• 한국시뮬레이션학회논문지
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• 제23권3호
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• pp.11-17
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• 2014

중심합성계획(CCD)은 2차 선형 모형을 추정하기 위해서 자주 활용된다. 본 연구는 CCD를 활용하는 시뮬레이션 실험에서 공통난수(CRN) 상관유도전략을 사용하여 모형의 파라미터를 효율적으로 추정하고자 한다. CCD의 축점을 적절히 선택하면 모든 표본점에 공통난수를 할당하는 전략으로 얻은 파라미터의 가중최소자승(WLS) 추정량은 정규최소자승(OLS) 추정량과 일치한다. 본 연구는 선형모형의 파라미터를 추정하는 공통난수 상관유도전략이 파라미터 추정 효율성 측면에서 독립 난수 할당전략보다 우수함을 계량적으로 분석하였다. 2차 선형모형에서 상수항을 제외한 나머지 파라미터를 추정하는데 있어서 공통난수 상관유도전략이 우수하며 시뮬레이션 결과도 이러한 분석을 지지하고 있다. 제안된 난수 할당전략이 CCD 시뮬레이션 실험에서 유용하게 활용될 수 있을 것으로 기대한다.

• 한국시뮬레이션학회:학술대회논문집
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• 한국시뮬레이션학회 1992년도 제2회 정기총회 및 추계학술 발표회 발표논문 초록
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• pp.8-8
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• 1992

Through a simulation experiment, often an experimenter is concerned with estimating the system parameters of the linear model consisting of m design points from the outputs oft the simulation model. To improve the estimation of the system parameters and reliability of these estimators, appropriate simulation techniques have been developed. For the first order linear model, Schruben and Margolin (1978) exploited the random number assignment rules which uses a combination of common random numbers and antithetic streams in a simulation experiment designed to estimate the system parameters when the design matrix of simulation model admits orthogonal blocking into two blocks. Nozari, Arnold and Pegden (1984) developed a method for appliying the method of control variates to the situation of the linear model having multiple design points. This talk deals with a different way of utilizing controls under the correlation induction strategy of Schruben and Margolin's to improve the simulation efficiency, and presents a procedure for obtaining the estimators of the system parameters analytically. Simulation results on a selected simulation model indicate a promising evidence that a proposed method may yield better results than Schruben and Margolin's method.

• Asian Pacific Journal of Cancer Prevention
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• 제15권10호
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• pp.4367-4372
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• 2014

We here document discovery of expression profile of myeloid derived suppressor cells (MDSCs) in chronic hepatitis B (CHB) patients and changes in the course of disease. The study population was composed of 75 outpatient HBV cases and 15 healthy control cases. Peripheral blood samples were collected for separation of mononuclear cells. Levels of MDSCs labeled with Lin-DR-CD11b+CD33+ obtained from peripheral blood mononuclear cells (PBMC), were revealed to have significant differences between the CHB and other groups. They were 0.414% for health control cases and 0.226% for CHB cases (Z=-2.356, p=0.0189). It also observed that the group of HBeAg positive cases had significant difference in MDSCs/PBMC median ($X^2=11.877$, p=0.003), compared with group of HBeAg negative cases and the healthy control group. It suggested considerable MDSCs might be involved in HBeAg immune tolerance. In addition, negative correlations between MDSCs/PBMC and parameters of ALT, AST and TBil, while positive correlation between MDSCs/PBMC and ALB parameter were found. Multiple comparisons between the four phases and health control phase again, there was a statistically sifnificant difference ($X^2=17.198$, p=0.002). Taken together, these findings may provide a new immunotherapy strategy for reduced the expression levels of MDSCs in CHB patients, through induction of an autoimmune response to virus removal.