• Steel and Composite Structures
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• 제28권1호
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• pp.63-71
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• 2018

This paper reports an experimental study that was accomplished to assess the seismic behavior of steel tube reinforced concrete bridge columns (SBCs). The motivation of this study was to verify a supposition that the core steel tube may be terminated at a rational position in the column to minimize the material cost while maintaining the seismic behavior of this composite column. Four SBC specimens were tested under combined constant axial load and cyclic reversed lateral loads. The unique variable in the test matrix was the core steel tube embedment length, which ranged from 1/3 to 3/3 of the column effective height. It is observed that SBCs showed two distinctly different failure patterns, namely brittle shear failure and ductile flexural failure. Tests results indicate that the hysteretic responses of SBCs were susceptible to the core steel tube embedment length. With the increase of this structural parameter, the lateral strength of SBC was progressively improved; the deformability and ductility, however, exhibited a tendency of first increase and then decrease. It is also found that in addition to maintained the rate of stiffness degradation and cumulative energy dissipation basically unchanged, both the ductility and deformability of SBC were significantly improved when the core steel tube was terminated at the mid-height of the column, and these were the most unexpected benefits accompanied with material cost reduction.

• Journal of Industrial and Engineering Chemistry
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• 제67권
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• pp.396-406
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• 2018

In this study, a polydioxanone (PDO) and poly(L-lactic acid) (PLLA) sheath-core biphasic monofilament was designed to develop an esophageal stent with improved mechanical properties and controlled biodegradability. The radial force of PDO/PLLA sheath-core stent was 10.24 N, while that of PDO stent was 5.64 N. Deteriorations of tensile strength, elastic modulus and elongation during degradation test were also delayed on PDO/PLLA group. Hyaluronic acid-dopamine conjugate and $BaSO_4/PDO$ conjugate coating layers provided improved tissue adhesion strength and reasonable X-ray contrast, respectively. Taken all together, the sheath-core filaments with tissue adhesive and radiopaque properties will be useful in designing esophageal stents.

• Nuclear Engineering and Technology
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• 제54권8호
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• pp.3154-3165
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• 2022

During a loss-of-coolant accident (LOCA) in the pressurized water reactor (PWR), there is a possibility that high temperature and internal pressure of the fuel rods lead to ballooning of the cladding, which causes a partial blockage of flow area in a subchannel. Such flow blockage would influence the core coolant flow, thus affecting the core heat transfer during a reflooding phase and subsequent severe accident. However, most of the system analysis codes simulate the accident process based on the assumed channel blockage ratio, resulting in the fact that the simulation results are not consistent with the actual situation. This paper integrates the developed core Fuel Rod Thermal-Mechanical Behavior analysis (FRTMB) module into the self-developed severe accident analysis code ISAA. At the same time, the existing flow blockage model is improved to make it possible to simulate the change of flow distribution due to fuel rod deformation. Finally, the ISAA-FRTMB is used to simulate the QUENCH-LOCA-0 experiment to verify the correctness and effectiveness of the improved flow blockage model, and then the effect of clad ballooning on core heat transfer and subsequent parts of core degradation is analyzed.

• 약학회지
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• 제39권6호
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• pp.593-599
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• 1995

Erythromycin was formulated as enteric-coated pellets in order to reduce degradation in stomach and gastromtestmal irritation, and to maximize the absorption in intestine followmg its oral administration. Core pellets were prepared using fluid-bed granulator with two different methods (powder layering and solvent spraying) and enteric-coated with two different coating polymers (HPMCP and Eudragit E30D). Physical characteristics md dissolution rates of core pellets and enteric-coated pellets were evaluated to optimize the formulation. Powder layering method resulted in shorter initial dissolution time than solvent spraying method, but physicochmical properties of the product were worse than solvent spraying method with respect to hardness, ftiability and density. The dissolution rate of the drug was increased with the addition of surfactants, showing concentration-dependence. The scanning electron microscopic observation of pellets revealed significant differences on the surface appearances prepared with solvent spraying method. The core pellet made with powder layering method had crystals on the surface, which resulted in poor physical properties of the pellets. The dissolution profiles of erythromycin pellets coated with HPMCP or Eudragit L30D were close to that of commercially available erythromycin enteric-coated product.

• 한국기계가공학회지
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• 제12권3호
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• pp.7-12
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• 2013

In Die casting process, the problem of die degradation is often issued. In oder to increase of die life the material degradation of die steel was investigated using test core pins. Three test core pins were positioned in front of the gate entry and observed washout and soldering resistance during Mg die casting process. The test parameters are set as different commercial die materials, coatings condition and hardness of die surface. Usign 220t magnesium die casting machine was employed to cast AZ91 magnesium alloys. After 150 shots, macroscopic observation of die surface was carried out. Additional 50 cycles later, test pins were chemically cleaned with 5% HCl aqueous solution to find out the existence of washout and soldering layers. Microstructural characterization of die surface and the die roughness measurement were performed together. Computational simulation using AnyCasting program was also beneficial to correlate the extent of die damage with the position of test pin inside die cavity. As results, the optimal combination of die steel with productive coating as well as its hardness was drawn out. it will be helpful to decide the material and condition considering increasing of tool life.

• Animal cells and systems
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• 제14권1호
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• pp.1-10
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• 2010

Previously we showed that CHIP, a co-chaperone of Hsp70 and E3 ubiquitin ligase, can promote the degradation of mutant SOD1 linked to familial amyotrophic lateral sclerosis (fALS) via a mechanism not involving SOD1 ubiquitylation. Here we present evidence that CHIP functions in the interaction of mutant SOD1 with 26S proteasomes. Bag-1, a coupling factor between molecular chaperones and the proteasomes, formed a complex with SOD1 in an hsp70-dependent manner but had no direct effect on the degradation of mutant SOD1. Instead, Bag-1 stimulated interaction between CHIP and the proteasome-associated protein VCP (p97), which do not associate normally. Over-expressed CHIP interfered with the association between mutant SOD1 and VCP. Conversely, the binding of CHIP to mutant SOD1 was inhibited by VCP, implying that the chaperone complex and proteolytic machinery are competing for the common substrates. Finally we observed that mutant SOD1 strongly associated with the 19S complex of proteasomes and CHIP over-expression specifically reduced the interaction between S6/S6' ATPase subunits and mutant SOD1. These results suggest that CHIP, together with ubiquitin-binding proteins such as Bag-1 and VCP, promotes the degradation of mutant SOD1 by facilitating its translocation from ATPase subunits of 19S complex to the 20S core particle.

• Computers and Concrete
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• 제23권5호
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• pp.335-349
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• 2019

A low-cycle loading experiment of 16 transfer column specimens was conducted to study the influence of parameters, likes the extension length of shape steel, the ratio of shape steel, the axial compression ratio and the volumetric ratio of stirrups, on the shear distribution between steel and concrete, the concrete damage state and the degradation of lateral stiffness. Shear force of shape steel reacted at the core area of concrete section and led to tension effect which accelerated the damage of concrete. At the same time, the damage of concrete diminished its shear capacity and resulted in the shear enlargement of shape steel. The interplay between concrete damage and shear force of shape steel ultimately made for the failures of transfer columns. With the increase of extension length, the lateral stiffness first increases and then decreases, but the stiffness degradation gets faster; With the increase of steel ratio, the lateral stiffness remains the same, but the degradation gets faster; With the increase of the axial compression ratio, the lateral stiffness increases, and the degradation is more significant. Using more stirrups can effectively restrain the development of cracks and increase the lateral stiffness at the yielding point. Also, a formula for calculating the yielding lateral stiffness is obtained by a regression analysis of the test data.

• Nuclear Engineering and Technology
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• 제56권2호
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• pp.526-535
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• 2024

This paper proposes a safety-critical standby component unavailability model that contains aging effects caused by the elapsed time from installation, component degradation due to surveillance tests, and imperfect maintenance actions. An application of the model to a Motor-Operated Valve and a Motor-Driven Pump involved in the HPIS of a VVER/1000-V446 nuclear power plant is demonstrated and compared with other existing models at component and system levels. In addition, the effects of different unavailability models are reflected in the NPP's risk criterion, i.e., core damage frequency, over five maintenance periods. The results show that, compared with other models that do not simultaneously consider the full effects of degradation and maintenance impacts, the proposed model realistically evaluates the unavailabilities of the safety-related components and the involved systems as a plant age function. Therefore, it can effectively reflect the age-dependent CDF impact of a given testing and maintenance policy in a specified time horizon.

• 생명과학회지
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• 제7권4호
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• pp.297-308
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• 1997

NAA, GA$_{3}$ 및 BA등의 식물 호르몬이 노화중인 강남콩 잎의 엽록소-단백질 복합체의 분해에 미치는 효과를 조사하였다. 노화의 대표적인 특징인 엽록소의 소실은 엽록소-단백질 복합체의 분해를 수반하였다. 암유도 노화과정동안, PSI 복합체는 급격히 감소한 반면 RC-Core3은 오히려 조화 중기까지 조금씩 증가하다가 이후 서서히 분해되었다. 그리고 LHCII는 노화 과정 후기부터 점진적으로 분해되었다. NAA와 GA$_{3}$는 노화동안 엽록소-단백질 복합체의 분해를 억제하는데 거의 영향을 미치지 못 하였다. 그러나 BA는 노화 과정동안 엽록소-단백질 복합체, 특히 RC-Core1, RC-Core2와 SC-1의 분해를 억제하는데 매우 효과적이었다. 한편 식물 호르몬과 광선의 동시 처리에 있어서, BA와 광선의 동시 처리는 노화 과정동안 엽록소-단백질 복합체, 특히 PSI, LHCII, RC-Core2, RC-Core3과 SC-1의 분해를 억제하는데 가장 효과적이었다. 이와 같은 결과에서 노화 과정동안 엽록소-단백질 복합체는 BA 혹은 광선의 단독 처리보다 BA와 광선의 동시 처리에 의하여 보다 높은 안정성을 가질 것으로 사료된다.

• 한국농공학회지
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• 제39권4호
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• pp.90-97
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• 1997

Field inspections and laboratory tests for 31 agricultural reservoirs in Kyungki province were performed to provide basic data for maintenance and rehabilitation of agricultural reservoirs and to evaluate structural degradation of agricultural reservoirs Results of the study are as follows : 1) From survey's results of embankments, signs of settlement and lateral movement are appeared in 17 reservoirs. Crest settlement of 20~80cm, downstream settlement of 10~90cm, and 20~160cm lateral movement of embankments are detected from settlement and movement analysis of 17 reservoirs. Crest and downstream settlements and lateral movement are greatly occurred in 20 ~ 40 years after embankment construction. 2) About 39% of total reservoirs shows seepage problems occurred in the lower part of berm and retaining wall located between embankment and spillway. Probability of seepage problems is higher at retaining wall than others. 3) Concrete strength estimated by Schmidt hammer in structures of reservoirs is a range of 100~l50kgf/$cm^2$ and average deviation of concrete strength is about l0kgf/$cm^2$. Strength difference$({\delta}S)$ between compressive strength estimated by Schmidt hammer and uniaxial compressive strength of concrete core is about $\pm$100kgf/$cm^2$. This difference is due to absence or presence of reinforced bar in concrete core, variable length of concrete core and limitation of Schmidt hammer. 4) About 68% of total reservoirs shows leaching, 58% alkali-aggregate reaction and 71 % abrasion/frost. Leaching, alkali-aggregate reaction and abrasion/frost occurred in most reservoirs when passed 10 years after construction of structure parts.