• 수면정신생리
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• 제12권2호
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• pp.87-92
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• 2005

Cytokines are the main regulatory molecules of not only immune system but also sleep system. Research on the role of cytokines on sleep has greatly been expanding since the first report of sleep-promoting effects of interleukin-1, the first cytokine molecule. Interleukin-1 and tumor necrosis factor are most widely studied among various cytokines. Studies over about twenty years demonstrate that most cytokines promote sleep but several cytokines inhibit sleep. Slow wave sleep is the main part that cytokines have effects on. Besides normal sleep physiology, cytokines have more major roles on pathophysiology of various sleep disorders. Obstructive sleep apnea is the representative sleep disorder that shows how deeply cytokines are involved in their pathophysiologic mechanisms of sleep disorders. Though there are many controversial issues on this topic, more mysterious part of normal sleep physiology and sleep disorders will be revealed in near future through thorough studies on sleep and cytokine.

• 대한기계학회논문집B
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• 제31권4호
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• pp.341-348
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• 2007

One of the controversial research issues on nanofluids is the temperature dependence of the thermal conductivity of nanofluids, that is, whether it will increase or decrease according to the temperature rise. To evaluate precisely the thermal conductivity behavior of nanofluids, a systematic way of validation experiments for the measuring instrument has been highly recommended. In this paper, procedure of the validation test for transient hot-wire method using the temperature dependence of the base fluids was explained comprehensively and the comparison of the temperature dependence of water-$Al_2O_3$ nanofluids is made between the present work and that of Das et al.

• 한국문헌정보학회지
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• 제11권
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• pp.117-146
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• 1984

The purpose of the study is to call forth a special attention to nonbook materials as part of library materials and to improve its bibliographic study of the Korean library community. For this purpose, this paper will concern the cataloging codes of nonbook materials in Anglo-American tradition for discussion, analyses and comparison. Furthermore, an emphasis was made on the general historical development of nonbook cataloging codes mainly used in U. S. and its impact on Anglo-American Cataloging Rules (AACR). In addition, in the part III of AACR1, several controversial issues will be argued for further revision in provision. As shown in the revised Chapter 12 of AACR 1, this thesis will try to identify common characteristics and requirements of the standard cataloging codes. It will require a comparison of various subjects with three other leading international cataloging codes, served as the principal sources of information for the revision. And my final discussion will be argued for the comparison of the differences between AACR 1 and AACR 2 with exemples.

• 대한불안의학회지
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• 제1권1호
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• pp.37-42
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• 2005

Benzodiazepines are widely used for a variety of conditions in psychiatric field. In this article, the author reviewed the indications, the effects on anxiety and sleep disorders, the side effects, the drug-drug interactions, and the tapering strategies. Benzodiazepines were relatively safe and useful for the treatment of anxiety and sleep disorders. However, used clinically, benzodiazepines can induce many adverse effects (e. g. over-sedation, cognitive impairments, paradoxical effects, dependence and withdrawal symptoms, and so on). Currently available informations about their effects on the developing fetus is controversial. For this reason, pregnant women and nursing mother should be cautioned against the use of benzodiazepines. Drug-drug interactions have to be considered in combination treatments. For the tapering issues, gradual tapering was important to prevent the withdrawal symptoms. Especially, the tapering schedules have to be individualized for the each long-term benzodiapzepine users.

• 한국언어정보학회지:언어와정보
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• 제5권1호
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• pp.55-71
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• 2001

One of the controversial issues in English locative inversion (LI) construction( e. g. Under the tree sat a woman) has been the functional status of preverbal PP and postverbal NP, i.e. whether they are a subject, a complement, or filer (topic) Based on the distributional parallelisms between the PP and NP on the one hand and an ordinary subject and filler on the other this paper proposes that the PP has a dual function as a subject and filler, while the NP also has some subject properties that the PP does not have These mixed functional properties are analyzed in the theory of HPSG expecially with the versions recently developed by Sag(1997) Manning and Sag(1999) and Ginzburg and Sag(to appear). This analysis claims that the LI construction needs to satisfy two general, independent constraints head-subject- phrase and head-filler-phrase. This position suggests that the English LI construction is an instance of the peripheral phenomena whose construction specific constraint is inherited from more general core constraints. (Dongseo University)

• Journal of Ginseng Research
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• 제39권1호
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• pp.1-6
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• 2015

Abnormal changes in skin color induce significant cosmetic problems and affect quality of life. There are two groups of abnormal change in skin color; hyperpigmentation and hypopigmentation. Hyperpigmentation, darkening skin color by excessive pigmentation, is a major concern for Asian people with yellowe-brown skin. A variety of hypopigmenting agents have been used, but treating the hyperpigmented condition is still challenging and the results are often discouraging. Panax ginseng has been used traditionally in eastern Asia to treat various diseases, due to its immunomodulatory, neuroprotective, antioxidative, and antitumor activities. Recently, several reports have shown that extract, powder, or some constituents of ginseng could inhibit melanogenesis in vivo or in vitro. The underlying mechanisms of antimelanogenic properties in ginseng or its components include the direct inhibition of key enzymes of melanogenesis, inhibition of transcription factors or signaling pathways involved in melanogenesis, decreasing production of inducers of melanogenesis, and enhancing production of antimelanogenic factor. Although there still remain some controversial issues surrounding the antimelanogenic activity of ginseng, especially in its effect on production of proinflammatory cytokines and nitric oxide, these recent findings suggest that ginseng and its constituents might be potential candidates for novel skin whitening agents.

• 대한안전경영과학회:학술대회논문집
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• 대한안전경영과학회 2008년도 추계학술대회
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• pp.405-419
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• 2008

It is expected that the change of industrial structure of Knowledge based economy, and service based economy would affect on economic life of physically-challenged person with no exceptions. There have been some former studies which have been misunderstood the employment of disabled due to the declining employment of the disabled and prejudice to the disabled based on biased perspective and public opinion. This study have analyzed the employment conditions of the ordinary workers and disabled workers out of those prejudices and biased opinions. Wage, economic activity ratio, age, educational background and industry those 5 parameters are brought for analyzing the two comparison group. Each parameter have compared based on the statistical data of ordinary workers and disabled workers for past 7 years. Weight between each parameter have been drawn by collecting the experts' opinion using AHP(Analytic Hierarchy Process), and utility of employment of two comparison groups have been estimated through progress inclination of each parameter. Through the estimated outcome, present condition and controversial issues and way of improvement of domestic employment of ordinary workers and the disabled is mentioned.

• Clinics in Shoulder and Elbow
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• 제22권2호
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• pp.113-117
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• 2019

Treating distal humerus fractures, especially those involving intra-articular lesions, is complex and often technically demanding. Although there still exist many controversial issues, the goal of treatment is to establish anatomical stable fixation by restoring the two columns and the articular surface. Universally, a posterior midline incision is applied, and the approach varies according to the further management of the triceps or olecranon. Evidence supports dual plate fixation as the optimal fixation method, and debates regarding appropriate plating configuration are still ongoing. As multiple clinical studies comparing results of parallel and perpendicular plate fixation have shown no actual difference, it is important to place the plates according to the fracture configuration.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2021년도 학술발표회
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• pp.135-135
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• 2021

In water resources management, rainfall prediction with high accuracy is still one of controversial issues particularly in countries facing heavy rainfall during wet seasons in the monsoon climate. The aim of this study is to develop an artificial neural network (ANN) for predicting future six months of rainfall data (from April to September 2020) from daily meteorological data (from 1971 to 2019) such as rainfall, temperature, wind speed, and humidity at Seoul, Korea. After normalizing these data, they were trained by using a multilayer perceptron (MLP) as a class of the feedforward ANN with 15,000 neurons. The results show that the proposed method can analyze the relation between meteorological datasets properly and predict rainfall data for future six months in 2020, with an overall accuracy over almost 70% and a root mean square error of 0.0098. This study demonstrates the possibility and potential of MLP's applications to predict future daily rainfall patterns, essential for managing flood risks and protecting water resources.

• 한국과학교육학회지
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• 제33권3호
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• pp.581-596
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• 2013

The aim of this study was to identify students' views on the orientation of science and to investigate the relationship between their views and decision-making on socio-scientific issues (SSI). In this study, 27 university students attending a science course were asked to discuss four controversial issues: the Toyota recall, the green car, the global warming and swine influenza (influenza A (H1N1)). The study was comprised of two stages. At the first stage, we examined students' views on the nature of science and on the orientation of science with the open-ended questionnaire based on VNOS and VOSTS. While they held relatively similar views on the nature of science, their views on the orientation of science were distinct as pragmatic, intrinsic, communal and ethical views. At the second stage, to examine the role of their views on the orientation of science in decision-making, we selected four students who had similar views on NOS but different views on the orientation of science. The four students were selected from each group of views on the orientation of science and their decision-making processes were analyzed following grounded theory. Across SSIs, they relied upon their views on the orientation of science as the strategies for decision, though considered different perception, and causal and contextual conditions. This study indicates that understanding students' views on the orientation of science would be helpful for achieving scientific literacy for informed decision.