• 대한수의사회지
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• 제15권3호
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• pp.143-148
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• 1979

A total of 360 Staphylococcus isolates from 26 raw cow milk sample in milk plants of Jeonju district during Octover 1977, identified by $7.5\%$ salt resistant reaction and other biological properties. Antibiotic sensitivity test was also perfor

• 한국식품영양과학회지
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• 제5권1호
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• pp.25-30
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• 1976

본연구(本硏究)에서는 한우유(韓牛乳)와 Holstein cow milk의 단백질(蛋白質)을 Zone electrophoresis에 의하여 분석(分析)하여 그 결과(結果)를 다음과 같이 얻었다. (1) 한우유(韓牛乳)와 Holstein cow milk의 이화학적(理化學的) 성질(性質)이 Table 1, Table 2에 나타나 있다. (2) 한우유(韓牛乳)의 유청단백질(乳淸蛋白質)의 단백질(蛋白質) 분포(分布)는 Lactoalbumin 1.74mg %, Alpha-1 globulin 1.19mg%, Alpha-2 globulin 0.68mg %, Beta globulin 2.57mg %, Gamma globulin 0.93mg %이었다. (3) Holstein cow milk protein의 단백질(蛋白質) 분포(分布)는 Lactoalbumin 1.23mg %, Alpha-1 globulin 1.93mg %, Alpha-2 globulin 0.86mg %, Beta globulin 2.56mg %, Gamma globulin 1.74mg %를 얻었다. (4) 한우(韓牛)(female)와 Holstein cow(male)와의 교잡종인 F-1인 유청단백질(乳淸蛋白質) 분포(分布)는 Lactoalbumin 1.30mg %, Alpha-1 globulin 1.58mg %, Alpha-2 globulin 2.46mg %, Beta globulin 1.39mg %이었고 F-2의 그것은 Lactoalbumin 1.57mg %, Alpha-1 globulin 1.74mg %, Alpha-2 globulin 2.19mg %, Beta globulin 1.17mg %, F-4에서는 Lactoalbumin 2.46mg %, Alpha-1 globulin 1.24mg %, Alpha-2 globulin 1.57mg %, Beta globulin 1.74mg %를 각각(各各) 얻었다.

• Preventive Nutrition and Food Science
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• 제16권3호
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• pp.248-252
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• 2011

Soy protein based formula (SPF) has been developed for infants who are at a high risk for atopic dermatitis (AD) and cow's milk protein allergy (CMA). We performed this study to evaluate the therapeutic efficacy and safety of SPF compared to conventional hydrolyzed cow's milk formula (hCMF) in the feeding of infants with AD and CMA. 38 infants (12 to 24 months of age) diagnosed with CMA and AD were randomized to receive either SPF or hCMF for 12 weeks. Follow-up was conducted at 4, 8 and 12 weeks. Growth parameters of the infants were evaluated during each visit. Clinical evaluations, including AD severity scores, pruritus, specific immunoglobulin E (IgE) (cow's milk protein and soy protein) levels of peripheral blood, were made at enrollment and week 12. Analysis was performed on the 32 infants (SPF: n=16, hCMF: n=16) who completed the 12-week intervention. Eczema area and severity index (EASI) scores, a measure of the severity of AD, and pruritus were significantly reduced after 12 weeks compared to enrollment in the both groups; however, the median changes for EASI scores and pruritus were not statistically different between the two groups. The growth parameters did not differ significantly between both groups at any assessed time point. This study suggests that SPF could be useful in decreasing the severity of AD without affecting infant growth status. Therefore SPF could provide an adequate and safe alternative to hCMF in treating infants with AD and CMA during the first 12 to 24 months of their life.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제24권4호
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• pp.392-402
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• 2021

Purpose: The present study assessed the role of an amino acid-based formula (AAF) in the growth of infants with cow's milk protein allergy (CMPA). Methods: Non-breastfed, term infants aged 0-6 months with symptoms suggestive of CMPA were recruited from 10 pediatric centers in China. After enrollment, infants were started on AAF for two weeks, followed by an open food challenge (OFC) with cow's milk-based formula (CMF). Infants with confirmed CMPA remained on AAF until 9 months of age, in conjunction with a cow's milk protein-free complementary diet. Body weight, length, and head circumference were measured at enrollment and 9 months of age. Measurements were converted to weight-for-age, length-for-age, and head circumference-for-age Z scores (WAZ, LAZ, HCAZ), based on the World Health Organization growth reference. Results: Of 254 infants (median age 16.1 weeks, 50.9% male), 218 (85.8%) were diagnosed with non-IgE-mediated CMPA, 33 (13.0%) tolerated CMF, and 3 (1.2%) did not complete the OFC. The mean WAZ decreased from 0.119 to -0.029 between birth and enrollment (p=0.067), with significant catch-up growth to 0.178 at 9 months of age (p=0.012) while being fed the AAF. There were no significant changes in LAZ (0.400 vs. 0.552; p=0.214) or HCAZ (-0.356 vs. -0.284; p=0.705) from the time of enrollment to age 9 months, suggesting normal linear and head growth velocity. Conclusion: The amino acid-based study formula, in conjunction with a cow's milk proteinfree complementary diet, supported normal growth till 9 months of age in a cohort of Chinese infants with challenge-confirmed non-IgE-mediated CMPA.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제7권1호
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• pp.40-47
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• 2004

목 적: 효율적인 진단과 치료 및 적절한 의학적 교류를 목적으로 소아 위장관 알레르기 질환의 새로운 분류법이 발표되었다(J Pediatr Gastroenterol Nutr 2000;30:S87-94). 그러나 명칭과 분류의 변경으로 이미 알려진 질환들이 새로운 질환으로 보고되기도 하는데, 저자들은 새로운 분류법에 따른 소아 위장관 알레르기 질환의 질병군에 관하여 알아보고, 국내에서 이미 보고된 관련 문헌을 함께 고찰하여 의학적 교류에 혼선을 최소화 하고자 한다. 방 법: 2003년 3월부터 7월까지 계명대학교 의과대학 소아과를 방문하여, 우유 유발 및 제거시험, 내시경을 이용한 조직생검 등을 이용하여 소아 GI-CMA로 진단된 37례(남 19, 여 18)를 대상으로 후향성 조사하였다. 새로운 분류에는 포함되지 않았으나 위식도역류 관련 알레르기를 추가하였다. 국내 문헌은 소아과학회지, 소아소화기영양학회지, 소아알레르기호흡기학회지를 근거로 고찰하였다. 결 과: 1) 대상 환아의 연령은 2주~15개월, 평균 $5.4{\pm}4.8$개월이었다. 2) 출생체중은 전례에서 10~90백분위수를 차지하였으며, 25~75백분위수가 25례(68%)를 차지하였다. 내원 당시 체중은 3백분위수 이하가 18례(49%)이었다. 3) 증상발현에서 진단까지 걸린 시간은 2주~12개월, 평균 $2.4{\pm}3.3$개월이었다. 4) IgE 군인 IgE 매개형 우유알레르기(IGE) 6례(16%), IgE와 Non-IgE 혼합군인 호산구성 위장관염(EOS) 2례(5%), Non-IgE군인 전형적 우유 단백질 유발 장관염(CMPIE-T) 7례(19%), 비전형적 우유 단백질 유발 장관염(CMPIE-AT) 5례(14%), 알레르기성 대장염(AC) 12례(32%)이었다. 위식도역류증 관련 우유 알레르기(GERA)는 5례(14%)이었다. CMPIE-T 전례에서 소장 조직생검상 장병증이 관찰되었다. 5) 진단 당시 연령은 IGE $4.3{\pm}0.8$개월, EOS 생후 2주와 14개월, CMPIE-T $3.8{\pm}4.6$개월, CMPIE-AT $10.4{\pm}3.8$개월, AC $3.4{\pm}3.9$개월, GERA $7.8{\pm}5.7$개월로 질환군간 유의한 차이를 보였다(p<0.05). 6) 내원 당시 3백분위수 이하를 보인 경우가 IGE 17%, EOS 0%, CMPIE-T 86%, CMPIE-AT 60%, AC 25%, GERA 100%로 질환군간 유의한 차이를 보였다(p<0.05). 7) 국내 문헌을 고찰하여 소아 위장관 우유 알레르기 질환은 만성설사, 난치성설사, 우유 불내성, 우유 알레르기, 위장관 알레르기, 우유 과민성 장병증, 호산구성 위장관염, 알레르기성 대장염 등의 용어로 보고되었다. 결 론: 새로운 분류법에 따른 소아 위장관 우유 알레르기 질환은 연령, 임상 증상, 위장관 침범 부위에 따라 특징적인 유형으로 구분할 수 있으며, 임상적으로 드물지 않다. 국내의 문헌을 통하여 다양한 용어로 각 유형의 알레르기 질환들은 연구 보고되어 왔다.

• 한국근적외분광분석학회:학술대회논문집
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• 한국근적외분광분석학회 2001년도 NIR-2001
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• pp.4104-4104
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• 2001

Milk somatic cell count (SCC) is a recognized indicator of cow health and milk quality. The potential of near infrared (NIR) spectroscopy in the region from 1100 to 2500nm to measure SCC content of cow milk was investigated. A total of 196 milk samples from 7 Holstein cows were collected for 28 days, consecutively, and analyzed for fat, protein, lactose and SCC. Three of the cows were healthy, and the rest had mastitis periods during the experiment. NIR transflectance milk spectra were obtained by the InfraAlyzer 500 spectrophotometer in a wavelength range from 1100 to 2500 nm. The calibration for logSCC was performed using partial least square (PLS) regression and different spectral data pretreatment. The best accuracy of determination was found for equation, obtained using smoothed absorbance data and 10 PLS factors. The standard error of calibration was 0.361, calibration coefficient of multiple correlation 0.868, standard error of prediction for independent validation set of samples 0.382, correlation coefficient 0.854 and the variation coefficient 7.63%. The accuracy of logSCC determination by NIR spectroscopy would allow health screening of cows, and differentiation between healthy and mastitic milk samples. When the spectral information was studied it has been found that SCC determination by NIR milk spectra was indirect and based on the related changes in milk composition. In the case of mastitis, when the disease occurred, the most significant factors that simultaneously influenced milk spectra were alteration of milk proteins and changes in ionic concentration of milk.

• Asian-Australasian Journal of Animal Sciences
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• 제19권7호
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• pp.915-921
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• 2006

Various random regression models with different order of Legendre polynomials for permanent environmental and genetic effects were constructed to predict future milk yield of Holstein cows in Korea. A total of 257,908 test-day (TD) milk yield records from a total of 28,135 cows belonging to 1,090 herds were considered for estimating (co)variance of the random covariate coefficients using an expectation-maximization REML algorithm in an animal mixed model. The variances did not change much between the models, having different order of Legendre polynomial, but a decreasing trend was observed with increase in the order of Legendre polynomial in the model. The R-squared value of the model increased and the residual variance reduced with the increase in order of Legendre polynomial in the model. Therefore, a model with $5^{th}$ order of Legendre polynomial was considered for predicting future milk yield. For predicting the future milk yield of cows, 132,771 TD records from 28,135 cows were randomly selected from the above data by way of preceding partial TD record, and then future milk yields were estimated using incomplete records from each cow randomly retained. Results suggested that we could predict the next four months milk yield with an error deviation of 4 kg. The correlation of more than 70% between predicted and observed values was estimated for the next four months milk yield. Even using only 3 TD records of some cows, the average milk yield of Korean Holstein cows would be predicted with high accuracy if compared with observed milk yield. Persistency of each cow was estimated which might be useful for selecting the cows with higher persistency. The results of the present study suggested the use of a $5^{th}$ order Legendre polynomial to predict the future milk yield of each cow.

• 대한수의학회지
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• 제4권1호
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• pp.19-22
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• 1964

The alcohol precipitation test(APT) is widely used in the inspection of cow milk, whereas the APT in goat milk inspection is not specifically known. The APT is used to determine the precipitating ability of milk by heat used in sterilization and evaporating process at the milk plant. The APT may also be used to detect abnormal milks such as acid milk, colostrum, and any milk in which the salt balance is disturbed so that it may be more subject to precipitation than normal milk. In the experiments the applicability of the APT of goat milk was studied. The results obtained by using 87 sample of goat milk are as follows: 1. As all the fresh samples(100%) were APT positive by using 70% ethanol which is used in the practice of cow milk and 3 out of 87 samples(3.7%) were positive by using 45% ethanol, it is suggested that 45% ethanol may be applied in the APT of goat milk. 2. The distribution of natural acidity (apparent acidity) was between 0.12%-0.30% and the amount of natural acidity did not significantly affect the precipitating ability of goat milk by APT. 3. The freshness of goat milk cannot be detected sharply by APT even though 45% ethanol is applied.

• Journal of Dairy Science and Biotechnology
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• 제31권2호
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• pp.93-98
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• 2013

For purposes of substantiation of organizing measures on industrial processing of goat's and sheep's milk in Mongolia and the production of dairy products we have conducted the studied physico-chemical characteristics of the Mongolian goat's and sheep's milks especially to recognize amino acids, minerals and vitamins in the milk and compare with the Mongolian cow's milk. And also was studied fractional structure of goat's milk whey proteins.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제24권4호
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• pp.384-391
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• 2021

Purpose: The Cow's Milk-related Symptom Score (CoMiSS^TM) was developed as an awareness tool for evaluating cow's milk-related symptoms in otherwise healthy children. Using a convenience sample of participants, this cross-sectional study aimed to determine CoMiSS^TM values of symptomatic infants based on retrospectively or prospectively obtained information. Methods: CoMiSS^TM values were determined in infants aged <12 months with symptoms suggestive of cow's milk protein allergy or functional gastrointestinal disorders. The exclusion criteria were previous diagnosis with acute or chronic disease, treatment with a therapeutic formula, and in case of breastfeeding, an elimination diet followed by the mother. Two CoMiSS^TM values were assessed. A retrospective collection was defined as the collection of data after initial contact with the medical center but before the first medical consultation. A prospective collection was defined as the collection of data within 24 hours from the time of medical consultation but before starting any therapeutic intervention. The CoMiSS^TM total and individual component scores obtained retrospectively or prospectively were compared between groups using the Wilcoxon signed-rank test. Results: This study was performed between August and November 2019. Data of 110 children (62 males and 48 females), with a mean±standard deviation age of 18.2±11.7 weeks, were obtained. The total CoMiSS^TM value (p<0.001) and some individual component scores (crying, regurgitation, and stool) were significantly lower when collected prospectively than when collected retrospectively. Conclusion: CoMiSS^TM values were retrospectively and prospectively determined. Lower CoMiSS^TM values were obtained during prospective evaluation. Possible differences should be considered when using CoMiSS^TM in clinical practice.