• 대한의생명과학회지
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• 제12권4호
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• pp.393-398
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• 2006

These studies were carried out to characterize the physiological functionalities of Codonopsis lanceolata, Cornus officinalis, and their mixtures. We investigated the antioxidative, fibrinolytic, and ${\alpha}$-glucosidase inhibitory activities of them. The antioxidative activities of Codonopsis lanceoiata and Cornus officinalis were 87% and 90%, respectively. Addition of salt to Codonopsis lanceolata and Cornus officinalis did not affect its antioxidative activities. In spite of fourfold addition of Codonopsis lanceolata to Cornus officinalis, the antioxidative activity was conserved at 90%. The fibrinolytic activities of Codonopsis lanceolata and Cornus officinalis were 0.78 plasmin unit/ml and 1.74 plasmin unit/ml, respectively. Addition of salt decreased the fibrinolytic activities of both Codonopsis lanceolata and Cornus officinalis. A mixture (3:1) of Codonopsis lanceolata and Cornus officinalis exhibited a 21% increase in activity. The ${\alpha}$-glucosidase inhibitory activities of Codonopsis ianceoiata and 100-fold diluted Cornus officinalis were 25% and 73%, respectively. The addition of salt to Codonopsis lanceolata and Cornus officinalis slightly decreased their ${\alpha}$-glucosidase inhibitory activities. According to the addition of Cornus officinalis to Codonopsis lanceoiata, the ${\alpha}$-glucosidase inhibitory activities of the resulting mixture were highly increased. We anticipate that these results will be used as basic data for the development of new bifunctional foods.

• 농촌계획
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• 제24권2호
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• pp.101-107
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• 2018

This study has been conducted to understand the relationships such as interspecific interactions between species and landscapes within and outside of agricultural land by identifying the flora features of Cornus officinalis farmlands in Gurye which designated as Korea's Important Agricultural Heritage System. For this, the flora of vascular plants was surveyed in every land uses of two representative districts. These two districts represent the own features of Cornus officinalis farming area which including land uses like forests(especially pine tree), valley, farmland(rice paddy, farms, Cornus officinalis farmland), and residence. Also differences in flora by stone wall's existence and Cornus officinalis's DBH were surveyed. As a result, Cornus officinalis farmlands showed the various vascular plants than the other land uses. According to the existence of stone wall in Cornus officinalis farmlands, there were no differences in appearance flora. But the flora in Cornus officinalis farmlands which have different Cornus officinalis' DBH(Divided into average over 15cm and under 8cm), various plants were showed in average over 15cm than average under 8cm. In conclusion, Cornus officinalis farmlands have been actively engaged in various types of land use and species exchanges, including forests, valleys, villages, and fields, and it has been confirmed that it acts as an ecological axis connecting forests to villages.

• 동아시아식생활학회지
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• 제22권5호
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• pp.692-700
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• 2012

The antibacterial activity of the ethanol extract of Cornus officinalis against some bacteria related to foodborne illness and food spoilage was investigated. In the case of the disc diffusion assay, clear zones due to the inhibition of proliferation by Cornus officinalis extract were 8.5~18.3 mm at $4,000{\mu}g/disc$. The inhibitory effect of Cornus officinalis was as follows: Escherichia. coli ${\geq}$ Listeria monocytogenes ${\geq}$ E. coli O157:H7 > Bacillus cereus > Staphylococcus aureus > Pseudomonas aeruginosa > Salmonella typhimurium. In addition, the MIC of Cornus officinalis extract toward B. cereus was the lowest at 1,000 ppm. The extract inhibited the growth of E. coli, L. monocytogenes, E. coli O157:H7, and Bacillus cereus throughout the growth stage. However, the growth of P. aeruginosa, S. aureus, and S. typhimurium was only inhibited by the extract during the lag phase. The constituents of all cells tested were released, especially E. coli and E. coli O157:H7. Observation of the cells using SEM demonstrated a morphological change and disruption of cells in response to treatment with Cornus officinalis extract. Based on these findings, the ethanol extracts of Cornus officinalis showed strong antimicrobial activity against all tested bacteria, indicating that Cornus officinalis can be a useful natural antimicrobial reagent.

• 대한의생명과학회지
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• 제12권4호
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• pp.355-359
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• 2006

This investigation was performed to study the antioxidant activities of Cornus officinalis Sieb extracts and the effect of Cornus officinalis Sieb extracts on glucose, lipid metabolism in diabetic rats. DPPH free radical scavanging activity and superoxide anion radical scavenging of Cornus officinalis Sieb extracts were 94.7% and 92.1%, respectively. Streptozotocin (45 mg/kg body weight, i.p.) induced diabetic rats showed a significant increases of plasma glucose, triglyceride and total cholesterol, concomitantly significant decrease of plasma high density lipoprotein. Glutathione level were decrease in cytosol of liver, lung and brain tissue of rats. Lipid peroxide were increase in microsome of liver cells. Group 1 and 2 were treated with Cornus officinalis Sieb extracts 200 mg/kg body weight and 100 mg/kg body weight for 24 days, individually. Group 1 and 2 rats showed decreased plasma glucose, triglyceride, total cholesterol and lipid peroxide in microsome of liver, and increased plasma high density lipoprotein and glutathione in cytosol of liver, lung and brain. The result suggest that Cornus officinalis Sieb extracts may normalize the Impaired antioxiants status in streptozotocin induced diabetic rats. Cornus officinalis Sieb extracts were used to improve the imbalance between free radicals and antioxidant system due to the diabetes.

• 생약학회지
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• 제48권4호
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• pp.268-272
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• 2017

Three tricyclic pyridone alkaloids, (-)-4,6'-anhydrooxysporidinone (1), (-)-6-deoxyoxysporidinoCne (2), and (-)-sambutoxin (3) were isolated from cultures of Fusarium lateritium SSF2 derived from the fruits of Cornus officinalis. Chemical structures of the isolated compounds were determined by spectroscopic method and comparisons with reported data values. The compounds 1-3 were isolated for the first time from this fungal strain.

• 한국응용과학기술학회지
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• 제33권2호
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• pp.333-341
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• 2016

산수유 종자 추출물의 천연 방부제로서 가능성을 평가하기 위하여 항균활성 및 화장품 방부 효능 평가를 실시하였다. 산수유 종자는 각각 1,3-부틸렌글리콜과 에탄올을 이용하여 추출하였다. Paper disc method로 항균활성을 평가한 결과 Staphylococcus aureus, Staphylococcus epidermidis와 Propionibacterium acnes에서 항균활성이 나타났으며 산수유 종자 1,3-부틸렌글리콜 추출물(COS-A)이 여드름균에대해 $26.7{\pm}4.0mm$로 가장 높았다. 최소저해농도(MIC) 측정 결과 산수유 종자 에탄올 추출물(COS-B)이 가장 낮은 농도에서 S. epidermidis균의 생장을 억제하였다. 에멀션에서의 방부효능 평가를 위해 Challenge test를 실시한 결과 COS-A와 COS-B를 첨가한 에멀션에서 균 접종 7일 후 피부상재균이 100% 사멸되었다. 이러한 결과는 산수유 종자 추출물이 화장품에서 합성방부제를 대체할 천연 방부제로서 가능성이 있을 것으로 사료된다.

• 생약학회지
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• 제42권3호
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• pp.260-264
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• 2011

The bacterial growth and pH of Cornus officinalis fermented with Lactobacillus rhamnosus during fermentation were evaluated. As the results, the number of the fermentation after fermentation always remained higher than 6 log CFU/mL and the pH of those ranged from 4 to 6. To evaluate the effect of Cornus officinalis fermented with Lactobacillus rhamnosus on hair growth promotion in C57BL/6 mice, Six weeks old male mice were divided into four groups including normal group (saline), negative control group (essence base), positive control group (minoxidil) and experimental group (Cornus officinalis and animal milk fermented with Lactobacillus rhamnosus mixed in negative control). And they were applied topically with test materials for 8 days. Hair regrowth effect in experimental group using gross and histological examination was higher than that in positive control group. Body weight and food intake of four groups didn't show significant difference. These results indicated that the Cornus officinalis fermented with Lactobacillus rhamnosus can be used practically for hair growth or prevention of hair loss.

• 한국식생활문화학회지
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• 제3권4호
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• pp.377-383
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• 1988

본 연구는 국산 전통차 개발에 관한 실험으로써 산수유, 구기자 및 그 혼합물이 생체에 미치는 효능을 구명하고자 이들의 추출물을 미생물(Saccharomyces cerevisiae)과 실험동물(spraque-dawely(male)200g)에 투여하여 생리조사를 실시하였다. 미생물에 있어서는 산수유와 구기자의 첨가량이 증가할수록 균체생육이 증가했으나, 그중 산수유보다 구기자가 더 현저한 증가를 보였고, 특히 그 혼합구에서는 상승효과가 인정되었다. 흰쥐의 경우에는 산수유, 구기자 및 그 추출물이 $CCl_4$로 야기된 간 손상에 미치는 영향을 관찰했다. GOT, GPT 활성도는 $CCl_4$ 중독에 의해서 대조군($S_1$)이 정상군($S_0$)에 비해 현저히 증가했으나 구기자군($S_3$)과 혼합군($S_4$)은 현저한 감소를 보였다(p<0.01). 그 혈액중의 creatinine, BUN, glucose 함량은 시험구 모두 정상치에 접근했으나, 그중 구기자군($S_3$)이 좀 더 안정된 수치를 보였다. 따라서 $CCl_4$의 저해에 대한 흰쥐의 간장보호 효과는 구기자, 그 혼합물, 산수유 순이고 이들 혼합물은 단일사용보다 상승효과가 인정되었다.

• 한국식생활문화학회지
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• 제21권5호
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• pp.550-558
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• 2006

We developed a kind of soy-based sauce for stews using three recipes and sensory evaluation processes, and examined the biological activities such as antioxidative, fibrinolytic and ${\alpha}$-glucosidase inhibitory activities of hot water extract of Cornus officinalis S. et Z in order to use as functional ingredient. The developed stew was composed of soy sauce $1\frac{1}{2}$ Tbsp, sugar $1\frac{1}{4}$ Tbsp, garlic, small green onion, powdered sesame and sesame seed oil $\frac{1}{2}$ tsp, respectively, ginger extract $\frac{1}{4}$ tsp, black pepper $\frac{1}{8}$ and water $\frac{2}{3}$C per 300 g of main ingredients(pork rib, chicken and dried pollack). It was evaluated more highly acceptable than the original recipes by sensory test. Replacement of water in the recipe of the developed stew sauce with hot water extract of Cornus officinalis S. et Z did' nt affect the sensory quality. From the above results. we concluded that hot water extract of Cornus officinalis S. et Z might be a excellent source to provide health functionality.

• Archives of Pharmacal Research
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• 제21권6호
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• pp.787-789
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• 1998

Dimethyltetrahydrofuran cis-2,5-dicarboxylate a furan derivative has been isolated from the fruits of Cornus officinalis, and it was isolated for the first time in the nature. The structure was elucidated by NMR spectroscopic techniques.