• Journal of Sensor Science and Technology
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• v.18 no.5
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• pp.385-392
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• 2009

This paper describes the algorithm development of a new body pressure detection sensor for occupant classification system. U.S. Government has required that advanced airbag system should be installed to every automobiles after 2006 according to FMVSS 208 regulation. Therefore, Occupant Classification System should be provided the passenger with safety in order to protect the infants or children that sit in the front passenger seat. When an occupant sits on the chair of the vehicle, deployment of the airbag depends on passenger's weigh distribution and postures. Authors have been developed a new pattern recognition of passenger and weight distribution at the same time by Force Sensing Resistor for the safety.

• Journal of Ocean Engineering and Technology
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• v.37 no.1
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• pp.20-30
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• 2023

Modeling a nonlinear ocean wave is one of the primary concerns in ocean engineering and naval architecture to perform an accurate numerical study of wave-structure interactions. The high-order spectral (HOS) method, which can simulate nonlinear waves accurately and efficiently, was investigated to see its capability for nonlinear wave generation. An open-source (distributed under the terms of GPLv3) project named "HOS-ocean" was used in the present study. A parametric study on the "HOS-ocean" was performed with three-hour simulations of long-crested ocean waves. The considered sea conditions ranged from sea state 3 to sea state 7. One hundred simulations with fixed computational parameters but different random seeds were conducted to obtain representative results. The influences of HOS computational parameters were investigated using spectral analysis and the distribution of wave crests. The probability distributions of the wave crest were compared with the Rayleigh (first-order), Forristall (second-order), and Huang (empirical formula) distributions. The results verified that the HOS method could simulate the nonlinearity of ocean waves. A set of HOS computational parameters was suggested for the long-crested irregular wave simulation in sea states 3 to 7.

• Nuclear Engineering and Technology
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• v.14 no.2
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• pp.86-91
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• 1982

In 1977, spent fuel storage capacity of Ko-Ri Unit 1 was raised to contain 4-2/3 core, by reducing the center-to-center spacing between fuel assemblies from 53.34cm to 36cm. In this paper the adequacy is discussed in detail by examining the previous design analysis report. According to the analytic method presented by Core Performance Branch, study on credible abnormal moderator density condition is performed by using KENO-IV for the redesigned spent fuel storage facility. Result shows that 36cm for the center-to-center spacing between fuel assemblies is not enough to keep the storage safe at water density of 0.1143g/㎤, which gives the maximum $K_{eff}$ 0.9958$\pm$0.0048, which exceeds the CPB regulation limit 0.98. From sensitivity study regarding to the center-to-center spacing, it should be maintained to space greater than 43cm in order to meet the CPB requirements.s.

• The Korean Journal of Physiology and Pharmacology
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• v.28 no.2
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• pp.145-152
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• 2024

Chemotherapy-induced cognitive impairment is recognized as the most typical symptom in patients with cancer that occurs during and following the chemotherapy treatment. Recently many studies focused on pharmaceutical strategies to control the chemotherapy side effects, however it is far from satisfactory. There may be a need for more effective treatment options. The aim of this study was to investigate the protective effect of exercise on cisplatin-induced neurotoxicity. Eight-week-old C57BL6 mice were separated into three group: normal control (CON, n = 8); cisplatin injection control (Cis-CON, n = 8); cisplatin with aerobic exercise (Cis-EXE, n = 8). Cisplatin was administered intraperitoneally at a dose of 3.5 mg/kg/day. The Cis-EXE group exercise by treadmill running (14-16 m/min for 45 min daily, 3 times/week) for 12 weeks. Compared to the CON group, the cisplatin injection groups showed significant decrease in body weight and food intake, indicating successful induction of cisplatin toxicity. The Cis-CON group showed significantly increased levels of pro-inflammatory cytokines including IL-6, IL-1β, and TNF-α in the hippocampus, while the Cis-EXE group was significantly decreased in the expression of IL-6, IL-1β, and TNF-α. In addition, compared to the CON group, the levels of synapse-related proteins including synapsin-1 and -2 were significantly reduced in the Cis-CON group, and there was a significant difference between the Cis-CON and Cis-EXE groups. Antioxidant and apoptosis factors were significantly improved in the Cis-EXE group compared with the Cis-CON group. This study suggest that exercise could be meaningful approach to prevent or improve cisplatin-induced cognitive impairment.

• Proceedings of the Korean Powder Metallurgy Institute Conference
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• 2006.09b
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• pp.944-945
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• 2006

A new tungsten heavy alloy with hybrid structure was manufactured for the kinetic energy penetrator. The tungsten heavy alloy is composed of two parts: core region is molybdenum added heavy alloy to promote the self-sharpening; outer part encompassing the core is conventional heavy alloy to sustain severe load in a muzzle during firing. From ballistic test, it was found that the penetration performance of the hybrid structure tungsten heavy alloy is higher than that of conventional heavy alloy. This heavy alloy is thought to be very useful for the penetrator in the near future.

• Bulletin of the Korean Chemical Society
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• v.32 no.8
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• pp.2683-2688
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• 2011

Silica-manganese oxides with a core-shell structure were synthesized via precipitation of manganese oxides on the $SiO_2$ core while varying the concentration of a precipitation agent. Elemental analysis, crystalline property investigation, and morphology observations using low- and high-resolution electron microscopes were applied to the synthesized silica-manganese oxides with the core-shell structure. As the concentration of the precipitating agent increased, the manganese oxide shells around the $SiO_2$ core sequentially appeared as $Mn_3O_4$ particles, $Mn_2O_3+Mn_3O_4$ thin layers, and ${\alpha}-MnO_2$ urchin-like phases. The prepared samples were assembled as electrodes in a supercapacitor with 0.1 M $Na_2SO_4$ electrolyte, and their electrochemical properties were examined using cyclic voltammetry and charge-discharge cycling. The maximum specific capacitance obtained was 197 F $g^{-1}$ for the $SiO_2-MnO_2$ electrode due to the higher electronic conductivity of the $MnO_2$ shell compared to those of the $Mn_2O_3$ and $Mn_3O_4$ phases.

• Proceedings of the Korean Magnestics Society Conference
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• 2007.05a
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• pp.117.1-117.1
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• 2007

• Proceedings of the Korean Magnestics Society Conference
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• 2008.12a
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• pp.230.1-230.1
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• 2008

• Proceedings of the Korean Magnestics Society Conference
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• 1999.04a
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• pp.40-41
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• 1999

• Interdisciplinary Bio Central
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• v.1 no.1
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• pp.3.1-3.6
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• 2009

Introduction: GTPases known as translation factor play a vital role as ribosomal subunit assembly chaperone. The bacterial Obg proteins ($Spo{\underline{0B}}$-associated ${\underline{G}}TP$-binding protein) belong to the subfamily of P-loop GTPase proteins and now it is considered as one of the new target for antibacterial drug. The majority of bacterial Obgs have been commonly found to be associated with ribosome, implying that these proteins may play a fundamental role in ribosome assembly or maturation. In addition, one of the experimental evidences suggested that Bacillus subtilis Obg (BsObg) protein binds to the L13 ribosomal protein (BsL13) which is known to be one of the early assembly proteins of the 50S ribosomal subunit in Escherichia coli. In order to investigate binding mode between the BsObg and the BsL13, protein-protein docking simulation was carried out after generating 3D structure of the BsL13 structure using homology modeling method. Materials and Methods: Homology model structure of BsL13 was generated using the EcL13 crystal structure as a template. Protein-protein docking of BsObg protein with ribosomal protein BsL13 was performed by DOT, a macro-molecular docking software, in order to predict a reasonable binding mode. The solvated energy minimization calculation of the docked conformation was carried out to refine the structure. Results and Discussion: The possible binding conformation of BsL13 along with activated Obg fold in BsObg was predicted by computational docking study. The final structure is obtained from the solvated energy minimization. From the analysis, three important H-bond interactions between the Obg fold and the L13 were detected: Obg:Tyr27-L13:Glu32, Obg:Asn76-L13:Glu139, and Obg:Ala136-L13:Glu142. The interaction between the BsObg and BsL13 structures were also analyzed by electrostatic potential calculations to examine the interface surfaces. From the results, the key residues for hydrogen bonding and hydrophobic interaction between the two proteins were predicted. Conclusion and Prospects: In this study, we have focused on the binding mode of the BsObg protein with the ribosomal BsL13 protein. The interaction between the activated Obg and target protein was investigated with protein-protein docking calculations. The binding pattern can be further used as a base for structure-based drug design to find a novel antibacterial drug.