• The Journal of Korean Medicine
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• v.31 no.3
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• pp.1-7
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• 2010

Objectives: To introduce to TKM scientific dose conversion methods of human to animal or animal to human for new drug investigations. Methods: We searched guidelines of the FDA and KFDA, and compared them with references for drug-dose conversion from various databases such as PubMed and Google. Then, we analyzed the potential issues and problems related to dose conversion in safety documentation of new herbal drugs based on our experiences during Investigational New Drug (IND) applications of TKM. Results: Dose conversion from human to animal or animal to human must be appropriately translated during new drug development. From time to time, investigators have some difficulty in determining the appropriate dose, because of misunderstandings of dose conversion, especially when they estimate starting dose in clinical or animal studies to investigate efficacy, toxicology and mechanisms. Therefore, education of appropriate dose calculation is crucial for investigators. The animal dose should not be extrapolated to humans by a simple conversion method based only on body weight, because many studies suggest the normalization method is based mainly on body surface area (BSA). In general, the body surface area seems to have good correlation among species with several parameters including oxygen utilization, caloric expenditure, basal metabolism, blood volume and circulating plasma protein. Likewise, a safety factor should be taken into consideration when deciding high dose in animal toxicology study. Conclusion: Herein, we explain the significance of dose conversion based on body surface area and starting dose estimation for clinical trials with safety factor.

• Journal of Digital Convergence
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• v.14 no.8
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• pp.441-451
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• 2016

The purpose of this study is to analyze the trend of spatial design education focusing on creativity based on design process. In this research, the theoretical frame of design process focused on creativity was organized and the trend of creativity education study in the spatial design and other design sectors was compared and analyzed. As a result of the research, the creativity education study of spatial design analyzed such a result showed the relatively low frequency, many of studies related to formative expression of idea. On the contrary, the creativity education of other design sectors is related to overall process the most, the major contents were represented as a creativity enhancement eduction through the conversion with other sectors, the utilization of study method and theology and the utilization of IT technology. The result of this study suggests that more various attempts are required for the spatial design education and that the attempts should orient the conversion between science and art, humanity and science and the integrated access of digital and analogue.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• v.9 no.2
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• pp.1023-1026
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• 2005

본 논문에서는 SDR(Software Defined Radio) 시스템을 위한 Digital IF(Intermediate Frequency) Up/Down 변환기를 설계하고 성능을 평가하였다. 설계한 시스템은 AD 변환부, DA 변환부 및 Up-Down conversion 기능을 수행하는 FPGA로 구성된다. AD 변환부는 Analog Device 사의 AD6645를 사용하였으며, DA 변환부는 Analog Device 사의 AD9775를 사용하였다. Up-Down conversion 기능을 수행하는 FPGA부는 샘플된 IF 입력을 혼합기와 NCO에 의해 기저대역(DC)으로 다운 시키는 역할을 하며, 14bit의 기저대역(DC) 신호를 혼합기와 NCO에 의해 IF 출력으로 올려주는 역할을 한다. 이러한 설계는 기존의 아날로그 헤테로다인 방식에 비하여 높은 유연성 및 우수한 성능 향상을 보여준다.

• Design & Manufacturing
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• v.16 no.2
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• pp.7-12
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• 2022

The purpose of this study is to develop an evaluation method for online design education. Online education has established itself as the primary form in the educational field, however, there are unsatisfactory response from instructors and students due to rapid conversion of online education. Due to the transition of educational method, online class contents have become optimized and online educational experiences became accumulated. However, clear education criteria is essential. This study states importance of two parts: establishing an evaluation system based on design thinking for online design education and finding appropriate online platforms for interaction between instructors and students. The research results provide implications for ensuring the efficiency of design education and are expected to contribute significantly to the future education field.

• Clean Technology
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• v.29 no.1
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• pp.39-45
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• 2023

To investigate the effects of Mg addition at different aging times and temperatures, Cu/MgO/Al₂O₃ catalysts were synthesized for the low-temperature water gas shift (LT-WGS) reaction. The co-precipitation method was employed to prepare the catalysts with a fixed Cu amount of 30 mol% and varied amounts of Mg/Al. Synthesized catalysts were characterized using XRD, BET, and H₂-TPR analysis. Among the prepared catalysts, the highest CO conversion was achieved by the Cu/MgO/Al₂O₃ catalyst (30/40/30 mol%) with a 60 ℃ aging temperature and a 24 h aging time under a CO₂-rich feed gas. Due to it having the lowest reduction temperature and a good dispersion of CuO, the catalyst exhibited around 65% CO conversion with a gas hourly space velocity (GHSV) of 14,089 h-1 at 300 ℃. However, it has been noted that aging temperatures greater or less than 60 ℃ and aging times longer than 24 h had an adverse impact, resulting in a lower surface area and a higher reduction temperature bulk-CuO phase, leading to lower catalytic activity. The main findings of this study confirmed that one of the main factors determining catalytic activity is the ease of reducibility in the absence of bulk-like CuO species. Finally, the long-term test revealed that the catalytic activity and stability remained constant under a high concentration of CO₂ in the feed gas for 19 h with an average CO conversion of 61.83%.

• Journal of Digital Convergence
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• v.11 no.1
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• pp.243-248
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• 2013

In this paper, depth of foreground is analysed by focus and color analysis grouping for 2D/3D video conversion and depth of foreground progressing method is preposed by using focus and motion information. Candidate foreground image is generated by estimated movement of image focus information for extracting foreground from 2D video. Area of foreground is extracted by filling progress using color analysis on hole area of inner object existing candidate foreground image. Depth information is generated by analysing value of focus existing on actual frame for allocating depth at generated foreground area. Depth information is allocated by weighting motion information. Results of previous proposed algorithm is compared with proposed method from this paper for evaluating the quality of generated depth information.

• Journal of Science Education
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• v.43 no.3
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• pp.284-299
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• 2019

The purpose of this study is to investigate elementary school students' conceptions about the energy represented in the integrated theme 'Energy and life' of the 2015 revised science curriculum. The instruments were developed to grasp students' understanding about 'the concepts of energy,' 'forms of energy,' 'conversion of energy,' and 'energy use of plants and animals.' The surveys were conducted on 92 elementary school students in Seoul. The students' answers were analyzed by descriptive statistics, clouds and semantic network analysis. The results are as follows: 'Electricity' and 'electric energy' were most frequently mentioned as the associated concepts to energy and forms of energy, respectively. Also, the daily use of energy was mixed to the use in science. According to conceptual hierarchy, understanding of energy conversion was dependent on the understanding of energy forms. Although students have basic concepts about the energy use of plants and animals, they had some misconceptions and lack of understanding. The educational implications were discussed to teach 'Energy and Life' as integrated theme in new elementary school curriculum.

• Journal of Power Electronics
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• v.18 no.6
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• pp.1791-1804
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• 2018

To achieve a fast dynamic response and to solve the multi-objective control problems of the output currents, capacitor voltages and system constraints, this paper proposes a deadbeat and hierarchical predictive control with space-vector modulation (DB-HPC-SVM) for five-level nested neutral point piloted (NNPP) converters. First, deadbeat control (DBC) is adopted to track the reference currents by calculating the deadbeat reference voltage vector (DB-RVV). After that, all of the candidate switching sequences that synthesize the DB-RVV are obtained by using the fast SVM principle. Furthermore, according to the redundancies of the switch combination and switching sequence, a hierarchical model predictive control (MPC) is presented to select the optimal switch combination (OSC) and optimal switching sequence (OSS). The proposed DB-HPC-SVM maintains the advantages of DBC and SVM, such as fast dynamic response, zero steady-state error and fixed switching frequency, and combines the characteristics of MPC, such as multi-objective control and simple inclusion of constraints. Finally, comparative simulation and experimental results of a five-level NNPP converter verify the correctness of the proposed DB-HPC-SVM.

• International Journal of Fluid Machinery and Systems
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• v.9 no.4
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• pp.300-306
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• 2016

A twin unidirectional impulse turbine for wave energy conversion has been suggested in our previous study, and the performance under unsteady flow has been investigated by quasi-steady analysis. In the present study, the performance of twin impulse turbine under unsteady flow condition has been investigated by unsteady analysis of Computational fluid dynamics. As a result, the mean efficiency of twin unidirectional impulse turbine under unsteady flow is lower than the maximum efficiency of unidirectional impulse turbine. Moreover, it is verified that airflow goes backward in the reverse turbine in low flow rates.

• Electronic Materials Letters
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• v.14 no.6
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• pp.718-724
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• 2018

With the development of photovoltaic industry, the cost of photovoltaic power generation has become the significant issue. And the metallization process has decided the cost of original materials and photovoltaic efficiency of the solar cells. Nowadays, double printing process has been introduced instead of one-step printing process for front contact of polycrystalline silicon solar cells, which can effectively improve the photovoltaic conversion efficiency of silicon solar cells. Here, the relative cheap Cu paste has replaced the expensive Ag paste to form Ag/Cu composite front contact of silicon solar cells. The photovoltaic performance and the cost of photovoltaic power generation have been investigated. With the optimization on structure and height of Cu finger layer for Ag/Cu composite double-printed front contact, the silicon solar cells have exhibited a photovoltaic conversion efficiency of 18.41%, which has reduced 3.42 cent per Watt for the cost of photovoltaic power generation.