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Determinants of Circulating Soluble Leptin Receptor and Free Leptin Index in Indonesian Pre-Pubertal Obese Male Children: A Preliminary CrossSectional Study

  • Hendarto, Aryono;Nagrani, Dimple G.;Meiliana, Anna;Sastroasmoro, Sudigdo;Sjarif, Damayanti R.
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.23 no.2
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    • pp.163-173
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    • 2020
  • Purpose: This study aimed to investigate the clinical and metabolic determinants of circulating soluble leptin receptor (CSLR) and free leptin index (FLI) in pre-pubertal obese male children. Methods: We conducted a preliminary cross-sectional study at three tertiary hospitals and one public primary school. Eighty obese male children without growth and developmental abnormalities aged 5-9 years were recruited. In these children, obesity was solely caused by excessive food intake, and not by acute illness, medications, endocrine abnormalities, or any syndrome. Body mass index (BMI), body fat mass, carbohydrate intake, fat intake, high density lipoprotein cholesterol level, low density lipoprotein cholesterol level, triglyceride level, and Homeostatic Model Assessment for Insulin Resistance are the potential determinants for leptin regulation, which is represented by CSLR level and FLI. Results: Carbohydrate was the main source of energy. BMI and body fat mass had negative weak correlation with CSLR and positive weak correlation with FLI. Furthermore, carbohydrate intake was found to be independently associated with CSLR based on the results of the multiple linear regression analysis. Following an increase in carbohydrate intake, CSLR level decreased progressively without any negative peak. Conclusion: Leptin regulation in prepubertal obese male children is associated with body composition and dietary intake. Carbohydrate intake is useful for predicting CSLR. Lipid profiles and insulin resistance are not related to both CSLR and FLI. Treatment and prevention of leptin resistance in obese children should focus on reducing BMI, fat mass, and carbohydrate intake.

Prediction of Chronic Hepatitis Susceptibility using Single Nucleotide Polymorphism Data and Support Vector Machine (Single Nucleotide Polymorphism(SNP) 데이타와 Support Vector Machine(SVM)을 이용한 만성 간염 감수성 예측)

  • Kim, Dong-Hoi;Uhmn, Saang-Yong;Hahm, Ki-Baik;Kim, Jin
    • Journal of KIISE:Computer Systems and Theory
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    • v.34 no.7
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    • pp.276-281
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    • 2007
  • In this paper, we use Support Vector Machine to predict the susceptibility of chronic hepatitis from single nucleotide polymorphism data. Our data set consists of SNP data for 328 patients based on 28 SNPs and patients classes(chronic hepatitis, healthy). We use leave-one-out cross validation method for estimation of the accuracy. The experimental results show that SVM with SNP is capable of classifying the SNP data successfully for chronic hepatitis susceptibility with accuracy value of 67.1%. The accuracy of all SNPs with health related feature(sex, age) is improved more than 7%(accuracy 74.9%). This result shows that the accuracy of predicting susceptibility can be improved with health related features. With more SNPs and other health related features, SVM prediction of SNP data is a potential tool for chronic hepatitis susceptibility.

A Study on 'Language-Letter' images and politics of 'écriture' in Kim, Soo-Yung's poems (김수영 시의 '언어-문자' 이미지와 '에크리튀르'의 정치학)

  • Lee, Chan
    • Cross-Cultural Studies
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    • v.26
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    • pp.173-200
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    • 2012
  • This paper examines ${\acute{e}}pist{\acute{e}}m{\grave{e}}$ of ${\acute{e}}criture$ and its politics in Kim, Soo-Yung's poems, focusing on 'language-letter' images such as "speech", "language", "printing type", "letter", "brush", "book" and so on. While the previous papers fail to present the overall framework of analysis on 'language-${\acute{e}}criture$' images and to show political dimensions of discourse analysis, this paper tries to overcome these limitations. It explains images of 'speech' and 'language' on the basis of Heidegger's ontological thought, and analyzes writing-images such as 'type', 'letters' using Derrida's concepts of 'archi-${\acute{e}}criture$' and '${\acute{e}}criture$'. It also gives a new name to multiple images of 'book' in his poems as 'politics of ${\acute{e}}criture$' based on problematic such as Badiou's 'ethics of truths' and Derrida's '${\acute{e}}criture$'.

PIV Measurement of Flow Inside of HVAC Blower Unit (자동차 HVAC용 Blower Unit 내부 유동장의 PIV 계측)

  • Ji, Ho-Seong;Kim, Bo-Ram;Lee, Sang-Joon
    • Transactions of the Korean Society of Automotive Engineers
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    • v.15 no.5
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    • pp.165-173
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    • 2007
  • Flow characteristics inside a blower unit of an automotive HVAC module were investigated experimentally using a high-resolution PIV technique. The PIV system consists of a 2-head Nd:YAG laser, a high-resolution CCD camera, optics and a synchronizer. The prototype siroco-fan with forward-curved blades was operated under the same condition of real car. The scroll casing was made transparently for capturing clear flow images. The time-averaged velocity fields were measured in three cross sections. Flow is accelerated with going toward the outer wall of scroll due to centrifugal force and large pressure gradient formed in the region between the fan and the outer casing wall. The presence of the cut-off region and diffusing duct of fan outlet influences largely the flow structure inside the blower unit.

Synthesis of [P(AA-co-PEGMM)] Copolymer Films and its Physicochemical Characteristics ([P(AA-co-PEGMM)] 공중합체 필름의 합성 및 물리화학적 특성)

  • Kim, Joun-Sik;Park, Jeong-Sook;Han, Kun
    • Journal of Pharmaceutical Investigation
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    • v.31 no.3
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    • pp.173-180
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    • 2001
  • The physicochemical characteristics such as glass transition temperature (Tg), surface energy, swelling and FT-IR of [P(AA-co-PEGMM)], a copolymer of acrylic acid (AA) and polyethyleneglycol monoethylether mono methacrylate (PEGMM), were evaluated. The Tg of [P(AA-co-PEGMM)] decreased with increasing PEGMM content. [P(AA-co-PEGMM)] with 18 mole% PEGMM had the Tg of about $40^{\circ}C$, the similar physiological temperature of human. Moreover, [P(AA-co-PEGMM)] with lower PEGMM content had higher hydration and expected lower mucoadhesive strengths. To predict the mucoadhesiveness of [P(AA-co-PEGMM)] films, the contact angle of films were measured. With the increasing content of PEGMM of films, the contact angle was increased and the higher mucoadhesive forces was expected. ATR-FTIR studies revealed that the addition of the PEG moiety in AA increased the potential of hydrogen bonding for [P(AA-co-PEGMM)] as compared to cross linking polyacrylic acid (cr-PAA) because the oxygen in the repeat unit of PEG contributed in the formation of hydrogen bonding in the presence of mucin solution.

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Factors Influencing Depression of Nurses among Comprehensive Nursing Care Service Ward (간호·간병통합서비스 병동 간호사의 우울 예측 요인)

  • Lee, Eliza;Chang, Sung Sook
    • Korean Journal of Occupational Health Nursing
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    • v.25 no.4
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    • pp.340-351
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    • 2016
  • Purpose: The purpose of this study was to identify depression and its influencing factor of nurses among comprehensive nursing care service ward. Methods: The research was cross-sectional descriptive study. The subjects of the study were 173 nurses of comprehensive nursing care service ward in Gyeonggi-do. Data collection was done using self-reported structured questionnaires asking about job stress, emotional labor, job burnout, somatic symptoms, turnover intention, depression and general characteristics from May 16 to June 3, 2016. Data were analyzed with SPSS/WIN 19.0 program. Results: Mean scores of job stress were 159.15(range 43~215), emotional labor 30.90(range: 9~45), job burnout 59.45 (range: 0~132), somatic symptoms 24.03 (range: 12~60), turnover intention 5.61 (range 0~18) and depression 19.25 (range: 0~60) and reported as depression in 63.6%. Somatic symptoms (${\beta}=.26$, p<.001), job burnout (${\beta}=.37$, p<.001) had significant associations with depression and the most important variable was job burnout. Conclusion: It is necessary to apply the developed program to reduce job burnout in hospitals and to prevent and/or control depression. And also, it needs to improve working conditions and increase the nursing staff to reduce somatic symptoms for nurses among comprehensive nursing care service ward.

Changes in Space Norms and Related Factors of Households in Ulsan, Korea (울산시 거주 가구의 공간규범 변화 특성과 관련요인 분석)

  • Yang, Sehwa;Ryu, Hyunjoo
    • Human Ecology Research
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    • v.52 no.2
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    • pp.165-173
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    • 2014
  • The study was conducted to analyze whether the recent trends in preference toward small and medium-sized housing in Korea represent changes in space norms. To accomplish this, the existing data from Statistics Korea and two different empirical data sets collected in 2007 and 2012 from Ulsan, Korea, were statistically analyzed through descriptive statistics, cross-tabulation analysis with a chi-squared test and multiple regression analysis. In the analyses, the space norms of households were compared and any changes in the space norms and the related factors were determined. The space norms were mainly investigated in terms of the housing size and the number of rooms. The results are as follows: 1) since 2010, there have been changes in the housing stock distribution in terms of size. Stocks of small housing increased, while those of medium and large housing decreased. Nevertheless, the overall conditions of spatial density have improved considerably in the recent 30 years. 2) It was found that there were statistically significant differences between 2007 and 2012 in space norms. The norms for housing sized less than 99 m2 and with one or two rooms were found to have increased, while that for housing sized more than 132 m2 decreased. 3) Household size, education of the head, monthly household income, housing type and the number of bedrooms in the current dwelling were the significant explanatory variables of space norms.

A Study on the Interpolation Characteristics of the Scattered Geographic Data according to the Gridding methods (격자화 기법에 따른 이산지형정보의 보간특성 연구)

  • Lee, Yong-Chang
    • Journal of Korean Society for Geospatial Information Science
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    • v.4 no.2 s.8
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    • pp.173-180
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    • 1996
  • In a grid based data transformation, the different gridding methods provide different interpretations of scattered data because each method calculate grid node values using a different weighted mathematical algorithms. Therefore, it is necessary to review the interpolated characteristics of some gridding methods according to search distance, search area and search options before determing the best method with a data set. For this, in this paper, six different gridding methods with the same search conditions are applied to a scattered data obtained from sterro-plotter. The interpolated characteristics of the scattered geographic data considered through comparison of coincidence between the data point and the grid node being interpolated. And also, shows the real application of gridding methods through calculating volumes and creating cross sections.

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A Cross Cultural Study of the Power Structure on the Conjugal Decision - making Process in Korea and Japan (의사결정 과정에 있어서 부부간의 세력구조에 관한 한ㆍ일 비교)

  • ;Kataka Yoshimi
    • Korean Journal of Rural Living Science
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    • v.8 no.2
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    • pp.173-187
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    • 1997
  • The objectives of this study were to research the power structure of the conjugal decision making process between husbands and wives and how to go about analyzing these processes. Furthermore, to statistically survey the similarities the differences of these between the Japanese and Korean cultures. The subjects of the study were women over the age of 20. The Korean wives resided in Taegu, the Japanese wives in Kobe. The questionnaire destributed to these subjects was bi-lingual in both Korean and Japanese. The data results are as follows : The frequency of negotiation was highest when the wife conceived an idealistic balance in the magnitude of authority arld control between she and her husband. On average, those wives who make decisions their husbands through negotiation do not have as high of a magnitude of control and authority as their husbands. These women idealistically believe that a balance of magnitude and authority exists between them and their husbands. On the other hand, in relationships where decisions are made without negotiation, the magnitude of the wife's authority increases as she idealistically perceives herself as being more powerful than her husband.

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Pathogenicity of Didymella bryoniae on the Seedlings of Cucurbits (오이류 유묘에 대한 덩굴마름병균의 병원성)

  • Lee Du Hyung
    • Korean Journal Plant Pathology
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    • v.1 no.3
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    • pp.173-177
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    • 1985
  • The objective of the study is to determine differences between cucurbits in the pathogenicity of Didymella bryoniae isolated from the naturally infected seeds of cucumber and pumpkin. Primary seedling infection of cucumber(Cucumis sativus L.), oriental melon(Cucumis melo var. makuwa Makino), pumpkin(Cucurbita pepo L.) and watermelon (Citrullus vulgaris Shrad.) occurred on the radicle, hypocotyl and cotyledons and symptoms on each crop were very similar. Infection of the radicle generally caused pre-emergence rot, while infection on the hypocotyl and cotyledons provided further inoculum for infection of the first true leaves and the stem. In cross inoculation tests, all isolates of D. bryoniae could infect cucumber, oriental melon, pumpkin and watermelon at different growth stages and there were not much differences in pathogenicity or susceptibility between isolates of the pathogen and crops tested. The susceptibility of cucumber and pumpkin was markedly influenced by prevailing humid conditions.

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