• The Korean Journal of Applied Statistics
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• v.36 no.5
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• pp.381-397
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• 2023

The most representative design used in clinical trials is randomization, which is used to accurately estimate the treatment effect. However, comparison between the treatment group and the control group in an observational study without randomization is biased due to various unadjusted differences, such as characteristics between patients. Propensity score weighting is a widely used method to address these problems and to minimize bias by adjusting those confounding and assess treatment effects. Inverse probability weighting, the most popular method, assigns weights that are proportional to the inverse of the conditional probability of receiving a specific treatment assignment, given observed covariates. However, this method is often suffered by extreme propensity scores, resulting in biased estimates and excessive variance. Several alternative methods including trimming, overlap weights, and matching weights have been proposed to mitigate these issues. In this paper, we conduct a simulation study to compare performance of various propensity score weighting methods under diverse situation, such as limited overlap, misspecified propensity score, and treatment contrary to prediction. From the simulation results overlap weights and matching weights consistently outperform inverse probability weighting and trimming in terms of bias, root mean squared error and coverage probability.

• Progress in Medical Physics
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• v.23 no.2
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• pp.81-90
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• 2012

The effect of setup uncertainties on CTV dose and the correlation between setup uncertainties and setup margin were evaluated by Monte Carlo based numerical simulation. Patient specific information of IMRT treatment plan for rectal cancer designed on the VARIAN Eclipse planning system was utilized for the Monte Carlo simulation program including the planned dose distribution and tumor volume information of a rectal cancer patient. The simulation program was developed for the purpose of the study on Linux environment using open source packages, GNU C++ and ROOT data analysis framework. All misalignments of patient setup were assumed to follow the central limit theorem. Thus systematic and random errors were generated according to the gaussian statistics with a given standard deviation as simulation input parameter. After the setup error simulations, the change of dose in CTV volume was analyzed with the simulation result. In order to verify the conventional margin recipe, the correlation between setup error and setup margin was compared with the margin formula developed on three dimensional conformal radiation therapy. The simulation was performed total 2,000 times for each simulation input of systematic and random errors independently. The size of standard deviation for generating patient setup errors was changed from 1 mm to 10 mm with 1 mm step. In case for the systematic error the minimum dose on CTV $D_{min}^{stat{\cdot}}$ was decreased from 100.4 to 72.50% and the mean dose $\bar{D}_{syst{\cdot}}$ was decreased from 100.45% to 97.88%. However the standard deviation of dose distribution in CTV volume was increased from 0.02% to 3.33%. The effect of random error gave the same result of a reduction of mean and minimum dose to CTV volume. It was found that the minimum dose on CTV volume $D_{min}^{rand{\cdot}}$ was reduced from 100.45% to 94.80% and the mean dose to CTV $\bar{D}_{rand{\cdot}}$ was decreased from 100.46% to 97.87%. Like systematic error, the standard deviation of CTV dose ${\Delta}D_{rand}$ was increased from 0.01% to 0.63%. After calculating a size of margin for each systematic and random error the "population ratio" was introduced and applied to verify margin recipe. It was found that the conventional margin formula satisfy margin object on IMRT treatment for rectal cancer. It is considered that the developed Monte-carlo based simulation program might be useful to study for patient setup error and dose coverage in CTV volume due to variations of margin size and setup error.

• The Korean Journal of Applied Statistics
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• v.29 no.7
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• pp.1459-1473
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• 2016

Both longitudinal data and survival data are collected simultaneously in longitudinal data which are observed throughout the passage of time. In this case, the effect of the independent variable becomes biased (provided that sole use of longitudinal data analysis does not consider the relation between both data used) if the missing that occurred in the longitudinal data is non-ignorable because it is caused by a correlation with the survival data. A joint model of longitudinal data and survival data was studied as a solution for such problem in order to obtain an unbiased result by considering the survival model for the cause of missing. In this paper, a joint model of the longitudinal zero-inflated count data and survival data is studied by replacing the longitudinal part with zero-inflated count data. A hurdle model and proportional hazards model were used for each longitudinal zero inflated count data and survival data; in addition, both sub-models were linked based on the assumption that the random effect of sub-models follow the multivariate normal distribution. We used the EM algorithm for the maximum likelihood estimator of parameters and estimated standard errors of parameters were calculated using the profile likelihood method. In simulation, we observed a better performance of the joint model in bias and coverage probability compared to the separate model.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.9 no.6
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• pp.136-150
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• 2010

Due to the effect of indoor coverage problem, the QoS of the indoor users will be degraded dramatically, with the number of indoor users. The femto cell is a popular solution for such problems. Since the price of the femto base station is usually cheap enough, one can sets up huge number of base stations in a small indoor area to reduce the size of communication cell. In this way, the QoS of the indoor users can be improved significantly. Moreover, the data rate can also be increased. However, how to decide an ideal transmitting power according to the surrounding radio environment is not a trivial problem, that still has not been addressed well. If the transmit power of femto base station is too large, the interference to the macro users will be increased. Conversely, if the transmit power of femto base station is too small; the coverage of femto base station will be reduced. To address this problem, we propose a power configuration method in femto base station using Genetic Algorithm by investigating a new fitness function. Furthermore, we adopt the weighted sum approach to improve the user performance in different modes. The simulation results show that the proposed power configuration method can not only improves the downlink SINR, but also enhance the channel capacity for both the Macro cell systems and Femto cell systems compared with some conventional methods.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.37 no.8A
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• pp.648-660
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• 2012

The low-power, low-cost femtocell network has been proposed not only to alleviate traffic load to the macro base station (eNB) but also to cover the indoor coverage hole problem. However, in the dense femtocell environment where many femtocells are deployed to cover the whole large office building, performance of such femtocell environment can be deteriorated due to severe co-channel interference problem between the eNB and femtocells and among neighboring femtocells. In particular, a macro UE(mUE) located within femtocell coverage may experience severe co-channel interference from surrounding femtocells. Therefore, In this paper, we propose a novel power control schemes to mitigate interference to a mUE under such dense LTE femtocell environment. With proposed femtocell power control schemes, performance of the mUE can be greatly improved in terms of the outage probability and the SINR while maintaining satisfying femtocell performance. Simulation based performance study shows that the proposed power control scheme is able to enhance mUE performance more than 30% than the conventional dense femtocell in terms of the two performance metrics.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.49 no.7
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• pp.39-47
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• 2012

The combination of the broadband property and the wide area coverage of satellite communications enables high speed transmission. Every user in the region under the satellite beam coverage can tranceiver and one can simultaneously communicate with multiple users. For these reasons, it is one of commendable telecommunication networks for information transfer. Since the satellite communications use open channels, it is likely to cause jamming with unwanted interference signals. In the thesis, APSK (Amplitude Phase Shift Keying) is employed, which is recommended for DVB-S2 due to high-speed transmission and excellent bandwidth efficiency. For obtaining reliable communication under the jamming environments, the communication satellite transponder rests on the polyphase filter bank structure, which enables switching among the subchannels and gain control on each subchannel, resulting in effectively eliminating jamming. Furthermore, the nulling scheme, one of the various anti-jamming approaches, is investigated, in which unwanted jamming signals are eliminated in the frequency domain after passing through the analysis part of the polyphase filter bank. The performance of the nulling scheme is evaluated for tone jamming and partial band jamming in terms of BER and EVM. The simulation results indicate that the nulling scheme improve the BER and EVM performance over the case without any anti-jamming approach.

• KIPS Transactions on Computer and Communication Systems
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• v.9 no.3
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• pp.67-76
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• 2020

With the fast development in wireless communications and vehicular technologies, vehicular ad hoc networks (VANETs) have enabled to deliver data between vehicles. Recently, VANETs introduce a Vehicular Cloud (VC) model for collaborating to share and use resources of vehicles to create value-added services. To construct a VC, a vehicle should search vehicles that intend to provide their own resource. The single-hop search cannot search enough provider vehicles due to a small coverage and non-line-of-sights of communications. On the other hand, the multi-hop search causes very high traffics for large coverage searching and frequent connection breakages. Recently, many Roadside Units (RSUs) have been deployed on roads to collect the information of vehicles in their own coverages and to connect them to Internet. Thus, we propose a RSU-aided vehicular resource search and cloud construction mechanism in VANETS. In the proposed mechanism, a RSU collects the information of location and mobility of vehicles and selects provider vehicles enabled to provide resources needed for constructing a VC of a requester vehicle based on the collected information. In the proposed mechanism, the criteria for determining provider vehicles to provide resources are the connection duration between each candidate vehicle and the requester vehicle, the resource size of each candidate vehicle, and its connection starting time to the requester vehicle. Simulation results verify that the proposed mechanism achieves better performance than the existing mechanism.

• Journal of Broadcast Engineering
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• v.15 no.1
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• pp.122-132
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• 2010

AT-DMB system has been developed to increase data rate up to double of conventional T-DMB in the same bandwidth while maintaining backward compatibility. The AT-DMB system adopted hierarchical modulation which adds BPSK or QPSK signal as enhancement layer to existing DQPSK signal. The enhancement layer signal should be small enough to maintain backward compatibility and to minimize the coverage loss of conventional T-DMB service coverage. But this causes the enhancement layer signal of AT-DMB susceptible to fading effect in transmission channel. A turbo code which has improved error correction capability than convolutional code, is applied to the enhancement layer signal of the AT-DMB system for compensating channel distortion. However there is a need for other solutions for better reception of AT-DMB signal in receiver side without increasing transmitting power. In this paper, we propose adaptive array antenna system with Eigen-space beamforming algorithm which benefits beamforming gain along with diversity gain. We analyzed the reception performances of AT-DMB system in indoor and mobile environments when this new smart antenna system and algorithm is introduced. The computer simulation results are presented along with analysis comments.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.30 no.1
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• pp.45-53
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• 2019

In this paper, three types of array antennas for 5G mobile devices operating at 28 GHz were designed, and their performances were compared. The isolation between antenna elements was compared based on $S_{21}$. The $S_{21}$ of dipole, slot, and patch type are -13.76 dB, -16.88 dB, and -11.47 dB, respectively, with the slot-type antenna having the highest isolation. In order to compare the beam coverage performance, several characteristics such as beam width and maximum beam steering angle were analyzed. The analysis shows that the slot type has the widest steering angle of $63^{\circ}$ while the patch type has narrowest with $36^{\circ}$. In addition, to verify the performance of the antennas in the actual usage environment of the device, antenna characteristics in talk mode and data mode were analyzed through simulation. The results confirmed that the slot-type array antenna is the most suitable array antenna element for 28 GHz 5G mobile devices.

• Radiation Oncology Journal
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• v.23 no.4
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• pp.236-242
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• 2005

Purpose: To evaluate the role of surgical clips and scars in determining electron boost field for early stage breast cancer undergoing conserving surgery and postoperative radiotherapy and to provide an optimal method in drawing the boost field. Materials and Methods: Twenty patients who had $4{\sim}7$ surgical clips in the excision cavity were selected for this study. The depth informations were obtained to determine electron energy by measuring the distance from the skin to chest wall (SCD) and to the clip implanted in the most posterior area of tumor bed. Three different electron fields were outlined on a simulation film. The radiological tumor bed was determined by connecting all the clips implanted during surgery Clinical field (CF) was drawn by adding 3 cm margin around surgical scar. Surgical field (SF) was drawn by adding 2 cm margin around surgical clips and an Ideal field (IF) was outlined by adding 2 cm margin around both scar and clips. These fields were digitized into our planning system to measure the area of each separate field. The areas of the three different electron boost fields were compared. Finally, surgical clips were contoured on axial CT images and dose volume histogram was plotted to investigate 3-dimensional coverage of the clips. Results : The average depth difference between SCD and the maximal clip location was $0.7{\pm}0.55cm$. Greater difference of 5 mm or more was seen in 12 patients. The average shift between the borders of scar and clips were 1.7 1.2, 1.2, and 0.9 cm in superior, inferior, medial, and lateral directions, respectively. The area of the CF was larger than SF and IF in 6y20 patients. In 15/20 patients, the area difference between SF and if was less than 5%. One to three clips were seen outside the CF in 15/20 patients. In addition, dosimetrically inadequate coverage of clips (less than 80% of prescribed dose) were observed in 17/20 patients when CF was used as the boost field. Conclusion: The electron field determined from clinical scar underestimates the tumor bed in superior-inferior direction significantly and thereby underdosing the tissue at risk. The electron field obtained from surgical clips alone dose not cover the entire scar properly As a consequence, our technique, which combines the surgical clips and clinical scars in determining electron boost field, was proved to be effective in minimizing the geographical miss as well as normal tissue complications.