a regeneration process rather than via the de novo synthesis of the active protein. Conclusion : The cells, in general, appeared to be equipped with an established system for regenerating inactivated Prxs, and this system may function as a molecular "on-off switch" in various oxidative signal transduction processes. The same mechanisms might applicable other proteins associated with signal transduction where the active catalytic site cysteines exist.