• International Journal of Computer Science & Network Security
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• 제22권8호
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• pp.357-361
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• 2022

The paper demonstrates how the Islamic governments in the Islamic history derived the authority for regulations and laws from the Qur'ān and the Sunna (sayings of the Prophet). These two laws are sovereign over public policy. Then, it shows the obstacles that prevented modern Muslim countries from formulating public policy based on Sharia law.

• 보건행정학회지
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• 제25권2호
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• pp.140-148
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• 2015

Vaccination is the most powerful and useful preparation against infectious diseases. However, developing vaccines costs a lot and requires extensive long-term efforts. Therefore, the government should research and develop vaccines with a national-level policy. To greatly enhance the success rate of vaccine development, the policy should be set up considering priorities such as the current status of domestic research, the importance for public health, the urgency of research. The Delphi technique was utilized to draft this survey, through a brainstorming stage, then two inquiries, and finally the final panel meeting where unresolved items were discussed, to draw the conclusion. Among the results, firstly, the highest ranked item on centralized fields for vaccine development by the Ministry of Health was 'self-sufficiency of vaccines.' Secondly, 'emerging infectious disease' was most highly ranked in prioritized fields of vaccine development and research. Thirdly, for the vaccine that needs to be improved and developed further by the government to improve its efficacy and safety, BCG (Bacille de Calmette) for tuberculosis was ranked the highest on both types (intradermal and subcutaneous injection) from National Immunization Programme (NIP) and non-NIP. As for the high risk pathogens, 'anthrax' and 'smallpox' were first and second, consecutively. Lastly, 'development and control of vaccine candidates' was ranked the highest for the area in need for technique development in order to improve domestic vaccine's research level. The results of this study will be put to good use as basic data for the national vaccine research and development (R&D) policy of the country. This study was first step and more studies should be carried out for the final decision of the national vaccine R&D priority.

• 한국응급구조학회지
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• 제6권1호
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• pp.185-197
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• 2002

Today, the basic problem of functional safe management of Korean Disaster Control system was separately administrated 33 acts that are relating to safe management in 13 ministries. Because of the facts that the fire service is not provided practically, the control system and risk management for safe administration are not operated, the information can not be shared with each other, and the various laws have the lacks of linkage, the National Safe System was appeared unsteady. The roles and functions of fire service have started with restriction to operate structurally and institutionally, which operational structure of fire service is becoming weak. As a result, the federal and local fire organizations have not reached yet to the institutionalization and the local fire service agencies have bias with the task regarding the fire service because of the relation between organizational structure and the local fire agency. With the enforcement of the federal and local fire system, professionality and autonomy for making policy, and dealing with changes of fire service positively, the national fire service on the policy performance can be established. Promotion of research and development and education training to strengthen innovation in technology and competition in fire industry will contribute to the firmly establishment of control system to prevent from fire, flood, terror and national disaster. This article proposed that (a) the established law and administration, agency are required efforts to effectively operate fire service system; (b) the national fire service agency, national college of fire, national institute of science fire, and national fire service hospital should be early established to make firmly policy to operate effectively and practically. These kinds of innovational acts are known the best ways of operating solid policy of national fire service system.

• 대한환경공학회지
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• 제37권5호
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• pp.312-323
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• 2015

본 논문은 국내 외 사용후핵연료 및 방사성폐기물 관리 현안 분석을 바탕으로 향후 나아갈 방향을 제시한다. 원자력 발전을 앞서 이용해 온 미국 사례를 중심으로 다양한 국가들의 처분장 확보 및 실패 사례와 최근의 관리 정책 기조를 정리하였다. 아울러, 원전 해체에 따른 고선량 방사성폐기물, 핵안보 사안 그리고 핵연료 전주기 관점에서 평가한 경제성 기반 정책 수립의 필요성을 논하였다. 사용후핵연료 및 방사성폐기물 관리의 핵심 사안을 세부적으로 중간저장, 영구처분 그리고 재처리로 분류하고 기술 검토와 인허가 체제 구축 및 연구 추진 방향성에 대한 정책 제언을 담았다.

• 한국컴퓨터정보학회논문지
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• 제12권5호
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• pp.273-284
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• 2007

본 논문은 재구성가능생산시스템 환경에서 e-MarketPlace를 통한 거래상황을 도입한 주기적 검토 재고모형을 연구한다. 의사결정권자는 고객의 확률적 수요를 만족시키기 위해서 생산용량/생산량을 확장/축소하거나 e-Marketplace를 통해 긴급으로 재고를 보충/처리한다. e-MarketPlace로부터의 거래 시 재고의 보충/처리에 걸리는 리드타임은 시스템의 생산리드타임보다 짧지만, 단위거래비용(구매/판매비용)은 생산용량/생산량을 한 단위 확장/축소하는 비용보다 높기 때문에 각 대안들의 비용-리드타임간의 trade-off가 고려된다. 추가적으로 e-MarketPlace로부터 재고를 보충하거나 생산용량을 확장하는 경우 그 수량에 따른 규모의 경제를 고려하기 위해 고정 비용이 포함된다. 우리는 제안되는 모형의 최적 정책형태를 규정하기 위해 동적계획모형과 K-convexity 기법을 적용하고, base stock policy와 (s,S) type policy의 조합으로 구성된 최적 생산-재고관리 정책을 제시한다.

• Journal of Korean Neurosurgical Society
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• 제63권5호
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• pp.566-578
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• 2020

Objective : Radiation is known to induce autophagy in malignant glioma cells whether it is cytocidal or cytoprotective. Dexamethasone is frequently used to reduce tumor-associated brain edema, especially during radiation therapy. The purpose of the study was to determine whether and how dexamethasone affects autophagy in irradiated malignant glioma cells and to identify possible intervening molecular pathways. Methods : We prepared p53 mutant U373 and LN229 glioma cell lines, which varied by phosphatase and tensin homolog (PTEN) mutational status and were used to make U373 stable transfected cells expressing GFP-LC3 protein. After performing cell survival assay after irradiation, the IC₅₀ radiation dose was determined. Dexamethasone dose (10 μM) was determined from the literature and added to the glioma cells 24 hours before the irradiation. The effect of adding dexamethasone was evaluated by cell survival assay or clonogenic assay and cell cycle analysis. Measurement of autophagy was visualized by western blot of LC3-I/LC3-II and quantified by the GFP-LC3 punctuated pattern under fluorescence microscopy and acridine orange staining for acidic vesicle organelles by flow cytometry. Results : Dexamethasone increased cell survival in both U373 and LN229 cells after irradiation. It interfered with autophagy after irradiation differently depending on the PTEN mutational status : the autophagy decreased in U373 (PTEN-mutated) cells but increased in LN229 (PTEN wild-type) cells. Inhibition of protein kinase B (AKT) phosphorylation after irradiation by LY294002 reversed the dexamethasone-induced decrease of autophagy and cell death in U373 cells but provoked no effect on both autophagy and cell survival in LN229 cells. After ATG5 knockdown, radiation-induced autophagy decreased and the effect of dexamethasone also diminished in both cell lines. The diminished autophagy resulted in a partial reversal of dexamethasone protection from cell death after irradiation in U373 cells; however, no significant change was observed in surviving fraction LN229 cells. Conclusion : Dexamethasone increased cell survival in p53 mutated malignant glioma cells and increased autophagy in PTEN-mutant malignant glioma cell but not in PTEN-wildtype cell. The difference of autophagy response could be mediated though the phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin signaling pathway.

• Yonsei Medical Journal
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• 제59권9호
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• pp.1026-1033
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• 2018

Purpose: Consistent evidence indicates that cervical and breast cancer screening rates are low among socioeconomically deprived women. This study aimed to assess trends in cervical and breast cancer screening rates and to analyze socioeconomic inequalities among Korean women from 2005 to 2015. Materials and Methods: Data from the Korean National Cancer Screening Survey, an annual nationwide cross-sectional survey, were utilized. A total of 19910 women were finally included for analysis. Inequalities in education and household income status were estimated by slope index of inequality (SII) and relative index of inequality (RII), along with calculation of annual percent changes (APCs), to show trends in cancer screening rates. Results: Cervical and breast cancer screening rates increased from 54.8% in 2005 to 65.6% in 2015 and from 37.6% in 2005 to 61.2% in 2015, respectively. APCs in breast cancer screening rates were significant among women with higher levels of household income and education status. Inequalities by household income in cervical cancer screening uptake were observed with a pooled SII estimate of 10.6% (95% CI: 8.1 to 13.2) and RII of 1.4 (95% CI: 1.3 to 1.6). Income inequalities in breast cancer screening were shown to gradually increase over time with a pooled SII of 5.9% (95% CI: 2.9 to 9.0) and RII of 1.2 (95% CI: 0.9 to 1.3). Educational inequalities appeared to diminish over the study period for both cervical and breast cancer screening. Conclusion: Our study identified significant inequalities among socioeconomically deprived women in cervical and breast cancer screening in Korea. Especially, income-related inequalities were greater than education-related inequalities, and these were constant from 2005 to 2015 for both cervical and breast cancer screening.

• 한국정보과학회논문지:정보통신
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• 제34권5호
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• pp.405-422
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• 2007

최근 네트워크의 발전에 따라 홈 네트워크에도 많은 연구가 진행되고 있다. 현재 홈 네트워크에서는 각 디바이스별로 ACL을 이용하여 접근 제어 정책을 관리하는 방법이 가장 많이 사용되고 있고, EAM(Extranet access management)이 솔루션 형태로 응용되고 있으며, 보안 운영체제에 대한 연구가 공개 운영체제를 바탕으로 진행되고 있다. 또한 흠 서버 중심의 흠 네트워크 사용자 인증 메커니즘 등도 연구되고 있다. 그러나 이러한 연구들은 다음과 같은 문제점이 있다. 첫째, 홈 네트워크에서 사용될 것으로 예상되는 접속기술의 전송범위가 넓어 인증되지 않은 외부 단말기의 접속이 가능하고, 둘째, 사용자가 별도의 필요 정보를 일일이 디바이스에 설정할 필요가 있어 불편하다. 셋째, 사용자 프라이버시나 편의성을 고려하고 있지 않다. 이질적인 다양한 기술들이 존재하는 홈 네트워크 환경에서 OSGi는 상호운용성을 보장하는 서비스 플랫폼을 제공한다. 여기에서 사용자 접근제어는 위와 같은 문제점이 있어서는 안되는 홈 네트워크 보안의 핵심 분야 중에 하나지만 아직 구체적인 연구가 진행되고 있지 않다. 따라서 본 논문에서는 OSGi 서비스 플랫폼이 운영되는 홈 네트워크 환경에서 사용자 접근제어를 위한 RBAC 기반의 권한부여 정책 관리 프레임워크와 접근제어 운영방법을 제안한다. 제시된 접근제어 프레임워크는 OSGi 표준에서 명확하게 언급되지 않았던 부분들을 고려사항으로 나열하고, 이 문제들을 해결하는 방법들을 프레임워크로 제안한다. 제안하는 프레임워크에서는 홈 게이트웨이의 제한된 자원에 대해 RBAC의 개념을 이용하여 사용자 접근제어에 대한 정책변경의 횟수를 줄이는 효율적이고 경제적인 운영 방법을 제시한다. 또한 본 논문에서 제안하는 정책은 사용자역할정책과 권한할당정책을 개별적으로 정의한 후 사용자 정보를 댁내에서 결정함으로써, 사용자 편의성을 높여주고 프라이버시 문제를 해결하도록 방안을 제시한다.

• 인터넷정보학회논문지
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• 제10권4호
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• pp.177-187
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• 2009

기존의 RFID 장치 관련 응용들은 사용자가 RFID 태그 또는 리더를 제어 관리할 수 있도록 지원하는 인터페이스를 특정 장치 벤더에 종속적인 형태로 제공하고 있다. 또한 기존의 RFID 비즈니스 응용들은 RFID 리더 또는 미들웨어 시스템들이 제공하는 고유의 태그 이벤트 데이터 포맷에 의존적으로 구현되고 있다. 따라서 RFID 인프라 관리자들은 관리 대상 태그, 장치 및 시스템들에 대한 개별적인 제어 관리 규격을 반드시 이해하고 있어야 하는 어려움을 가진다. 이와 더불어 현재 대부분의 RFID 응용서비스들은 태그 아이템의 실시간 정보 가시화 및 비즈니스 스텝 추적과 같은 단순 정보 제공에 국한된 한계를 가지고 있다. 이와 같은 문제들을 해결하기 위하여, 본 논문에서는 벤더마다 상이한 인터페이스 규격을 가지는 이기종 RFID 장치, 미들웨어 및 다양한 유형의 응용들에 대한 통합적인 제어 관리 방법을 기술할 수 있는 RFID 서비스 관리 정책 모델을 제안한다. 또한, 본 논문에서는 제안 모델을 기반으로 정의된 RFID 서비스 관리 정책이 특정 RFID 하부 인프라에 적응적으로 변환 및 처리되는 과정을 예제 시나리오를 통해 설명한다.

• Parasites, Hosts and Diseases
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• 제59권5호
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• pp.447-455
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• 2021

Vivax malaria incidence in Korea is now decreased and showing a low plateau. Nowadays, vivax malaria in Korea is expected to be successfully eliminated with anti-malaria chemotherapy, primaquine, and vector control. The glucose-6-phosphate dehydrogenase (G6PD) deficiency is associated with potential hemolytic anemia after primaquine administration. This inborn disorder has a pivotal polymorphism with genetic variants and is the most prevalent X-chromosome-linked disorder. The prevalence of G6PD deficiency was previously reported negligible in Korea. As the population of multicultural families pertaining marriage immigrants and their adolescents increases, it is necessary to check G6PD deficiency for them prior to primaquine treatment for vivax malaria. The prevalence of G6PD variants and G6PD deficiency in multicultural families was performed in 7 counties and 2 cities of Jeollanam-do (Province), Gyeonggi-do, and Gangwon-do. A total of 733 blood samples of multicultural family participants were subjected to test the phenotypic and genetic G6PD deficiency status using G6PD enzyme activity quantitation kit and PCR-based G6PD genotyping kit. The G6PD phenotypic deficiency was observed in 7.8% of male adolescent participants and 3.2% of materfamilias population. Based on the PCR-based genotyping, we observed total 35 participants carrying the mutated alleles. It is proposed that primaquine prescription should seriously be considered prior to malaria treatment.