• 한국지진공학회논문집
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• 제15권3호
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• pp.1-9
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• 2011

자기부상열차가 중 저속 및 초고속 주행 시 차량의 주행특성 및 교량의 동적 응답 결과를 제시하고자 한다. 수직 자유도 및 회전 자유도를 포함한 10자유도 자기부상열차에 대한 운동방정식을 유도하고, 모드 중첩법을 이용하여 교량의 운동방정식을 구성하였다. 또한 제어 방법으로 UTM01제어기법을 적용하여 수치해석을 수행하였다. 해석 예제로 노면조도, 가이드웨이의 처짐비, 차량 속도 등이 교량의 처짐과 차량의 부상공극 및 여러 가지 변수에 미치는 영향을 파악하였다. 부상공극은 조도의 조건에 따라 그 차이가 확연히 드러나고 또한 자기부상열차의 속도가 증가함에 따라 부상공극이 증가함을 알 수 있었다. 그리고 자기부상열차가 중, 저속 주행 시에는 교량에 대한 영향이 미비하지만 초고속 주행 시 교량에 대한 동적확대계수가 큰 값을 보여주었다.

• 대한화장품학회지
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• 제25권2호
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• pp.59-75
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• 1999

Skin is continuously exposed to external stimuli including ultraviolet radiation, which is a major cause of skin photoaging. According to recent discoveries, UVA with a lower energy but deep-penetrating properties, compared to UVB, is likely to play a major part in causing skin photoaging. The clinical and histochemical changes of photoaging are well characterized, but the biochemical mechanisms are poorly understood partly due to the lack of suitable experimental systems. In this work, three-dimensional, reconstituted skin culture models were prepared. After certain period of maturation, the equivalent models were shown to be similar in structure and biochemical characteristics to normal skin. Mature dermal and skin equivalent models were exposed to sub-lethal doses of UVA, and the effects of UVA relevant to dermal photoaging were monitored, including the production of elastin, collagen, collagenase(MMP-1), and tissue inhibitor of metalloproteinases-1 (TIMP-1). Interestingly, dermal and skin equivalents reacted differently to acute and chronic exposure to UVA. Elastin production was increased as soon as one week after commencing UVA irradiation by chronic exposure, although a single exposure failed to do so. This early response could be an important advantage of equivalent models in studying elastosis in photoaged skin. Collagenase activity was increased by acute UVA irradiation, but returned to control levels after repeated exposure. On the other hand, collagen biosynthesis, which was increased by a single exposure, decreased slightly during 5 weeks of prolonged UVA exposure. Collagenase has been thought to be responsible for collagen degeneration in dermal photoaging. However, according to the results obtained in this study, elevated collagenase activity is not likely to be responsible for the degeneration of collagen in dermal photoagig, while reduced production of collagen may be the main reason. It can be concluded that reconstituted skin culture models can serve as useful experimental tools for the study of skin photoaging. These culture models are relatively simple to construct, easy to handle, and are reproducible Moreover the changes of dermal photoaging can be observed within 1-4 weeks of exposure to ultraviolet light compared to 4 months to 2 years for human or animal studies. These models will be useful for biochemical and mechanistic studies in a large number of fields including dermatology, toxicology, and pharmacology.

• 한국농공학회지
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• 제26권2호
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• pp.106-124
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• 1984

Monthly streanflow of watersheds is one of the most important elements for the planning, design, and management of water resources development projects, e.g., determination of storage requirement of reservoirs and control of release-water in lowflow rivers. Modeling of longterm runoff is theoretically based on water-balance analysis for a certain time interval. The effect of the casual factors of rainfall, evaporation, and soil-moisture storage on streamflow might be explained by multiple regression analysis. Using the basic concepts of water-balance and regression analysis, it was possible to develop a generalized model called the Regionalized Regression Model for Monthly Streamflow in Korean Watersheds. Based on model verification, it is felt that the model can be reliably applied to any proposed station in Korean watersheds to estimate monthly streamflow for the planning, design, and management of water resources development projects, especially those involving irrigation. Modeling processes and properties are summarized as follows; 1. From a simplified equation of water-balance on a watershed a regression model for monthly streamflow using the variables of rainfall, pan evaporation, and previous-month streamflow was formulated. 2. The hydrologic response of a watershed was represented lumpedly, qualitatively, and deductively using the regression coefficients of the water-balance regression model. 3. Regionalization was carried out to classify 33 watersheds on the basis of similarity through cluster analysis and resulted in 4 regional groups. 4. Prediction equations for the regional coefficients were derived from the stepwise regression analysis of watershed characteristics. It was also possible to explain geographic influences on streamflow through those prediction equations. 5. A model requiring the simple input of the data for rainfall, pan evaporation, and geographic factors was developed to estimate monthly streamflow at ungaged stations. The results of evaluating the performance of the model generally satisfactory.

• 산업식품공학
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• 제21권3호
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• pp.233-241
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• 2017

Scaffolds of cell substrates are biophysical platforms for cell attachment, proliferation, and differentiation. They ultimately play a leading-edge role in the regeneration of tissues. Recent studies have shown the potential of bioactive scaffolds (i.e., osteo-inductive) through 3D printing. In this study, rice bran-derived biocomposite was fabricated for fused deposition modeling (FDM)-based 3D printing as a potential bone-graft analogue. Rice bran by-product was blended with poly caprolactone (PCL), a synthetic commercial biodegradable polymer. An extruder with extrusion process molding was adopted to manufacture the newly blended "green material." Processing conditions affected the performance of these blends. Bio-filament composite was characterized using field emission scanning electron microscopy (FE-SEM) and energy dispersive X-ray spectroscopy (EDX). Mechanical characterization of bio-filament composite was carried out to determine stress-strain and compressive strength. Biological behaviors of bio-filament composites were also investigated by assessing cell cytotoxicity and water contact angle. EDX results of bio-filament composites indicated the presence of organic compounds. These bio-filament composites were found to have higher tensile strength than conventional PCL filament. They exhibited positive response in cytotoxicity. Biological analysis revealed better compatibility of r-PCL with rice bran. Such rice bran blended bio-filament composite was found to have higher elongation and strength compared to control PCL.

• Journal of Yeungnam Medical Science
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• 제20권2호
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• pp.187-196
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• 2003

The cytokines are the hormone-like proteins, which are produced in the mononuclear cells. They have many roles, such as immune mediators, cell differentiations, angiogenesis. The chemokines have chemotactic effects which control the host immune response. There were few reports about the cytokines associated with musculoskeletal tumors. From late 1980s, the cytokine studies of bone tumors such as osteosarcoma were started, but most studies for benign and malignant musculoskeletal tumors were left to be explored. To evaluate the characteristics of the cytokines in variable musculoskeletal tumors, tissues were obtained from the seven patients who visited the Yeungnam University hospital from February to July 2000. They were lipoma (1 case), parosteal osteoma (1 case), enchondroma (2 cases), pigmented villonodular synovitis (1 case), ganglion (1 case), and metastaic squamous cell carcinoma (1 case). The gene experession of the cytokines were analyzed by RNase protection assay (RPA) and reverse transcription-polymerase chain reaction (RT-PCR). The lipoma and parosteal osteoma expressed MIP-$1{\beta}$, and IP-10 genes. The two enchondromas showed different results, one expressed all of MIP-$1{\alpha}$, MIP-$1{\beta}$ and IP-10 genes but the other expressed none of above. The pigmented villonodular synovitis strongly expressed MIP-$1{\alpha}$ and IP-10 when compared with the other cases. The ganglion did not express all of the chemokines mentioned above. And the metastatic squamous cell carcinoma expressed all of the chemokines and especially IP-10 was highly expressed. Even though this study has only a few cases, these results provide a basis for the cytokine mediating network study in musculoskeletal tumors.

• 대한치과보철학회지
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• 제44권5호
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• pp.549-560
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• 2006

Purpose : This experiment examined the effects of anodization on commercially pure titanium implant fixtures. Material & methods : The implant fixtures were anodized at three different voltage levels, producing three different levels of oxidation on the surface of the fixure. Implant were divided into four groups according to the level of oxidation. Group 1 consist of the control group of machined surface implants, Group 2 implants were treated by anodizing to 100 voltage, Group 3 implants were treated by anodizing oxidation to 200 voltage Group 4 implants were treated by anodizing oxidation to 350 voltage. Surface morphology was observed by Scanning Electron Microscope(SEM) and the surface roughness was measured using NanoScan $E-1000^{\circledR}$. Implantation of the fixtures were performed using New Zealand white rabbits. $Periotest^{\circledR}$ value(PTV) resonance frequency analysis(RFA), and removal torque were measured in 0, 2, 4, 8, 12 weeks after implantation. Results : The results of the study were as follows: 1. Values for the measured surface roughness indicate statistically significant differences in Ra, Rq, and Rt values among group 1, 2, 3, and 4 at the top portion of the thread,(p<0.05) while values at the base of the threads indicated no significant difference in these values. 2. A direct correlation between the firming voltage, and surface roughness and irregularities were observed using scanning electron microscope. 3. No statistically significant differences were found between test groups regarding $Periotest^{\circledR}$ values. 4. Analysis of the data produced by RFA, significant differences were found between group 1 and group 4 at 12 weeks after implantation.(p<0.05) Conclusions : In conclusion, no significant differences could be found among test groups up to a certain level of forming voltage threshold, beyond this firming voltage threshold, statistically significant differences occurred as the surface area of the oxide layer increased with the increase in surface porosity, resulting in enhanced bone response and osseointegration.

• Asian-Australasian Journal of Animal Sciences
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• 제13권12호
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• pp.1726-1730
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• 2000

High fibre (CF, 242 g/kg) sunflower seed meal (SSM) was incorporated in standard grower and layer quail diets at 0, 50, 75 or 100 g/kg replacing part of the soybean meal (SBM) and deoiled rice bran (DORB). Each grower diet was offered to 30 quails housed in battery cages from day one to 5 weeks of age. At the end of the growing period, Twelve female quails from each of the four respective dietary groups were transferred to the individual laying cages and their laying performance from 7 to 20 weeks of age were evaluated on diets containing SSM at similar levels as that during the growing period. The results of growth bioassay revealed that the live weight gain, feed intake, nutrient retention and carcass characteristics of quails in different dietary groups did not vary significantly (p>0.05), although the quails fed SSM based diets utilized the feed less (p<0.05) efficiently than those fed the control diet. During the laying period, the egg production and egg quality traits remained unaffected due to dietary treatments but feed required per unit egg production increased (p<0.05) as the level of SSM in diet was increased to 100 g/kg. Although, the cost of feed per kg decreased due to the incorporation of SSM in diet but the same was not reflected in feed cost per unit gain, meat or egg production as such parameters were comparable on all the diets. It could thus be concluded that the SSM can be incorporated in quail diets upto 100 g/kg for part of SBM, an item usually expensive and also in short supply in developing countries including India.

• 한국물환경학회지
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• 제40권2호
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• pp.89-100
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• 2024

Climate change has a broad impact on the entire water environment, and this impact is growing. Climate adaptation in water supply systems often involves quantity and quality control, but there has been a lack of research examining the impacts of climatic factors on water supply productivity and operation conditions. Therefore, the present study focused on, first, building a database of climatic factors and water purification operating conditions, and then identifying the correlations between factors to reveal their impacts. News big data was analyzed with keywords of climatic factors and water supply systems in either nationwide or region-wide analyses. Metropolitan area exhibited more issues with cold waves whereas there were more issues with drought in the Southern Chungcheong area. A survey was conducted to seek experts' opinions on the climatic impacts leading to these effects. Pre-chlorination due to drought, high-turbidity of intake water due to rainfall, an increase of toxins in intake water due to heat waves, and low water temperature due to cold waves were expected. Pearson correlation analysis was conducted based on meteorological data and the operating data of a water purification plant. Heavy rain resulted in 13 days of high turbidity, and the subsequent low turbidity conditions required 3 days of high coagulant dosage. This insight is expected to help inform the design of operation manuals for waterworks in response to climate change.

• Biotechnology and Bioprocess Engineering:BBE
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• 제6권4호
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• pp.205-212
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• 2001

One of the important characteristics of biological systems os their ability to change im-portant properties in response to small environmental signals. The molecular mechanisms that biological molecules utilize to sense and respond provide interesting models for the development of "smart" polymeric biomaterials with biomimetic properties. An important example of this is the protein coat of viruses, which contains peptide units that facilitate the trafficking of the virus into the cell via endocytosis, then out of the endosome into the cytoplasm, and from there into the nucleus, We have designed a family of synthetic polymers whose compositions have been de-signed to mimic specific peptides on viral coats that facilitate endosomal escape. Our biomimetic polymers are responsive to the lowered pH whinin endosomes, leading to distruption of the en-dosomal membrane and release of important biomolecular druges such as DNA, RNA, peptides and proteins to the cytoplasm before they are trafficked to lysosomes and degraded by lysosomal en-zymes. In this article, we review our work on the design, synthesis and action of such smart, pH-sensitive polymers.

• 조명전기설비학회논문지
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• 제23권4호
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• pp.29-38
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• 2009

GHP(Gas Heating Pump) 시스템은 가스 엔진으로 구동되는 압축기로 구성되는 효율적인 냉/난방기이고, 학교나 사무용 빌딩에 널리 쓰이고 있다. GHP는 느린 응답, 큰 시정수와 시간에 따라 변하는 시스템으로 제어하기가 어렵다. 이들 비선형 부하는 고조파 전류를 발생시키고, 전력계통의 정현파 전압을 왜곡시킨다. 고조파 측정 결과로 고조파는 시간에 따라 변하는 특성이 관측되었다. 시간에 따라 변하는 고조파를 해결하기 위해서 쓰이는 가장 보편적인 방법은 누적확률을 사용하는 것이다. 본 논문에서는 GHP부하의 고조파 특성, IEC 61000-3-2에 의한 고조파 평가와 사례연구 시스템의 고조파 시뮬레이션 및 고조파 필터 적용을 심도있게 다루고자 하였다.