• Title/Summary/Keyword: Core affect

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Preparation and Dissolution Characteristics of the Compression-Coated Controlled Release Tablet Exhibiting Three-step Release (압축코팅법에 의한 3단계 약물방출형 지속성제제의 제조 및 용출특성)

  • Kim, Cheol-Soo;Kwon, Hyeok-Lo;Cha, Bong-Jin;Kwon, Jong-Won;Yang, Joong-Ik;Min, Shin-Hong
    • Journal of Pharmaceutical Investigation
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    • v.22 no.2
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    • pp.133-137
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    • 1992
  • A novel oral controlled release tablet which may offer more uniform drug level in the body than simple zero-order was developed. The tablet is composed of three layers; outer film layer, middle part compression-coated hydroxypropylmethylcellulose (HPMC) matrix layer, and inner core layer. Each layer contains nicardipine HCl as a model drug. In vitro dissolution test showed that the tablet released the drug in clear three steps; a rapid initial release, followed by a constant rate of release, and then a second phase of fast release of drug. The dissolution characteristics could be modified easily by changing the grade of HPMC, thickness of matrix layer, content of methylcellulose in matrix layer, content of active ingredient in each layer. The pH of dissolution medium did not affect the release profile. This three-step release system is expected to raise the blood concentration rapidly to effective level and to maintain effective blood level longer than simple slow-release systems.

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Acquiring Vitellogenic Competence in the Rice Pest Nilaparvata lugens Stal: Effects of a Juvenile Hormone Analogue, Hydroprene

  • Pradeep A. R.;Nair V. S. K.
    • International Journal of Industrial Entomology and Biomaterials
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    • v.10 no.2
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    • pp.137-141
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    • 2005
  • Though many insecticides are commercially available, development of resistance, pest resurgence and effects on non-target organisms led to the search for alternate insect pest management (IPM) strategy based on larval growth and reproductive fitness. Reproductive potential of insects depends on its acquiring of vitellogenic competence which is under hormonal control. Exogenous application of analogues of JR (JHAs) and ecdysterone could derail normal development and reproduction in insects by manipulating an array of physiological processes. In the rice pest, brown planthopper, Nilaparvata lugens, JHA, hydroprene induced metathetely from the fifth (final) instar nymphs in an age-dependent manner. Day 0 of the final instar showed highest sensitivity to induce this abnormal development. Adults emerged from treated day 3 nymphs looked normal. Both the morphotypes were reproductively incompetent and showed partial to complete sterility. Pre-adult exposure of the ovarian tissue to hydroprene suppressed mitotic division of germinal cells and induced abnormalities in the later s1ages of growth and differentiation of ovary in N. lugens. More over the nymphal exposure to hydroprene inhibited patency changes of follicular epithelium and affected competence of the follicles for yolk sequestration. In the absence of ovarian growth and oocyte differentiation, germarium found disintegrated, trophic core regressed and terminal oocytes resorbed. Hydroprene exposure to newly ecdysed brachypterous females did not affect ovarian development and egg production. Proper larval-adult transition appeared as a. prerequisite for vitellogenic competence in N. lugens for which the ovarian tissues must be exposed to ecdysterone in the internal milieu devoid of JH.

Compressive Behavior for Smart Skin of Sandwich Structure (스마트 스킨 샌드위치 시편의 압축거동 연구)

  • Kim, Young-Sung;Kim, Yong-Bum;Park, Hoon-Cheol;Yoon, Kwang-Joon;Lee, Jeo-Hwa
    • Journal of the Korean Society for Aeronautical & Space Sciences
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    • v.30 no.8
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    • pp.56-64
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    • 2002
  • In this work, a smart skin of multi-layer structure is designed and manufactured. Through the compression test, the characteristic of smart skin behavior was examined. We have predicted stress of each layer and the first failed layer of the smart skin structure by using MSC/NASTRAN. The finite element model was verified by comparing measured data from the compression test and result from the geometrically linear/non-linear analysis. The finite element model was used for obtaining design data from the parametric study. It was confirmed that shear moduli of honeycomb core affect the buckling load of smart skin where shear deformation was considerable.

Effects Recognition and Elective Attributes on Satisfaction and Recommendation for Medicinal Foods (약선음식의 인지도와 선택속성이 만족도와 추천의향에 미치는 영향)

  • Lee, Sang-Mi
    • The Journal of the Korea Contents Association
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    • v.13 no.6
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    • pp.459-468
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    • 2013
  • This paper is 1) to find out how they recognize medicinal foods, 2) to analyze what make it select for functional restaurants, then which attributes affect on satisfaction and recommendation, 3) and to suggest distinguished guidelines for attracting core customers continuously. The questionnaires are distributed 200 who had only visited in medicinal restaurants and used for data analysis 181 except 19. The findings are summed up as follows; 1. All three factors which are showed 'health managing & prevention', 'functional foods', and 'cuisine presentation' had significant on satisfaction, recommendation, and revisited intention in medicinal restaurant. Among them, 'health managing & prevention' factor had significant highly. 2. Satisfaction variable had affected strongly on recommendation, and also, recommendation had affected on revisited intention.

The Public Sphere and the Conflict-Structure in Spent Nuclear Fuel Management (사용후핵 연료 관리 이슈 공론장과 그 갈등구조에 관한 소고)

  • Choi, Seong-Kyung
    • Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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    • v.7 no.1
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    • pp.49-62
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    • 2009
  • Social Acceptance is important to decide policy of spent nuclear fuel management. The idea of a public sphere as a receptacle of dynamic process is the core in this discussion. The purpose of this study is to examine the concept, participants, the conflict-structure and agreeable conditions of a public sphere. A public sphere means in this paper, mechanism and systems that various stakeholders' and public's participation with spontaneous will can affect decision-making process. For good designing and implementing a public sphere, it is necessary to analysis and cope with political, foreign and security, economic, sociocultural environments, the law and systems around spent nuclear fuel management.

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Compressive behaviour of circular steel tube-confined concrete stub columns with active and passive confinement

  • Nematzadeh, Mahdi;Hajirasouliha, Iman;Haghinejad, Akbar;Naghipour, Morteza
    • Steel and Composite Structures
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    • v.24 no.3
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    • pp.323-337
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    • 2017
  • This paper presents the results of a comprehensive experimental investigation on the compressive behaviour of steel tube-confined concrete (STCC) stub columns with active and passive confinement. To create active confinement in STCC columns, an innovative technique is used in which steel tube is laterally pre-tensioned while the concrete core is simultaneously pre-compressed by applying pressure on fresh concrete. A total of 135 STCC specimens with active and passive confinement are tested under axial compression load and their compressive strength, ultimate strain capacity, axial and lateral stress-strain curves and failure mode are evaluated. The test variables include concrete compressive strength, outer diameter to wall thickness ratio of steel tube and prestressing level. It is shown that applying active confinement on STCC specimens can considerably improve their mechanical properties. However, applying higher prestressing levels and keeping the applied pressure for a long time do not considerably affect the mechanical properties of actively confined specimens. Based on the results of this study, new empirical equations are proposed to estimate the axial strength and ultimate strain capacity of STCC stub columns with active and passive confinement.

A SOA based Framework Using AOP for Reliable Service Applications (AOP를 이용한 신뢰성 있는 서비스 어플리케이션의 SOA 기반 프레임워크)

  • Kim, Eun-Sun;Lee, Jae-Jeong;Lee, Byung-Jeong
    • Journal of Information Technology Services
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    • v.10 no.2
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    • pp.223-234
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    • 2011
  • Loosely coupled properties of SOA(Service Oriented Architecture) services do not guarantee that service applications always work properly. Service errors may also influence other services of SOA. These characteristics adversely affect software reliability. Therefore, it is a challenge to effectively manage system change and errors for operating services normally. In this study, we propose a SOA based framework using AOP(Aspect Oriented Programming) for reliable service applications. AOP provides a way to manipulate cross-cutting concerns such as logging, security and reliability and these concerns can be added to applications through weaving process. We define a service specification and an aspect specification for this framework. This framework also includes service provider, requester, repository, platform, manager, and aspect weaver to handle changes and exceptions of applications. Independent Exception Handler is stored to exhibited external Aspect Service Repository. When exception happened, Exception Handler is linked dynamically according to aspect rule that is defined in aspect specification and offer function that handle exception alternate suitable service in systematic error situation. By separating cross-cutting concerns independently, we expect that developer can concentrate on core service implementation and reusability, understanding, maintainability increase. Finally, we have implemented a prototype system to demonstrate the feasibility of our framework in case study.

A Study on the Optimization of Sabot Assembly Design for Micro Ball Velocity Multiplication (소형구 속도 증폭을 위한 사보조립체 디자인 최적화 연구)

  • Park, Geunhwee;Jin, Doohan;Kim, Teayeon;Kang, Hyung;Chung, Dongteak
    • Journal of the Korea Institute of Military Science and Technology
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    • v.23 no.1
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    • pp.37-42
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    • 2020
  • This study is for a bulletproof experiment through speed acceleration of steel ball(2.385 mm) at the laboratory level. The secondary propulsion method is used for speed acceleration, which uses a sabot assembly consisting of a sabot body, a plunger, water, and a sabot cap. At the core of the secondary drive, it is important that the energy in the water of the private particle is transferred well to the steel ball. The experiment was conducted by selecting a plunger that pushes water and water charged with variables. judging that the longer the contact time, the greater the energy transferred to the steel ball. As a result of experiments with each variable, the amount of water does not affect the speed acceleration efficiency of the steel ball and, when the length of the plunger is increased by 200 %, the speed of the steel ball can be accelerated up to 130 m/s.

Strategic Vitalization Method of AMP Installation through SWOT/AHP Analysis (SWOT/AHP 분석을 통한 전략적 AMP 설치 활성화 방안)

  • Kim, In-Ho;Lee, Kang-Won
    • Journal of Korean Society of Industrial and Systems Engineering
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    • v.42 no.4
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    • pp.49-60
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    • 2019
  • Recently the concentration of fine dust and ultra fine dust becomes so bad, which seriously threatens the health and even the life of people. So, government started to investigate several ways to reduce the amount of fine dust and ultra fine dust. From a few years ago it has been known that ships anchored at port emit a lot of pollution and seriously affect air quality of neighboring cities. To reduce the pollution emitted by ship AMP (Alternative Maritime Power Supply) has been proposed, which uses the electricity instead of bunker C oil or diesel. Many developed countries already installed AMP to improve air quality in port area. Korea is in the stage of planning to install AMP at port. However, there are many complicated problems to be handled before AMP installation. Due to huge initial cost and long period of construction ship owner and habour operating company are reluctant to AMP installation. And there are serious technological difficulties in constructing AMP in existing harbour. Lack of AMP core technology and operational difficulties of AMP are also big challenges to be conquered. In this study SWOT/AHP method is used to find strategic and efficient ways to handle above complicated challenges and then to vitalize the AMP installation.

Improvement and application of DeCART/MUSAD for uncertainty analysis of HTGR neutronic parameters

  • Han, Tae Young;Lee, Hyun Chul;Cho, Jin Young;Jo, Chang Keun
    • Nuclear Engineering and Technology
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    • v.52 no.3
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    • pp.461-468
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    • 2020
  • The improvements of the DeCART/MUSAD code system for uncertainty analysis of HTGR neutronic parameters are presented in this paper. The function for quantifying an uncertainty of critical-spectrumweighted few group cross section was implemented using the generalized adjoint B1 equation solver. Though the changes between the infinite and critical spectra cause a considerable difference in the contribution by the graphite scattering cross section, it does not significantly affect the total uncertainty. To reduce the number of iterations of the generalized adjoint transport equation solver, the generalized adjoint B1 solution was used as the initial value for it and the number of iterations decreased to 50%. To reflect the implicit uncertainty, the correction factor was derived with the resonance integral. Moreover, an additional correction factor for the double heterogeneity was derived with the effective cross section of the DH region and it reduces the difference from the complete uncertainty. The code system was examined with the MHTGR-350 Ex.II-2 3D core benchmark. The keff uncertainty for Ex.II-2a with only the fresh fuel block was similar to that of the block and the uncertainty for Ex.II-2b with the fresh fuel and the burnt fuel blocks was smaller than that of the fresh fuel block.