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Single beam acoustic tweezers for biomedical applications (단일 빔 음향 집게를 이용한 바이오메디컬 응용 연구)

  • Hae Gyun Lim
    • The Journal of the Acoustical Society of Korea
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    • v.42 no.5
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    • pp.452-459
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    • 2023
  • Acoustic tweezers represent an exceptionally versatile and adaptable collection of instruments that harness the intrinsic power of sound waves to manipulate a wide spectrum of bioparticles, ranging from minuscule extracellular vesicles at the nanoscale to more substantial multicellular organisms measuring in millimeters. This field of research has witnessed remarkable progress over the course of the past few decades, primarily in the domain of Single Beam Acoustic Tweezers (SBAT) which utilizes a single element transducer for its operation. Initially conceived as a method for particle trapping, SBAT has since evolved into an advanced platform capable of achieving precise translation of cells and organisms. Recent groundbreaking advancements have significantly enhanced the capabilities of SBAT, unlocking new functionalities such as particle/cell separation and controlled deformation of single cells. These advancements have propelled SBAT to the forefront of bioparticle/cell manipulation, gathering attention within the scientific community. This review explores the core principles of SBAT and how sound waves affect bioparticles/cells. We aim to build a strong conceptual foundation for understanding advancements in this field by detailing its principles and methodologies.

Technology Trends in CubeSat-Based Space Laser Communication (큐브위성 기반 우주 레이저 통신 기술 동향)

  • Chanil Yeo;Young Soon Heo;Siwoong Park;Hyoung Jun Park
    • Journal of Space Technology and Applications
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    • v.4 no.2
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    • pp.87-104
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    • 2024
  • CubeSats are being utilized in various fields such as Earth observation, space exploration, and verification of space science and technology due to their low cost, short development period, enhanced mission-oriented performance, and ability to perform various missions through constellation and formation flights. Recently, as the availability of CubeSats has increased and their application areas have expanded, the demand for high-speed transmission of large amounts of data obtained by CubeSats has increased unprecedentedly. Laser-based free space optical communication technology is capable of transmitting large amounts of data at high speeds compared to the existing radio communication methods, and provides various advantages such as use of unlicensed spectrum, low cost, low power, high security characteristics, and of use a small communication platform. For this reason, it is suitable as a high-performance communication technology to support CubeSat missions. In this paper, we will present the core components and characteristics of CubeSat-based space laser communication system, and recent research trends, as well as representative technology development results.

The Study for Results of Complex Cystic Breast Masses by Biopsy on Ultrasound (초음파상 복합성 낭성 유방 종괴의 조직 검사 결과에 관한 연구)

  • Kang, Hye-Kyoung;Dong, Kyung-Rae
    • Journal of radiological science and technology
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    • v.31 no.2
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    • pp.129-134
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    • 2008
  • Purpose: We examined the roles of Ultrasonography conductors by analyzing the results of tissue biopsy of complex cystic masse under the guidance of breast US. Objects and methods: This study was performed to a group of 178 who showed breast US indicating complex cystic masses among 342 patients who were definitely diagnosed by tissue biopsies and operations in our hospital from June 30th, 2003 to June 30th, 2007. The evaluation of tissues around, calcification, the distribution state of blood flow were excluded from the analysis subjects and logic 200 made by GE corporation and gun for core biopsy(Kimal corp., K7/MBD23) were used in this study. Results: The biopsy results of 178 subjects showed FCC (fibrocystic change)(n=56 : 31.4%), Fibrosis (n=41 : 23.0%), Fibroadenoma (n=20 : 11.2%), Epithelial hyperplasia (n=17 : 9.6%), Carcinoma (n=15 : 8.4%), Fibroadipose (n=8 : 4.5%), Sclerosing adenosis (n=7 : 3.9%), Duct ectasia (n=5 : 2.8%), Papiloma (n=5 : 2.8%), and Fat necrosis (n=1 : 0.6%), Hemangioma (n=1 : 0.6%), Abscess (n=1 : 0.6%), Dystrophic calcification(n=1 : 0.6%). Conclusion: The US showed that the results of the tissue biopsy of complex cystic masses were mostly carcinoma(8.4%). Most of them were benign and only 9.6% of epithelial hyperplasia which has high progression rate into malignant tumors epidemically showed malignancy. Most of them were included in the spectrum of fibrous cystic nodule. Even though these results are confirmed, further studies are required. As a result, a nodule which is not certified by US should be right to take the tissue biopsy, but if it's difficult due to patients or another reasons, re-check tests in three months are required. And systemic ultrasonography evaluation should be well recognized to conduct more careful and specific tests.

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Palaeomagnetism of the Okchon Belt, Korea: Paleozoic Rocks in Yemi Area (옥천대에 대한 고자기 연구: 예미지역 고생대 지층의 잔류자기)

  • 김인수;김성욱;최은경
    • Economic and Environmental Geology
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    • v.34 no.4
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    • pp.355-373
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    • 2001
  • Palaeomagnesim of Paleozoic Tuwibong Type Sequence in Yemi area was studied with a total of 256 core-samples collected from 23 sites. The study area (geographical coordinates: 37.l8$^{\circ}$N, l28.610E) is located between Taebaek and Yongwol belonging to the northeastern part of the Okchon Belt. Thermal cleaning was a most effective method to extract stable characteristic remanent magnetization (ChRM) direction, even though AF cleaning also worked on some specimens. Mean ChRM direction of the Cambrian Hwajol Formation was different from the present-day field direction and showed maximum clustering (max. k value) at 100% bedding-tilt correction. However, it could not pass the fold test. Ordovician Makkol and Kosong Limestones as well as Permian Sadong and Kobangsan Formations have very weak NRM, and were remagnetized into the present-day field direction. ChRM directions from the Carboniferous Hongjom Formation passed both fold and reversal tests. IRM experiments and blocking temperature spectrum indicate that both magnetite and haematite are carrier of the primary magnetization. Palaeomagnetic pole position from the Carboniferous Hongjom Formation is very similar to that of contemporary North China Block (NCB) suggesting that the study area was a part of, or located very near to, the NCB during Carboniferous.

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Development of Software Correlator for KJJVC (한일공동VLBI상관기를 위한 소프트웨어 상관기의 개발)

  • Yeom, J.H.;Oh, S.J.;Roh, D.G.;Kang, Y.W.;Park, S.Y.;Lee, C.H.;Chung, H.S.
    • Journal of Astronomy and Space Sciences
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    • v.26 no.4
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    • pp.567-588
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    • 2009
  • Korea-Japan Joint VLBI Correlator (KJJVC) is being developed by collaborating KASI (Korea Astronomy and Space Science Institute), Korea, and NAOJ(National Observatory of Japan), Japan. In early 2010, KJJVC will work in normal operation. In this study, we developed the software correlator which is based on VCS (VLBI Correlation Subsystem) hardware specification as the core component of KJJVC. The main specification of software correlator is 8 Gbps, 8192 output channels, and 262,144-points FFT (Fast Fourier Transform) function same as VCS. And the functional algorithm which is same as specification of VCS and arithmetic register are adopted in this software correlator. To verify the performance of developed software correlator, the correlation experiments were carried out using the spectral line and continuum sources which were observed by VERA (VLBI Exploration of Radio Astrometry), NAOJ. And the experimental results were compared to the output of Mitaka FX correlator by referring spectrum shape, phase rate, and fringe detection and so on. Through the experimental results, we confirmed that the correlation results of software correlator are the same as Mitaka FX correlator and verified the effectiveness of it. In future, we expect that the developed software correlator will be the possible software correlator of KVN (Korean VLBI Network) with KJJVC by introducing the correlation post-processing and modifying the user interface as like GUI (Graphic User Interface).

Performance and Jitter Effects Analysis of Single Bit Electro-Optical Sigma-Delta Modulators (단일 비트 전자-광학 시그마-델타 변조기의 성능 및 지터 효과 분석)

  • Nam, Chang-Ho;Ra, Sung-Woong
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.23 no.6
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    • pp.706-715
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    • 2012
  • Electro-optical sigma-delta modulators are the core module of digital receiver to digitize wideband radio-frequency signals directly at an antenna. Electro-optical sigma-delta modulators use a pulsed laser to oversample an input radio-frequency signals at two Mach-Zehnder Interferometer(MZI) and shape the quantization noise using a fiber-lattice accumulator. Decimation filtering is applied to the quantizer output to construct the input signal with high resolution. The jitter affects greatly on reconstructing the original input signal of modulator. This paper analyzes the performance of first order single bit electro-optical sigma-delta modulator in the time domain and the frequency domain. The performance of modulator is analyzed by using asynchronous spectral averaging of the reconstructed signal's spectrum in the frequency domain. The reference value of time jitter is presented by analyzing the performance of jitter effects. This kind of jitter value can be used as a reference value on the design of modulators.

Radiation Shielding Analysis on The Spent Fuel Storage Facility for the Extended Fuel Cycle (장주기(長週期) 핵연료(核燃料) 저장시설(貯藏施設)에서의 방사선차폐해석(放射線遮蔽解析))

  • Lee, Tae-Young;Ha, Chung-Woo;Yook, Chong-Chul
    • Journal of Radiation Protection and Research
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    • v.9 no.2
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    • pp.90-96
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    • 1984
  • Estimated dose rates in spent fuel pool storage with the extended fuel cycle core management were reviewed and compared with design limit after calculation with the aid of DLC-23/CASK(22 n, 18 g) nuclear data and ANISN code. Radioactivity and gamma spectrum within spent fuel assemblies were calculated with ORIGEN code by extended fuel cycle model. In the calculation of dose rate, the fuel pool geometry was assumed to be infinite slab. Also, composition materials and radiation source within assemblies which are being stored in pool storage were assumed to be uniformly distributed throughout all the assemblies. As a result of culculation of dose rate from stored assemblies and waterborne radionuclides in pool water, the calculated dose rates appear to be lower than design basis limit under normal condition as well as abnormal condition.

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Reinterpretation of the protein identification process for proteomics data

  • Kwon, Kyung-Hoon;Lee, Sang-Kwang;Cho, Kun;Park, Gun-Wook;Kang, Byeong-Soo;Park, Young-Mok
    • Interdisciplinary Bio Central
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    • v.1 no.3
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    • pp.9.1-9.6
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    • 2009
  • Introduction: In the mass spectrometry-based proteomics, biological samples are analyzed to identify proteins by mass spectrometer and database search. Database search is the process to select the best matches to the experimental mass spectra among the amino acid sequence database and we identify the protein as the matched sequence. The match score is defined to find the matches from the database and declare the highest scored hit as the most probable protein. According to the score definition, search result varies. In this study, the difference among search results of different search engines or different databases was investigated, in order to suggest a better way to identify more proteins with higher reliability. Materials and Methods: The protein extract of human mesenchymal stem cell was separated by several bands by one-dimensional electrophorysis. One-dimensional gel was excised one by one, digested by trypsin and analyzed by a mass spectrometer, FT LTQ. The tandem mass (MS/MS) spectra of peptide ions were applied to the database search of X!Tandem, Mascot and Sequest search engines with IPI human database and SwissProt database. The search result was filtered by several threshold probability values of the Trans-Proteomic Pipeline (TPP) of the Institute for Systems Biology. The analysis of the output which was generated from TPP was performed. Results and Discussion: For each MS/MS spectrum, the peptide sequences which were identified from different conditions such as search engines, threshold probability, and sequence database were compared. The main difference of peptide identification at high threshold probability was caused by not the difference of sequence database but the difference of the score. As the threshold probability decreases, the missed peptides appeared. Conversely, in the extremely high threshold level, we missed many true assignments. Conclusion and Prospects: The different identification result of the search engines was mainly caused by the different scoring algorithms. Usually in proteomics high-scored peptides are selected and low-scored peptides are discarded. Many of them are true negatives. By integrating the search results from different parameter and different search engines, the protein identification process can be improved.

Near-Field Analysis of Vehicle LF Antennas for Estimating the Reading Range of a Smart Key (스마트 키 인식 거리 예측을 위한 차량 LF 안테나의 Near-Field 분석)

  • Kim, Heeyoung;Byun, Gangil;Seong, Jaeyong;Jung, Hankil;Choo, Hosung
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.24 no.7
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    • pp.671-677
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    • 2013
  • In this paper, we propose a method of near-field analysis for vehicle LF antennas in order to estimate the accurate reading range of a smart key. The LF antenna consists of a ferrite core and a conducting wire which is coated with polyethylene for insulation, and it is mounted at the rear bumper frame of a commercial vehicle. The reading range of a smart key is measured at nine azimuthal directions distributed around the rear bumper, and then, the received power at each maximum reading range is measured by using a spectrum analyzer. The measurement shows that the maximum reading range exists between 1.38 m and 1.53 m, and the radiated power is between -83.6 dBmW and -75.0 dBmW. We further conducted EM simulation to estimate the reading range and the received power under the same condition that we applied for the measurement. The results demonstrate that an accurate reading range and received power can be achieved by simulation.

Ernst Bloch and Jürgen Moltmann: The Hope for What? (블로흐와 몰트만: 무엇을 위한 희망인가?)

  • Kim, Jin
    • Journal of Korean Philosophical Society
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    • v.145
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    • pp.217-244
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    • 2018
  • This paper reviews how $J{\ddot{u}}rgen$ Moltmann embraces and transforms the philosophy of Ernst Bloch. For what are the hopes of the two thinkers who presuppose opposing worldviews? This question will provide a good opportunity to look at how different religious types, based on different worldviews in modern philosophy of religion, can understand and communicate with one another. Ernst Bloch was a philosopher who originally interpreted Judeo-Christian thought through Marxism and Persian Dualism and helped to carry out the intrinsic criticism of the doctrine of Christian eschatology by developing atheism of Christianity into a philosophy of hope. Bloch and Moltmann deal with the concepts of future, humanity, nation, and hope in the eschatological horizon, but their worldviews are so different. For example, the connection between the Beginning and Ending, Disjunction or Continuation, the Core of Existence and Resurrection, Messianism and Marxism, Atheism and Theism, Persian Dualism and Judeo-Christian Monotheism. Therefore, a one-sided interpretation that ignores worldview differences in the hopes of these two thinkers should be avoided. Moltmann actively embraced the Messianism of the Jewish thinker, Bloch, by excluding Marxism, made the spectrum of broad-minded horizons diminished in the union of Messianism and Marxism. Moltmann replaced the utopian possibilities of matter in the Ontology of Not-Yet-Being, with the resurrection of Christ, who was crucified, and with the God of Creation and the God of Exodus. By overthrowing the position of atheism in Christianity, which was very important for Bloch, with the system of Trinitarian Monotheism, it resulted in the disconnection and conflict between the Old Testament and the New Testament, especially the ignorance of the tension between God the Lord and Jesus Christ.