• Molecules and Cells
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• v.41 no.12
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• pp.1008-1015
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• 2018

$I{\kappa}B$, a cytoplasmic inhibitor of nuclear factor-${\kappa}B$ ($NF-{\kappa}B$), is reportedly degraded via the proteasome. However, we recently found that long-term incubation with proteasome inhibitors (PIs) such as PS-341 or MG132 induces $I{\kappa}B{\alpha}$ degradation via an alternative pathway, lysosome, which results in $NF-{\kappa}B$ activation and confers resistance to PI-induced lung cancer cell death. To enhance the anti-cancer efficacy of PIs, elucidation of the regulatory mechanism of PI-induced $I{\kappa}B{\alpha}$ degradation is necessary. Here, we demonstrated that PI up-regulates nuclear factor (erythroid-derived 2)-like 2 (Nrf2) via both de novo protein synthesis and Kelch-like ECH-associated protein 1 (KEAP1) degradation, which is responsible for $I{\kappa}B{\alpha}$ degradation via macroautophagy activation. PIs increased the protein level of light chain 3B (LC3B, macroautophagy marker), but not lysosome-associated membrane protein 2a (Lamp2a, the receptor for chaperone-mediated autophagy) in NCI-H157 and A549 lung cancer cells. Pretreatment with macroautophagy inhibitor or knock-down of LC3B blocked PI-induced $I{\kappa}B{\alpha}$ degradation. PIs up-regulated Nrf2 by increasing its transcription and mediating degradation of KEAP1 (cytoplasmic inhibitor of Nrf2). Overexpression of dominant-negative Nrf2, which lacks an N-terminal transactivating domain, or knock-down of Nrf2 suppressed PI-induced LC3B protein expression and subsequent $I{\kappa}B{\alpha}$ degradation. Thus, blocking of the Nrf2 pathway enhanced PI-induced cell death. These findings suggest that Nrf2-driven induction of LC3B plays an essential role in PI-induced activation of the $I{\kappa}B$/$NF-{\kappa}B$ pathway, which attenuates the anti-tumor efficacy of PIs.

• The Journal of Society for e-Business Studies
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• v.18 no.3
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• pp.125-142
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• 2013

As a reinforcing strategic-alignment of IT business, Financial Service becomes more rely on IT systems. It needs to continuous information security activities to provide a secure and reliable finance service. Performance measurement of information security activities can be useful for decision and management support. The purpose of this study is to derive CSF(Critical Success Factor) and KPI(Key Performance Indicator) based on K-ISMS, Financial IT Information Security Standards. Providing a rationale can be used to determine key performance indicators, which are utilized as basic data for establishing security policies for financial IT security competency.

• Korean Journal of Child Studies
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• v.12 no.1
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• pp.91-112
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• 1991

The impact of gender, sex-role identity and cultural background on self - control behaviors was studied with the use of reports from 410 college students(201 Koreans and 209 Americans), who were administered both the Bem Sex Role Inventory and the Missouri Self Control Instrument. Gender, sex - role identity and cultural background significantly affected self - control and satisfaction. Regardless of cultural background, males showed a higher level of self - control and satisfaction than females. Androgenous students from both nations used a higher level of expressed/yielded self - control and more satisfied than the students with other sex - role identities. There were some differences in self - control between the Korean and American students. For the American students, the level of expressed self - control was the critical factor in explaining self - control behavior, whereas the level of yielded self - control was the critical factor for the Korean students. This was explained as a phenomenon of culture - bound relationships. Regardless of sex and sex - role identity, the level of satisfaction of Korean students was significantly lower than that of American students. The present results suggested that Korean students have some sort of conflict between self - control and satisfaction. The conflict can probably be attributed to the recent influx of western culture emphasizing goal - oriented control.

• Proceedings of the Korean Society For Composite Materials Conference
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• 2001.10a
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• pp.158-162
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• 2001

The effects of chemical treatment on Kevlar-29 fibers have been studied in a composite system. The surface characteristics of the Kevlar-29 fibers were characterized by pH, acid-base value and X-ray photoelectron spectroscopy (XPS). The mechanical interfacial properties of final composites were studied by interlaminar shear strength (ILSS) and critical stress intensity factor ($K_{IC}$). Also, the impact properties of the composites were investigated in the differentiating studies between initiation and propagation energies, and ductile index (DI) along with maximum farce and total energy. It was found that the chemical treatment with phosphoric acid ($H_3PO_4$) solution significantly affected the degree of adhesion at interfaces between fibers and resin matrix, resulting in improving the mechanical interfacial strength of the composites. This was probably due to the presence of chemical polar groups on Kevlar surfaces, leading to an increment of interfacial binding force in a composite system.

• Journal of the Korean Society for Precision Engineering
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• v.27 no.4
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• pp.14-19
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• 2010

In this paper, using interleaved power factor correction how to improve the inverter efficiency studied. Interleaved method can reduce the conduction losses and the inductor energy. Generally, critical conduction mode (CRM) boost PFC converter used low power level because of the high peak currents. if you use the interleaved mode, CRM PFC can be used medium or high power application. interleaved CRM PFC can reduce current ripple for higher system reliability and size of buck capacitor and EMI filter size. Interleaved CRM PFC that is installed in front of inverter can maintain the constant voltage regardless of the input voltage.

• Polymer(Korea)
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• v.26 no.3
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• pp.344-352
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• 2002

In this work, two thermal cationic latent catalysts, i.e., triphenyl benzyl phosphonium hexafluoroantimonate (TBPH) and benzyl 2-methylpyrazinium hexafluoroantimonate (BMPH) were newly synthesized. And the thermal and mechanical properties of difunctional epoxy (diglycidylether of bisphenol h, DGEBA) resins initiated by 1 phr of either TBPH or BMPH catalyst were investigated. As experimental results, the epoxy/TBPH system showed higher curing temperature and critical stress intensity factor ($K_{IC}$) than those of epoxy/BMPH. This could be interpreted in terms of slow thermal diffusion rate and bulk structure of four phenyl groups in TBPH. However, the decomposed activation energy determined from Coats-Redfern method was lower in the case of epoxy/TBPH. This result was probably due to the fact that broken short chain structure was developed by steric hindrance of TBPH.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2001.10a
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• pp.35-38
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• 2001

This study was conducted a comparative study to identify the differences in service quality between Incheon and Kimpo international Airport and critical factors influencing satisfaction of airport customers. According the results of this study, all service quality factors except the service factor of geographical location of Incheon international airport are better than those of Kimpo international airport. However, all of service quality factors of Incheon airport are evaluated as inferior to those of american, western european and japanese international airports by both the airport visitors and the employees of one korean airliner. In addition the service factors such as response, safety, airport facility and geographical location are found as critical factors influencing satisfaction of the airport visitors and the airliner's employees. Among them the service quality factor of geographical location of Incheon airport is much inferior to that of Kimpo airport comparing with other service quality factors. Thus, the results of this study suggest that the managing team implement TQM and six sigma to enhance the service quality level of the Incheon international airport up to that of the american and western european international airport. Especially, it is strongly required that the Korean governmen deliberate in deciding the geographical location in case of planning new international airport because geographical location is related to not only traffic to airport but also safety of landing, taking off and flying.

• Journal of Korean Society of Transportation
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• v.1 no.1
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• pp.56-63
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• 1983

Intersection control has dual-purposes; increasing capacity and reducing delay. The primary concern of efficient intersection control under oversaturated condition as in Korea is to increase capacity. Prevailing intersection operation technique permits thru traffic to utilize left turn lane, because the intersection without left turn pocket has left turn signal interval. In this situation, it seems not to be valid to calculate capacity, delay, and signal timings by conventional methods. By critical lane technique, capacity increases as cycle length increases. However, when thru traffic utilize LT lane, the capacity varies according to LT volume, LT interval as well as cycle length, which implies that specific cycle length and LT interval exist to maximize capacity for given LT volume. The study is designed is designed to calculate utilization factors of LT lane for thru traffic and capacities, and identify signal timings to yield maximum capacity. The experimental design involved has 3 variables; 1)LT volumes at each approach(20-300 vph), 2)cycle lengths (60-220 sec), and 3)LT intervals(2.6-42 sec) for one scenario of isolated intersection crossing two 6-lanes streets. For LT volume of 50-150 vph, capacity calculated by using the utilization factor is about 25% higher than that by critical lane method. The range of optimum cycle length to yield maximum capapcity for LT volume less than 120 vph is 140-180 sec, and increases as LT volume increases. The optimum LT interval to yield maximum capacity is longer than the intrval necessary to accommodate LT volume at saturation flow rate.

• Nuclear Engineering and Technology
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• v.52 no.3
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• pp.461-468
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• 2020

The improvements of the DeCART/MUSAD code system for uncertainty analysis of HTGR neutronic parameters are presented in this paper. The function for quantifying an uncertainty of critical-spectrumweighted few group cross section was implemented using the generalized adjoint B₁ equation solver. Though the changes between the infinite and critical spectra cause a considerable difference in the contribution by the graphite scattering cross section, it does not significantly affect the total uncertainty. To reduce the number of iterations of the generalized adjoint transport equation solver, the generalized adjoint B₁ solution was used as the initial value for it and the number of iterations decreased to 50%. To reflect the implicit uncertainty, the correction factor was derived with the resonance integral. Moreover, an additional correction factor for the double heterogeneity was derived with the effective cross section of the DH region and it reduces the difference from the complete uncertainty. The code system was examined with the MHTGR-350 Ex.II-2 3D core benchmark. The k_eff uncertainty for Ex.II-2a with only the fresh fuel block was similar to that of the block and the uncertainty for Ex.II-2b with the fresh fuel and the burnt fuel blocks was smaller than that of the fresh fuel block.

• Sleep Medicine and Psychophysiology
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• v.16 no.2
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• pp.61-64
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• 2009

Obstructive sleep apnea (OSA) has been definitively shown to be a risk factor for the development of cardiovascular disease and mortality. Recent reports have indicated that obstructive sleep apnea is associated with insulin resistance and impaired glucose metabolism, also have type 2 diabetes. The potential mechanisms leading to the development of type 2 diabetes in OSA patients are likely to be various. Reduced physical activity resulting from daytime somnolence, sympathetic nervous system activation, intermittent hypoxia, sleep fragmentation and sleep loss, dysregulation of the hypothalamic-pituitary axis, alteration in adipokine profiles, and activation of inflammatory pathways have been proposed. Based on the current evidence, clinicians should assess the risk of OSA in patients with type 2 diabetes and, conversely, consider that possibility of glucose intolerance in patients with OSA. Further large-scale and long-term follow-up studies in patient populations with selected by reliable but inexpensive diagnostic measures, controlled for potential confounder factor, are needed.