• Bulletin of the Korean Chemical Society
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• 제32권12호
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• pp.4397-4402
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• 2011

The NF-${\kappa}B$ system of transcription factors plays a crucial role in inflammatory diseases, making it an important drug target. We combined quantitative structure activity relationships for predicting the activity of new compounds and quantitative dynamic models for the NF-${\kappa}B$ network with intracellular concentration models. GFA-MLR QSAR analysis was employed to determine the optimal QSAR equation. To validate the predictability of the $IKK{\beta}$ QSAR model for an external set of inhibitors, a set of ordinary differential equations and mass action kinetics were used for modeling the NF-${\kappa}B$ dynamic system. The reaction parameters were obtained from previously reported research. In the IKKb QSAR model, good cross-validated $q^2$ (0.782) and conventional $r^2$ (0.808) values demonstrated the correlation between the descriptors and each of their activities and reliably predicted the $IKK{\beta}$ activities. Using a developed simulation model of the NF-${\kappa}B$ signaling pathway, we demonstrated differences in $I{\kappa}B$ mRNA expression between normal and different inhibitory states. When the inhibition efficiency increased, inhibitor 1 (PS-1145) led to long-term oscillations. The combined computational modeling and NF-${\kappa}B$ dynamic simulations can be used to understand the inhibition mechanisms and thereby result in the design of mechanism-based inhibitors.

• 센서학회지
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• 제19권2호
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• pp.99-111
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• 2010

This paper proposes an efficient hardware architecture to estimate disparities between 2D images for generating 3D depth images in a stereo vision system. Stereo matching methods are classified into global and local methods. The local matching method uses the cost functions based on pixel windows such as SAD(sum of absolute difference), SSD(sum of squared difference) and NCC(normalized cross correlation). The NCC-based cost function is less susceptible to differences in noise and lighting condition between left and right images than the subtraction-based functions such as SAD and SSD, and for this reason, the NCC is preferred to the other functions. However, software-based implementations are not adequate for the NCC-based real-time stereo matching, due to its numerous complex operations. Therefore, we propose a fast pipelined hardware architecture suitable for real-time operations of the NCC function. By adopting a block-based box-filtering scheme to perform NCC operations in parallel, the proposed architecture improves processing speed compared with the previous researches. In this architecture, it takes almost the same number of cycles to process all the pixels, irrespective of the window size. Also, the simulation results show that its disparity estimation has low error rate.

• Structural Engineering and Mechanics
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• 제43권2호
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• pp.179-197
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• 2012

This study presents the findings of the structural health monitoring and the real time system identification of one of the first large scale building instrumentations in Turkey for earthquake safety. Within this context, a thorough review of steps in the instrumentation, monitoring is presented and seismic performance evaluation of structures using both nonlinear pushover and nonlinear dynamic time history analysis is carried out. The sensor locations are determined using the optimal sensor placement techniques used in NASA for on orbit modal identification of large space structures. System identification is carried out via the stochastic subspace technique. The results of the study show that under ambient vibrations, stocky buildings can be substantially stiffer than what is predicted by the finite element models due to the presence of a large number of partitioning walls. However, in a severe earthquake, it will not be safe to rely on this resistance due to the fact that once the partitioning walls crack, the bare frame contributes to the lateral stiffness of the building alone. Consequently, the periods obtained from system identification will be closer to those obtained from the FE analysis. A technique to control the validity of the proportional damping assumption is employed that checks the presence of phase difference in displacements of different stories obtained from band pass filtered records and it is confirmed that the "proportional damping assumption" is valid for this structure. Two different techniques are implemented for identifying the influence of the soil structure interaction. The first technique uses the transfer function between the roof and the basement in both directions. The second technique uses a pre-whitening filter on the data obtained from both the basement and the roof. Subsequently the impulse response function is computed from the scaled cross correlation between the input and the output. The overall results showed that the structure will satisfy the life safety performance level in a future earthquake but some soil structure interaction effects should be expected in the North South direction.

• 대한간호학회지
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• 제46권1호
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• pp.19-28
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• 2016

Purpose: The purpose of this study was to test the mediating effect of psychological distress in the relationship between chemotherapy related cognitive impairment (CRCI) and quality of life (QOL) in people with cancer. Methods: A purposive sample of 130 patients undergoing chemotherapy was recruited for the cross-sectional survey design. Data were collected from November 2014 to June 2015. The instruments were K-MMSE (Korean Mini-Mental State Examination), Everyday Cognition (ECog), Hospital Anxiety Depression Scale (HADS), and Functional Assessment of Cancer Therapy-General (FACT-G). Data were analyzed using descriptive statistics, correlation, and multiple regression using Baron and Kenny steps for mediation. Results: The mean score for objective cognitive function was 27.95 and 69.32 for perceived cognitive decline. Overall quality of life was 91.74. The mean score was 17.52 for psychological distress. The prevalence was 56.2% for anxiety and 63.1% for depression, and 20.0% for CRCI. There were significant correlations among the variables, objective cognitive function and self-reported cognitive decline, psychological distress, and quality of life. Psychological distress was directly affected by CRCI. ($R^2=29%$). QOL was directly affected by CRCI. Psychological distress and CRCI effected QOL ($R^2=43%$). Psychological distress had a partial mediating effect (${\beta}=-.56$, p <.001) in the relationship between self-reported cognitive decline and quality of life (Sobel test: Z= -5.08, p <.001). Conclusion: Based on the findings of this study, nursing intervention programs focusing on managing cognitive decline, and decreasing psychological distress are highly recommended to improve quality of life in cancer patients.

• 한국임상보건과학회지
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• 제7권2호
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• pp.1298-1307
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• 2019

Purpose. This study was to correlations between oral health education experience and subjective oral health level of elderly in Yeongnam region. Methods. The data were collected from 254 elderly in Yeongnam region. Data analysis was performed using cross Analysis, t-test(One-way ANOVA), logistic regression by SPSS WIN 17.0 program. Results. According to the general characteristics of the study subjects, 42.8% of those under 75 years and 57.2% of those over 75 years of age had never been educated, 50.7% of living expenses less than 1 million won and 37.3% of those below 2 million won had never received oral health education (p<.05). The differences in subjective oral health levels with or without oral health education experience showed higher limitations of function and impairment of social psychic function in the elderly with no experience than those with oral health education experience(p<.05). Correlation between oral health education experience and subjective health level of the elderly showed a positive relationship with each factor, meaning that the subjective oral health level was higher with oral health education(p<.05). Subjective oral health levels for functional limitations or social and psychological disorders were high in the elderly without oral health education(p<.05). Conclusion. Considering the impact of oral health education experience on the subjective oral health level of the elderly as above, we should develop various continuous and systematic programs that can increase prevention and post-education practices for the increase of education beneficiaries through diverse approaches to enhance their usability.

• Physical Therapy Rehabilitation Science
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• 제8권2호
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• pp.79-85
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• 2019

Objective: The purpose of this study was to investigate the relationship between physical features, strength, function, and upper extremity musculoskeletal pain during rehabilitation of manual wheelchair users with spinal cord injuries. Design: Cross-sectional study. Methods: The degree and frequency of upper extremity musculoskeletal pain were measured in persons with spinal cord injuries using manual wheelchairs with the use of questionnaires. The pain scores of the hand, wrist, and shoulder joints were calculated by multiplying the seriousness and frequency of pain. We collected data on the manual muscle test, Spinal Cord Independent Measure-III, and the Body Mass Index. Statistical analysis was performed by descriptive analysis and Pearson's correlation analysis. Results: A total of 47 patients participated in this study and the neurological level of the injuries ranged from C2 to S5. Pain in the shoulder joints was the most common in persons with tetraplegia and paraplegia. Pain was experienced as mild to moderate, and occurred one or more times a week. Of the 32 persons with paraplegia, the most common area of complaint was the shoulder. Of the 15 persons with paraplegia, the shoulder joints were the most common site of pain. The independence levels of the persons with spinal cord injuries were highly correlated to muscle strength levels (p<0.05). Conclusions: This study investigated upper extremity musculoskeletal pain during rehabilitation of manual wheelchair users with spinal cord injuries and the relationship between physical features, strength, and function. In most persons with spinal cord injuries, pain and frequency of shoulder joints were high and pain levels were also related to functional levels.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제27권4호
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• pp.215-223
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• 2024

Purpose: Patients who receive frequent blood transfusions are at an elevated risk of developing hepatic fibrosis due to iron overload in the liver. In this study, we evaluated the effectiveness of transient elastography (TE) (FibroScan^®) for assessing liver fibrosis in patients with pediatric cancer. Methods: We enrolled 106 consecutive cases of acute leukemia in individuals under 21 years of age. The participants were followed for 2 years. Based on their serum ferritin (SF) levels, the patients were divided into two groups: group 1 (SF≥300 ng/mL) and group 2 (SF<300 ng/mL). A liver FibroScan^® was performed, and a p-value of less than 0.05 was considered statistically significant. Results: Among the various parameters in the liver function test (LFT), alkaline phosphatase was significantly higher in a subgroup of patients aged 5-8 years in group 2 compared to those in group 1. The indices of liver fibrosis determined by TE, including the FibroScan score, controlled attenuation parameter score, steatosis percentage, and meta-analysis of histological data in viral hepatitis score, as well as indirect serum markers of liver fibrosis such as the aminotransferase (AST)/alanine aminotransferase (ALT) ratio, Fibrosis 4 score, and AST to platelet ratio index, did not differ significantly between the two groups. The association between the TE results and LFT parameters was only significant for ALT. Conclusion: Transfusion-associated iron overload does not have a significant correlation with severe liver fibrosis. FibroScan^® is not a sensitive tool for detecting early stages of fibrosis in survivors of pediatric leukemia.

• Physical Therapy Rehabilitation Science
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• 제13권2호
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• pp.179-186
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• 2024

Objective: This study aims to assess the reliability and validity of the new hand-held spirometer as a potential substitute for traditional pulmonary function testing (PFT) devices. Design: Cross-sectional study. Methods: In this study, thirty healthy adults underwent spirometry using both the new hand-held spirometer and the MIR spirometer, which is a standard PFT device. Parameters including peak expiratory flow (PEF), forced expiratory volume in one second (FEV₁), and forced vital capacity (FVC) were measured and analyzed for validity and reliability. Inter-rater reliability and validity were evaluated through 95% limits of agreement (LOA) and intraclass correlation coefficients (ICC). Statistical analyses, including the Bland-Altman plots and the ICC, were utilized to assess agreement between the two devices. Results: The new hand-held spirometer exhibited a good agreement with intra-class coefficient (ICC [2,1]) ranging 0.762 to 0.956 and 95% LOA of -1.94 to 1.80 when compared with MIR. The test-retest reliability of the hand-held spirometer analyzed using - ICC [2,1] demonstrated a good level of consistency (ICC [2,1] =0.849-0.934). Conclusions: In conclusion, the study aimed to assess the potential of the new hand-held spirometer as a viable alternative to traditional PFT devices, with a specific focus on its reliability and validity in spirometric measurements. The new hand-held spirometer exhibited good test-retest reliability across all measured variables, suggesting its potential as a valid and reliable tool for simultaneous PFT measurements.

• 경영과정보연구
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• 제30권2호
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• pp.257-275
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• 2011

선물시장은 기초자산이 거래되는 현물시장을 대상으로 하여 거래가 이루어지기 때문에 양 시장간에는 필연적인 관련성을 가진다. 이러한 관련성에 관한 연구의 일환으로 본 연구에서는 국내시장에서 국채선물시장과 현물시장간의 일별 가격변화의 선-후행관계를 실증적으로 분석함으로써 양 시장간의 가격발견기능이 존재하는지를 살펴보았다. 2006년 3월 10일부터 2011년 5월 13일까지의 전체 분석기간을 글로벌 금융위기 전(2006. 3. 10~2008. 9. 12)과 후(2008. 9. 16~2011. 5. 13)로 구분하여 분석하였다. 분석한 결과를 종합하면, 국채선물 및 국채현물시장의 자기상관관계에서는 현물수익률의 경우 전날 현물가격이 다음날 현물가격에 유의한 영향을 미치는 것을 나타났으나, 선물수익률의 경우에는 유의한 상관관계가 나타나지 않았다. 다음으로 전체기간 및 하위기간에서의 교차상관관계의 분석에서는 양시장간에 유의한 가격적 선-후행관계가 존재하지 않는 것으로 나타났다. 마지막으로 회귀분석을 통한 양시장간 선-후행관계 분석에서도 양 시장간 유의한 선-후행관계가 존재하지 않는 것으로 나타났다.

• Journal of the Korean Wood Science and Technology
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• 제45권5호
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• pp.661-670
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• 2017

지리산 아고산대 주요 침엽수(주목, 잣나무, 구상나무)와 신갈나무를 이용하여 50년간의 산소동위원소연대기(1966~2015)를 작성하였다. 산소동위원소연대기 작성은 크로스데이팅(cross-dating) 결과가 우수한 4본을 각 수종에서 선발하여 실시하였다. 동일 수종 내 임목 간 산소동위원소연대기의 상관분석 결과 모두 유의성(p < 0.001) 높은 상관이 있는 것으로 확인되었으며, EPS도 0.85 이상이었다. 동일 수종 내 임목 간 상관분석뿐만 아니라 수종간 상관분석에서도 유의성(p < 0.001) 높은 상관관계가 확인되었다. 기후요소(강수량, 기온)와 산소동위원소와의 관계를 조사하기 위한 반응함수 분석에서 주목은 당년 5월 강수량과 유의성 있는 부의 상관을 보였으며, 구상나무는 4월 강수량과 유의성 있는 부의 상관을 보였다. 향후 주목과 구상나무에 대한 장기간의 산소동위원소연대기가 작성된다면 과거 측정하지 못한 장기간의 4월과 5월 강수량 복원이 가능할 것이다.