• Journal of the HCI Society of Korea
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• v.12 no.4
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• pp.45-55
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• 2017

In recent years, some service providers have introduced chatbot agents to provide engagement in the healthcare field. However, current research on chatbot agents is still limited to designing various chatbot identities for healthcare services. By contrast, this study aims to investigate how various agent identities affect users' perceptions and behaviors differently. We developed three chatbot agents with different identities: a doctor (an individual), a hospital (an institution), and a virtual agent (a machine). Then, we recruited 36 users and divided them into three groups, each using a different chatbot agent. They were asked to track their behaviors and review advice from the chatbot agent for six days. Post-hoc surveys and interviews were conducted in order to investigate users' perceptions. The findings are as follows: participants felt more trusting and intimate with the doctor and hospital agents than with the virtual agent. Many of the participants preferred the hospital agent due to its higher reliability. However, all three agents did not lead the participants to change their behaviors. This study contributes to providing practical guidelines for designing chatbots in the healthcare field by studying users' perceptions and behaviors depending on chatbot identities.

• Tuberculosis and Respiratory Diseases
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• v.79 no.4
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• pp.241-247
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• 2016

Bronchodilators are the cornerstone of symptomatic chronic obstructive pulmonary disease (COPD) treatment. They are routinely recommended for symptom reduction, with a preference of long-acting over short-acting drugs. Bronchodilators are classified into two classes based on distinct modes of action, i.e., long-acting antimuscarinics (LAMA, once-daily and twice-daily), and long-acting ${\beta}2$-agonists (LABA, once-daily and twice-daily). In contrast to asthma management, evidence supports the efficacy of both classes of long-acting bronchodilators as monotherapy in preventing COPD exacerbations, with greater efficacy of LAMA drugs versus LABAs. Several novel LAMA/LABA fixed dose combination inhalers are currently approved for COPD maintenance treatment. These agents show superior symptom control to monotherapies, and some of these combinations have also demonstrated superior efficacy in exacerbation prevention versus monotherapies, or combinations of inhaled corticosteroids plus LABA. This review summarizes the current data on clinical effectiveness of bronchodilators alone or in combination to prevent exacerbations of COPD.

• Toxicological Research
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• v.34 no.4
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• pp.297-302
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• 2018

Cells are constantly exposed to endogenous and exogenous chemical and physical agents that damage their genome by forming DNA lesions. These lesions interfere with the normal functions of DNA such as transcription and replication, and need to be either repaired or tolerated. DNA lesions are accurately removed via various repair pathways. In contrast, tolerance mechanisms do not remove lesions but only allow replication to proceed despite the presence of unrepaired lesions. Cells possess two major tolerance strategies, namely translesion synthesis (TLS), which is an error-prone strategy and an accurate strategy based on homologous recombination (homology-dependent gap repair [HDGR]). Thus, the mutation frequency reflects the relative extent to which the two tolerance pathways operate in vivo. In the present paper, we review the present understanding of the mechanisms of TLS and HDGR and propose a novel and comprehensive view of the way both strategies interact and are regulated in vivo.

• Journal of Sericultural and Entomological Science
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• v.43 no.1
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• pp.26-28
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• 2001

The cytotoxicity of the ethanol extracts of varietal samples of mulberry leaves and branches and silkworm feces was measured using CT-26 cells originated from murine metastatic colon cancer, using dye uptake assay in order to find potential anticancer agents. Two ethanol extracts (varietal mulberry leaves and mulberry branches) were prepared from 16 varietal mulberries and used as partial extract materials for the activity assay. Among these, the ethanol extracts from Shinkwangppong leaves showed a little anticancer activity, and those from Sugaeppong, Cheongunppong and Gumsulppong branches showed some anticancer activity as well as cytotoxicity. In contrast, ethanol extracts from freeze-dried, the 3rd day of 5th instar feces showed more potent anticancer activity than that of other mulberry leaves, mulberry branches and other 5th silkworm instar larva feces on the basis of high UV absorbance at 665 nm.

• 대한핵의학회:학술대회논문집
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• 2005.11a
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• pp.326.2-326.2
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• 2005

• Journal of the Korean Graphic Arts Communication Society
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• v.16 no.1
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• pp.25-38
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• 1998

The developing agent is the materials which first acts on silver grain and make it into metallic silver by reducing reaction. There are several types in developing agent, and according to Lumiere-Andresen principle, substitution product which has amino or hydroxyl group in benzen nucleus has a developing power, but all reduing substances are not in used. In the developing effect, not only the role of developing agent but also that of assistant materials are important. But in this work, we have studied effect, change by lith developing agent which require high contrast image. We made an developing experiment after having manufactured developing solution used hydroquinone and another developing agents like chlorohydroquinone, pyrocatechol and pyrogallol as developing agent. And we added that did in addition of diethanolamine and ascorbic acid, and then we examined the possibility of use.

• Journal of fish pathology
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• v.7 no.1
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• pp.7-11
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• 1994

The viral hemorrhagic septicemia of rainbow trout, Salmo gairdneri was studied. The hematocrit values of diseased fish were very low than those of normal fish. And, the GOT and GPT values of serum of diseased fish were a little high than those of normal fish. Cytopathic effect of viral agents(serum and organs of diseased fish) was observed with inverted phase contrast microscopy. After 24hrs infection, the cells were showed the cytopathic effect.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2002.10a
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• pp.636-640
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• 2002

In contrast to conventional CNC, PC-NC opens a new era for machine tools to be more intelligent. For instance, machine tool with PC-NC can be a machine agent system with capability of reacting autonomously to changing operating conditions. This paper introduces a concept of intelligent machine agent system, composed of machine agent and cell manager. Machine agent performs the functions such as process monitoring, diagnosis, maintenance management, condition assessment and schedule negotiation, while cell manager coordinates the negotiation process among multiple machine agents.

• Journal of the Optical Society of Korea
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• v.18 no.2
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• pp.151-155
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• 2014

Although various ophthalmic imaging methods, including fundus photography and optical coherence tomography, have been applied for effective diagnosis of ocular diseases with high spatial resolution, most of them are limited by shallow imaging penetration depth and a narrow field of view. Also, many of those imaging modalities are optimized to provide microscopic anatomical information, while functional or cellular information is lacking. Compared to other ocular imaging modalities, photoacoustic imaging can achieve relatively deep penetration depth and provide more detailed functional and cellular data based on photoacoustic signal generation from endogenous contrast agents such as hemoglobin and melanin. In this paper, array-based ultrasound and photoacoustic imaging was demonstrated to visualize pigmentation in the eye as well as overall ocular structure. Fresh porcine eyes were visualized using a real-time ultrasound micro-imaging system and an imaging probe supporting laser pulse delivery. In addition, limited photoacoustic imaging field of view was improved by an imaging probe tilting method, enabling visualization of most regions of the retina covered in the ultrasound imaging.

• YAKHAK HOEJI
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• v.30 no.2
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• pp.79-86
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• 1986

In order to study 2-formylpyridine dithiocarbohydrazones (DTCH's) and their Cu(II) chelates as potential effective antimicrobial agents, twelve new compounds of six DTCH's and their Cu(II) chelates were synthesized. The compositions of Cu(II) chelates were determined on the basis of the data obtained from elemental analysis, electronic and IR spectrophotometry, and other method. They were tested for antimicrobial activity in vitro against a gram-positive, seven gram-negative bacterial species and three fungal species. DTCH's exhibited high antibacterial activity against the gram-positive Staphylococcus aureus, but low activity against the various gram negative bacterial species. In contrast to DTCH'S, their Cu(II) chelates exhibited higher antibacterial activity against St. aureus, but weaker, if any, activity against the gram-negative bacterial species. Both DTCH's and their Cu(II) chelates showed relatively potent antifungal activity against Cryptococcus neoformans, but weak activity against Candida albicans and Candida pseudotropicalis.