• Title/Summary/Keyword: Crad

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Treatment of Malignant Melanoma by Downregulation of XIAP and Overexpression of TRAIL with a Conditionally Replicating Oncolytic Adenovirus

  • Li, Xin-Qiu;Ke, Xian-Zhu;Wang, Yu-Ming
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.4
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    • pp.1471-1476
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    • 2012
  • Background and Aim: Currently available systemic therapies for malignant melanoma produce low response rates in patients, and more effective treatment modalities are clearly needed. The tumor necrosis factor (TNF)-related apoptosis-inducing ligand has a significant impact on therapy for patients with X-linked inhibitor of apoptosis protein-downregulation malignant melanoma. The primary objective of this study was to assess its therapeutic potential. Materials and Methods: We employed a conditionally replicating oncolytic adenoviral vector, named CRAd5.TRAIL/siXIAP, with the characteristics of over-expression of the therapeutic gene TRAIL and downregulation of XIAP in one vector. B16F10-luc cells were employed to detect anti-tumor activity of CRAd5.TRAIL/siXIAP in vitro and in vivo. Results: CRAd5.TRAIL/siXIAP enhanced caspase-8 activation and caspase-3 maturation in B16F10 cells in vitro. Furthermore, it more effectively infected and killed melanoma cells in vitro and in vivo than other adenoviruses. Conclusion: Taken together, the combination of upregulation of TRAIL and downregulation of siXIAP with one oncolytic adenoviral vector holds promise for development of an effective therapy for melanomas and other common cancers.

Interaction and main effects of physical and depressive symptoms on quality of life in Korean women seeking care for rectal prolapse: a cross-sectional observational study

  • Moon, Hee;Park, Youngrye;Kim, Mili;Lee, Seonah
    • Women's Health Nursing
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    • v.27 no.4
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    • pp.297-306
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    • 2021
  • Purpose: Rectal prolapse is still a relatively understudied medical condition, especially in women, whereas physical symptoms, depressive symptoms, and quality of life (QOL) in women with pelvic organ prolapse have been steadily studied. This study aimed to examine the interaction and main effects of physical and depressive symptoms on physical and mental QOL of women seeking care for rectal prolapse in Korea. Methods: Ninety-two women with rectal prolapse were recruited from a colorectal surgery clinic of a tertiary teaching hospital in Gwangju, Korea. Physical symptoms related to rectal prolapse (pelvic organ prolapse distress, POPD; colorectal-anal distress, CRAD; and urinary distress, UD), depression, and QOL were measured. The data were analyzed using descriptive statistics, Pearson correlation coefficient, and two-way analysis of variance. Results: The interaction between POPD symptoms and depressive symptoms (F=4.51, p=.037) affected physical QOL. The interaction between POPD (F=9.66, p=.003) and CRAD symptoms (F=7.48, p=.008), respectively, and depressive symptoms affected mental QOL. Depressive symptoms had a significant main effect on the physical QOL in the CRAD (F=6.22, p=.014) and UD (F=6.01, p=.016) groups and on mental QOL in the UD group (F=24.54, p<.001). Conclusion: Physical and depressive symptoms should be considered together to improve the QOL in women with rectal prolapse. Nursing interventions and medical treatments to decrease rectal prolapse-related physical and depressive symptoms are required to improve QOL in women with symptomatic rectal prolapse.

Evaluation technique for phase displacement of current transformer comparator (전류변성기 비교기의 위상오차 평가 기술)

  • Kim, Yoon-Hyoung;Han, Sang-Gil;Jung, Jae-Kap;Han, Sang-Ok
    • Proceedings of the KIEE Conference
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    • 2008.07a
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    • pp.2032-2033
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    • 2008
  • We have developed an evaluation technique for phase displacement of current transformer (CT) comparator by using the precise standard capacitors and resistors. By applying this technique for equivalent circuit of CT comparator evaluation system, we can obtain the calculated and measured phase displacement in the CT comparator. Thus we can evaluate phase displacement of CT comparator by comparing the calculated and measured phase displacement. The method was applied to CT comparator under test with the phase displacement ranges of $0{\sim}{\pm}7.5$ crad. Finally we have compared the phase displacement of the CT comparator under test theoretically obtained in this method with the specification.

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Evaluation Technique for Ratio Error and Phase Displacement of Current Transformer Comparator (전류변성기 비교기의 비오차 및 위상오차 평가기술)

  • Kim, Yoon-Hyoung;Han, Sang-Gil;Jung, Jae-Kap;Han, Sang-Ok
    • The Transactions of the Korean Institute of Electrical Engineers P
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    • v.57 no.4
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    • pp.437-443
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    • 2008
  • We have developed an evaluation technique for both ratio error and phase displacement of current transformer (CT) comparator by using the precise standard capacitors and resistors. By applying this technique to equivalent circuit of CT comparator evaluation system, we can obtain the calculated and measured ratio errors (or phase displacements) in the CT comparator. Thus we can evaluate ratio errors and phase displacement of CT comparator by comparing the calculated and measured ratio errors (or phase displacements). The method was applied to CT comparator under test with the ratio errors and phase displacement ranges of $0{\sim}{\pm}10%$ and $0{\sim}{\pm}7.5$ crad, respectively. Finally we have compared the ratio error and phase displacement of the CT comparator obtained in this method with specifications of two companies.

Design and fabrication of a zoom optics having 20 magnification range for mid-IR(3.7-4.8$\mu$m) FLIR system (3.7-4.8$\mu$m 파장대역 FLIR 시스템을 위한 20:1 줌 렌즈 광학계 설계 및 제작)

  • 김현숙;김창우;홍석민
    • Korean Journal of Optics and Photonics
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    • v.10 no.6
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    • pp.462-467
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    • 1999
  • This paper describes the design and fabrication of mid-IR $(3.7-4.8{\mu}m)$ zoom optics which is used for FUR (Forward Looking Infra-Red) system with 320 $\times$ 240 focal plane arrays. The zoom optics has 20 magnification range and maximun 40$^{\circ}$$\times$30$^{\circ}$ of super wide field of view. The locus of zoom is almost linear, which gives easy access of mechanical and electro-mechanical design. The on-axis MTF of zoom optics has been measured and it shows diffraction limited optical performance. For example, it gives 0.692 at 24 cycles/mm at highest magnification, and 7.6 cycles/mradof resolving power is achieved with the operation of attached micro-scanning system.system.

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Semantische Unbestimmtheit der Skalaradjektiven (척도형용사의 의미적 불확정성에 대한 연구)

  • Chung Dong-Gyu
    • Koreanishche Zeitschrift fur Deutsche Sprachwissenschaft
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    • v.10
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    • pp.277-296
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    • 2004
  • Ein sprachlicher Ausdruck ist in verschiedenen Situationen in einer Vielzahl unterschiedlicher Lesarten oder $Pr\"{a}zisierungen$ verwendbar, und zwar mil dom Grad an $Pr\"{a}zision$, der den jeweiligen kormmunikativen Erfordernissen angemessen ist. Sokommt Vagheit/$Ambiguit\"{a}t$ in sprachlichen Ausdrucken fast $durchg\"{a}ngig$ vol. In der vorliegenden Albeit wird die $M\"{o}glichkeit$ der semantischen $\"{U}bersetzung$ der Skalaradjektiven($gro{\ss}$, klein, $hei{\ss}$, kalt, schwer, leicht, schnell, langsam usw.) untersucht, die eigentlich die Vagheit als eine der konstitutiven Eigenschaften haben. Den Schwerpunkt $daf\"{u}r$ bildet die semantische Analyse $\"{u}ber$ die Graduierbarkeit und Vergleichbarkeit der Positivformen der Adjektiven, die vol allem M.J.Cresswell 1976 in seiner Albeit formuliert hat. V(pos) is the function $\eta$ in $D_{{\lll}{0,1}>,<{0,1}{\gg}.{\ll}{0,1,1},>,<{0.1}{\ggg}$ such that where ${\xi}{\in}D_{{\ll}{0,1,1},><{0,1}{\gg}$,$\eta({\xi})$ is the following function: For any ${\omega}{\in}D_{<0,1>$and a ${\in}D_1$ and w$\in$W, w${\in}{\eta}({\xi})({\omega})$(a) iff w ${\in}{\omega}$(a) and there is exactly one b such that ${\xi}({\omega})$(a,b); and for that b, b=$\gg$(for some > and u ${\in}{ \scr}{Z}(>))$ and u is toward the top of the scale determined by > when restricted to those v such that for some c, w${\in} {\xi}({\omega})$$(c,{\;} and w${\in}{\omega}(c)$. (Cresswell, 1976: 272) Obwohl sein Verfahren anhnd von dem semantischen Symbol eine methodische und theoretische $Ad\"{a}quatheit$ erf\"{u}llt$, bleibt der Vergleichwert noch unterspezifiziert. Fur die Behandlung dieser semantischen Unterspezifikation ist eine neue Semantik erforderlich, die den Wahrheitwert fur die $Zugeh\"{o}rigkeitsgrade$ der Skalaradjektive $einschlie{\ss}t$.

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