• 정신간호학회지
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• 제27권4호
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• pp.406-414
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• 2018

Purpose: The purpose of this study was to investigate the relationship between cell phone dependency and aggression in elementary school students with the mediating effect of leisure activities in South Korea. Methods: Data were cross-sectional in study design with 1,555 fourth grade elementary school students participating in the 4th-year Korean Children and Youth Panel Survey. Data analysis was performed using the SPSS/WIN 23.0 and AMOS 21.0 program. Results: Cell phone dependency has a significant effect on aggression, but it did not act as a control variable in the relationship between the protective factor, weekly book reading time and the amount of daytime play with aggression. Weekly entertainment time and weekly TV and video viewing time had a significant statistical effect on aggression, thus this study confirmed that cell phone dependency acts as a control variable in relation to aggression. Conclusion: As the entertainment time for elementary school students, the time spent watching TV and videos play a negative role, it is necessary to prepare a leisure activity management practice and strategies with an emphasis on entertainment time as well as, TV and video viewing as elementary school students' leisure activities for a healthy school life.

• Journal of Preventive Medicine and Public Health
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• 제52권1호
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• pp.60-65
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• 2019

Objectives: This study examined cancer knowledge, beliefs, and practice among faith-based Chinese in the USA versus Taiwan to gain better understandings on how environment and culture might play a role for tailored cancer education programs. Methods: A self-administered survey included a validated 10-item Cancer Screening Belief Scale (CSBS), an 8-item Cancer Screening Knowledge Test (CSKT), and a 14-item cancer Warning Signs Test (CWST) was administered. Participants were recruited from 9 Chinese churches (5 in the USA and 4 in Taiwan). Results: A total of 372 Chinese participated, 50% lived in the USA and 50% in Taiwan. Mean age was 44.31 (standard deviation, 14.74), 60% males, and majority had college education (85%). Taiwan participants scored higher on both CSKT (6.13 vs. 5.52; p<0.001) and CWST (6.80 vs. 5.38; p<0.001). Although perceived screening benefits and barriers were similar, Taiwan participants endorsed higher on screening norms (11.67 vs. 10.82; p<0.001). Taiwan participants also indicated more doctor recommending cancer screenings (42.1% vs. 29.6%; p=0.015), USA participants were more likely to have had annual health exams (65.4% vs. 48.9%; p=0.002). Regression results showed that those resided in the USA were 2.38 times more likely to report annual health exams. Married status (odds ratio [OR], 2.85), college education (OR, 2.38), doctor's recommendation (OR, 2.87), no family cancer history (OR, 2.47), and those with lower barriers were significant factors on annual health exams. Conclusions: Taiwan participants scored higher on cancer knowledge and screening norms, while more USA participants reported annual health exams. Taiwan's universal healthcare might play a role on the different healthcare seeking patterns.

• Journal of Audiology & Otology
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• 제23권3호
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• pp.121-128
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• 2019

Background and Objectives: There is a scant evidence on the use of simulations in audiology (especially in Malaysia) for case-history taking, although this technique is widely used for training medical and nursing students. Feedback is one of the important components in simulations training; however, it is unknown if feedback by instructors could influence the simulated patient (SP) training outcome for case-history taking among audiology students. Aim of the present study is to determine whether the SP training with feedback in addition to the standard role-play and seminar training is an effective learning tool for audiology case-history taking. Subjects and Methods: Twenty-six second-year undergraduate audiology students participated. A cross-over study design was used. All students initially attended two hours of seminar and role-play sessions. They were then divided into three types of training, 1) SP training (Group A), 2) SP with feedback (Group B), and 3) a non-additional training group (Group C). After two training sessions, the students changed their types of training to, 1) Group A and C: SP training with feedback, and 2) Group B: non-additional training. All the groups were assessed at three points: 1) pre-test, 2) intermediate, and 3) post-test. The normalized median score differences between and within the respective groups were analysed using non-parametric tests at 95% confidence intervals. Results: Groups with additional SP trainings (with and without feedback) showed a significantly higher normalized gain score than no training group (p<0.05). Conclusions: The SP training (with/without feedback) is a beneficial learning tool for history taking to students in audiology major.

• 대한청각학회지
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• 제23권3호
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• pp.121-128
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• 2019

Background and Objectives: There is a scant evidence on the use of simulations in audiology (especially in Malaysia) for case-history taking, although this technique is widely used for training medical and nursing students. Feedback is one of the important components in simulations training; however, it is unknown if feedback by instructors could influence the simulated patient (SP) training outcome for case-history taking among audiology students. Aim of the present study is to determine whether the SP training with feedback in addition to the standard role-play and seminar training is an effective learning tool for audiology case-history taking. Subjects and Methods: Twenty-six second-year undergraduate audiology students participated. A cross-over study design was used. All students initially attended two hours of seminar and role-play sessions. They were then divided into three types of training, 1) SP training (Group A), 2) SP with feedback (Group B), and 3) a non-additional training group (Group C). After two training sessions, the students changed their types of training to, 1) Group A and C: SP training with feedback, and 2) Group B: non-additional training. All the groups were assessed at three points: 1) pre-test, 2) intermediate, and 3) post-test. The normalized median score differences between and within the respective groups were analysed using non-parametric tests at 95% confidence intervals. Results: Groups with additional SP trainings (with and without feedback) showed a significantly higher normalized gain score than no training group (p<0.05). Conclusions: The SP training (with/without feedback) is a beneficial learning tool for history taking to students in audiology major.

• 대한화장품학회지
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• 제34권1호
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• pp.43-50
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• 2008

세라마이드는 콜레스테롤, 지방산과 함께 각질층을 구성하는 주요성분으로 각질층의 피부장벽 기능에 중요한 역할을 하며, 아토피 피부염, 건선, 건성습진, 주부습진 등과 같은 염증성 피부질환 방지에 도움이 되는 것으로 알려져 있다. 본 연구에서 2-(2-amino-ethylamino)-ethanol(AEEA)을 출발물질로 하여 신규 유사세라마이드 BPC-16을 합성하고, 그 물리화학적 성질과 화장품의 신규 소재로 활용하기 위하여 세포독성, 보습, 각질제거효능 등을 평가하였다. 합성된 BPC-16을 이용하여 콜레스테롤, 스테아린산을 포함하는 에멀젼을 제조했고, 편광현미경에서 'Maltese Cross'를 확인함으로써 BPC-1이 라멜라 에멀젼을 형성함을 확인하였다. 단층배양세포와 삼차원배양세포에서의 세포독성 실험에서 BPC-16은 보습과 피부손상회복 효과를 보이는 10 mM 이하의 농도에서 독성이 없음을 확인하였다. BPC-16의 보습효능을 확인하기 위하여 Vapormeter와 Corneometer를 이용하여 임상실험을 실시하였으며, 우수한 효과를 확인할 수 있었다. 또한, 피부손상에 대한 회복효과와 Visioscan을 이용한 각질량의 변화 실험에서도 우수한 효과를 확인하였다.

• Journal of Microbiology and Biotechnology
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• 제21권6호
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• pp.617-626
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• 2011

Transglutaminase from Streptomyces mobaraensis is an enzyme of unknown function that cross-links proteins to high molecular weight aggregates. Previously, we characterized two intrinsic transglutaminase substrates with inactivating activities against subtilisin and dispase. This report now describes a novel substrate that inhibits papain, bromelain, and trypsin. Papain was the most sensitive protease; thus, the protein was designated Streptomyces papain inhibitor (SPI). To avoid transglutaminase-mediated glutamine deamidation during culture, SPI was produced by Streptomyces mobaraensis at various growth temperatures. The best results were achieved by culturing for 30-50 h at $42^{\circ}C$, which yielded high SPI concentrations and negligibly small amounts of mature transglutaminase. Transglutaminasespecific biotinylation displayed largely unmodified glutamine and lysine residues. In contrast, purified SPI from the $28^{\circ}C$ culture lost the potential to be cross-linked, but exhibited higher inhibitory activity as indicated by a significantly lower $K_i$ (60 nM vs. 140 nM). Despite similarities in molecular mass (12 kDa) and high thermostability, SPI exhibits clear differences in comparison with all members of the wellknown family of Streptomyces subtilisin inhibitors. The neutral protein (pI of 7.3) shares sequence homology with a putative protein from Streptomyces lavendulae, whose conformation is most likely stabilized by two disulfide bridges. However, cysteine residues are not localized in the typical regions of subtilisin inhibitors. SPI and the formerly characterized dispase-inactivating substrate are unique proteins of distinct Streptomycetes such as Streptomyces mobaraensis. Along with the subtilisin inhibitory protein, they could play a crucial role in the defense of vulnerable protein layers that are solidified by transglutaminase.

• IMMUNE NETWORK
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• 제3권1호
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• pp.8-15
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• 2003

Background: CD30 is a member of TNF receptor family and expressed on lymphocytes and other hematopoietic cells following activation as well as Hodgkin and Reed-Sternberg cells in Hodgkin's lymphoma. In this study, CD30-mediated regulation of cell adhesion molecule expression on normal activated mouse T cells was investigated. Methods: Mouse T cells were activated with anti-CD3 antibody for induction of CD30, which was cross-linked by immobilized anti-CD30 antibody. Results: High level of CD30 expression on T cells was observed on day 5, but only little on day 3 even under culture condition resulting in an identical T cell proliferation, indicating that CD30 expression requires a prolonged stimulation up to 5 days. Cross-linking of CD30 alone altered neither proliferation nor apoptosis of normal activated T cells. Instead, CD30 appeared to promote cell adherence to culture substrate, and considerably upregulated ICAM-1 and, to a lesser extent, ICAM-2 expression on activated T cells, whereas CD2 and CD18 (LFA-1) expression was not affected. None of cytokines known as main regulators of ICAM-1 expression on tissue cells (IL 4, $IFN{\gamma}$ and $IFN{\alpha}$) enhanced ICAM-1 expression in the absence of CD30 signals. On the other hand, addition of $NF-{\kappa}B$ inhibitor, PDTC (0.1 mM) completely abrogated the CD30-mediated upregulation of ICAM-1 expression, but not CD2 and ICAM-2 expression. Conclusion: This results support that CD30 upregulates ICAM-1 expression of T cell and such regulation is not mediated by higher cytokine production but $NF-{\kappa}B$ activation. Therefore, CD30 may play important roles in T-T or T-B cell interaction through regulation of ICAM-1, and -2 expression.

• 대한토목학회논문집
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• 제7권1호
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• pp.121-129
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• 1987

본(本) 논문(論文)은 홍수(洪水)터 관리면(管理面)에 중요(重要)한 역할(役割)을 하는 하천단면(河川斷面)에서 유량(流量)의 분포형태(分布形態)와 홍수(洪水)터에 영향을 주는 여러 인자(因子)들에 대해 분석(分析)하였으며, 그 결과(結果)는 다음과 같다. 만제수위(滿堤水位)의 재현기간(再現期間)은 금강유역(錦江流域)에서는 1~2.5년(年)에 해당됨을 알았으며, 또한 $Q_{100}$, 유역면적(流域面積), 하천(河川)길이 들이 홍수(洪水)터에 가장 크게 영향을 주는 인자(因子)들로 밝혀졌으며, 휴식공간(休息空間)을 가진 공주지점(公州地點)의 통수능(通水能)은 금강(錦江)에 있어서의 다른 자기수위표지점(自己水位標地點) 값보다 더 작으며, 이는 복합단면(複合斷面)이 홍수(洪水)터에 있어서의 통수능(通水能) 분포(分布)에 중요(重要)한 역할(役割)이 됨을 알 수 있다.

• Wind and Structures
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• 제23권6호
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• pp.595-613
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• 2016

Large amplitude oscillation of steepled main cables usually presents during construction of a long-span bridge. To study this phenomenon, six typical main cables with different cross sections during construction are investigated. Two main foci have been conducted. Firstly, aerodynamic coefficients of a main cable are obtained and compared through simulation and wind tunnel test: (1) to ensure the simulation accuracy, influences of the numerical model's grid size, and the jaggy edges of main cable's cross section on main cable's aerodynamic coefficients are investigated; (2) aerodynamic coefficients of main cables at different wind attack angles are obtained based on the wind tunnel test in which the experimental model is made by rigid plastic using the 3D Printing Technology; (3) then numerical results are compared with wind tunnel test results, and they are in good agreement. Secondly, aerodynamic coefficients of the six main cables at different wind attack angles are obtained through numerical simulation. Then Den Hartog criterion is used to analyze the transverse galloping of main cables during construction. Results show all the six main cables may undergo galloping, which may be an important reason for the large amplitude oscillation of steepled main cables during construction. The flow structures around the main cables indicate that the characteristic of the airflow trajectory over a steepled main cable may play an important role in the galloping generation. Engineers should take some effective measures to control this harmful phenomenon due to the big possibility of the onset of galloping during the construction period.

• 한국주거학회논문집
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• 제6권2호
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• pp.181-189
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• 1995

It is thought as more important for us to understand foreign countrie's culture in the modern society. because the world is becoming closer day by day thiough the develepment of communication and mass-media. Cross-cultural study could play a role to give an opportunity for people to understand foreign countrie’s culture easily.In this respect, this study was planned to find out similarity and difference between Danish and Korean folk tables made and used before the 20th century during the 18th-l9th century as a part of the comparative study of folk furniture between the two countries. It would be very interesting if we could find something valuable between Danish and Korean folk furniture. because they are located very far away each other geographically with less cultural communication before.There were more differences than similarity between the folk tables of the two countries and major findings were as followings : Firstly, there were many kinds of space-saving tables in Denmark. whereas only a few kinds of tables which could be removed easily after their usage were found in KoreaSecondly, Banish folk tables were more emphasized on the function rather than decoration. Whereas Korean folk tables were smaller lower and more decorative than Danish ones to fit their life-style of sitting on the floor.Thirdly, many Danish folk tables were made of bare wood. while Korean ones were finished by transparent lacquer or vegetable oil. Stone tops if tables were rare in both countries. Lastly. there were common factors in the design of legs of folk tables in both countries. It was interesting that animal legs such as deg tiger cat. lion, and eagle were used for design motif of the table legs. But trestle leg, cross leg and gate leg were not found in Korean folk tables. As a conclusion, throughout this study, it became obvious that life-style was one of the most important factor influencing on the design of furniture.