• Title/Summary/Keyword: Cost Parameter

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Drug Evaluation of Ursodeoxycholic Acid Use for Treatment of Cholestasis Associated with TPN Therapy in Neonate (신생아의 TPN 요법 시 발생되는 Cholestasis 치료를 위한 Ursodeoxycholic Acid의 약물사용 평가)

  • Lee, Jung-Ok;Song, Tae-Beom;Lee, Myung-Koo;Lim, Sung-Cil
    • YAKHAK HOEJI
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    • v.54 no.4
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    • pp.270-281
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    • 2010
  • Total parenteral nutrition (TPN) is necessary to neonates in neonatal intensive care unit (NICU) for survival and growth because of impossible of enteral feeding. Long-term TPN can be associated with a broad spectrum of hepatobiliary disorder, ranging from mild hepatic dysfunction to severe end-stage liver disease. Cholestasis developed most commonly in neonate, ursodeoxycholic acid (UDCA) is widely used in adult with cholestatic and non-cholestatic liver diseases but there have been limited data on the effects in neonate with PNAC. This study was performed retrospectively to review all medical histories of the total 30 neonates with was administrated UDCA for treatment to parenteral nutrition associated cholestasis (PNAC) at Chungbuk National University Hospital NICU from April 2002 to December 2008. UDCA was administrated at bilirubin is over 2 mg/dl. The criterias for drug evaluation were included hepatic biochemical marker such as direct bilirubin, total bilirubin, AST, ALT, ALP and GGT, TPN therapy period, cholestasis development period, UDCA treatment period, UDCA dosage and adverse effect. In the results, Post-UDCA treatment significant was decreased direct bilirubin, total bilirubin, AST and ALP (p<0.05), and was decreased GGT (p>0.05) and slightly was increased ALT (p>0.05). Reffective timect biDCA was appear at mean $10.5{\pm}1.3$ days, iDCA administration period was mean $64.4{\pm}5.9$ days, cholestasis period was mean $71.9{\pm}6.4$ days and UDCA dosage was mean $22.9{\pm}0.9$ mg/kg/day. Common adverse effects is diarrhea, 5 patients arised mild diarrhea but it possible also related with increased enteral feeding. In conclusion, iDCA can decrease direct bilirubin that major parameter t bcholestasis and oher hepatic biochemical makers. UDCA is effective on PNAC without any serious side effect and cost-effective. Although no greatly shortening cholestasis period, but can protect to develop into severe liver disease and other complication or death. Based on these result, UDCA is recommended for treatment of cholestasis at direct bilirubin is over 2 mg/dl.

Numerical Study on the Development of the Seismic Response Prediction Method for the Low-rise Building Structures using the Limited Information (제한된 정보를 이용한 저층 건물 구조물의 지진 응답 예측 기법 개발을 위한 해석적 연구)

  • Choi, Se-Woon
    • Journal of the Computational Structural Engineering Institute of Korea
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    • v.33 no.4
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    • pp.271-277
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    • 2020
  • There are increasing cases of monitoring the structural response of structures using multiple sensors. However, owing to cost and management problems, limited sensors are installed in the structure. Thus, few structural responses are collected, which hinders analyzing the behavior of the structure. Therefore, a technique to predict responses at a location where sensors are not installed to a reliable level using limited sensors is necessary. In this study, a numerical study is conducted to predict the seismic response of low-rise buildings using limited information. It is assumed that the available response information is only the acceleration responses of the first and top floors. Using both information, the first natural frequency of the structure can be obtained. The acceleration information on the first floor is used as the ground motion information. To minimize the error on the acceleration history response of the top floor and the first natural frequency error of the target structure, the method for predicting the mass and stiffness information of a structure using the genetic algorithm is presented. However, the constraints are not considered. To determine the range of design variables that mean the search space, the parameter prediction method based on artificial neural networks is proposed. To verify the proposed method, a five-story structure is used as an example.

A Hybrid Search Method of A* and Dijkstra Algorithms to Find Minimal Path Lengths for Navigation Route Planning (내비게이션 경로설정에서 최단거리경로 탐색을 위한 A*와 Dijkstra 알고리즘의 하이브리드 검색법)

  • Lee, Yong-Hu;Kim, Sang-Woon
    • Journal of the Institute of Electronics and Information Engineers
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    • v.51 no.10
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    • pp.109-117
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    • 2014
  • In navigation route planning systems using A* algorithms, the cardinality of an Open list, which is a list of candidate nodes through which a terminal node can be accessed, increases as the path length increases. In this paper, a method of alternately utilizing the Dijkstra's algorithm and the A* algorithm to reduce the cardinality of the Open list is investigated. In particular, by employing a depth parameter, named Level, the two algorithms are alternately performed depending on the Level's value. Using the hybrid searching approach, the Open list constructed in the Dijkstra's algorithm is transferred into the Open list of the A* algorithm, and consequently, the unconstricted increase of the cardinality of the Open list of the former algorithm can be avoided and controlled appropriately. In addition, an optimal or nearly optimal path similar to the Dijkstra's route, but not available in the A* algorithm, can be found. The experimental results, obtained with synthetic and real-life benchmark data, demonstrate that the computational cost, measured with the number of nodes to be compared, was remarkably reduced compared to the traditional searching algorithms, while maintaining the similar distance to those of the latter algorithms. Here, the values of Level were empirically selected. Thus, a study on finding the optimal Level values, while taking into consideration the actual road conditions remains open.

Modeling the Competition Effect of Sagittaria trifolia and Monochoria vaginalis Weed Density on Rice in Transplanted Rice Cultivation (벼 기계이앙재배에서 벼와 물달개비 및 벗풀 경합에 따른 예측모델)

  • Moon, Byeong-Chul;Kwon, Oh-Do;Cho, Seung-Hyun;Lee, Sun-Gye;Won, Jong-Gun;Lee, In-Yong;Park, Jae-Eup;Kim, Do-Soon
    • Korean Journal of Weed Science
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    • v.32 no.3
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    • pp.188-194
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    • 2012
  • Field experiments were conducted to investigate the competition relationships of main paddy weeds with transplanted rice grown in paddy conditions. Data were used to predict crop yield as a function of weed density using a rectangular hyperbola model and determine weed economic threshold (ET) levels. The rectangular hyperbola (equation 2) was fitted to rice yield to estimate weed-free rice yield ($Y_o$) and weed competitivity (${\beta}$). Its competitivity for M. vaginalis was 0.0007445, 0.0005713, 0.000988 and 0.0008846 in Daejeon, Suwon, Iksan and Naju, respectively. The competitivity at harvest represented by parameter ${\beta}$ ranged from 0.001611 in Naju to 0.002437 in Iksan for S. trifolia. The ET levels of main paddy weeds in machine transplanted rice cultivation were well estimated based on the herbicides applied and its application cost. Therefore, our results can be used to support decision-making on herbicide application for weed management in transplanted rice cultivation.

Professional Nursing Quality Assurance (전문직 간호의 질적보장)

  • Kim, Hea-Sook
    • Journal of Korean Academy of Nursing
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    • v.22 no.2
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    • pp.248-259
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    • 1992
  • 질적 보장은 전문직 종사자에 의하여 수혜받는 대상자를 보호하기 위하여 전적으로 필요한 프로그램이다. 이러한 질적보장을 통하여 전문직의 자율성과 책임을 튼튼히 할 수 있는 의무는 전문직 종사자 모두의 관심사가 되어야 한다. 미국에 있어서 질적 간호에 대한 관심은 이제 새로운 이유가 아니다. Beyers(1988)는 건강체계 지도자 사이에 가장 중요한 문제로 강조하는 것이 수혜자의 이용의 용이성(Access), 숫가(Cost) 그리고 질적인 제공(Quality)이 라고 피력 하였다. 미국 건강사업 평가자와 조정자(Regulator)들은 질(Quality)을 위한 자율적인 프로그램에 많은 에너지를 투입하여 전반적인 건강사업 즉 의료계의 질보장, 더 나아가서는 간호의 질을 향상 시키기 위한 많은 프로그램을 분석 연구한다. 이 논문은 간호에 있어서 질적 보장을 위한 내용으로 주요점은 질적 보장에 사용되는 용어, 역사적 배경, 질적 보장을 강조하는 이유, 질적 보장제도의 개발, 질 사정(euali assessment)과 질적 보장에 있어서 간호 전문직 개입을 차례대로 설명하였다. 구미의 경우 1970년대부터 간호직에 있어서는 질적보장제도개발에 우선순위를 두게되어 미 간호협회에서는 Professional Standards Review Organizations (PSRO)에 근거하여 간호실무를 위한 표준을 내어놓았다. 질적보장을 위한 평가방법으로 구조, 과정, 결과 그리고 수혜자가 간호계획을 세우는데 사정에 참여하는 방법 등 4가지를 간략하게 설명하였다. 질적 보장을 향상시키기 위해서는 전문직과 공공의료기간이 서로 협동체가 되어 중추역할을 해야함을 강조하고 이렇게 서로 협력하므로써만이 비로서 우리의 목적을 성취할 수 있다고 생각된다.구 등이 이용된다. $^{166}$ Ho, $^{198}$ Au, $^{32}$P, $^{90}$ Y, $^{169}$ Er, $^{186}$ Rc, $^{131}$ I, $^{211}$ At 등 의 방사성 핵종의 교질, 미소구 또는 단세포군 항체표지 형태로 직접 종양내 또는 공동이나 체강에 투여하는 치료법이 있다. 류마치스 관절염의 슬관절에 $^{165}$ Dy colloid를 주사하는 $^{166}$ Ho-MAA도 활발히 이용되고 있다. and computed groundwater levels. 본 논문에서는 가파른 산사면에서 산사태의 발생을 예측하기 위한 수문학적 인 지하수 흐름 모델을 개발하였다. 이 모델은 물리적인 개념에 기본하였으며, Lumped-parameter를 이용하였다. 개발된 지하수 흐름 모델은 두 모델을 조합하여 구성되어 있으며, 비포화대 흐름을 위해서는 수정된 abcd 모델을, 포화대 흐름에 대해서는 시간 지체 효과를 고려할 수 있는 선형 저수지 모델을 이용하였다. 지하수 흐름 모델은 토층의 두께, 산사면의 경사각, 포화투수계수, 잠재 증발산 량과 같은 불확실한 상수들과 a, b, c, 그리고 K와 같은 자유모델변수들을 가진다. 자유모델변수들은 유입-유출 자료들로부터 평가할 수 있으며, 이를 위해서 본 논문에서는 Gauss-Newton 방법을 이용한 Bard 알고리즘을 사용하였다. 서울 구로구 시흥동 산사태 발생 지역의 산사면에 대하여 개발된 모델을 적용하여 예제 해석을 수행함으로써, 지하수 흐름 모델이 산사태 발생

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A Study on Early Termination Payment Option of BTO PPI Projects (BTO 민간투자사업 해지시지급금 매수청구권 가치에 관한 연구)

  • Shin, Sung-Hwan
    • Korean Journal of Construction Engineering and Management
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    • v.12 no.3
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    • pp.121-130
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    • 2011
  • Real option values of early termination payment for selected BTO PPI projects are studied using binomial models. Two cases of early termination payments are considered; an option with the condition of private participants' default, and an option without the condition. Values vary depending upon parameter values such as revenues, costs, discount rates, debt ratio, and volatility of revenues. For selected projects, the option values without the default condition are estimated as 1%~7% of total project costs, whereas the option values with the default condition are estimated as 0%~1.89% of total project cost. When actual revenues differ from the forecasted revenues, apparently the option values deviate from the values based upon the forecasted revenues. When actual revenues fall short of the forecasted revenues, the option values increase by a large amount whereas the option values decrease by a small amount in the opposite case. This implies that the option values can be quite bigger than the values based upon the forecasted revenue especially when the revenue forecast uncertainty is large. This study is expected to play an important role in improving the early termination payment option policy of the government in PPI projects in Korea.

Human Motion Tracking by Combining View-based and Model-based Methods for Monocular Video Sequences (하나의 비디오 입력을 위한 모습 기반법과 모델 사용법을 혼용한 사람 동작 추적법)

  • Park, Ji-Hun;Park, Sang-Ho;Aggarwal, J.K.
    • The KIPS Transactions:PartB
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    • v.10B no.6
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    • pp.657-664
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    • 2003
  • Reliable tracking of moving humans is essential to motion estimation, video surveillance and human-computer interface. This paper presents a new approach to human motion tracking that combines appearance-based and model-based techniques. Monocular color video is processed at both pixel level and object level. At the pixel level, a Gaussian mixture model is used to train and classily individual pixel colors. At the object level, a 3D human body model projected on a 2D image plane is used to fit the image data. Our method does not use inverse kinematics due to the singularity problem. While many others use stochastic sampling for model-based motion tracking, our method is purely dependent on nonlinear programming. We convert the human motion tracking problem into a nonlinear programming problem. A cost function for parameter optimization is used to estimate the degree of the overlapping between the foreground input image silhouette and a projected 3D model body silhouette. The overlapping is computed using computational geometry by converting a set of pixels from the image domain to a polygon in the real projection plane domain. Our method is used to recognize various human motions. Motion tracking results from video sequences are very encouraging.

Experimental Study on GFRP Reinforcing Bars with Hollow Section (중공형 GFRP 보강근의 인장성능 실험연구)

  • You, Young-Jun;Park, Ki-Tae;Seo, Dong-Woo;Hwang, Ji-Hyun
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.19 no.1
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    • pp.45-52
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    • 2015
  • Fiber-reinforced polymer (FRP) has been generally accepted by civil engineers as an alternative for steel reinforcing bars (rebar) due to its advantageous specific tensile strength and non-corrosiveness. Even though some glass fiber reinforced polymer (GFRP) rebars are available on a market, GFRP is still somewhat uncompetitive over steel rebar due to their high cost and relatively low elastic modulus, and brittle failure characteristic. If the price of component materials of GFRP rebar is not reduced, it would be another solution to increase the performance of each material to the highest degree. The tensile strength generally decreases with increasing diameter of FRP rebar. One of the reasons is that only fibers except for fibers in center resist the external force due to the lack of force transfer and the deformation of only outer fibers by gripping system. Eliminating fibers in the center, which do not play an aimed role fully, are helpful to reduce the price and finally FRP rebar would be optimized over the price. In this study, the effect of the hollow section in a cross-section of a GFRP rebar was investigated. A GFRP rebar with 19 mm diameter was selected and an analysis was performed for the tensile test results. Parameter was the ratio of hollow section over solid cross-section. Four kinds of hollow sections were planned. A total of 27 specimens, six specimens for each hollow section and three specimens with a solid cross-section were manufactured and tested. The change by the ratio of hollow section over solid cross-section was analyzed and an optimized cross-section design was proposed.

Development and Implementation of a 2-Phase Calibration Method for Gravity Model Considering Accessibility (접근성 지표를 도입한 중력모형의 2단계 정산기법 개발 및 적용)

  • CHOI, Sung Taek;RHO, Jeong Hyun
    • Journal of Korean Society of Transportation
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    • v.33 no.4
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    • pp.393-404
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    • 2015
  • Gravity model has had the major problem that the model explains the characteristics of travel behavior with only deterrence factors such as travel time or cost. In modern society, travel behavior can be affected not only deterrence factors but also zonal characteristics or transportation service. Therefore, those features have to be considered to estimate the future travel demand accurately. In this regard, there are two primary aims of this study: 1. to identify the characteristics of inter-zonal travel, 2. to develop the new type of calibration method. By employing accessibility variable which can explain the manifold pattern of trip, we define the zonal travel behavior newly. Furthermore, we suggest 2-phase calibration method, since existing calibration method cannot find the optimum solution when organizing the deterrence function with the new variables. The new method proceeds with 2 steps; step 1.estimating deterrence parameter, step 2. finding balancing factors. The validation results with RMSE, E-norm, C.R show that this study model explains the inter-zonal travel pattern adequately and estimate the O/D pairs precisely than existing gravity model. Especially, the problem with estimation of short distance trip is overcomed. In conclusion, it is possible to draw the conclusion that this study suggests the possibility of improvement for trip distribution model.

Estimating Concrete Compressive Strength Using Shear Wave Velocity (전단파 속도를 이용한 콘크리트의 압축강도 추정연구)

  • An, Ji-Hwan;Nam, Jeong-Hee;Kwon, Soo-Ahn;Joh, Sung-Ho
    • International Journal of Highway Engineering
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    • v.10 no.3
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    • pp.171-178
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    • 2008
  • Compressive strength of concrete has been regarded as a very important parameter of the quality control both in new and existing concrete pavement. It has been used a lot as the concrete strength evaluation both in the various-mixture-using laboratory and construction field using the same mixture. An error usually occurs in the test experiments of the strength, even in the test experiments with evenly mixed and compacted specimens of the compressive strength. It is caused by the 'manually operated' compressing testing, or by the specimens preparation with eccentricity. When compressive strength of evenly mixed concrete is investigated by the curing ages at the construction field, there have to be lots of specimens. And it needs much labor and cost. To substitute the endlessly repeated test experiments of compressive strength, presumption of compressive strength, by nondestructive tests, is needed. In this study, elastic waves were used among various nondestructive tests. Compressive strength of concrete was presumed according to the curing ages, by using the shear wave velocity which is not affected by restricted conditions. In the result, shear wave velocity is very closely related to the compressive strength at the evenly mixed concrete.

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