• Journal of Oriental Neuropsychiatry
• /
• v.14 no.2
• /
• pp.191-198
• /
• 2003

Dissociative amnesia is a psychiatric disorder charicterized by a sudden loss of memory, but which has no organic disease or explanation, It usually occurs after severe psychosocial stress or traumatic experience. As for medical treatment, medicine, psychotherapy and hypnosis are used. This case describes a 35-years-old woman who developed amnesia and depression following severe troublesome events. So she suited without expression and appealed against headache, dizziness, chest discomfort and weakness. Psychoanalytic psychotherapy was enforced for three days with hypnosis. She expressed the felling over the incident which she dose not like, and canceled in the past. She became reconciled with the family and left the husband by the heart. Then she recovered memory completely and body condition also improved. Recovery and growth of self were helped using supportive expression in order to prevent a recurrence. The prognosis is good with complete recovery, and there was no relapse.

• Journal of Oriental Neuropsychiatry
• /
• v.14 no.2
• /
• pp.183-189
• /
• 2003

Hysterical aphonia is one of the frequent symptoms in conversion disorders. If it has a recent onset, a manifest induced factor, and a good premorbid adaptation, and another mental disorder is not accompanied, its prognosis is good. We report one case of hysterical aphonia that was bad prognosis. This patient was suffering traumatic event before and after onset, and major depressive disorder was accompanied. Having hysterical aphonia, the patient who had no progress after over an years medicine therapy and often felt strong suicidal urge, was successfully treated by TFT(Thought field therapy) and oriental medicine therapy. Several case studies on hypnotic cure of hysterical aphonia has been reported but they are uncommon internally and have good prognosis. In addition, there were no relevant studies concerning alternative therapy and oriental medication. Our case report is focused on treatment through these methods.

• Journal of Oriental Neuropsychiatry
• /
• v.20 no.4
• /
• pp.161-172
• /
• 2009

Objectives : This study was designed to research the effect of oriental treatments for Hwabyung with Blepharoptosis. Methods : A 51 year-old female patient has been suffered by Hwabyung for 5 months and by Blepharoptosis for 2 weeks. We treated the patient with Herbal medication, oriental psychotherapy and acupuncture. Results : As a result of oriental treatments, Blepharoptosis was disappeared, and the symptoms of Hwabyung was improved gradually. Conclusions : These result suggest that oriental treatments have an effect on Hwabyung with Blepharoptosis.

• The Korean Journal of Nuclear Medicine
• /
• v.23 no.2
• /
• pp.215-218
• /
• 1989

Tc-99m-tin colloid distribution in the hip is studied in 76 patients with no hepatic and hip disorder, because knowledge of normal uptake pattern in the hip is important in evaluation of femoral head vasculature after a fracture. The uptake in femoral head is decreased or disappeared with increasing age due to conversion of red marrow to white marrow.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.20 no.3
• /
• pp.748-752
• /
• 2006

Wei symptom(?證) is symptom that reveals muscle relaxation without contraction and muscle relaxation occurs in the lower or upper limb, in severe case, leads to death. This is the clinical report about the Wei symptom(?證)-patient doubt as Transverse Myelitis and Conversion Disorder. The patient was treated by acupuncture, moxibustion, herb medication(十全大補湯), electriccal stimulation theraphy, Bee Venom acupuncture, and had significant improvement in Wei symptom(?證). these results suggest the surface temperature differ remarkably from before being treated. The temperature is measured by using Digital Infrared Thermal Imaging(DITI). The results suggest that oriental medicare is an effective treatment for Wei symptom. We expected that therapeutic value of treatment of both leg Paralysis in the oriental medicine will be higher if more clinical studies and researches are accomplished.

• Korean Journal of Veterinary Service
• /
• v.22 no.1
• /
• pp.9-13
• /
• 1999

Mycoplasmal pneumonia of swine(MPS) cause by Mycoplasma hyopneumoniae has been recognized as a serious impediment to swine production due to chronic respiratory disorder which result in the weight loss and decreased feed conversion. The disease causes a great economic losses in pig industry by characterizing with high morbidity, low mortality, growth retardation and low feed efficiency. The present study was conducted to investigate the titers of antibody against M hyopneumoniae from the regional and seasonal groups of the slaughtered pigs by enzyme-linked immunosorbent assay(ELISA). The result have shown that the average seropositive rate of M hyopneumoniae infection was 84.6% . The regional seropositive rate in Korea showed 87.4% in Kyonggj, 83.4n in Kangwon, 89.2% in Chungnam and 77.6% in Chungbuk area, respectively. Also the seasonal seropositive rate was appeared as 78.6% in spring,90.1% in summer, 76.9% in autumn and 83.8% in winter, respectively.

• Clinical and Experimental Pediatrics
• /
• v.48 no.6
• /
• pp.665-668
• /
• 2005

"Rickets" is the term applied to impaired mineralization at epiphyseal growth plate, resulting in deformity and impaired linear growth of long bones. Rickets may arise as a result of vitamin D deficiency or abnormality in metabolism. Vitamin D-dependent rickets(VDDR) is rare autosomal recessive disorder in which affected individuals have clinical features of vitamin D deficiency. In 1961, Prader first described this disorder including severe clinical features of rickets, such as hypophosphatemia, hypocalcemia, muscle weakness and seizure. Two distinctive hereditary defects, type I VDDR and type II VDDR have been recognized in vitamin D metabolism. Type I VDDR may be due to congenital defects of renal 1 ${\alpha}$-hydroxylase, the enzyme responsible for conversion of $25(OH)D_3$. These patients have low to detectable $1,25(OH)_2D_3$ in presence of normal to raised $25(OH)D_3$. In type II VDDR, renal production of $1,25(OH)_2D_3$ is intact but $1,25(OH)_2D_3$ is not used effectively and target organ resistant to $1,25(OH)_2D_3$ is respectively derived from the abnormality in the vitamin D receptor. We report a case of a 25 month-old girl with typical clinical features of VDDR type I rickets, hypocalcemia, increased alkaline phosphatase and secondary hyperparathyroidism.

• Korean Journal of Psychosomatic Medicine
• /
• v.5 no.1
• /
• pp.12-30
• /
• 1997

The psychiatric interview is not a random or arbitrary meeting between doctor and patient. It is a systematic attempt to understand the relationship of psychopathology to emotional conflicts in patient, and interviewing is an in rather than a science, a skill that can be acquired but probably not taught. The faculty of the Seoul National University Hospital, Department of Psychiatry, have been providing 12 sessions of seminar on Psychiatric Interview and Psychopathology every year for the first year residents for the past 15 years. The authors presented three cases materials with their understandings of psychopathology and psychodynamics, each of which the authors had performed live interviews for 50 minutes in front of the residents. Those are a young male with conversion disorder whose chief complaints was motor aphasia, a young college girl with paranoid schizophrenia whose chief complaints were persecutory and erotic delusions with auditory hallucination, and a climacteric female in delusional disorder who had a delusion of infidelity. The most frequent questions the residents raised after the presentations were on the significances of the first interview, danger of making the diagnoses with short interviews, and methodology of questionings and not-questionings. In reply the authors discussed the importance of understandings of psychopathology and psychodynamics, the flexibility of the techniques of interviewing, and priority-related matters in which the understanding of psychodynamics proceed to the diagnoses.

• Korean Journal of Biological Psychiatry
• /
• v.12 no.1
• /
• pp.20-31
• /
• 2005

Objectives:This study was designed to investigate the characteristics of personality changes and emotional distress using the Personality Assessment Inventory (PAI) in patients with traumatic brain injury(TBI), divided into mild (MTBI) and severe (STBI) groups according to the severity of injury. Methods:The subjects were consisted of 25 patients with MTBI, 25 patients with STBI, and 25 normal controls. They were interviewed with the PAI. The data were analyzed by ${\chi}^2$ test, analysis of variance and Tukey test. Results:The results were the followings. First, Negative Impression in validity scales was elevated above cutoff point(T score 70) in both MTBI and STBI groups. Second, the clinical scales of which scores elevated above the cutoff point were Somatic Complaints, Anxiety, Anxiety-Related Disorders, Depression, and Schizophrenia in the MTBI, and Somatic Complaints and Depression in the STBI. Third, the clinical subscales above the cutoff point were Conversion, Somatization, Health Concerns, Affective Anxiety, Physiological Anxiety, Traumatic Stress, Cognitive Depression, Affective Depression, Physiological Depression, Thought Disorder, and Affective Instability in the MTBI, and Health Concerns, Cognitive Depression, Affective Depression, and Physiological Depression in the STBI. Fourth, Suicide Ideation in treatment scales was the only scale above the cutoff point in the MTBI and the others of the treatment and interpersonal scales in the MTBI and all of these scales of the STBI were not elevated above the cutoff point. Fifth, the scales of which scores showed significant difference between the MTBI and the STBI were Somatic Complaints, Anxiety, Depression, and Suicide Ideation, the subscales were Conversion, Somatization, Health Concerns, Affective Anxiety, Physiological Anxiety, Physiological Depression, and Psychotic Experiences. Conclusion:These results suggest that the patients with MTBI had more somatic and anxiety symptoms, depressed mood, and suicidal ideation than the patients with STBI. These characteristics are generally consistent with clinical observation and findings from previous studies of the patients with TBI, and the PAI seems to be a beneficial adjunctive assessment tool for the evaluation of patients with traumatic brain injury.

• Biomolecules & Therapeutics
• /
• v.31 no.3
• /
• pp.264-275
• /
• 2023

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by tremors, bradykinesia, and rigidity. PD is caused by loss of dopaminergic (DA) neurons in the midbrain substantia nigra (SN) and therefore, replenishment of DA neurons via stem cell-based therapy is a potential treatment option. Astrocytes are the most abundant non-neuronal cells in the central nervous system and are promising candidates for reprogramming into neuronal cells because they share a common origin with neurons. The ability of neural progenitor cells (NPCs) to proliferate and differentiate may overcome the limitations of the reduced viability and function of transplanted cells after cell replacement therapy. Achaete-scute complex homolog-like 1 (Ascl1) is a well-known neuronal-specific factor that induces various cell types such as human and mouse astrocytes and fibroblasts to differentiate into neurons. Nurr1 is involved in the differentiation and maintenance of DA neurons, and decreased Nurr1 expression is known to be a major risk factor for PD. Previous studies have shown that direct conversion of astrocytes into DA neurons and NPCs can be induced by overexpression of Ascl1 and Nurr1 and additional transcription factors genes such as superoxide dismutase 1 and SRY-box 2. Here, we demonstrate that astrocytes isolated from the ventral midbrain, the origin of SN DA neurons, can be effectively converted into DA neurons and NPCs with enhanced viability. In addition, when these NPCs are inducted to differentiate, they exhibit key characteristics of DA neurons. Thus, direct conversion of midbrain astrocytes is a possible cell therapy strategy to treat neurodegenerative diseases.