• KSBB Journal
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• 제26권3호
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• pp.255-259
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• 2011

This study was to suggest the method for wrinkle improvement using Mugil cephalus extract. In order to evaluate the cosmetic product made of M. cephalus extract, the experiments were conducted with subjects and skin states for 4 weeks. Effect of cosmetics containing M. cephalus extract on the water holding capacity and evaporation of the women skin were investigated. The water holding capacity was increased after 1 h of application. But after 2 h, it was decreased. In the case of the water evaporation, it was increased with the increase of time. On the clinical trial, it was also found that water, oil, and rough level on the women skin were increased and wrinkles were improved. Side effects were also not detected during the application and treatment of cosmetics. Based on this result, the application of M. cephalus extract had positive effects on the improvement of wrinkles and skin in women. Therefore, it will be used to develop the wrinkle improvement therapy for women.

• 문화기술의 융합
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• 제9권1호
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• pp.565-570
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• 2023

임산부나 피부질환자 등 화장품 성분에 예민한 사람들이 있다. 또 화장품으로 인한 부작용을 경험하는 사람들이 있다. 이를 피하기 위해, 쇼핑 시에 일일이 화장품에 유해 성분이 있는지 검색하는 것은 번거롭다. 또한 본인에게 잘 맞는 기능성 성분을 알고 기억하는 것은 새로운 화장품을 구매할 때 도움이 된다. 사진 촬영을 통해 현장에서 즉시 화장품 성분을 알 수 있는 시스템이 필요하다. 본 논문은 화장품에 표기된 성분을 촬영해 즉각적으로 화장품 성분을 알 수 있는 스마트폰용 애플리케이션 <화안>을 소개한다. 본 시스템은 효과적인 텍스트 인식 기법을 적용하여, 카메라를 화장품 성분에 비추거나 앨범에서 화장품 성분 사진을 불러올 경우, 해당 화장품의 성분을 자동 인식 및 자동 분류하여 그 화장품의 성분을 현장에서 즉시 제공한다는 점에서 기존의 시스템에 비해 효과적이고 편리하다. 이 시스템이 널리 활용된다면, 일상생활 속 화장품으로 인한 피부 질환을 예방하고 본인에게 맞지 않는 화장품 구매를 줄일 수 있을 것으로 기대된다.

• 한국콘텐츠학회논문지
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• 제2권2호
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• pp.27-35
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• 2002

본 연구는 얼굴 성형을 시뮬레이션하거나 성형 상담 자료로 활용할 목적으로 한 쌍의 제어점을 이용한 쌍선형 워핑 및 쌍선형 보간에 의한 성형 시스템에 관한 것이다. 우선, 주어진 영상을 대상으로 제어점을 설정하고, 이 제어점을 이용하여 워핑 영역을 결정한다. 그리고, 이 워핑 영역은 제어 점을 한 꼭지점으로 하는 4개의 부분 영역으로 나눈다. 그런 후, 4개의 부분 영역 각각에 대한 역방향 사상의 워핑 계수를 구한다. 결과 영상의 부분 영역에 있는 모든 화소 위치에 대하여 대응하는 워핑 계수를 적용하여 원 영상에서 대응되는 화소 위치를 구한다. 이 위치에 최인접하는 네 화소값을 이용하여 쌍선형 보간에 의해 결과 영상의 화소에 대한 화소값을 구한다. 이와 같은 방식으로 4개의 부분 영역에 대하여 동일하게 처리함으로써 성형 효과를 얻게 된다. 실험 결과, 워핑 영역의 경계에서 끊김이 없는 자연스런 성형 효과를 얻을 수 있었다.

• 대한화장품학회지
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• 제29권1호
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• pp.151-167
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• 2003

Melanin biosynthesis is a human defense mechanism to protect skin from UV irradiation and also determines colors of hair and skin. However, as a interest on skin-whitening increases, researches to prevent pigmentation and hypersynthesis of melanin in skin are being actively in progress. Active components used as a whitening agent in cosmeceuticals are kojic acid, arbutin, vitamin C and hydroquinone. However, until now, because comparison researches among them in the aspect of both melanin formation and cellular toxicity have not been performed, we can't exactly estimate merits and defects of them as a whitening agent. To this end, we performed experiments to compare their effects on cell viability and melanin formation. As a first step, in vitro tyrosinase inhibition assay was done. While kojic acid and hydroquinone showed strong inhibition activities(their IC$\_$50/s are all < 100uM), arbutin and vitamin C showed weak activities. IC$\_$50/s of arbutin and vitamin C are 100uM and 400∼500uM, respectively. In B16BL6 melanoma cells, like in vitro tyrosinase inhibition assay, arbutin and kojic acid showed more strong inhibition effect on melanin synthesis than vitamin C. And unlike arbutin, vitamin C and kojic acid induced cell death at high concentration. Although arbutin showed no cytotoxicity, it has side effect to induce morphological change at high concentration.. In this paper, we suggest both kojic acid and arbutin have stronger ability to inhibit melanogenesis than vitamin C. And they also have side effect, that is, kojic acid induces cell death like vitamin C and arbutin changes cell morphology respectively.

• Asian Pacific Journal of Cancer Prevention
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• 제13권4호
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• pp.1131-1135
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• 2012

Objective: To evaluate interoperative radiotherapy after breast conservative surgery in early breast cancer patients in terms of postoperative complications, cosmetic outcome and recurrence events. Methods: From June 2007 to Dec 2011, 143 early breast cancer patients received breast conservative surgery. Seventy-two (study group) received interoperative radiotherapy, compared with 71 patients (control group) given routine radiotherapy. Postoperative complications were evaluated 1 month after surgery; cosmetic outcome was evaluated 1 year postoperatively; recurrence and death events were followed up. Results: The average wound healing time was 13~22 d in the study group and 9~14 d in the control group. In the study group, 2 patients developed lyponecrosis, 16 patients showed wound edema while no such side effects were found in the control group. No infection or hematomas were found in either group. In the study group (59 cases), overall cosmetic outcome in 53 patients was graded as excellent or good, and in 6 as fair or poor. Meanwhile in the control group (56 cases), 42 patients were graded as excellent or good, and 14 as fair or poor (P=0.032). After a follow-up from 3 to 54 months (median: 32 months), two patients (2.78%) in study group developed local relapses, one of them (1.39%) died, 2 patients (2.78%) developed bone metastases. In control group, one patient (1.41%) developed local relapse, 2 patients (2.82%) developed bone metastases, and no one died. Conclusion: Intraoperative radiotherapy is safe and reliable with good cosmetic outcome.

• Journal of Yeungnam Medical Science
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• 제10권2호
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• pp.380-387
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• 1993

초기 유방암의 일차적인 치료법으로 시행한 보존적 유방절제술과 근치적인 방사선 치료의 효과를 확인하기 위하여 1988년 3월 1일부터 1992년 8월 31일까지 영남대학교 의과대학 부속병원에서 침윤성 유방암으로 확진되어 치료를 시행한 환자중 진료기록이 충실하고 최근까지 추적이 가능하였던 28명을 대상으로 임상적특징, 치료방법, 치료방법에 따른 치료성적, 치료와 연관된 부작용, 치료 후 미용상 만족도를 분석하여 아래의 결과를 얻었다. 평균 연령은 43.5세(중앙값)이었으며, 폐경기 이전이 17명, 폐경기 이후가 11명이었고, 임상적 병기는 I기가 12명, II기가 16명이었다. 수술은 단순 절제가 17명, 광범위 절제가 4명, 유선 1/4절제가 7명이었으며 대상환자 모두에서 액와 임파선 절제를 시행한 결과 7명에서 임파선 전이를 보였다. 치료법은 15명에서 방사선 치료, 항암제 투여 및 내분비 요법을 시행하였으며, 치료 방법에 따른 치료 성적의 차이는 없었다. 일반적으로 수술후 2-3주에 시행된 방사선 치료는 원발 병소의 상태에 따라 다양하게 시행되었으며 원발 병소는 55-65Gy, 지역 임파선부위는 45-50Gy를 조사하였다. 방사선 치료와 연관된 부작용의 발생은 병합요법시 현저히 증가하여 18명중 5명이었으나 방사선 치료만 시행된 경우는 10명중 1명이었다. 치료 완료후 27개월간 추적 조사한 결과 유방이나 지역 임파선 부위의 재발 및 원격 전이는 없었으며 미용상 28명중 26명에서 우수한 성적을 보였다. 그러나 전체 대상 환자가 적고 추적 기간이 한정된 관계로 추후 더 많은 환자를 대상으로 장기간의 추적 조사가 필요하리라 사료된다.

• 디지털융복합연구
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• 제17권7호
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• pp.395-400
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• 2019

4차 산업혁명시대인 현대사회는 뷰티산업에 대한 뜨거운 관심 속에 새로운 기술 개발을 통한 화학 소재의 화장품 출시가 줄을 이으면서 화장품산업이 호황을 누리고 있지만 화학 화장품에 대한 안구 건조증, 피부 트러블, 소화 장애, 호르몬 교란 등 수 많은 부작용들이 노출되고 있는 실정이다. 이와 같이 인체에 유해(有害)한 기존 화학성분 화장품의 부작용을 보완할 수 있는 솔잎의 천연화장품 소재로서의 범용적(汎用的) 활용가치를 과학적으로 검증하고 바람직한 천연화장품의 롤 모델을 제시하고자 솔잎에 대한 DPPH 라디칼 소거 활성실험, ABTS assay, flavonoid 함량을 연구하였다. 실험 결과 $70^{\circ}C$와 $100^{\circ}C$ 솔잎 열수(熱水) 추출물은 DPPH radical과 ABTS radical 소거능 모두 농도 의존적인 증가가 나타났으며 $70^{\circ}C$와 $100^{\circ}C$의 솔잎 열수 추출물에서 각각 $32.0{\pm}2.5mg\;QE/ml$와 $116.8{\pm}5.5mg\;QE/ml$의 총 flavonoid가 검출되었다. 따라서 인체에 이로운 항산화물이 다량 검출된 솔잎 열수 추출물은 인체에 무해(無害)한 천연화장품의 소재로서 활용 가능성이 매우 높다고 사료한다.

• 대한화장품학회지
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• 제23권3호
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• pp.9-23
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• 1997

Retinoids are essential regulators of spithelial cell growth and celluar differentiation. They are also known to be effective in photoaging. It was reported that topical application of retinoic acid improves facial wrinkle carsed by collagen synthesis reduction in photodamaged skin. Collagen synthesis by retinoic acid may contribute to the wrinkle effacement. Since celluar retinoic acid binding protein II is slsctively induced in human skin and dermal fibroblasts in vitro by retinoic acid, this response can be used to mesure retinoids potency and activity. In order to know the activity of retinoids and their relations with collagen synthesis, we treated dermal fibroblasts with retinoids for 48 hours at 10-6-10-7M and measured CRABPII mRNA level by quantitative Nortern blotting. We also measured the rate of collagen systhesis by retinoids using 3-dimensional dermal equivalent. CRABPII mRNA level was increased 3-fold by retinoic acid, 2.1-fold by retinol and 1.4-fold by retinaldehyde. Collagen systhesis was increased 34% by all-trans retinioc acid, 26% by retinol, 17% by retinaldehyde and 7% by retinyl palmitate. From the above results, retinoids were found to be a potent indecers of CRABPII mRNA and collagen synthesis. Though retinoic acid was the most effective, its use has been restricted because of the side effects. Instead, retinol can be a best candidate in cosmetics for the treatment of photodamaged skin in terms of efficacy and safety.

• Human Ecology Research
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• 제51권5호
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• pp.513-526
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• 2013

In an effort to protect consumers' rights to information and to promote their freedom of choice, the South Korean government has been enforcing a policy called the cosmetics full ingredients list system since 2008, which requires cosmetics manufacturers to list all of the ingredients used in their products. This policy aims to assist consumers in identifying the causes of possible side effects of cosmetic products. This study uses consumers' demographic information addition to their cosmetics purchase and usage characteristics to learn about consumers' attitudes and utilization intentions and the influence of information from the cosmetics full ingredients list. This study was conducted through a questionnaire based survey administered to women above the age of 20 years across South Korea who use cosmetic products. The questionnaire was distributed to 300 members on the panel of M Brain, an online research institute. The findings of this study are as follows: (1) The level of knowledge on cosmetics' ingredients positively affected the consumers' attitude and utilization intention of information on the cosmetics full ingredients list. (2) The higher the utilization intention for information, the more often consumers checked the packaging of goods. This implies that habitual behavior, such as checking information, leads to increasing intention to utilize of new information. (3) The brand, as a decision-making factor, negatively affected consumers' attitudes regarding information.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제35권5호
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• pp.384-387
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• 2009

Tumors of the deep lobe of parotid gland are rare. These benign tumors have usually been treated by total parotidectomy, which has functional and esthetic side effects. Recently, there has been a trend for operations of parotid gland benign tumors to be less radical and selective deep lobe parotidectomy has been introduced. This technique preserves the superficial lobe and facial nerve when tumor is located in the deep lobe. Selective deep lobe parotidectomy preserves parotid salivary function, minimizes the incidence of facial nerve damage and gustatory sweating (Frey's syndrome) and improves cosmetic outcome. We report a case of pleomorphic adenoma of the deep lobe that was successfully treated by selective deep lobe parotidectomy with satisfactory result.