• Transactions of the Korean Society of Mechanical Engineers
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• v.17 no.5
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• pp.1029-1040
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• 1993

Recently the Time Delay Control (TDC) method has been proposed as a promising technique in the robust control area, where the plants have nonlinear dynamics with parameter variations and substantial disturbances are present. TDC method, however, requires the measurements of all the state variables, together with their derivatives. This requirement imposes a severe limitation on the applications to most real systems. In order to solve this measurement problem, we proposed an observer design method that can stably reconstruct the state variables and their derivatives. the stability of the overall system has been analyzed and proved. Then, for a simulation study, the controller/observer based on our design method has been applied to a nonlinear plant, the result of which confirmed that the controller/observer performs satisfactorily as predicted, Finally we made experimentations on a DC servo motor that is substantial amount of inertia variations and external disturbances. the results showed that the controller/observer performs quite robustly under those variations and disturbances, and is much less sensitive to sensor noise than the controller using numerical differentiations.

• Korean Journal of Veterinary Research
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• v.14 no.2
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• pp.237-241
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• 1974

A number of chemotherapeutic agents, namely antibiotics, sulfonamides and nitrofuran derivatives have been used, as a fred additive, for the purposes of growth improvement of chicken, increase of feed efficiency, decrease of animal mortality, and disease prevention. In these experiments, furamizole which is one of nitrofuran derivatives and feed additive was test, in field, its antibacterial activity against Mycoplasma gallisepticum causing air sac disease, its effect on pullorum disease control, its effect on the lowering the mortality of chicken and finally the increase of feed efficiency. Throughout the studies, furamizole, in concentration of 0.025% in feed fed to baby chicken continuously resulted as following: 1. Tested chicken showed no avian mycoplasma infection compared to 3.7% outbreak in control chicken. 2. Tested chicken showed a low degree of outbreak of pullorum disease. However, its outbreak was much more surpresed compared to that of control chicken. 3. Total mortality rate of 5.5% and 30.8% were obtained in test and control chicken respectively. 4. Feed efficiency were 2.83 and 2.97 in test and control chicken respectively.

• Biomolecules & Therapeutics
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• v.12 no.2
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• pp.74-78
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• 2004

Paecilomyces tenuipes, a caterpillar fungus, contains many health-promoting ingredients. Recent reports indicate that consumption of P. tenuipes helps reducing blood sugar content for diabetes. Mechanism for reduction in the circulatory sugar content, however, still remains least understood. Methanolic extraction of P. tenuipes (MPT) was prepared and acetoxyscirpendiol (ASD) was subsequently purified limn MPT. Glucose transporter-1 (GLUT-1) was expressed in the Xenopus oocytes and the effect of MPT or ASD on the expressed GLUT-1 was analyzed according to the uptake of 2-dideoxy-D-glucose (2-DOG). MPT was shown to inhibit GLUT-1 activity significant1y compared to the non-treated control. In the presence of ASD and its derivatives, GLUT-1 activity was greatly inhibited in a dose-dependent manner. Among ASD and its derivatives, AS-1 showed most significant inhibition. Taken together, these results strongly indicate that ASD in P. tenuipes may serve as a functional substance in lowering blood sugar in the circulatory system. ASD and its derivatives can be utilized as inhibitors of GLUT-1.

• International Journal of Automotive Technology
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• v.7 no.3
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• pp.283-288
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• 2006

A mathematical methodology is proposed for designing nozzle hole shapes producing controlled geometric cavitation. The proposed methodology uses an unstructured RANS flow solver, with the ability to compute sensitivity derivatives via an adjoint algorithm. The adjoint formulation for the N-S equations is presented while variation of the turbulence viscosity is not taken into account during the geometry modifications. The sensitivities are calculated in a mode independently of the shape parameterisation. The method is used to develop and evaluate conceptual shapes for nozzle hole cavitation reduction. The localized region at the hole inlet producing cavitation, is parameterised using its radius of curvature, while a cost function is formulated to eliminate the negative pressures present at this location. Sensitivity derivatives are used to assess the dependence of the localized region on the minimum pressure, and to drive the geometry to the targeted shape. The results show that the computer model can provide nozzle hole entry shapes that produce predefined flow characteristics, and thus can be used as an inverse design tool for nozzle hole cavitation control.

• Journal of Ocean Engineering and Technology
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• v.30 no.4
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• pp.243-252
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• 2016

Conventionally, the static angle of attack and static elevator tests are carried out separately to estimate hydrodynamic stability derivatives of underwater vehicles. However, it is difficult to verify the interaction between the angle of attack and elevator angle in such cases. In this study, we perform a static elevator with angle of attack test where both the angle of attack and elevator angle are varied simultaneously. The experimental results show that the angle of attack has an influence on the elevator control force and that this tendency is dependent on the sense in which the angle of attack and elevator angle are varied. We predict level flight performance using hydrodynamic derivatives estimated through this experiment. The predictions considering the effect of angle of attack show good agreement with trials conducted in the open sea.

• Archives of Pharmacal Research
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• v.27 no.5
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• pp.495-501
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• 2004

A series of N-substituted-1,3-isoindolinedione derivatives (2-16) were synthesized for the purpose of defining the effect of N-substitution on the anticonvulsant activity of these derivatives. The target compounds (2-16) were obtained by condensation of phthalic anhydride with the corresponding amine derivative. The structures of the synthesized derivatives (2-16) were confirmed by means of IR, $^1$H-NMR, $^{13}$ C-NMR, MS and elemental analyses. The anticonvulsant activity of all compounds (2-16) were evaluated by subcutaneous pentylenetetrazole seizure threshold test at doses of 0.2, 0.4 and 0.8 mmol/kg compared with sodium valproate as a positive control. Their neurotoxicity were determined by the rotorod test. Many of the present series of compounds showed good anticonvulsant activity at the tested doses, as compared to sodium valproate. Three of them (4, 6 and 11) exhibited 100 % protection against convulsions, neurotoxicity and death at all tested doses. Out of the series, two compounds (12 and 13) were completely inactive with 100% mortality. 3-(p-chlorophenyl)-4-(1 ,3-dioxo-2,3-dihydro-1 H-2-isoindolyl) butanoic acid derivative (11) has emerged as the most active compound which is 20 times more active than valproate with ED$_{50}$ 8.7, 169 mg/kg; TD$_{50}$ 413, 406 mg/kg and PI 47.5, 2.4. The results revealed the importance of the combination of baclofenic and phthalimide moieties (compound 11) as a promising anticonvulsant candidate.

• Food Science and Biotechnology
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• v.18 no.3
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• pp.755-760
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• 2009

The growth-inhibiting activities of persimmon roots-derived materials against intestinal bacteria were evaluated and compared with that of 1,4-naphthoquinone as a positive control. The active constituent isolated from persimmon roots was characterized as 5-hydroxy-2-methyl-1,4-naphthoquinone using various spectroscopic analyses. Treatment with 1,4-naphthoquinone at a dose of 1.0 mg/disc strongly inhibited the growth of 6 intestinal bacteria. Furthermore, when the structure-activity relationships of 1,4-naphthoquinone's derivatives were evaluated, 5-hydroxy-2-methyl-1,4-naphthoquinone and 2-methyl-1,4-naphthoquinone were found to strongly inhibit the growth of Clostridium difficile, Clostridium perfringens, and Escherichia coli without adversely affecting the growth of Bifidobacterium adolescentis, Bifidobacterium longum, and Lactobacillus acidophilus. Additionally, 2-hydroxy-1,4-naphthoquinone and 5-hydroxy-1,4-naphthoquinone strongly inhibited the growth of C. difficile and C. perfringens, but did not inhibit the growth of E. coli. Taken together, these results indicate that persimmon roots-derived materials and some of 1,4-naphthoquinone's derivatives could be useful preventive agents against diseases caused by harmful intestinal bacteria.

• Journal of Institute of Control, Robotics and Systems
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• v.16 no.12
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• pp.1137-1142
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• 2010

This paper studied the speech parameters less affected by the human emotion for the development of the robust speech recognition system. For this purpose, the effect of emotion on the speech recognition system and robust speech parameters of speech recognition system were studied using speech database containing various emotions. In this study, mel-cepstral coefficient, delta-cepstral coefficient, RASTA mel-cepstral coefficient and frequency warped mel-cepstral coefficient were used as feature parameters. And CMS (Cepstral Mean Subtraction) method were used as a signal bias removal technique. Experimental results showed that the HMM based speaker independent word recognizer using vocal tract length normalized mel-cepstral coefficient, its derivatives and CMS as a signal bias removal showed the best performance of 0.78% word error rate. This corresponds to about a 50% word error reduction as compare to the performance of baseline system using mel-cepstral coefficient, its derivatives and CMS.

• International Journal of Aerospace System Engineering
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• v.5 no.1
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• pp.9-18
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• 2018

The longitudinal flight parameters of a light airplane are estimated from flight test data by use of the output error method. The reliability of the flight test measurement is examined in engineering judgment, scatter and Cramer-Rao bound, which turns out to be satisfactory with minor defects. Estimated parameter values are validated by comparing the simulated responses with the ones from actual flight tests. The FTD(Flight Training Device) of a light airplane turns out to satisfy the qualification of FAA Level 5 FTD in longitudinal motion. All the necessary practices for generation of high-fidelity data in longitudinal motion of a light aircraft are successfully performed in this study.

• Journal of Institute of Control, Robotics and Systems
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• v.3 no.6
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• pp.619-625
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• 1997

In this paper, we show that the rotor position of the bifilar-wound hybrid stepping motors for the closed-loop drives is detected by the phase current measurement. We propose an instantaneous phase current equation, which is the function of electrical angle, by modeling the stepping motor including motor driving circuits. We also analyze the relationship between phase current and rotor position from the computer simulation results. We show that the information about the rotor position is obtained from the phase current amplitude and its derivatives at the instance of ${\pi}/2$ electrical angle of excitation voltage.