• Title/Summary/Keyword: Cross bridge dynamics

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Mechanical Analysis of heart muscle using a computational model of cardiac myocyte (심근세포 모델을 이용한 심장근육의 역학적 분석)

  • 심은보;김헌영;임채헌
    • Proceedings of the Korean Society of Precision Engineering Conference
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    • 2004.10a
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    • pp.1176-1179
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    • 2004
  • A new cell-cross bridge mechanics model is proposed to analyze the mechanics of heart muscle. Electrophysiology of a cardiac cell is numerically approximated using the previous model of human ventricular myocyte. Ion transports across cell membrane initiated by action potential induce excitation-contraction mechanism in the cell via cross bridge dynamics. Negroni and Lascano model (NL model) is employed to compute the tension of cross bridge closely related to ion dynamics in cytoplasm.

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Numerical analysis of the effect of the age-related increase of arterial wall stiffness on the Cross-bridge dynamics of the cardiac myocyte (노화에 따른 동맥벽 탄성도 저하가 심실세포의 Cross-bridge 동역학에 미치는 영향에 대한 수치적 연구)

  • Jun, Hyung-Min;Shim, Eun-Bo
    • Proceedings of the KSME Conference
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    • 2008.11a
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    • pp.1674-1678
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    • 2008
  • 본 연구에서는 심장의 세포 변화에서부터 혈류 순환의 시스템 변화까지 일련의 과정을 시뮬레이션 할 수 있는 통합모델을 개발하였다. 본 통합 모델을 이용하여 대동맥의 탄성도 변화 따른 Pulse Wave Velocity를 추정하였으며 심근의 수축 Mechanics의 변화를 시뮬레이션 하였다. 심장은 단순한 구 형상으로 모델링 되었다. 특히 동맥순환의 특성인 Wave propagation 과 Wave deflection의 현상을 모델링하기 위해 기존 모델에서 사용된 동맥계 순환 모델을 수정하였다. 즉 기존의 동맥 모델을 1차원의 운동방정식과 연속방정식을 기반으로 하는 Distributed arterial model로 대체하였다. Distributed arterial model은 혈액의 점성에 의한 에너지 손실, 혈관의 점탄성 효과 그리고 분지 되는 혈관에서의 에너지 손실을 포함하는 정교한 동맥 순환 모델이다. 정교한 동맥계 순환 모델의 동맥 탄성도 값을 조절함으로써 탄성도 변화에 대한 PWV를 계산 할 수 있었다. 이러한 수치적 방법을 사용하여 노화에 따른 동맥벽 탄성도의 저하가 심근세포의 Cross-bridge 동역학에 미치는 영향을 시뮬레이션 하였다.

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Static aerodynamic force coefficients for an arch bridge girder with two cross sections

  • Guo, Jian;Zhu, Minjun
    • Wind and Structures
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    • v.31 no.3
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    • pp.209-216
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    • 2020
  • Aiming at the wind-resistant design of a sea-crossing arch bridge, the static aerodynamic coefficients of its girder (composed of stretches of π-shaped cross-section and box cross-section) were studied by using computational fluid dynamics (CFD) numerical simulation and wind tunnel test. Based on the comparison between numerical simulation, wind tunnel test and specification recommendation, a combined calculation method for the horizontal force coefficient of intermediate and small span bridges is proposed. The results show that the two-dimensional CFD numerical simulations of the individual cross sections are sufficient to meet the accuracy requirements of engineering practice.

Nonlinear fluid-structure interaction of bridge deck: CFD analysis and semi-analytical modeling

  • Grinderslev, Christian;Lubek, Mikkel;Zhang, Zili
    • Wind and Structures
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    • v.27 no.6
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    • pp.381-397
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    • 2018
  • Nonlinear behavior in fluid-structure interaction (FSI) of bridge decks becomes increasingly significant for modern bridges with increasing spans, larger flexibility and new aerodynamic deck configurations. Better understanding of the nonlinear aeroelasticity of bridge decks and further development of reduced-order nonlinear models for the aeroelastic forces become necessary. In this paper, the amplitude-dependent and neutral angle dependent nonlinearities of the motion-induced loads are further highlighted by series of computational fluid dynamics (CFD) simulations. An effort has been made to investigate a semi-analytical time-domain model of the nonlinear motion induced loads on the deck, which enables nonlinear time domain simulations of the aeroelastic responses of the bridge deck. First, the computational schemes used here are validated through theoretically well-known cases. Then, static aerodynamic coefficients of the Great Belt East Bridge (GBEB) cross section are evaluated at various angles of attack, leading to the so-called nonlinear backbone curves. Flutter derivatives of the bridge are identified by CFD simulations using forced harmonic motion of the cross-section with various frequencies. By varying the amplitude of the forced motion, it is observed that the identified flutter derivatives are amplitude-dependent, especially for $A^*_2$ and $H^*_2$ parameters. Another nonlinear feature is observed from the change of hysteresis loop (between angle of attack and lift/moment) when the neutral angles of the cross-section are changed. Based on the CFD results, a semi-analytical time-domain model for describing the nonlinear motion-induced loads is proposed and calibrated. This model is based on accounting for the delay effect with respect to the nonlinear backbone curve and is established in the state-space form. Reasonable agreement between the results from the semi-analytical model and CFD demonstrates the potential application of the proposed model for nonlinear aeroelastic analysis of bridge decks.

Prediction of Aerodynamic Coefficients of Bridges Using Computational Fluid Dynamics (전산유체역학 해석에 의한 교량 단면의 공력 특성값 추정)

  • Hong, Young-Kil
    • Journal of the Korean Society of Safety
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    • v.28 no.1
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    • pp.57-62
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    • 2013
  • Aerodynamic characteristics of cross section shape is an important parameter for the wind response and structural stability of long span bridges. Numerical simulation methods have been introduced to estimate the aerodynamic characteristics for more detailed flow analysis and cost saving in place of existing wind tunnel experiment. In this study, the computational fluid dynamics(CFD) simulation and large eddy simulation( LES) technique were used to estimate lift, drag and moment coefficients of four cross sections. The Strouhal numbers were also determined by the fast Fourier transform of time series of the lift coefficient. The values from simulations and references were in a good agreement with average difference of 16.7% in coefficients and 8.5% in the Strouhal numbers. The success of the simulations is expected to attribute to the practical use of numerical estimation in construction engineering and wind load analysis.

A Multi-scale Simulation Model of Circulation Combining Cardiovascular Hemodynamics with Cardiac Cell Mechanism (심근세포-심혈관계 혈류역학이 결합된 복합적 순환계 모델에 관한 연구)

  • Ko Hyung Jong;Leem Chae Hun;Shim Eun Bo
    • Journal of Institute of Control, Robotics and Systems
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    • v.10 no.12
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    • pp.1164-1171
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    • 2004
  • A new multi-scale simulation model is proposed to analyze heart mechanics. Electrophysiology of a cardiac cell is numerically approximated using the previous model of human ventricular myocyte. The ion transports across cell membrane initiated by action potential induce an excitation-contraction mechanism in the cell via cross bridge dynamics. Negroni and Lascano model (NL model) is employed to calculate the tension of cross bridge which is closely related to the ion dynamics in cytoplasm. To convert the tension on cell level into contraction force of cardiac muscle, we introduce a simple geometric model of ventricle with a thin-walled hemispheric shape. It is assumed that cardiac tissue is composed of a set of cardiac myocytes and its orientation on the hemispheric surface of ventricle remains constant everywhere in the domain. Application of Laplace law to the ventricle model enables us to determine the ventricular pressure that induces blood circulation in a body. A lumped parameter model with 7 compartments is utilized to describe the systemic circulation interacting with the cardiac cell mechanism via NL model and Laplace law. Numerical simulation shows that the ion transports in cell level eventually generate blood hemodynamics on system level via cross bridge dynamics and Laplace law. Computational results using the present multi-scale model are well compared with the existing ones. Especially it is shown that the typical characteristics of heart mechanics, such as pressure volume relation, stroke volume and ejection fraction, can be generated by the present multi-scale cardiovascular model, covering from cardiac cells to circulation system.

Numerical investigations on the effect of mean incident wind on flutter onset of bridge deck sections

  • Keerthana, M.;Harikrishna, P.
    • Structural Engineering and Mechanics
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    • v.82 no.4
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    • pp.517-542
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    • 2022
  • The effect of mean angle of wind attack on the flutter critical wind speed of two generic bridge deck cross-sections, viz, one closed box type streamlined section (deck-1) and closed box trapezoidal bluff type section with extended flanges/overhangs (deck-2) type of section have been studied using Computational Fluid Dynamics (CFD) based forced vibration simulation method. Owing to the importance of the effect of the amplitude of forcing oscillation on the flutter onset, its effect on the flutter derivatives and flutter onset have been studied, especially at non-zero mean angles of wind attack. The flutter derivatives obtained have been used to evaluate flutter critical wind speeds and flutter index of the deck sections at non-zero mean angles of wind attack studied and the same have been validated with those based on experimental results reported in literature. The value of amplitude of forcing oscillation in torsional degree of freedom for CFD based simulations is suggested to be in the range of 0.5° to 2°, especially for bluff bridge deck sections. Early onset of flutter from numerical simulations, thereby conservative estimate of occurrence of instability has been observed from numerical simulations in case of bluff bridge deck section. The study aids in gaining confidence and the extent of applicability of CFD during early stages of bridge design, especially towards carrying out studies on mean incident wind effects.

Flutter performance of central-slotted plate at large angles of attack

  • Tang, Haojun;Li, Yongle;Chen, Xinzhong;Shum, K.M.;Liao, Haili
    • Wind and Structures
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    • v.24 no.5
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    • pp.447-464
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    • 2017
  • The flutter instability is one of the most important themes need to be carefully investigated in the design of long-span bridges. This study takes the central-slotted ideal thin flat plate as an object, and examines the characteristics of unsteady surface pressures of stationary and vibrating cross sections based on computational fluid dynamics (CFD) simulations. The flutter derivatives are extracted from the surface pressure distribution and the critical flutter wind speed of a long span suspension bridge is then calculated. The influences of angle of attack and the slot ratio on the flutter performance of central-slotted plate are investigated. The results show that the critical flutter wind speed reduces with increase in angle of attack. At lower angles of attack where the plate shows the characteristics of a streamlined cross-section, the existence of central slot can improve the critical flutter wind speed. On the other hand, at larger angles of attack, where the plate becomes a bluff body, the existence of central slot further reduces the flutter performance.

Analysis on running safety of train on bridge with wind barriers subjected to cross wind

  • Zhang, T.;Xia, H.;Guo, W.W.
    • Wind and Structures
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    • v.17 no.2
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    • pp.203-225
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    • 2013
  • An analysis framework for vehicle-bridge dynamic interaction system under turbulent wind is proposed based on the relevant theory of wind engineering and dynamics. Considering the fluctuating properties of wind field, the stochastic wind velocity time history is simulated by the Auto-Regressive method in terms of power spectral density function of wind field. The bridge is represented by three-dimensional finite element model and the vehicle by a multi-rigid-body system connected by springs and dashpots. The detailed calculation formulas of unsteady aerodynamic forces on bridge and vehicle are derived. In addition, the form selection of wind barriers, which are applied as the windbreak measures of newly-built railways in northwest China, is studied based on the suggested evaluation index, and the suitable values about height and porosity rate of wind barriers are studied. By taking a multi-span simply-supported box-girder bridge as a case study, the dynamic response of the bridge and the running safety indices of the train traveling on the bridge with and without wind barriers are calculated. The limit values of train speed with respect to different wind velocities are proposed according to the allowance values in the design code.