• Tuberculosis and Respiratory Diseases
• /
• v.85 no.4
• /
• pp.332-340
• /
• 2022

Background: Cardiac dysfunction patients have long been considered at high risk of reintubation. However, it is based on past studies in which only conventional oxygen therapy was applied after extubation. We investigated association between cardiac dysfunction and reintubation rate in situation where high-flow nasal cannula (HFNC) was widely used during post-extubation period. Methods: We conducted a retrospective observational cohort study of patients treated with HFNC after planned extubation in medical intensive care unit of single tertiary center. Patients were divided into normal function group (ejection fraction [EF] ≥45%) and cardiac dysfunction group (EF <45%). The primary outcome was reintubation rate within 72 hours following extubation. Results: Of 270 patients, 35 (13%) had cardiac dysfunction. Baseline characteristics were similar in both groups. There were no differences in the changes in vital signs between the two groups during the first 12 hours after extubation except diastolic blood pressure. The reintubation rates were 20% and 17% for cardiac dysfunction group and normal function group, respectively (p=0.637). In a multivariate Cox regression analysis, cardiac dysfunction was not associated with an increased risk of reintubation within 72 hours following extubation (hazard ratio, 1.56; p=0.292). Conclusion: Cardiac dysfunction was not associated with increased reintubation rate within 72 hours when HFNC is immediately applied after planned extubation.

• Clinical and Experimental Pediatrics
• /
• v.53 no.6
• /
• pp.669-679
• /
• 2010

The risk of mortality and morbidity of patients with congenital heart defects (CHDs) is highest during neonatal period and increases when diagnosis and proper management are delayed. Neonates with critical CHDs may present with severe cyanosis, respiratory distress, shock, or collapse, all of which are also frequent clinical presentations of various respiratory problems or sepsis in the newborn. Early diagnosis and stabilization and timely referral to a tertiary cardiac center are crucial to improve the outcomes in neonates with CHDs. In this review, the clinical presentation of critical and potentially life-threatening CHDs is discussed along with brief case reviews to help understand the hemodynamics of these defects and ensure proper decision-making in critically ill patients.

• The Korean Journal of Physiology and Pharmacology
• /
• v.17 no.2
• /
• pp.111-120
• /
• 2013

Prolyl 4 hydroxylases (P4H) are iron- and 2-oxoglutamate-dependent dioxygenase enzymes and hypoxia-inducible transcription factor (HIF)-P4Hs play a critical role in the regulating oxygen homeostasis in the local tissues as well in the systemic circulation. Over a period of time, a number of prolyl hydroxylase inhibitors and activators have been developed. By employing the pharmacological tools and transgenic knock out animals, the critical role of these enzymes has been established in the pathophysiology of number of diseases including myocardial infarction, congestive heart failure, stroke, neurodegeneration, inflammatory disease, respiratory diseases, retinopathy and others. The present review discusses the different aspects of these enzymes including their pathophysiological role in disease development.

• Transactions of the Korean Society of Mechanical Engineers A
• /
• v.24 no.5 s.176
• /
• pp.1231-1237
• /
• 2000

Dynamics of a rotating cantilever beam near its critical angular speed is investigated in this paper. The external, force is idealized as a periodic function which has the same period as the rotati ng frequency of the beam. The equations of motion are derived and transformed into a dimensionless form. A prescribed spin-up motion is employed for the rotating motion. Numerical study shows that the steady state and the transient responses of the beam are affected by the spin-up time constant and there exists a time constant at which the maximum transient response becomes minimum.

• Journal of Mechanical Science and Technology
• /
• v.18 no.12
• /
• pp.2148-2157
• /
• 2004

The paper deals with the vibration and dynamic stability of cantilevered pipes conveying fluid on elastic foundations. The relationship between the eigenvalue branches and corresponding unstable modes associated with the flutter of the pipe is thoroughly investigated. Governing equations of motion are derived from the extended Hamilton's principle, and a numerical scheme using finite element methods is applied to obtain the discretized equations. The critical flow velocity and stability maps of the pipe are obtained for various elastic foundation parameters, mass ratios of the pipe, and structural damping coefficients. Especially critical mass ratios, at which the transference of the eigenvalue branches related to flutter takes place, are precisely determined. Finally, the flutter configuration of the pipe at the critical flow velocities is drawn graphically at every twelfth period to define the order of the quasi-mode of flutter configuration.

• Transactions of the Korean Society for Noise and Vibration Engineering
• /
• v.13 no.12
• /
• pp.956-964
• /
• 2003

The paper describes the relationship between the eigenvalue branches and the corresponding flutter modes of cantilevered pipes with a tip mass conveying fluid. Governing equations of motion are derived by extended Hamilton's principle, and the numerical scheme using finite element method is applied to obtain the discretized equations. The flutter configurations of the pipes at the critical flow velocities are drawn graphically at every twelfth period to define the order of quasi-mode of flutter configuration. The critical mass ratios, at which the transference of the eigenvalue branches related to flutter takes place. are definitely determined. Also, in the case of haying internal damping, the critical tip mass ratios, at which the consistency between eigenvalue braches and quasi-modes occurs. are thoroughly obtained.

• Journal of the Korean Society of Safety
• /
• v.27 no.1
• /
• pp.44-48
• /
• 2012

The seismic safety of long-period cable-stayed bridges is assessed by probabilistic finite element analysis and reliability analysis under NFE. The structural response of critical members of cable-stayed bridges is evaluated using the developed probabilistic analysis algorithm. In this study, the real earthquake recording(Chi-Chi Earthquake; 1997) was selected as the input NFE earthquake for investigating response characteristics. The probabilistic response and reliability index shows the different aspect comparing the result from FFE earthquake. Therefore, the probabilistic seismic safety assessment on NFE earthquakes should be performed for the exact evaluation of long-period cable-stayed bridges and the earthquake resistant design criteria should be complemented.

• Earthquakes and Structures
• /
• v.13 no.3
• /
• pp.231-239
• /
• 2017

Fundamental period is one of the most critical parameters affecting the seismic design of buildings. In this paper, a very simple approach is presented for estimating the fundamental period of multiple-degree-of-freedom (MDOF) structures. The basic idea behind this approach is to replace the complicated MDOF system with an equivalent single-degree-of-freedom (SDOF) system. To realize this equivalence, a procedure for replacing a two-degree-of-freedom (2-DOF) system with an SDOF system, known as a two-to-single (TTS) procedure, is developed first; then, using the TTS procedure successively, an MDOF system is replaced with an equivalent SDOF system. The proposed approach is expressed in terms of mass, stiffness, and number of stories, without mode shape or any other parameters; thus, it is a very simple method. The accuracy of the proposed method is investigated by estimating the fundamental periods of many MDOF models; it is found that the results obtained by the proposed method agree very well with those obtained by eigenvalue analysis.

• Journal of Korean Society of Water and Wastewater
• /
• v.24 no.5
• /
• pp.573-580
• /
• 2010

Average pressure in a pipe network is one of critical factors to estimate the flow distribution and to calculate UARL (Unavoidable Annual Real Losses) value in ILI (Infrastructure Leakage Index). While its collection period and measuring location are essential to obtain average pressure, their standard method have not been established so far. In this study, proper method including its procedure for data collection period and measuring point for average pressure were suggested using non-exceedance probability concept in the water distribution network.

• Journal of Navigation and Port Research
• /
• v.33 no.2
• /
• pp.105-110
• /
• 2009

Shipwaves am have harmful effects on ships working on the sea, in a harbour or navigational channel and caused beach erosion, seawall destruction. This study aims to investigate describe the characteristics of the wave pattern generated by an individual model ship tested at different velocities and hull forms for a given water depth and to investigate the variations at a given distance from the sailing line under the same conditions. As a result, the angles a's by model ship tests are smaller than those by real ship ones. Wave heights decreases with an increasing the mid-ship cross sectional area $A_s$. The maximum wave height and period increase rapidly in the subcritical speed, and beyond the critical speed the height and period decrease with increasing depth Froude number. And the period keeps constant with the distance from the sailing line.