• Radiation Oncology Journal
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• v.36 no.3
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• pp.172-181
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• 2018

Successful anticancer strategies require a differential response between tumor and normal tissue (i.e., a therapeutic ratio). In fact, improving the effectiveness of a cancer therapeutic is of no clinical value in the absence of a significant increase in the differential response between tumor and normal tissue. Although radiation dose escalation with the use of intensity modulated radiation therapy has permitted the maximum tolerable dose for most locally advanced cancers, improvements in tumor control without damaging normal adjacent tissues are needed. As a means of increasing the therapeutic ratio, several new approaches are under development. Drugs targeting signal transduction pathways in cancer progression and more recently, immunotherapeutics targeting specific immune cell subsets have entered the clinic with promising early results. Radiobiological research is underway to address pressing questions as to the dose per fraction, irradiated tumor volume and time sequence of the drug administration. To exploit these exciting novel strategies, a better understanding is needed of the cellular and molecular pathways responsible for both cancer and normal tissue and organ response, including the role of radiation-induced accelerated senescence. This review will highlight the current understanding of promising biologically targeted therapies to enhance the radiation therapeutic ratio.

• Journal of Korean Association for Spatial Structures
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• v.23 no.4
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• pp.27-34
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• 2023

In this study, the seismic response characteristics of the three analysis model with or without TMD were investigated to find out the effective dome shape. The three analysis models are rib type, lattice type and geodesic type dome structure composed of space frame. The maximum vertical and horizontal displacements were evaluated at 1/4 point of the span by applying the resonance harmonic load and historical earthquake loads (El Centro, Kobe, Northridge earthquakes). The study of the effective TMD installation position for the dome structure shows that seismic response control was effective when eight TMDs were installed in all types of analysis model. The investigation of the efficiency of TMD according to dome shape presents that lattice dome and geodesic dome show excellent control performance, while rib dome shows different control performance depending on the historical seismic loads. Therefore, lattice and geodesic types are desirable for seismic response reduction using TMD compared to rib type.

• Journal of Korean Association for Spatial Structures
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• v.24 no.1
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• pp.89-98
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• 2024

In this study, we investigated the dynamic characteristics of three irregular building models to analyze the effectiveness of displacement response control with Tuned Mass Damper (TMD) installation in twisted irregular buildings. The three irregular models were developed with a fixed angle of twist per story at one degree, subjected to three historical seismic loads and resonant harmonic loads. By designing TMDs with linear and dashpot attributes, we varied the total mass ratio of the installed TMDs from 0.00625% to 1.0%, encompassing a total of 10 values. Two TMDs were installed at the center of the top story of the analysis model in both X and Y directions to evaluate displacement response control performance based on TMD installation. Our findings suggest that the top displacement response control performance was most effective when a 1.0% TMD was installed at the top layer of the analysis model.

• International Journal of Control, Automation, and Systems
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• v.6 no.1
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• pp.54-61
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• 2008

This paper presents a method for reducing modelling error in the linear motion system with voicecoil actuator (VCA). A model of linear motion system composed of a mechanism and control was prepared to verify the proposed method. In modeling of the system, the damping coefficient obtained experimentally is applied to the model in order to consider the effect of the viscous friction for the moving part in VCA. The response velocity of VCA for duty ratio of PWM signal was analyzed in the time domain. Consequently, the relation between velocity and duty ratio was obtained. The result from the experiment showed an error of 9% when compared with that of simulation. In order to reduce the modeling error, impedance variation according to input frequency was analyzed, and equivalent impedance with multi-frequency was applied to the control part. As a result, the modeling error decreased to 5%.

• Journal of Korean Association for Spatial Structures
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• v.6 no.2 s.20
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• pp.61-68
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• 2006

In this thesis, a full-scale K shape damper test model was constructed in which a passive vibration control system. This passive vibration control system was incorporated with the use of a newly developed turbulent flow damper sealed by viscoelastic material. A series of tests and earthquake observation has been conducted in this test model. The purpose of the present thesis is to investigate the vibration response characteristics of the building and to verify the effectiveness of the vibration control system. By the static loading test, it was recognized that incorporation of the dampers had little influence on static horizontal stiffness of the building. Free vibration tests revealed that the dampers incorporated increased the damping ratio of the building up to 3 times compared with the undamped case. The effectiveness of the developed vibration control system was confirmed based on the excitation tests and earthquake response observation.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2005.05a
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• pp.181-184
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• 2005

In this paper, we have improved a novel fast response time liquid crystal operating mode using tilt angle in the unique condition by hot-plate equipment. The new control of tilt angle for nematic liquid crystal (NLC) with negative and positive dielectric anisotropy on the rubbed homeotropic polyimide (PI) using baking method by Hot-plate equipment was investigated. LC tilt angle decreased with increasing baking temperature and time. Especially, the low LC tilt angle of positive type NLC (${\Delta}n$>0) on the rubbed homeotropic PI surface by increasing temperature and time was measured. The EO characteristics of the high tilted OCB(HTOCB) mode using control of tilt angle on the homeotropic surface than that of conventional OCB cell can be improved. We suggest that the developed the HTOCB cell using control of tilt angle on the homeotropic surface is a promising technique for the achievement of a fast response time and a high contrast ratio.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.25 no.2
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• pp.108-115
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• 2015

Electro-mechanical actuator installed on aircraft consists of a decelerator which magnifies the torque in order to rotate an axis connected with aircraft control surface, a control section which controls the motor assembly through receiving orders from cockpit and a motor assembly which rotates the decelerator. Electro-mechanical actuator controls aircraft altitude, position, landing, takeoff, etc. It is an important part of a aircraft. Aircraft maneuvering causes vibrations to electro-mechanical actuator. Vibrations may result in structural fatigue. For that reason, it is necessary to analyze the system structural safety. In order to analyze the system structural safety. It is needed reasonable finite element model and structural response stress closed to real value. In this paper, analytic model is derived by using the simplified finite element model, and damping ratio which is closely related to response stress is derived by using modal test. So, we developed analytic model in less than 10 % error rate, compared with modal test. Vibration response stress close to real value was estimated from analytic model modified with modal experimental damping ratio. Estimation method for damping ratio with empirical formula was suggested partly. Finally, It was proved that electro-mechanical actuator had reasonable structure margin of safety at environmental random $3{\sigma}$ stress during life cycle.

• Journal of the Korean Society of Industry Convergence
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• v.5 no.1
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• pp.21-26
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• 2002

Response time of actuator in a hydraulic system may be important and necessary to avoid failures and to improve the efficiency of operation. Flow restricting devices can result in a decrease in the peak pressure, but may change the response time. The response time has an important effect on both operator and operator perceived smoothness. The response time should correspond to how fast a system responds to a given disturbance at the system boundary, Occasionally the appropriate response time is not easily determined. This study is on the characteristics of response time in the hydraulic system.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.26 no.11
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• pp.1488-1495
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• 2002

The response time represents how fast a system responds to a given disturbance at the system boundary. Flow restricting devices for controlling transients can result in a decrease in the peakm pressure, but may change response time. Response lag in a hydraulic system leads to inefficient working cycle and operator discomfort. The experiments were conducted in order to get information on the parameters which exert appreciable influence on the response time. The experimental apparatu including a hydraulic actuator, orifice and a hydraulic pump was an idealization of a bucket hydraulic shifting system. Experimental results show that the response time depends on operating pressure and flow rate. The effects of orifice type and size on the response time are quantified.

• Journal of Biosystems Engineering
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• v.23 no.3
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• pp.211-218
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• 1998

A variable flow-controlled boom sprayer was developed and evaluated. Field tests were conducted to evaluate the adoptability of the sprayerr with optimal conditions. Negative response time was obtained from the field test because pump and PTO were interlocked with the speed of sprayer. Another reason for the negative value was due to the definition of the response time. With constant on-time control, the system was unstable at the conditions of small tolerance and long control interval. The performances of the spray system were stable and accurate. The stable and synchronous responses were achieved with a variable on-time control. The flow control system with an optimal condition (1.0 sec of control interval, 2 of damping ratio, 1% of tolerance) provided the proper performance for uniform spraying. A standard operating procedure of the flow compensating boom sprayer for the ground speed variation was presented and recommended.