• Journal of Periodontal and Implant Science
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• 제38권4호
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• pp.565-578
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• 2008

Purpose: Porphyromonas gingivalis(P. gingivalis) heat shock protein (HSP)60 may play a role in the immunopathogenesis of periodontitis as well as atherosclerosis by modulating autoimmune reaction due to its high level of sequence homology between bacteria and human counterpart. The purpose of this study was to identify immunodomiant epitope of P. gingivalis HSP60 that is reactive exclusively to the homologous bacteria without reacting with human HSP. Materials and methods: The present study was performed to identify the peptide specifically recognized by anti-P. gingivalis HSP60 monoclonal antibodies mono-reactive to P. gingivalis HSP60. Results: Four different hybridomas were cloned producing monoclonal IgG antibodies exclusively to P. gingivalis HSP60. Thirty seven synthetic peptides (20-mer with 5-amino acid overlapping) were synthesized. All of these peptide were subject to SDS-PAGE for immunblot analysis. One peptide (TVPGGGTTYIRAIAALEGLK) and the other peptide (TLVVNRLRGSLKICAVKAPG) were recognized by all and one of the four monoclonal antibodies, respectively, that reacted solely with P. gingivalis HSP60. Immunohistochemistry to identify the localization of the HSP60 in the diseased gingival tissues revealed that all of the four monoclonal antibodies were highly reacted with the diseased gingival tissue than normal gingival tissue. Conclusion: The P. gingivalis HSP60 peptides (TVPGGGTTYIRAIAALEGLK and TLVVNRLRGSLKICAVKAPG, respectively) are positively involved in the immunopathologic process of periodontal disease. The peptide may potentially be developed as vaccine candidates. Further investigations are under way to identify more clones producing monoclonal antibodies reactive to P. gingivalis HSP and to other periodontopathogenic bacteria as well, while maintaining specificities to human counterpart.

• 한국대기환경학회지
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• 제13권2호
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• pp.161-170
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• 1997

The concentrations of dimethylsulfide (DMS) were determined using samples collected from a station located at Kosan, Cheju Island during two field campaigns held in December 1996 and January 1997. The atmospheric DMS concentrations measured at 6-hr intervals during the entire campaign periods, after excluding a few extreme values, spanned in the range of 14 to 410 pptv with mean and 1 SD value of 127 $\pm$ 94 pptv (N=42). Between two month periods during which the field campaigns were conducted, a notable reduction in DMS levels was observed which was comparable to the dramatic shift in air temperature. A considerable difference was also noted in DMS levels, when data were grouped by day/night basis. The cause of unexpected, high day-to-night DMS ratios is best explained in terms of high efficiency of daytime source processes relative to low efficiency of nighttime sink processes due to the characteristics of the study location. The surface water DMS of the study site, although scarcely measured, also behaved similarly to its atmospheric counterpart with its range from 0.3 to 19 nM (N=11). When correlation analysis was conducted between the atmospheric DMS concentration and other concurrently determined parameters, significant correlations were observed from most basic meteorological parameters such as windspeed, relative humidy, and air temperature. However, the existence of "not-so-strong" correlations between air temperature and DMS concentrations relative to other ones indicated that the effect of temperature on DMS behavior must be reflected in more complicated manners at the study site. The sea-to-air flux of DMS was approximated through an application of the mass-balance flux calculation method of Wylie and de Mora (1996) under the assumption that sink mechanism within the marine boundary layer is in steady-state condition with its counterpart, source mechanism. Based on this estimation method, we reached a conclusion that oceanic DMS emitted from the southwest sea of the Korean Peninsula can amount to approximately 9 $\sim$ 36 Gg S $yr^{-1}$.$yr^{-1}$.

• 한국컴퓨터정보학회논문지
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• 제15권7호
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• pp.75-81
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• 2010

본 논문에서는 웹캠을 이용하여 사용자의 안면 또는 손동작을 인식하고, 그 제스쳐가 나타내는 감성(희노애락)을 플래시 콘으로 표현하여 상대방에게 전송하는 감성 메신저를 구현한다. 이 메신저는 안면 인식 모듈과 손동작 인식 모듈, 메신저 모듈로 구성된다. 안면 인식 모듈에서는 눈, 입의 각 영역을 이진 영상으로 변환하여 눈과 입의 모양 변화에 따라 윙크, 입맞춤, 하품 등을 인식한다. 또한 손동작 인식 모듈에서는 인식한 손가락 수에 따라 가위-바위-보로 인식한다. 메신저 모듈은 안면 인식 모듈과 손동작 인식 모듈에서 인식한 윙크, 입맞춤, 하품과 가위-바위-보를 플래시 콘으로 표현하여 상대방에게 전달한다. 본 논문에서는 시뮬레이션을 통하여 감성 메신저의 CPU 점유율이 최소임을 검증한다. 또한 감성 메신저의 손동작 인식 모듈의 성능이 안면 인식 모듈에 비해 우수함을 보인다.

• 한국한의학연구원논문집
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• 제8권1호
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• pp.93-104
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• 2002

The following is a list of morphologic and genetic characteristics of Pinellia tuber. 1. The original plant of Pinellia tuber is Pinellia ternata$(T_{HUNB})$$B_{REIT}$. With regards to its external morphology, it is smaller than other Araceae species and its spadix is longer than its leaves, which trifurcate. 2. As regards its internal morphology, its mucous cell is elliptical and the vessel is helical or annular-shaped. Granules exist in abundance and in various shapes. 3. Distribution and size of laticifers are the key criteria on which to differentiate between domestic and imported Pinellia tuber. Laticifers are mainly distributed in the epidermis in domestic Pinellia tuber and in the cortical parenchyma in imported Pinellia tuber. The size of laticifers is somewhere between 1,3 and $8{\mu}m$ in diameter in imported Pinellia tuber bigger than its domestic counterpart. 4. RAPD markers display a great similarity in bands between domestic and Chinese Pinellia tuber. However, RAPD primers 352, 358, 365, 368 and 374 are distinctive markers for domestic Pinellia tuber. In the meantime, North Korean Pinellia tuber, morphologically similar to domestic Pinellia tuber, is genertically distinctive from its domestic counterpart in primers 354, 358, 365, 368, 374 and 379, a finding that supports the postulation that North Korean Pinellia tuber is tuber of another Araceae species.

• 콘크리트학회논문집
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• 제13권6호
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• pp.637-644
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• 2001

본 논문에서는 콘크리트 댐체의 균열 발생 및 진전해석을 포함하는 비선형 지진해석에서 유한요소망 의존성을 제거시키고 안정적인 해를 얻기 위하여 균열모형으로 사용되는 소성손상모형 및 손상역학모형을 duvaut-lions모형에 기초한 점소성모형으로 정규화하는 방법을 기술하였다. 제안된 방법으로 정규화된 소성손상모형과 그렇지 않은 소성손상모형를 이용하여 지진하중을 받는 콘크리트 댐체의 동적 손상해석을 수행하여 여러 형태의 유한요소망이 해석결과에 미치는 영향을 분석하였다. 해석결과로부터 정규화한 소성손상모형은 유한요소망의 크기 및 배열에 영향을 크게 받지 않고 객관적이며 안정적인 해를 계산하는 반면, 정규화되지 않은 균열모형은 요소망에 의존적인 불안정한 결과를 산출함을 관찰할 수 있었다.

• International Journal of Contents
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• 제15권1호
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• pp.39-51
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• 2019

Spontaneous speech provides rich information defining the linguistic characteristics of individuals. As such, computational analysis of speech would enhance the efficiency involved in evaluating patients' speech. This study aims to provide a method to differentiate the persons with and without aphasia based on language usage. Ten aphasic patients and their counterpart normal controls participated, and they were all tasked to describe a set of given words. Their utterances were linguistically processed and compared to each other. Computational analyses from PCA (Principle Component Analysis) to machine learning were conducted to select the relevant linguistic features, and consequently to classify the two groups based on the features selected. It was found that functional words, not content words, were the main differentiator of the two groups. The most viable discriminators were demonstratives, function words, sentence final endings, and postpositions. The machine learning classification model was found to be quite accurate (90%), and to impressively be stable. This study is noteworthy as it is the first attempt that uses computational analysis to characterize the word usage patterns in Korean aphasic patients, thereby discriminating from the normal group.

• 한국정밀공학회지
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• 제26권8호
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• pp.79-88
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• 2009

This paper presents the analytical stiffness analysis method for a low-DOF planar parallel manipulator. An n-DOF (n<3) planar parallel manipulator to which 1- or 2-DOF serial mechanism is connected in series may be used as a positioning device in planar tasks requring high payload and high speed. Differently from a 3-DOF planar parallel manipulator, an n-DOF planar parallel counterpart may be subject to constraint forces as well as actuation forces. Using the theory of reciprocal screws, the planar stiffness is modeled such that the moving platform is supported by three springs related to the reciprocal screws of actuations (n) and constraints (3-n). Then, the spring constants can be precisely determined by modeling the compliances of joints and links in serial chains. Finally, the stiffness of two kinds of 2-DOF planar parallel manipulators with simple and complex springs is analyzed. In order to show the effectiveness of the suggested method, the results of analytical stiffness analysis are compared to those of numerical stiffness analysis by using ADAMS.

• Structural Engineering and Mechanics
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• 제47권1호
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• pp.119-129
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• 2013

Nonlinear Static Procedures (NSPs) have been developed as a practical tool to estimate the seismic demand of structures. Several researches have accomplished to minimize errors of NSPs, namely pushover procedures, in the Nonlinear Time History Analysis (NTHA), as the most exact method. The most important issue in a typical pushover procedure is the pattern and technique of loading which are extracted based on structural dynamic fundamentals. In this paper, the coefficients of modal force combination is focused involving a meta-heuristic optimization algorithm to find the optimum load pattern which results in a response with minimum amount of errors in comparison to the NTHA counterpart. Other parameters of the problem are based on the FEMA recommendations for pushover analysis of building structures. The proposed approach is implemented on a high-rise 20 storey concrete moment resisting frame under three earthquake records. In order to demonstrate the effectiveness and robustness of the studied procedure the results are presented beside other well-known pushover methods such as MPA and the FEMA procedures, and the results show the efficiency of the proposed load patterns.

• 한국컴퓨터정보학회논문지
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• 제23권11호
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• pp.193-201
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• 2018

In this paper, we extracted relevant patent data and conducted statistical analysis to understand the technical development trend related to Wireless Power Transfer (WPT) for Light Rail Transit (LRT). Recently, with the development of WPT technologies, the Light Rail Transit (LRT) industry is concentrating on applying WPT to the power supply system of trains because of their advantages compared wired counterpart, such as low maintenance cost and high stability. This technology is divided into three areas: wireless feeding and collecting technology, high-frequency power converter technology and orbital and infrastructure technology. From each specific area, key words in patent document were extracted by TF-IDF method and analyzed by social network. In the keyword network, core word of each specific technology were extracted according to their degree centrality. Then, the multi-word phrases were also built to represent the concept of core technologies. Finally, based on the analysis results, the development strategies for each specifics technical area of WPT in LRT filed will be provided.

• 한국윤활학회:학술대회논문집
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• 한국윤활학회 2002년도 proceedings of the second asia international conference on tribology
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• pp.167-168
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• 2002

In this study, the effects of oxide layer formed on the wear tracks of TiN coated silicon wafer on friction characteristics were investigated. Silicon wafer was used for the substrate of coated disk specimens, which were prepared by depositing TiN coating with $1\;{\mu}m$ in coating thickness. AISI 52100 steel balls were used for the counterpart. The tests were performed both in air for forming oxide layer on the wear track and in nitrogen to avoid oxidation. This paper reports characterization of the oxide layer effects on friction characteristics using X-ray diffraction (XRD). scanning electron microscopy (SEM) and friction force microscope (FFM).