• 제목/요약/키워드: Crad

검색결과 6건 처리시간 0.027초

Treatment of Malignant Melanoma by Downregulation of XIAP and Overexpression of TRAIL with a Conditionally Replicating Oncolytic Adenovirus

  • Li, Xin-Qiu;Ke, Xian-Zhu;Wang, Yu-Ming
    • Asian Pacific Journal of Cancer Prevention
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    • 제13권4호
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    • pp.1471-1476
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    • 2012
  • Background and Aim: Currently available systemic therapies for malignant melanoma produce low response rates in patients, and more effective treatment modalities are clearly needed. The tumor necrosis factor (TNF)-related apoptosis-inducing ligand has a significant impact on therapy for patients with X-linked inhibitor of apoptosis protein-downregulation malignant melanoma. The primary objective of this study was to assess its therapeutic potential. Materials and Methods: We employed a conditionally replicating oncolytic adenoviral vector, named CRAd5.TRAIL/siXIAP, with the characteristics of over-expression of the therapeutic gene TRAIL and downregulation of XIAP in one vector. B16F10-luc cells were employed to detect anti-tumor activity of CRAd5.TRAIL/siXIAP in vitro and in vivo. Results: CRAd5.TRAIL/siXIAP enhanced caspase-8 activation and caspase-3 maturation in B16F10 cells in vitro. Furthermore, it more effectively infected and killed melanoma cells in vitro and in vivo than other adenoviruses. Conclusion: Taken together, the combination of upregulation of TRAIL and downregulation of siXIAP with one oncolytic adenoviral vector holds promise for development of an effective therapy for melanomas and other common cancers.

Interaction and main effects of physical and depressive symptoms on quality of life in Korean women seeking care for rectal prolapse: a cross-sectional observational study

  • Moon, Hee;Park, Youngrye;Kim, Mili;Lee, Seonah
    • 여성건강간호학회지
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    • 제27권4호
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    • pp.297-306
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    • 2021
  • Purpose: Rectal prolapse is still a relatively understudied medical condition, especially in women, whereas physical symptoms, depressive symptoms, and quality of life (QOL) in women with pelvic organ prolapse have been steadily studied. This study aimed to examine the interaction and main effects of physical and depressive symptoms on physical and mental QOL of women seeking care for rectal prolapse in Korea. Methods: Ninety-two women with rectal prolapse were recruited from a colorectal surgery clinic of a tertiary teaching hospital in Gwangju, Korea. Physical symptoms related to rectal prolapse (pelvic organ prolapse distress, POPD; colorectal-anal distress, CRAD; and urinary distress, UD), depression, and QOL were measured. The data were analyzed using descriptive statistics, Pearson correlation coefficient, and two-way analysis of variance. Results: The interaction between POPD symptoms and depressive symptoms (F=4.51, p=.037) affected physical QOL. The interaction between POPD (F=9.66, p=.003) and CRAD symptoms (F=7.48, p=.008), respectively, and depressive symptoms affected mental QOL. Depressive symptoms had a significant main effect on the physical QOL in the CRAD (F=6.22, p=.014) and UD (F=6.01, p=.016) groups and on mental QOL in the UD group (F=24.54, p<.001). Conclusion: Physical and depressive symptoms should be considered together to improve the QOL in women with rectal prolapse. Nursing interventions and medical treatments to decrease rectal prolapse-related physical and depressive symptoms are required to improve QOL in women with symptomatic rectal prolapse.

전류변성기 비교기의 위상오차 평가 기술 (Evaluation technique for phase displacement of current transformer comparator)

  • 김윤형;한상길;정재갑;한상옥
    • 대한전기학회:학술대회논문집
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    • 대한전기학회 2008년도 제39회 하계학술대회
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    • pp.2032-2033
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    • 2008
  • We have developed an evaluation technique for phase displacement of current transformer (CT) comparator by using the precise standard capacitors and resistors. By applying this technique for equivalent circuit of CT comparator evaluation system, we can obtain the calculated and measured phase displacement in the CT comparator. Thus we can evaluate phase displacement of CT comparator by comparing the calculated and measured phase displacement. The method was applied to CT comparator under test with the phase displacement ranges of $0{\sim}{\pm}7.5$ crad. Finally we have compared the phase displacement of the CT comparator under test theoretically obtained in this method with the specification.

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전류변성기 비교기의 비오차 및 위상오차 평가기술 (Evaluation Technique for Ratio Error and Phase Displacement of Current Transformer Comparator)

  • 김윤형;한상길;정재갑;한상옥
    • 전기학회논문지P
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    • 제57권4호
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    • pp.437-443
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    • 2008
  • We have developed an evaluation technique for both ratio error and phase displacement of current transformer (CT) comparator by using the precise standard capacitors and resistors. By applying this technique to equivalent circuit of CT comparator evaluation system, we can obtain the calculated and measured ratio errors (or phase displacements) in the CT comparator. Thus we can evaluate ratio errors and phase displacement of CT comparator by comparing the calculated and measured ratio errors (or phase displacements). The method was applied to CT comparator under test with the ratio errors and phase displacement ranges of $0{\sim}{\pm}10%$ and $0{\sim}{\pm}7.5$ crad, respectively. Finally we have compared the ratio error and phase displacement of the CT comparator obtained in this method with specifications of two companies.

3.7-4.8$\mu$m 파장대역 FLIR 시스템을 위한 20:1 줌 렌즈 광학계 설계 및 제작 (Design and fabrication of a zoom optics having 20 magnification range for mid-IR(3.7-4.8$\mu$m) FLIR system)

  • 김현숙;김창우;홍석민
    • 한국광학회지
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    • 제10권6호
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    • pp.462-467
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    • 1999
  • 중적외선 파장대역$(3.7-4.8{\mu}m)$에서 20:1의 줌 비(zoom ratio)를 가지며 최저배율에서는 40$^{\circ}$$\times$30$^{\circ}$의 광시계를 갖는 연속 줌렌즈 광학계를 설계, 제작하였다. 설계된 줌 렌즈 광학계는 F/2.5에 총 7매의 렌즈로 구성되며 실리콘(Si)과 게르마늄(Ge)이 광학재질로 사용된다. 줌 광학계는 적외선 검출기를 최종 상면에 놓을 때 비네트(vignett)에 의한 광학적 errors를 줄이면서도 줌 대물렌즈의 크기를 최소화하기 위한 릴레이 형태의 재결상계(reimaging system)로 설계하였으며, 줌 렌즈의 배율 변화와 1차적인 결상을 담당하는 줌 대물부와 이를 다시 검출기에 재결상 시켜주는 결상부는 구성된다. 줌 대물부는 기계보정식 4군 줌 렌즈 형태로 구성되며 각 군을 구성하는 렌즈 매수를 최소화하여 광학계의 질량 및 크기를 줄이면서도 광학적 성능은 우수하게 유지되도록 설계하였으며 결상부는 1개의 렌즈군으로 구성하였다. 제작된 줌 렌즈 광학계의 축상 MTF를 측정한 결과 최고 배율인 20배에서 공간주파수가 24cycle/mm일 때 4.0$\mu$m파장에 대한 MTF 측정값이 0.692로 회절한계에 가까운 성능을 보였으며, 분해능은 7.6 cycles/crad까지 분해되는 것을 확인하였다.

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척도형용사의 의미적 불확정성에 대한 연구 (Semantische Unbestimmtheit der Skalaradjektiven)

  • 정동규
    • 한국독어학회지:독어학
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    • 제10집
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    • pp.277-296
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    • 2004
  • Ein sprachlicher Ausdruck ist in verschiedenen Situationen in einer Vielzahl unterschiedlicher Lesarten oder $Pr\"{a}zisierungen$ verwendbar, und zwar mil dom Grad an $Pr\"{a}zision$, der den jeweiligen kormmunikativen Erfordernissen angemessen ist. Sokommt Vagheit/$Ambiguit\"{a}t$ in sprachlichen Ausdrucken fast $durchg\"{a}ngig$ vol. In der vorliegenden Albeit wird die $M\"{o}glichkeit$ der semantischen $\"{U}bersetzung$ der Skalaradjektiven($gro{\ss}$, klein, $hei{\ss}$, kalt, schwer, leicht, schnell, langsam usw.) untersucht, die eigentlich die Vagheit als eine der konstitutiven Eigenschaften haben. Den Schwerpunkt $daf\"{u}r$ bildet die semantische Analyse $\"{u}ber$ die Graduierbarkeit und Vergleichbarkeit der Positivformen der Adjektiven, die vol allem M.J.Cresswell 1976 in seiner Albeit formuliert hat. V(pos) is the function $\eta$ in $D_{{\lll}{0,1}>,<{0,1}{\gg}.{\ll}{0,1,1},>,<{0.1}{\ggg}$ such that where ${\xi}{\in}D_{{\ll}{0,1,1},><{0,1}{\gg}$,$\eta({\xi})$ is the following function: For any ${\omega}{\in}D_{<0,1>$and a ${\in}D_1$ and w$\in$W, w${\in}{\eta}({\xi})({\omega})$(a) iff w ${\in}{\omega}$(a) and there is exactly one b such that ${\xi}({\omega})$(a,b); and for that b, b=$\gg$(for some > and u ${\in}{ \scr}{Z}(>))$ and u is toward the top of the scale determined by > when restricted to those v such that for some c, w${\in} {\xi}({\omega})$$(c,{\;} and w${\in}{\omega}(c)$. (Cresswell, 1976: 272) Obwohl sein Verfahren anhnd von dem semantischen Symbol eine methodische und theoretische $Ad\"{a}quatheit$ erf\"{u}llt$, bleibt der Vergleichwert noch unterspezifiziert. Fur die Behandlung dieser semantischen Unterspezifikation ist eine neue Semantik erforderlich, die den Wahrheitwert fur die $Zugeh\"{o}rigkeitsgrade$ der Skalaradjektive $einschlie{\ss}t$.

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