• Nuclear Medicine and Molecular Imaging
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• v.40 no.2
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• pp.66-73
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• 2006

Monoclonal antibodies are designed to bind specifically to certain antigen, give therapeutic effect to the target and to be produced in large scale with homogeneity. The monoclonal antibodies conjugated with radionuclide can deliver therapeutic irradiation to the target, and showed successful results in certain malignancies, which is known as radioimmunotherapy. The target-to-background ratio depends on the antigen expression in the target and normal tissues, which is related to the therapeutic efficacy and toxicity in radioimmunotherapy. For the solid tumor beta-ray energy should be high, but lower beta energy is better for the hematological malignancies. I-l31 is widely used in thyroid cancer with low cost and high availability. Labeling monoclonal antibody with I-131 is relatively simple and reproducible. Some preclinical data for the I-131 labeled monoclonal antibodies including acute toxicity and efficacy are available from already published literatures in KIRAMS, physician sponsored clinical trial protocols using Rituximab, KFDA approved anti-CD20 chimeric monoclonal antibody and I-131 were approved by KFDA and currently are ongoing.

• Journal of the Korean Society of Safety
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• v.30 no.3
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• pp.32-37
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• 2015

In the fields of plant layout optimization, the main goal is to minimize the construction cost including pipelines as satisfying all constraints such as safety and operating issues. However, what is the lacking of considerations in previous researches is to consider proper safety and maintenance spaces for a complex plant. Based on the mathematical programming, MILP(Mixed Integer Linear Programming) problems including various constraints can be formulated to find the optimal solution which is to achieve the best economic benefits. The objective function of this problem is the sum of piping cost, pumping cost and area cost. In general, many conventional optimization solvers are used to find a MILP problem. However, it is really hard to solve this problem due to complex inequality and equality constraints, since it is impossible to use the derivatives of objective functions and constraints. To resolve this problem, the PSO (Particle Swarm Optimization), which is one of the representative sampling approaches and does not need to use derivatives of equations, is employed to find the optimal solution considering various complex constraints in this study. The EO (Ethylene Oxide) plant is tested to verify the efficacy of the proposed method.

• 한국정보디스플레이학회:학술대회논문집
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• 2004.08a
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• pp.55-58
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• 2004

High Xe-content PDP characteristics are discussed. A high efficacy, up to 5 lm/W for a 50% Xe in Ne gas mixture, is realized in 4-inch color PDP test panel designs with low cost stripe-type barrier rib structures, that are powder blasted in soda lime glass. Furthermore, for a high Xe-content a high luminance can be obtained with a relatively small electrode area. Therefore the inter cell gap and the driving margin can be increased in a stripe-type barrier rib structure. Finally, for a high Xe-content the panel lifetime increases, due to increasing luminance and firing voltage stability. Clearly, these findings may direct the design development for next generation PDPs towards a high Xe-content

• Proceedings of the Korean Society of Medical Physics Conference
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• 2002.09a
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• pp.6-8
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• 2002

Intensity modulated radiotherapy (IMRT) is an advanced but expensive form of 3-dimensional conformal radiation therapy technique. While the initial clinical data appear to be promising for some treatment sites, the cost effectiveness of the treatment modality has yet to be justified by long-term clinical outcome. This presentation reviews the potential efficacy and limitation of IMRT in respect of the practicality, dosimetry, and resource aspects. It tries to explore and draw conclusions on the strategies for using this sophisticated and expensive treatment technique from AFOMP perspective.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.19 no.3
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• pp.322-333
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• 2012

Purpose: The purpose of this study was to evaluate the effects of a newly developed Introduction to Clinical Nursing (ICN) program on critical thinking skills, communication competence, self-efficacy, and clinical performance self-confidence in nursing students in their third year. Methods: One group pre-test and post-test design was used with three data collection time points (pre-test, post-test1 and post-test2). Participants were 74 third year nursing students approaching their first clinical practicum. The new program included (a) simulated clinical encounters regarding situations of assessing hospitalized patents and caring for patients with oxygenation needs, (b) objective structured clinical examination of skills, (c) lectures, and (e) field trips. Data were analyzed using paired t-tests. Results: After the ICN course, critical thinking skills(significant only between pretest and post-test2), communication competence, and clinical performance self-confidence improved significantly (p<.05). There was no improvement in the self-efficacy total score but there was significant improvement in the subscale, self-regulatory efficacy. Conclusions: The study results indicate that the ICN course may be effective in increasing critical thinking skills, communication competence, and clinical performance self-confidence in nursing students. However, the effect size was very small and modifications of this program should be considered to develop more cost-effective educational programs.

• Journal of Information Technology Services
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• v.15 no.1
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• pp.81-96
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• 2016

This study analyzes how breach fee under long-term contract and/or cap regulation on the breach fee can affect the impacts of "Mobile Device Distribution Improvement Act" on handset bundle price, average revenue per unit (ARPU), and social welfare. We conduct comparative analysis with an economic model of duopoly competition in price when users are under long-term contract and the breach fee can be regulated. The results show that the Act lowers the equilibrium prices, lower than incumbent price without the Act. Price of non-dominant Mobile Network Operator (MNO) can be lower than poaching price without the Act if significant portion of switching cost is breach fee or the market is significantly asymmetric. Under the significant circumstances, the Act can raise ARPU even though it improves social welfare. By contrast, the Act increases consumer surplus without affecting social welfare if breach fee is the only source of user's switching cost and is capped by the regulation, and more symmetric market and the stronger cap leads to higher consumer surplus.

• Journal of the Korean Operations Research and Management Science Society
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• v.30 no.1
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• pp.1-15
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• 2005

In this paper, we deal with a mesh network design problem arising from the deployment of WDM for the optical internet. The mesh network consists of mesh topology for satisfying traffic demand while minimizing the cost of WDM, OXC, and fiber cables. The problem seeks to find an optimal routing of traffic demands in the network such that the total cost is minimized. We formulate the problem as a mixed-integer programming model and devise a tabu search heuristic procedure. Also we develop an optical internet design system that implements the proposed tabu search heuristic procedure. We demonstrate the computational efficacy of the proposed algorithm, compared with CPLEX 8.0.

• The Journal of Information Systems
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• v.28 no.3
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• pp.123-139
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• 2019

Purpose With the development of information and communication technologies. fintech industry is rapidly growing as a major financial service. Previous research literatures mainly focused on overall characteristics and technical aspects of fintech including security issues. Therefore, this study investigated the effect of individual features influencing the resistance of adopting a fintech service. Moreover, this paper included the guidelines in practical development of fintech mechanism. Design/methodology/approach For research purposes, this study developed research hypotheses in order to empirically examine the effect of the factors that might have a significant effect on the resistance of the wearable device. The empirical research was based on a survey which carried through 359 participants. Research hypotheses were evaluated via SPSS Statistics 21.0 and AMOS 19 statistical package program. Findings Results showed that self-efficacy and individual innovation had a significant effect on the technostress and switching cost. In addition, technostress, security and switching cost had a significant effect on the resistance of adopting a fintech service. However, more factors are needed to including in research model to generalize these results.

• Journal of KIISE
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• v.42 no.10
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• pp.1207-1221
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• 2015

This research was conducted both to analyze the determining factors of and to suggest resolution methods for the smart divide of adults over 65 years of age in the rapidly aging society of the 2000s and the smart society of the 2010s following the information society of the 1990s. The research model based on the Technology Acceptance Model (TAM) includes 6 determining factors derived from existing studies: Self Efficacy, Training, Accessibility, Playfulness, Cost Rationality, and Policy Support. Research data were collected through a survey given to a total of 243 older adults in 14 Senior Welfare Centers nationwide, and research hypotheses were verified by structural equation model (SEM) analysis. The results of this research that gives priority to the order of Political Support, Playfulness, Self Efficacy, Accessibility, Cost Rationality, and Training can be used to develop various resolution methods for the smart divide of adults over 65 years of age.

• Clinical and Experimental Pediatrics
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• v.61 no.4
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• pp.114-120
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• 2018

Purpose: Routine screening for toxoplasmosis, rubella, cytomegalovirus (CMV), and herpes simplex virus (TORCH) in intrauterine growth restriction (IUGR) and small for gestational age (SGA) neonates has become a common practice. However, the incidence of TORCH varies across countries, and the cost of TORCH testing may be disadvantageous compared to disease-specific screening. To evaluate the efficacy of TORCH screening, the medical charts of IUGR or SGA neonates born in a single institution in Bucheon, Korea from 2011 to 2015 were reviewed. Methods: The clinical data of the 126 IUGR or SGA neonates were gathered, including gestational age, Apgar scores, neonatal sonographic findings, chromosome study, morbidities, developmental follow-up, and growth catch-up. Maternal factors including underlying maternal disease and fetal sonography were collected, and placental findings were recorded when available. TORCH screening was done using serum IgM, CMV urine culture, quantification of CMV DNA with real-time polymerase chain reaction, and rapid plasma reagin qualitative test for syphilis. Tests were repeated only for those with positive results. Results: Of the 119 TORCH screenings, only one was positive for toxoplasmosis IgM. This result was deemed false positive due to negative IgM on repeated testing and the absence of clinical symptoms. Conclusion: Considering the incidence and risk of TORCH in Korea, the financial burden of TORCH screening, and the single positive TORCH finding in our study, we suggest disease-specific screening based on maternal history and the clinical symptoms of the neonate. Regarding CMV, which may present asymptomatically, universal screening may be appropriate upon cost-benefit analysis.