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Recent Advances in Tyrosinase Research as An Industrial Enzyme (산업용 효소로써 티로시나아제 연구의 최근 동향)

  • Kim, Hyerin;Kim, Hyunmi;Choi, Yoo Seong
    • KSBB Journal
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    • v.29 no.1
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    • pp.1-8
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    • 2014
  • Tyrosinases catalyze the hydroxylation of monophenolic compounds and the conversion of o-diphenols to oquinones. The enzymes are mainly involved in the modification of tyrosine into L-3,4-dihydroxyphenyl-alanine (L-DOPA) and DOPA/DOPAquinone-drived intermolecular cross-linking, which play the key roles of pigmentation to the cells. It is ubiquitously distributed in microorganisms, plants, and animals all around the nature world. They are classified as copper- containing dioxygen activating enzymes; two copper ions are coordinated with six histidine residues in their active sites and they are distinguished as met-, deoxy-, and oxy-form depending on their oxidative states. Natural extraction and recombinant protein approaches have been tried to obtain practical amounts of the enzymes for industrial application. Tyrosinases have been widely applied to industrial and biomedical usages such as detoxification of waste water containing phenolic compounds, L-DOPA as a drug of Parkinson's disease, biomaterials preparation based on the cross-linking ability and biosensors for the detection of phenolic compounds. Therefore, this review reports the mechanism of tyrosinase, biochemical and structural features and potential applications in industrial field.

Analysis of effects of the roll forming process parameters of side sill (롤 포밍용 차체 부품 공정 변수 영향도 해석)

  • Kim, D.K.;Sohn, S.M.;Lee, K.H.;Lee, M.Y.
    • Proceedings of the Korean Society for Technology of Plasticity Conference
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    • 2007.10a
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    • pp.310-313
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    • 2007
  • In roll forming process, a sheet metal is continuously progressively formed into a product with required cross-section and longitudinal shape, such as a circular tube with required diameter, wall-thickness and straightness, by passing through a series of forming rolls in arranged in tandem. In this process, each pair of forming rolls installed in a forming machine play a particular role in making up the required cross-section and longitudinal shape of the product. In recent years, that process is often applied to the bumper rail in the automotive industries. In this study, a optimal roll flower model and proper roll-pass sequence can be suggested by analyzing courcenter strain and longitudinal strain according to the roll-pass with FEM simulation. And also effects of the process parameters on the final shape formed by roll forming defects a evaluated.

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The effect of mandibular position on measurement in spiral tomography (나선형 단층방사선사진촬영에서 하악골 위치가 측정치에 미치는 영향)

  • Jung Yun-Hoa
    • Imaging Science in Dentistry
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    • v.35 no.2
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    • pp.83-86
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    • 2005
  • Purpose : To evaluate the effect of deviation of mandibular positioning, by changing the mandibular plane inclination, on the measured height and width of mandible in spiral conventional tomography. Materials and Methods : By means of the Scanora multifunctional unit, cross-sectional tomograms were taken from two human dried mandibles at the mandibular angulations: -15 degree, -10 degree, -5 degree, and 0 degree. Twenty-eight sites in two dried mandibles were imaged. One examiner measured the bone heights and widths at selected sites on the images and the actual bone heights were recorded. Results : The bone heights at the four mandibular inclinations overestimated real bone heights and the mean difference between actual heights and image heights on 0 degrees was the smallest (P<0.01). The bone widths on -15 degrees were narrowest and there were significant differences between bone widths measured at the four mandibular inclinations (P<0.001). We found statistically significant differences between both bone heights and widths as measured according to the mandibular plane angle for the posterior region (P<0.01). Conclusion : The use of different mandibular positioning may result in discrepancies in heights and widths when measured from the cross-sectional tomographic images. It is suggested that the mandibular positioning may play a significant role in the measurement of mandibular heights and widths.

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The Psychiatrist and the Revolutionary: Frantz Fanon's Critique of Colonial Discourse

  • Rasmussen, Kim Su;Sorensen, Eli Park
    • Cross-Cultural Studies
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    • v.24
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    • pp.5-18
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    • 2011
  • This article offers a reflection on Frantz Fanon's diagnosis and analysis of French colonialism in Algeria. We will attempt to demonstrate that there is a concrete and clear connection between Fanon as the psychiatrist diagnosing the devastating effects of the French colonial system, and his subsequent political involvement in the Algerian revolution. This is not to say that each part does not contain valuable insights in their own rights, but rather to stress that without being read together, as a whole, one would miss a significant element in the understanding of the importance Fanon's thought subsequently came to play in the emancipation struggles of the colonized worldwide. Furthermore, we argue that it is crucial to understand the intimate connection between Fanon's psychiatric work, his diagnosis of colonial mental disorders, as well as diagnosis of the colonial system as such, and then his political engagement, in order to understand the particular context in which he favourably discusses the use of violence in the name of fighting against the oppressive system of colonialism. Above all, we argue that Fanon's critique of colonialism continues to spark controversy because it still represents the most powerful and incisive analysis of, as well as answer to, the troubled relationship between the blessed and the wretched of the earth.

A Study on the Buddhist Worldview and Aesthetics of Secular Humor in Jo Oh-Hyeon's Literature: With a Focus on For Vupasama(Extinction) (조오현 문학에 나타난 불교적 세계관과 세속적 해학미 - 『적멸을 위하여: 조오현문학전집』을 중심으로)

  • Lee, Chan
    • Cross-Cultural Studies
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    • v.35
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    • pp.155-184
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    • 2014
  • The present study aims at exploring in detail the Buddhist worldview and aesthetics of humor in Jo O-hyeon's literary works. This includes the same context as an elucidation of the ways in which his poems closely correspond in expressive forms and thematic contents. It is because, in Jo's literary world, where short poems and prose poems form a contrast, the expressive forms and thematic contents sharply differ depending on the ways in which prajnapti (provisional designation) is either foregrounded or backgrounded. In his literary world, when such a view of language and a worldview based on prajnapti are foregrounded, works that either inherit or play a variation on the fixed structure of the sijo emerge; and when they recede to the rear and are backgrounded, verses in the form of the prose poem are formulated. In addition, in Jo's literary works, where such a worldview of prajnapti and an aesthetics of secular humor intersect together, the thoughts on bheda-abheda(difference-non-difference) and the madhyama-pratipad (middle way) are formed. Such thoughts have considerable significance because they not only harbor a possibility of deconstructing and overcoming the opposition of the sacred/profane but also present a vision of a new unity.

(Per)Forming at the Threshold: Diasporic Imagination in Korean American Drama (횡단의 연극, 공연의 정치학: 한국계 미국드라마의 디아스포라적 상상력)

  • Choi, Sung Hee
    • Cross-Cultural Studies
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    • v.26
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    • pp.249-272
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    • 2012
  • Diaspora studies has become one of the fastest growing field in the humanities over the past several decades, and the use of term diaspora has been widening to include almost any population on the move. Diaspora literature not only mirrors but actively incorporates this new notion of diaspora with characters "at the threshold" navigating new territories and identities. Querying how diaspora studies intersects with theatre and performance, this paper attempts to probe how recent Korean American drama parallels and promotes diaspora studies' radical departure from traditional notions of identities and territories. For this purpose, this essay 1) examines theoretical affinities between diaspora studies and performance studies 2) investigates how Sung Rno's plays, Cleveland Raining and wAve, explore and embody multiple and evolving meanings of Korean diaspora on the stage 3) examines how theatre can create the third space that transcends both Korean and American nationalism and 4) speculates possibilities of reframing Asian American Studies as Asian diaspora studies. Korean American characters in Rno's play redirect diasporic identities, as their concern gradually moves from "where I come from" to "where I go to." Instead of remaining in the dark as a mere spectator, both Rno and his characters choose to be 'on' the stage where they can imagine, perform, and realize (however temporarily) "unimaginable community" by confronting their own social, political, and cultural ambivalence. Stage, the threshold between reality and fiction, Korea and America, and past and future, becomes their true 'home' where they incubate and precipitate "nation in transformation" that Yan Haiping argues for as "another transnational."

Anthropology of power and passion, active nihilism: theme analysis on Sung, Suk-je's novel

  • Lee, Chan
    • Cross-Cultural Studies
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    • v.28
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    • pp.37-53
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    • 2012
  • This paper examines 'an active nihilism' in Suk-je Sung's novels in detail. The focus of this study is formed from the critical mind in a critical perspective that in Korean novels before and after 2000s, characters who embody 'problematic individuals' of $Luk{\acute{a}}cs$ have disappeared and those close to 'active nihilists' has become the mainstream. The most representative example of this phenomenon is Suk-je Sung's novels. 'Active nihilists' in his novels are described as 'ascetics' who mastered various spheres such as 'billiard', 'baduk gambling', 'alcohol', 'dance', and 'book collecting', and so on. In the sense that they reject the transcendental conditions of the modern world and live in the space and time of play in which they can display their passion and potentiality to the maximum, they beings jumping over the 'reality principle'. Also, what they want to repeat is not the endless exchange of labor and capital according to the capitalist system of exchange but rather the repeated existence of their power and passion. This 'anthropology of power and passion' is 'active nihilism' which could be expressed as the 'subject of creating new value' and 'Dionysian affirmation' by Nietzsche. Suk-je Sung's novels sharply prove the stylistic essence of 'a novel' which has to create its own form every time, constantly renewing the narrative style of the past ideal model. In this respect, they are very problematic and his innovation of a form draws the attention. Further, this will certainly be the important object of research in the diachronic dimension of contemporary Korean novel.

Effective Method to Improve the Competence of the Vocabulary by the Image and Listening (이미지와 듣기자료를 중심으로 어휘력 향상을 위한 효율적 학습 적용 방안)

  • JUNG, Il Young
    • Cross-Cultural Studies
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    • v.38
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    • pp.461-500
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    • 2015
  • This study aims to investigate the effective method to improve the competence of the Vocabulary by the image and listening towards the ELF. In the first part, we observed the problems and point improvement on learning vocabulary based on learner survey. In the second part, we analyzed two remarkable studies: - consistent and adapt method, communicational context - method based on the lexical, morphological semantical, notional and thematic field Then we proposed effective methods that are applicable to the vocabulary's learning in the class : - learning vocabulary by combining the words - learning vocabulary based on the meaning field - learning vocabulary as concrete characters - learning vocabulary by the descriptive character - learning vocabulary with the type "who am I?" - learning vocabulary by listening For teachers, one of the difficulties to the conduct of vocabulary course is that learners take passive position. Specifically, it is the teachers who play an important role because it runs in the direction of the course. However, learners do not show the active attitude for vocabulary lessons despite the course to take to improve their vocabulary skills. Therefore, teachers must prepare course materials that can both improve the competence of the vocabulary of learners and cause their interest or desire on the current vocabulary. This is why teachers should exploit various materials depending on the skill level of the learner vocabulary.

An Intelligent Gold Price Prediction Based on Automated Machine and k-fold Cross Validation Learning

  • Baguda, Yakubu S.;Al-Jahdali, Hani Meateg
    • International Journal of Computer Science & Network Security
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    • v.21 no.4
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    • pp.65-74
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    • 2021
  • The rapid change in gold price is an issue of concern in the global economy and financial markets. Gold has been used as a means for trading and transaction around the world for long period of time and it plays an integral role in monetary, business, commercial and financial activities. More importantly, it is used as economic measure for the global economy and will continue to play an important economic vital role - both locally and globally. There has been an explosive growth in demand for efficient and effective scheme to predict gold price due its volatility and fluctuation. Hence, there is need for the development of gold price prediction scheme to assist and support investors, marketers, and financial institutions in making effective economic and monetary decisions. This paper primarily proposed an intelligent based system for predicting and characterizing the gold market trend. The simulation result shows that the proposed intelligent gold price scheme has been able to predict the gold price with high accuracy and precision, and ultimately it has significantly reduced the prediction error when compared to baseline neural network (NN).

Factors associated with the prescription of probiotics in patients with inflammatory bowel disease: a cross-sectional study

  • Joo Kyung Kim;Jae Hee Cheon
    • Journal of Yeungnam Medical Science
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    • v.40 no.1
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    • pp.37-48
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    • 2023
  • Background: Commensal bacteria play an important role in the pathogenesis of inflammatory bowel disease (IBD) and probiotics have been used as treatment options. We aimed to explore the current use of probiotics and factors associated with their prescription in patients with IBD. Methods: This cross-sectional study was conducted on a single hospital-based cohort. Patients were eligible if they were ≥18 years old, visited the IBD clinic as an outpatient more than twice during the study period, and had a confirmed diagnosis of IBD. Patients were divided into two groups based on the prescription of probiotics. Clinical assessments were compared between the two groups. Results: In total, 217 patients were enrolled in this study. In patients with Crohn disease (CD), moderate or severe abdominal pain; prior use of methotrexate (MTX), iron, thiopurines, or biologics; history of IBD-related surgery; and stool frequency were independently associated with the prescription of probiotics. In patients with ulcerative colitis (UC), moderate or severe abdominal pain, hematochezia, stool frequency, and moderate or severe physician global assessment score were independently associated with the prescription of probiotics. Conclusion: Increased disease activity may be associated with fewer prescriptions of probiotics in patients with IBD. However, physicians prescribed probiotics to control symptoms, such as abdominal pain and increased stool frequency in patients with UC and CD, and hematochezia in patients with UC. Additionally, the use of MTX and iron, and a history of IBD-related surgeries were associated with more frequent probiotic prescriptions in patients with CD.