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Proteomic Analysis of Haptoglobin and Amyloid A Protein Levels in Patients with Vivax Malaria

  • Bahk, Young-Yil;Na, Byoung-Kuk;Cho, Shin-Hyeong;Kim, Jung-Yeon;Lim, Kook-Jin;Kim, Tong-Soo
    • Parasites, Hosts and Diseases
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    • v.48 no.3
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    • pp.203-211
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    • 2010
  • Advancements in the field of proteomics have provided great opportunities for the development of diagnostic and therapeutic tools against human diseases. In this study, we analyzed haptoglobin and amyloid A protein levels of vivax malaria patients with combinations of depletion of the abundant plasma proteins, 2-dimensional gel electrophoresis (2-DE), image analysis, and mass spectrometry in the plasma between normal healthy donors and vivax malaria patients. The results showed that the expression level of haptoglobin had become significantly lower or undetectable in the plasma of vivax malaria patients due to proteolytic cleavage when compared to healthy donors on 2-DE gels. Meanwhile, serum amyloid A protein was significantly increased in vivax malaria patient's plasma with high statistical values. These 2 proteins are common acute phase reactants and further large scale evaluation with a larger number of patient's will be necessary to establish the possible clinical meaning of the existential changes of these proteins in vivax malaria patients. However, our proteomic analysis suggests the feasible values of some plasma proteins, such as haptoglobin and serum amyloid A, as associating factor candidates for vivax malaria.

Development of Double Rotation C-Scanning System and Program for Under-Sodium Viewing of Sodium-Cooled Fast Reactor (소듐냉각고속로 소듐 내부 가시화를 위한 이중회전구동 C-스캔 시스템 및 프로그램 개발)

  • Joo, Young-Sang;Bae, Jin-Ho;Park, Chang-Gyu;Lee, Jae-Han;Kim, Jong-Bum
    • Journal of the Korean Society for Nondestructive Testing
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    • v.30 no.4
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    • pp.338-344
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    • 2010
  • A double rotation C-scanning system and a software program Under-Sodium MultiVIEW have been developed for the under-sodium viewing of a reactor core and in-vessel structures of a sodium-cooled fast reactor KALIMER-600. Double rotation C-scanning system has been designed and manufactured by the reproduction of double rotation plug of a reactor head in KALIMER-600. Hardware system which consists of a double rotating scanner, ultrasonic waveguide sensors, a high power ultrasonic pulser-receiver, a scanner driving module and a multi channel A/D board have been constructed. The functions of scanner control, image mapping and signal processing of Under-Sodium MultiVIEW program have been implemented by using a LabVIEW graphical programming language. The performance of Under-Sodium MultiVIEW program was verified by a double rotation C-scanning test in water.

A Study For the Standardization Design of Ginseng Cultivating Facility for the Improvement of Farming Environment (영농환경 개선을 위한 인삼재배사 표준화 디자인)

  • 신택균
    • Archives of design research
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    • v.16 no.1
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    • pp.93-102
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    • 2003
  • This thesis is a study for the standardization of the design of ginseng cultivating facility (also known as the sun off facility) for the improvement of farming environment. The core background of this study is to propose a basic study for introducing, for the first time, the modern ginseng cultivating facility that matches the position of korea as a main nation cultivating ginseng and to secure the production and quality value of Koryo Ginseng, which is a special world-level agricultural product of Korea, under the present WTO agricultural product open system. Right now, wood, rice straw, or vinyls, which are non-standardized or are for one-time use only are used. Therefore, as a concept of the design, 1 tried to revise the fact that these materials are being used to set up the facility repeatedly every year which is creating environmental pollution and wasting of our countries labor and resource. Concrete factors to be improved are as follows: First, standardization of the form and structure of mass production system; Second, introduction of new materials such as semi-permanent resin etc., for standardization of materials; 1 tried to make the above two factors into a shape based on a Korean image. As for the design, designed a standard unit model of the ginseng cultivation facility especially keeping in mind to design it so the facility can be freely connected and assembled according to the size and shape of the cultivation area.

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Application of Gold Exploration Using Three-dimensional Resistivity Inversion in Sambo mine (3차원 전기비저항 역산 방법을 이용한 삼보 광산에서 금광 탐사)

  • Park Jong-Oh;Kim Hee-Joon;Song Moo-Young;You Young-June
    • The Journal of Engineering Geology
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    • v.15 no.1
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    • pp.19-27
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    • 2005
  • The Sambo mine is located in Hae-je Myeon, Moo-an Gun, Chollanamdo, which consists of host gneiss and rhyolite possessing quartzite veins with other compositions such as gold, silver, and sublimated sulfur. The ore grade estimated from the core was 0.05~10.9g/t or less in gold and 0.05~389g/t or less in silver, indicating a partial mineralization. The purpose of this paper is to understand the subsurface structures and the distribution of mineralized bodies in the Sambo mine using a combined method of Schlumberger, Wenner, and Dipole-di-pole resistivity surveys on the surface and the resistivity tomography survey in boreholes. The result of three-dimensional resistivity inversion showed that the mineralized body is extended to 240m long in the N10°~20°E direction, with 30m wide and 80 m thick from the surface. The low resistivity zones (<1,000ohm-m) determined from the resistivity image were in good agreement with the mineralized bodies and weak zones identified from the logged cores.

Development of Advanced Rendering Library for CAD/CAM Moduler (CAD/CAM 모델러용 고급 렌더링 라이브러리의 개발)

  • Choe, Hun-Gyu;Lee, Tae-Hyeon;Han, Hun
    • Journal of KIISE:Computing Practices and Letters
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    • v.5 no.4
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    • pp.385-394
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    • 1999
  • 제품을 설계하는 디자이너나 엔지니어는 많은 시간과 노력을 들이지 않고서 그들이 설계한 3차원 제품 모델에 대한 사실적인 이미지를 원한다. 디자인 프로세스의 초기인 개념 설계에서부터 설계검증, 그리고 가공 과정에서 사실적인 이미지가 매우 유용하므로, 대부분의 주요 CAD 제작사는 그들의 CAD 소프트웨어에 고급 렌더링 기능을 추가하고 있다. 상용의 CAD/CAM 모델러에서는 NURB 곡면을 기초로 모델링을 수행하므로, NURB 곡면을 렌더링할 수 있는 패키지가 필요하다. VIF(Visual InterFace) 렌더링 라이브러리는 A-buffer 방식과 Ray tracing 방식의 두 가지 고급 렌더링 모드를 제공한다. 다각형은 물론 NURB 곡면을 입력으로 받아 사용자가 설정한 표면의 각종 계수, 원하는 view와 설정된 광원에 따라 이미지를 만들고 다양한 형태로 출력시킬 수 있는 다양한 기능을 제공한다. 본 논문에서는 VIF 렌더링 라이브러리에 대한 구조와 기능별로 분류된 함수에 대하여 설명하며, 실제로 CAD/CAM 시스템과 통합되어 구상설계에서부터 3차원 설계 모델링에 이르기까지의 제조공정에서 설계검증 툴로써 어떻게 활용되고 있는가에 대하여 기술한다.Abstract Engineers and industrial designers want to produce a realistic-looking images of a 3D model without spending a lot of time and money. Photo-realistic images are so useful from the conceptual design, through its verification, to the machining, that most major CAD venders offer built-in as well as add-on photo-realistic rendering capability to their core CAD software. Since 3D model is consists of a set of NURB surfaces in commercial CAD packages, we need a renderer which handles NURB surface as well as other primitives.A new rendering library called VIF (Visual InterFace) provides two photo-realistic rendering modes: A-buffer and Ray tracing. As an input data it takes NURB surfaces as well as polygonal data and produces images in accordance with the surface parameters, view and lights set by user and outputs image with different formats. This paper describes the overall architecture of VIF and its library functions classified by their functionalities, and discusses how VIF is used as a graphical verification tool in manufacturing processes from the conceptual design to 3D modeling.

Study on the Ship Detection Method Using SAR Imagery (SAR 영상을 이용한 선박탐지에 관한 연구)

  • Kwon, Seung-Joon;Shin, Sung-Woong
    • Journal of Korean Society for Geospatial Information Science
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    • v.17 no.1
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    • pp.131-139
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    • 2009
  • The existing vessel monitoring system using the ground surveillance radar has a difficulty in monitoring ships continuously due to the limited range of detecting ships. For resolving this problem, we carry out a research on ship detection which is to be the core technology of vessel monitoring system for ocean monitoring using SAR imagery. There are two different methods of detecting ships in SAR imagery: detection of the ship target itself and detection of the ship wake. In this paper, we mainly focus on algorithms which detect the ship itself, and also present the accuracy test after extracting positional and directional figures of the ships. After rectifying input SAR imagery using polynomial transformation, we use Wiener filter to remove speckle noises. A labeling technique and morphological filtering in conjunction with Otsu's method are used to automatically detect the ships based on the image processing domain. For ground truth data, information from a radar system is used, which allows assessing the accuracy of the proposed method. The results show that the proposed method has the high potential in automatically detecting the ships and its positional/directional figures in a fast way.

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Imaging on a Vapor Deposited Film by Photopolymerization of a Rod-Like Molecule Consisting of Two Diacetylenic Groups

  • Chang, Ji-Young;Kyung Seo;Cho, Hyun-Ju;Lee, Cheol-Ju;Lee, Changjin;Yongku Kang;Kim, Jaehyung
    • Macromolecular Research
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    • v.10 no.4
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    • pp.204-208
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    • 2002
  • A linear rod-like molecule, bis[4-(1,3-octadynyl)phenyl] terephthalate (2), consisting of two diacetylenic groups, was prepared. The unsymmetric diacetylene was prepared by the Cadiot-Chodkiewicz coupling reaction of 1-bromohexyne with 4-ethynylphenol and linked to a benzene core by an esterification reaction with terephthaloyl chloride in tetrahydrofuran. The thin film (200 nm thickness) of compound 2 was fabricated by the physical vapor deposition on a glass plate with a thermal evaporator. In the X-ray diffraction (XRD) study, the vapor deposited film on the glass plate showed peaks with d spacings of 19.4, 5.7, and 4.5 $\AA$. This XRD pattern was quite different from that observed for compound 2 isolated by recrystallization from methylene chloride/hexane. The vapor deposited film was polymerized by UV irradiation. Photopolymerization was carried out through a photomask, resulting in a patterned image, where the irradiated part became isotropic.

Mathematical Creativity in the View of General Creativity Theory (창의성 이론을 통해 본 수학 창의성)

  • Kim, Pan-Soo
    • Journal of Gifted/Talented Education
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    • v.18 no.3
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    • pp.465-496
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    • 2008
  • With leadership and speciality, creativity is cutting a fine figure among major values of human resource in 21C knowledge-based society. In the 7th school curriculum much emphasis is put on the importance of creativity by pursuing the image of human being based on creativity based on basic capabilities'. Also creativity is one of major factors of giftedness, and developing one's creativity is the core of the program for gifted education. Doing mathematics requires high order thinking and knowledgeable understandings. Thus mathematical creativity is used as a measure to test one's flexibility, and therefore it is the basic tool for creativity study. But theoretical study for mathematical creativity is not common. In this paper, we discuss mathematical creativity applied to 6 approaches suggested by Sternberg and Lubart in educational theory. That is, mystical approaches, pragmatical approaches, psycho-dynamic approaches, cognitive approaches, psychometric approaches and scio-personal approaches. This study expects to give useful tips for understanding mathematical creativity and understanding recent research results by reviewing various aspects of mathematical creativity.

Effect McDonald's Brand Personality on Preference, Satisfaction, and Revisiting in Restaurants : Japanese College Students (맥도날드의 브랜드 개성이 선호도, 만족도, 재방문에 미치는 영향 -일본 대학생을 중심으로-)

  • Lee, Sang-Mi;Moon, Bo-Young
    • The Journal of the Korea Contents Association
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    • v.10 no.1
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    • pp.399-406
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    • 2010
  • This paper is to analyze which factors affect preference, satisfaction, and revisiting on McDonald's brand personality and to suggest distinguished guidelines for drawing core customers. The questionary distributed 150 who is college students in dokyo, Japan, then used for data analysis 128. The results come up with; First, 4 variables which are 'up-to-date', 'spirited', 'darling', and 'young' showed up importantly in brand personality. These mean young generation would like to enjoy playing on-line game and contents with computer on the table during wait their order. Second, 3 factors (sincerity, intelligence/specialization, and wholesome) in brand personality had highly significant in preference and satisfaction. When they feel strongly specialization and trust in product, it should be showed highly with preference and satisfaction. Third, 2 factors (sincerity, and intelligence/specialization) had strongly significant in revisiting. As marketer reinforce darling and specialized image about McDonald, Therefore, they should make customer to purchase again. Finally, if customer prefered and satisfied with product in the restaurant, it could be connected rebuying.

The Animal symbol in Lee Hyo-seok's short story (이효석 단편소설 「돈(豚)」에 나타나는 동물상징)

  • Jeong, Moun-Kwon
    • The Journal of the Korea Contents Association
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    • v.18 no.6
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    • pp.545-553
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    • 2018
  • This study analyzes the animal symbolism shown in the novella by Hyoseok Lee and seeks to shed light on the consciousness of the author expressed through such symbolism. Lee used animal symbolism since 1933 which was a literary turning point for him. Animal symbolism in his novels are more than an analogical theme but is used as a core meaning and image. This has a clear intention of the author underneath. Novella which is seen as the starting point of pure literature for Lee, uses the animal pig as a key symbol. The pig serves as a symbol of the capital for poor farmers, while also serving as an amplifier for the desires of the protagonist. The death of the pig that appears at the closing of the novella stands for the tragic reality of the farmers of the time who could not seek growth in their capital or realization of their desires. As such, has characteristics of pure literature but also represents the consciousness of the author who brings attention to the tragic reality of farmers. That is, is a work that realized the unique writing style of Lee and his animal symbolism to bring to life a middle way appraoch to realism and romanticism.