• 생명과학회지
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• 제19권10호
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• pp.1346-1351
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• 2009

Neural crest는 신경계의 발생과정에서 생긴 특정화된 외배엽으로서 말초신경계(peripheral nervous system)의 모든 sensory cells과 peripheral cells, unipolar spinal ganglion cell, cranial sensory ganglia, peripheral nerve의 neurolemmal sheath cells, ganglia의 capsule cells, sympathetic ganglia, chromaffin cells, pigment cell 등의 자율신 경계의 대부분의 세포로 분화 한다. 최근pluripotetic neural crest cells의 운명이 이미 제한되어 있으며, 이러한 fate-restricted crest cells이 neural tube에서 emigration된다고 보고된바 있다. 또한 본 연구자는 Wnt와 Wnt의 antagonist가 neural crest cell의 specification이 일어나는 시기에 발현하여, neural crest cell의 segregation과 differentiation에 직접적으로 관여함을 밝혔다. 이를 보다 명확히 규명하기 위해, 본 연구에서는 neural tube에 Wnt-3a expressing cell의 grafting 혹은 dominant negative GSK construct의 electroporation을 통해 Wnt signaling을 modulation 하여 downstream mediator를 조사하였다. Wnt signaling의 stimulation은 neural crest cell의 melanoblast 로의 commitment를 유도하였으며, 이와 더불어 cadherin 7과 slug의 발현을 조절함을 확인하였다.

• 한국전문물리치료학회지
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• 제19권4호
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• pp.55-60
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• 2012

The trochanteric prominence angle test (TPAT) has been used to measure the femoral anteversion angle between the tibial crest and the vertical line. However, the exact anatomical reference of the tibial crest has not yet been identified in the literature. Thus, the purposes of this research were twofold: first, to compare the femoral anteversion angle measured at three different anatomical references of the tibial crest (the proximal tibial crest, the proximal third of tibial crest, and the proximal half of tibial crest) and, second, to determine inter-and intra-rater reliabilities of the femoral anteversion angle measured at these three different anatomical references of the tibial crest during the TPAT. We recruited 14 healthy subjects, and a total of 28 legs were examined. The TPAT was measured using a digital inclinometer. A 1-way repeated-measure analysis of variance was used to compare the femoral anteversion angle measured at three different anatomical references of the tibial crest, and intraclass correlation coefficients (ICCs) were calculated to determine reliability. The femoral anteversion angle measured at the proximal tibial crest was significantly higher than that at the proximal third of the tibial crest and the proximal half of the tibial crest. The inter-and intra-rater reliabilities of femoral anteversion angle were measured at three anatomic references of the tibial crest were all found to be high during the TPAT (ICC=.9 0~.98). In conclusion, clinicians should recognize that the different degrees of the femoral anteversion angle could be measured when different anatomical references of the tibial crest were used, and that reliabilities were high when an exact anatomical reference of the tibial crest was used during the TPAT.

• 한국초전도학회:학술대회논문집
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• 한국초전도학회 2006년도 High Temperature Superconductivity Vol.XVI
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• pp.17-17
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• 2006

• Animal cells and systems
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• 제6권1호
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• pp.69-74
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• 2002

Recent evidence has suggested that trunk neural crest cell generally assumed to have equivalent differentiation potentials, demonstrate differentiation bias along the anterior/posterior axis. In amphibian and fish, neural crest cells give rise to three chromatophore types, melanophores, xantho-phores, and iridophores. Each pigment cell type has distinct characteristics but there is speculation about the cellular plasticity that exists among them. Neural crest cells migrate along specific routes, ventromedially and dorsolaterally. Neural crest cells that travel dorsolaterally are the first cells to begin migration in the axolotl and are the major contributors to the visible pigment pattern. Many factors and mechanisms that are responsible for guiding migratory neural crest cells along potential pathways or determining their fate remain unknown. A single lineage of the crest, which becomes restricted to one of the three pigment cell types, gives us the opportunity to examine the existence of neural crest stem cell populations and cellular plasticity. Study presented here showed results from recent in vitro studies designed to identify parameters influencing differentiation events of individual neural crest-derived pigment cell lineages. Melanophore production from neural crest explants originating from different levels along the anterior/posterior axis of wild type-axolotl embryos were compared and demonstrate that the differentiation of melanophores is enhanced in subpopulation of neural crest treated with forskolin. Forskolin (an adenylate cyclase activator) increases intracellular CAMP concentration and eventually activates the protein kinase-A signaling pathway. Melanophore number, melanin content, and tyrosinase activity in explants taken from the anterior-most region of the crest increased significantly in response to forskolin treatment. This study suggests implications of region specific influences and developmental regulation in the development of pigment pattern.

• 한국통신학회논문지
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• 제31권9C호
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• pp.889-896
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• 2006

본 논문은 직교 주파수 분할 다중 반송파 (OFDM) 시스템에서 입력 심볼 시퀀스의 주기와 연관하여 crest 값의 확률 분포를 유도하였고, 이로부터 입력 심볼 시퀀스의 주기가 짧을수록 OFDM 신호가 확률적으로 큰 crest 값을 갖는다는 것을 보인다. 다음으로 해밍 거리가 D인 두 입력 심볼 시퀀스의 crest 값 관계를 유도 한다. 이 두 결과를 이용하여 OFDM 시스템의 crest 값을 감소하기 위한 선택 사상 기법(SLM)에서 사용되는 위상 시퀀스 집합의 두 가지 조건을 제시한다. 마지막으로 m-시퀀스를 순환 이동하여 생성한 순환 하다마드 (cyclic Hadamard) 행렬의 행들로 구성한 집합을 최적에 근사한 위상 시퀀스 집합으로 제안한다.

• 한국자기학회:학술대회 개요집
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• 한국자기학회 2005년도 동계학술연구발표회 및 2차 아시안포럼
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• pp.211-211
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• 2005

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2005년도 춘계 학술발표회 논문집
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• pp.1219-1226
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• 2005

In this study, crest settlement characteristics of CFRD (Concrete Faced Rockfill Dam) and ECRD (Earth Cored Rockfill Dam) were analysed through the instrumentation data from representative 7 large dams in Korea. Also, We have studied the effect of valley shape and uniaxial compressive strength of intact rock to better understand the impact of the parent rock strength and the valley shape on the long term crest settlement of CFRDs. From the results, we found that the valley shape and strength of intact rock on crest settlement of dams are an important parameters. As a result, we obtained that the maximum crest settlement of CFRD is larger than that of ECRD and long term crest settlement rate per dam height of rockfill dams is less than 0.60% during service period.

• 한국지진공학회:학술대회논문집
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• 한국지진공학회 2006년도 학술발표회 논문집
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• pp.351-357
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• 2006

In this study, quantitative sensitivity analysis on rockfill material influencing the dam crest displacement of Concrete-Faced Rockfill Dam(CFRD) subjected to earthquake loading was carried out. The purpose of this study is to indicate the most important input parameter and to show the quantitative variation of displacement at the crest of CFR type dam during earthquake loading with this input parameter. From the sensitivity analysis, it was found that the crest displacement of CFR type dam subjected to dynamic loading was absolutely affected by the shear modulus of rockfill material and the effect of friction angle of it was negligible. This relative difference of sensitivity was more outstanding in case of crest settlement than in case of crest horizontal displacement. Also, it was found that the extent of effect of shear modulus on the displacement at the crest of CFRD due to dynamic loading decreased as maximum amplitude of input acceleration increased.

• Archives of Plastic Surgery
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• 제38권1호
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• pp.15-18
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• 2011

Purpose: The anterior iliac crest is a common source for autologous cancellous bone graft. For patients who have previously received cancellous bone grafts from bilateral anterior iliac crests, there may be concerns of whether a sufficient quantity of autologous cancellous bone remains for additional grafts without harvesting it from other sites, such as the posterior iliac crest. Methods: We experienced 3 cases of reharvesting in 2 patients. The diagnosis of the first patient was bilateral facial cleft number 3. This patient received bilateral side cleft alveoloplasty with corticocancellous bone graft from the both anterior iliac crest respectively by a previous surgeon. This patient then needed reharvesting of the anterior iliac crest cancellous bone to correct an ongoing skeletal problem for the bilateral cleft. The other patient had bilateral incomplete cleft of the primary palate. This patient received left side cleft alveoloplasty with cancellous bone graft from the right anterior iliac crest. Before the patient could receive the alveoloplasty on the other side, a radial head osteotomy and cancellous bone graft was performed by orthopedic surgeons who then used the remaining left iliac crest in order to treat a pulled elbow. For the completion of the right side cleft alveoplasty, the anterior iliac crest cancellous bone needed to be reharvested. Prior to the reharvesting, a preoperative computed tomography scan of the pelvis was obtained to assess the maturity of the donor site regeneration. The grafts were then taken from site where a greater amount of regeneration was evident. Results: Long term follow ups showed that the grafts were successfully taken. This sufficient volume was obtainable 14 months after the first harvest. Conclusion: Satisfactory results were achieved after the reharvesting of iliac cancellous bone. Thus, it appears that the reharvesting of the iliac bone is a possible alternative to multiple site grafting, use of allograft or bone substitute materials.

• International Journal of Naval Architecture and Ocean Engineering
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• 제9권2호
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• pp.160-176
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• 2017

The interaction of focused wave groups with a vertical wall is investigated based on the second order potential theory. The NewWave theory, which represents the most probable surface elevation under a large crest, is adopted. The analytical solutions of the surface elevation, velocity potential and wave force exerted on the vertical wall are derived, up to the second order. Then, a parametric study is made on the interaction between nonlinear focused wave groups and a vertical wall by considering the effects of angles of incidence, wave steepness, focal positions, water depth, frequency bandwidth and the peak lifting factor. Results show that the wave force on the vertical wall for obliquely-incident wave groups is larger than that for normally-incident waves. The normalized peak crest of wave forces reduces with the increase of wave steepness. With the increase of the distance of focal positions from the vertical wall, the peak crest of surface elevation, although fluctuates, decreases gradually. Both the normalized peak crest and adjacent crest and trough of wave forces become larger for shallower water depth. For focused wave groups reflected by a vertical wall, the frequency bandwidth has little effects on the peak crest of wave elevation or forces, but the adjacent crest and trough become smaller for larger frequency bandwidth. There is no significant change of the peak crest and adjacent trough of surface elevation and wave forces for variation of the peak lifting factor. However, the adjacent crest increases with the increase of the peak lifting factor.