• Asian Pacific Journal of Cancer Prevention
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• 제13권8호
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• pp.3879-3887
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• 2012

Background: Development of effective educational strategies should accompany increases in public awareness and the availability of genetic testing for breast cancer (BC). These educational strategies should be designed to fulfill the knowledge gap while considering factors that influence women's interest in order to facilitate decision making. Objective: To determine the possible correlates of Saudi women's interest in BC genes testing including socio-demographics, the level of awareness towards BC genes, the family history of BC and the perceived personal risk among adult Saudi women in Al Hassa, Saudi Arabia. Subjects and methods: This cross-sectional study was carried out during the second BC community-based campaign in Al Hassa, Saudi Arabia. All Saudi women aged ${\geq}18$ years (n=781) attending the educational components of the campaign were invited to a personal interview. Data collection included gathering information about sociodemographics, family history of BC, the perceived personal risk for BC, awareness and attitude towards BC genes and the women's interest in BC genes testing. Results: Of the included women (n=599), 19.5% perceived higher risk for BC development, significantly more among < 40 years of age, and with positive family history of BC before 50 years of age. The participants demonstrated a poor level of awareness regarding the inheritance, risk, and availability of BC genetic testing. The median summated knowledge score was 1.0 (out of 7 points) with a knowledge deficit of 87.8%. The level of knowledge showed significant decline with age (> 40 years). Of the included women 54.7% expressed an interest in BC genetic testing for assessing their BC risk. Multivariate regression model showed that being middle aged (Odds Ratio 'OR'=1.88, confidence intervals 'C.I'=1.14-3.11), with higher knowledge level (OR=1.67, C.I=1.08-2.57) and perceiving higher risk for BC (OR=2.11, C.I=1.61-2.76) were the significant positive correlates for Saudi women interest in BC genetic testing. Conclusion: Saudi women express high interest in genetic testing for BC risk despite their poor awareness. This great interest may reflect the presence of inappropriate information regarding BC genetic testing and its role in risk analysis.

• Asian Pacific Journal of Cancer Prevention
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• 제17권1호
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• pp.85-88
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• 2016

Background: Cervical cancer is the second most common malignancy among women worldwide, and women of reproductive age in Thailand. However, information on the behavior regarding cervical cancer in rural community Thailand is sparse. Objective: To assess the knowledge, attitude, and practice regarding cervical cancer (CC) among rural community women in Nakhon Ratchasima, Thailand, using predesigned structured questionnaires. Materials and Methods: A cross-sectional survey was conducted in 8 villages of Non Sung district, Nakhon Ratchasima province, Thailand, during January to April 2015. Bloom's taxonomy was used as a framework for the study. 265 women aged between 30-60 years old were selected by simple random sampling. All participants completed predesigned questionnaires with 4 parts: demographic data, knowledge, attitude, and practice regarding cervical cancer. Descriptive statistics were used for analysis in this study. Results: The majority of participants were in the age group of 41-50 years old (42.6%) with senior secondary school level of education (32.1%), marriage status (85.0%), agricultural employment (59.6%), and family income between 6,000-10,000 baht per month (54.3%). Some 63.4% and 68.7% participants had high knowledge and moderate level of attitudes regarding CC, while 41.1%, 48.7%, and 10.2% had neem regularly, irregularly or never screened for CC, respectively. The main reasons for not screening were were shyness (44.4%) and no time (55.6%). Vaginal discharge and itching were the common signs and symptoms of participants who were screened at a health promotion hospital of sub-district. Conclusions: CC is still a health problem in the rural community. Therefore, health education is required, particularly for those who have never undergone screening.

• Asian Pacific Journal of Cancer Prevention
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• 제17권sup3호
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• pp.113-117
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• 2016

Quantile regression is an efficient method for predicting and estimating the relationship between explanatory variables and percentile points of the response distribution, particularly for extreme percentiles of the distribution. To study the relationship between urbanization and cancer morbidity, we here applied quantile regression. This cross-sectional study was conducted for 9 cancers in 345 cities in 2007 in Iran. Data were obtained from the Ministry of Health and Medical Education and the relationship between urbanization and cancer morbidity was investigated using quantile regression and least square regression. Fitting models were compared using AIC criteria. R (3.0.1) software and the Quantreg package were used for statistical analysis. With the quantile regression model all percentiles for breast, colorectal, prostate, lung and pancreas cancers demonstrated increasing incidence rate with urbanization. The maximum increase for breast cancer was in the 90th percentile (${\beta}$=0.13, p-value<0.001), for colorectal cancer was in the 75th percentile (${\beta}$=0.048, p-value<0.001), for prostate cancer the 95th percentile (${\beta}$=0.55, p-value<0.001), for lung cancer was in 95th percentile (${\beta}$=0.52, p-value=0.006), for pancreas cancer was in 10th percentile (${\beta}$=0.011, p-value<0.001). For gastric, esophageal and skin cancers, with increasing urbanization, the incidence rate was decreased. The maximum decrease for gastric cancer was in the 90th percentile(${\beta}$=0.003, p-value<0.001), for esophageal cancer the 95th (${\beta}$=0.04, p-value=0.4) and for skin cancer also the 95th (${\beta}$=0.145, p-value=0.071). The AIC showed that for upper percentiles, the fitting of quantile regression was better than least square regression. According to the results of this study, the significant impact of urbanization on cancer morbidity requirs more effort and planning by policymakers and administrators in order to reduce risk factors such as pollution in urban areas and ensure proper nutrition recommendations are made.

• Asian Pacific Journal of Cancer Prevention
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• 제16권3호
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• pp.903-907
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• 2015

Background: Among human epidermal growth factor receptor 2 (HER2)-positive breast cancer, more than half are also hormone receptor (HR)-positive. Although HR is a predictive factor for the efficacy of hormone therapy, there are still some uncertainties in regard to the effects on patients with HR-positive and HER2-positive metastatic breast cancers due to the potential resistance to hormone therapy caused by co-expression of HR and HER2. There are no clinical trials directly comparing the efficacy of hormonal therapy with chemotherapy. Materials and Methods: To examine the real-world effect of hormone therapy on patients with HR-positive and HER2-positive metastatic breast cancers, a cross-sectional study of a representative sample of the Chinese population was conducted. The study included 113 patients who received first-line and second-line palliative treatment between 2005 and 2010 in the Cancer Institute and Hospital, Chinese Academy of Medical Science. The effect of hormone therapy on overall survival (OS) was studied. Results: The patients who received hormone therapy (n=51) had better overall survival in contrast to those who received chemotherapy with anti-HER2 therapy (n=62) in first- or second-line treatment. The difference was of borderline statistical significance (51.8m vs 31.9m, p=0.065). In addition, the effect of hormone therapy did not differ significantly with other prognostic factors, including age (${\leq}50$ years or >50 years), disease free survival (${\geq}2$ years or < 2 years) and site of metastasis (visceral or bone/soft tissue). On multivariate analysis, administration of hormone therapy was associated with a trend toward a favorable prognosis (p=0.148, HR=0.693, 95%CI 0.422-1.139). Age more than 50 years was the sole independent harmful prognostic factor (p<0.001, HR=2.797, 95%CI 1.676-4.668). Conclusions: Our data suggest that hormonel therapy may improve outcomes of the patients with ER-positive and HER2-positive metastatic breast cancer.

• Asian Pacific Journal of Cancer Prevention
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• 제13권5호
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• pp.2369-2378
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• 2012

Objectives: To assess knowledge of HPV and attitudes towards HPV vaccination among the general female population, government officials, and healthcare providers in China to assist the development of an effective national HPV vaccination program. Methods: A cross-sectional epidemiologic survey was conducted across 21 urban and rural sites in China using a short questionnaire. 763 government officials, 760 healthcare providers, and 11,681 women aged 15-59 years were included in the final analysis. Data were analyzed using standard descriptive statistics and logistic regression. Results: Knowledge of HPV among the general female population was low; only 24% had heard of HPV. Less than 20% of healthcare providers recognized sexually na$\ddot{i}$ve women as the most appropriate population for HPV vaccination. There was high acceptance of the HPV vaccine for all categories of respondents. Only 6% of women were willing to pay more than US $300 for the vaccine. Conclusions: Aggressive education is necessary to increase knowledge of HPV and its vaccine. Further proof of vaccine safety and efficacy and government subsidies combined with increased awareness could facilitate development and implementation of HPV vaccination in China.

• 한국산학기술학회논문지
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• 제18권10호
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• pp.344-353
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• 2017

본 연구는 한국 기혼여성과 이민 기혼여성을 대상으로 정신건강 도움추구행동에 영향을 미치는 요인을 파악하고 비교하고자 수행된 서술적 조사연구이다. 본 연구대상은 D 광역시에 거주하는 21-45세의 기혼자인 한국여성 110명과 이민여성 91명 총 201명이다. 자료수집기간은 2015년 7월 1일에서 8월 3일까지였으며, 자기보고식 설문지로 조사하였다. 수집된 자료는 SPSS 21.0 version을 이용하여, 서술통계, ${\chi}^2$-test, t-test, ANOVA, ANCOVA, Pearson Correlation Coefficient, multiple regression으로 분석하였다. 본 연구결과, 정신건강 도움추구행동은 한국여성에서 우울, 정신질환에 대한 신념, 정신건강서비스에 대한 요구와 유의한 상관관계가 나타났다. 또한, 이민여성에서는 한국어 유창성, 정신질환에 대한 신념, 사회적 지지와 유의한 상관관계가 나타났다. 다중회귀분석결과, 정신건강 도움추구행동 영향요인은 한국여성에서는 정신질환에 대한 신념으로 나타났으며, 총 설명력은 10.5%이었고, 이민여성에서는 한국어 유창성, 정신질환에 대한 신념, 사회적 지지로 나타났으며, 총 설명력은 59.0%였다. 따라서 추후 대상자를 확대하여 정신건강 도움추구행동을 예측할 수 있는 다양한 영향요인을 파악하고, 본 연구결과에서 유의한 변수들을 고려하여 기혼여성의 정신건강 도움추구행동을 증진시키기 위한 중재의 개발을 제언한다.

• Nutrition Research and Practice
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• 제8권4호
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• pp.453-462
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• 2014

BACKGROUND/OBJECTIVES: The inverse relationships of combined fruits and vegetables intake with blood pressure have been reported. However, whether there are such relationships with salty vegetables has rarely been investigated in epidemiologic studies. We evaluated the relation of combined and separate intake of fruits, vegetable intakes, and salty vegetables, as well as sodium and potassium, with blood pressure among the middle-aged and elderly populations. SUBJECTS/METHODS: The present cross-sectional analysis of a prospective cohort baseline survey was performed with 6,283 subjects (2,443 men and 3,840 women) and free of hypertension, diabetes, cardiovascular diseases, and cancer. Dietary data were collected by trained interviewers using food frequency questionnaire. RESULTS: The significantly inverse linear trend of diastolic blood pressure (DBP) was found in fruits and non-pickled vegetables (81.2 mmHg in the lowest quintile vs 79.0 mmHg in the highest quintile, P for trend = 0.0040) and fruits only (80.9 mmHg in the lowest quintile vs 79.4 mmHg in the highest quintile, P for trend = 0.0430) among men. In contrast, sodium and sodium to potassium ratio were positively related with blood pressure among men (DBP, 78.8 mmHg in the lowest quintile vs 80.6 mmHg in the highest quintile, P for trend = 0.0079 for sodium; DBP, 79.0 mmHg in the lowest quintile vs 80.7 mmHg in the highest quintile, P for trend = 0.0199 and SBP, 123.8 mmHg in the lowest quintile vs 125.9 mmHg in the highest quintile for sodium/potassium). Kimchies consumption was positively related to DBP for men (78.2 mmHg in the lowest quintile vs 80.9 mmHg in the highest quintile for DBP, P for trend = 0.0003). Among women, these relations were not found. CONCLUSION: Fruits and/or non-pickled vegetables may be inversely, but sodium, sodium to potassium, and Kimchies may be positively related to blood pressure among men.

• 한국식품영양과학회지
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• 제31권6호
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• pp.1018-1025
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• 2002

본 연구는 체중조절 관련 행위의 실천실태 파악과 실천내용에 따라 한국인의 식이섭취 양상에 차이가 있는지 여부를 규명해 보기 위해 수행되었다. 1998년 국민건강.영양조사의 대상이 되었던 20세이상 성인 7370명의 체중관련 실천행위와 그들의 식품 및 영양소섭취 자료가 분석에 이용되었다. 체중관련 실천 행위로는 체중감량 노력, 체중증가 노력, 노력 안 함 등의 실천행위와 체중감소 노력이유, 체중감소 노력시 사용한 방법 등이 조사되었고 자료수집은 설문지를 이용한 면접 조사를 통해 수행되었다 식품 및 영양소 섭취조사는 24시간 회상법이 이용되었다. 분석결과 한국인의 32%가 체중조절 행위를 실천하고 있는 것으로 나타났으며 이는 미국등의 실천 수준보다 훨씬 낮은 수준이었다. 이들 실천 양상에는 남녀간의 차이가 있어 체중조절 실천 남성의 60%가 체중감소 노력을 하고 있으며 40%는 체중증가 노력을 하고 있어 체중감소노력자가 체중증가노력자의 1.5배였다. 반면 여성 체중조절 실천자중 줄이려는 노력자는 전체 노력자의 88%로써 줄이려는 노력자 12%의 7배로 나타났다. 체중조절 노력에 따른 식품 및 영양소 섭취양상은 체중감소 노력을 하는 대상자가 남녀 모두 늘리려는 노력을 하는 사람들보다는 곡류 등 대부분의 식품군에서 낮은 섭취 수준을 보이나 아무 노력도 하지 않는 군보다는 높은 섭취 수준을 보여주고 있다. 이러한 식품 섭취 결과는 영양소섭취 양상에 그대로 반영되어 줄이려는 노력군의 에너지 단백질 지방 등 대부분의 영양소의 섭취가 노력하지 않는 군보다 높게 나타나 이들이 궁극적 목적인 체중감량에 성공할 수 없었을 가능성을 본 연구 결과는 시사하고 있다 이러한 격과는 체중 감량 노력 대상자의 대부분이 체중감량이 필요한 비만인이나 질병을 앓고 있는 대상자라는 배경 때문으로 간주된다. 그러므로 비만인들이 건강하지 못한 오래된 식습관을 극복하지 못한 결과로 사료되어 성인기 이전 성장기에 올바른 식습관에 대한 영양교육이 성인 비만의 예방과 치료에 중요함을 본 연구 결과는 시사하고 있다.

• 한국산학기술학회논문지
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• 제15권3호
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• pp.1566-1575
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• 2014

본 연구는 저소득층 재가노인의 지각된 건강상태, 수면, 우울, 통증이 삶의 질에 미치는 영향을 알아보고자 시행된 서술적 조사연구이다. J시에 소재하는 보건소에 등록된 저소득층 재가노인을 대상으로 2012년 12월 20일부터 2013년 2월 15일까지 설문지를 통하여 수집되었으며, t-test, ANOVA, 상관분석, 다중회귀분석으로 분석하였다. 그 결과 지각된 건강상태는 평균 $9.89{\pm}2.21$점, 수면은 평균 $39.72{\pm}8.79$점, 우울은 평균 $7.13{\pm}7.54$점, 통증은 평균 $5.37{\pm}1.90$점, 삶의 질의 평균은 $7.61{\pm}2.25$점이었다. 저소득층 재가노인의 지각된 건강상태가 좋고, 수면양상이 좋으며, 통증정도가 낮고, 우울정도가 낮을수록 삶의 질이 좋은 것으로 나타났다. 삶의 질에 영향을 미치는 요인으로는 지각된 건강상태, 통증, 수면이었으며, 44.6%의 설명력을 보였다. 그러므로 저소득층 재가노인의 삶의 질을 향상시키기 위해서는 체계적인 건강관리를 위한 프로그램 개발 및 적용이 필요하다.

• 대한지역사회영양학회지
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• 제6권4호
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• pp.604-616
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• 2001

This study was to investigate weight-control experience disorder and nutrient intake of college student attending web class via the internet. The subject were 1200 college students(392 male, 808 female) attending web class concerned with nutrition and weight control. This cross-sectional survey was conducted by self-administered questionnaire and data were analyzed by Students t-test and $\chi$$^2$-test. Nutrient intake collected from 3 day-recalls were analyzed by the Computer Aided Nutritional Analysis Program. Mean height, weight and RBW(relative body weight) of the male college students were 174.7 cm, 68.0 kg and 101.2%, respectively. Mean height, weight and RBW of the female college students were 162.3% cm, 52.7% kg and 95.3% respectively. Among the male college students, low weight were 1.0%, underweight were 12.8%, overweight were 12.5%, obese were 6.9% by RBW standard. Among the female college students, low weight were 5.1%, underweight 30.2%, overweight were 5.2%, obese were 1.5% by RBW standard. Percentages of weight control experience were 21.7% and 67.0% in the male and female college students, respectively. According to RBW, 22.4% of the weight control experience group were low weight or underweight in the female college students but none of weight control experience group were low weight or underweight in the male college students. Percentage of eating disorder were 6.8%(2.8%, male, 8.7% female) in the college students. Among the female college students, most nutrient intakes were significantly lower in the weight-control experienced group compared to the weight-control nonexperienced group. Among the male college students, there was a tendency that the intake of nutrients, except carbohydrate, calcium and vitamin A was higher in the eating disorder group compared to the non-eating disorder group. However, among the female college students, there was a tendency that the intake of nutrients, except calcium and thiamin was lower in the eating disorder group compared to the non-eating disorder group. Therefore, nutrition education via the internet is required for college students to know proper weight loss methods, desirable eating habits and eating disorder problem well.