• International Journal of Computer Science & Network Security
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• v.22 no.7
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• pp.294-300
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• 2022

The article highlights the European experience of innovative educational technologies of training management specialists. Based on existing strategies, relevant in the European educational space, the introduction of regulatory elements to maintain a balance between the traditional and innovative format of the educational process, which is typical for the Ukrainian education system is proposed. The article aims to single out educational and technological innovations into a separate cluster of managerial training at different levels in the context of the principles of the modern synergetic sociocultural paradigm. The main objectives of the work are to develop settings to ensure the effective functioning of innovative educational technologies. Among the synergetic principles of educational technologies, providing the formation of necessary competencies of future managers, are: self-organization, interdisciplinarity, nonlinearity, individuality, and technologization. The methods used in the scientific study can be attributed to the group of scientific synergetic methodology. So, the training of specialists in management, implemented in the European practice assumes the use of new educational strategies. These technologies provide both the necessary skills of different levels (hard-soft-digital skills) and the observance of value components (solidarity, ethics, inclusiveness, openness).

• International Journal of Computer Science & Network Security
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• v.22 no.7
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• pp.75-84
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• 2022

The efficiency of the regional fiscal policy implementation is based on the achievement of target criteria in the formation and distribution of own financial resources of local budgets, reducing their deficit and reducing dependence on transfers. It is also relevant to compare the development of financial autonomy of regions in the course of decentralisation of fiscal relations. The study consists in the cluster analysis of the effectiveness of fiscal policy implementation in the context of 24 regions and the capital city of Kyiv (except for temporarily occupied territories) under conditions of fiscal decentralisation. Clustering of the regions of Ukraine by 18 indicators of fiscal policy implementation efficiency was carried out using Ward's minimum variance method and k-means clustering algorithm. As a result, the regions of Ukraine are grouped into 5 homogeneous clusters. For each cluster measures were developed to increase own revenues and minimize dependence on official transfers to increase the level of financial autonomy of the regions. It has been proved that clustering algorithms are an effective tool in assessing the effectiveness of fiscal policy implementation at the regional level and stimulating further expansion of financial decentralisation of regions.

• Journal of Korean Medical classics
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• v.35 no.3
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• pp.71-90
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• 2022

Objectives : This paper summarizes contents on fish in the Injeji and Jeoneo-Ji parts in the Imwon-Gyeongje-Ji and compares them with those in the Dong-uibogam from a Korean Medical perspective. Methods : Most of the knowledge of fish in the Imwon-Gyeongje-Ji is based on preceding material medica studies such as the Dongui-bogam in Joseon, the Bencao-gangmu in China, and the Hwahan Samjaedohoe in Japan. The influential relationships and the process of change among these knowledge information were examined within the context of each literature's development or through identifiable changes in knowledge on each particular kind of fish. Results & Conclusions : In the Imwon-Gyeongje-Ji, the consisting 16 parts are organically connected, sometimes functioning as cross-references. In particular, the medical contents on the efficacy of fish for treating disease is closely linked to contents on fish ecology and environment as written in the Jeoneo-Ji, which deals with the field of living things. On the more detailed knowledge on about 30 kinds of fish, one could grasp the formation process and changes of East Asian traditional knowledge on fishkind among historical study of influential Chinese texts, new stimulation and methodology through Japanese literature on natural history, and dynamic processes of inheriting and selectively accepting traditional knowledge of Joseon.

• BMB Reports
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• v.55 no.12
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• pp.595-601
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• 2022

Polycomb Repressive Complex 2 (PRC2) exhibits key roles in mammalian development through its temporospatial repression of gene expression. EZH1 or EZH2 is the catalytic subunit of PRC2 that mediates the mono-, di- and tri-methylation of histone H3 lysine 27 (H3K27me1/2/3), H3K27me2/me3 being a hallmark of facultative heterochromatin. PRC2 is a chromatin-modifying enzyme that is recruited to a limited number of "nucleation sites", spreads H3K27 methylation and fosters chromatin compaction. EZH1 and EZH2 exhibit differences in their expression patterns, levels of histone methyltransferase activity (HMT) in the context of PRC2, and DNA/nucleosome binding activity. This suggests that their roles in heterochromatin formation are disparate. Dysregulation of PRC2 activity leads to aberrant gene expression and is implicated in cancer and developmental diseases. In this review, we discuss the distinct function of PRC2/EZH1 and PRC2/EZH2 in the early and late developmental stages. We then discuss the cancers associated with PRC2/EZH1 and PRC2/EZH2.

• The Bulletin of The Korean Astronomical Society
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• v.46 no.1
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• pp.35.2-35.2
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• 2021

Blue straggler stars (BSs) are "rejuvenated" main sequence stars first recognized by Allan Sandage from his observation of the prominent northern globular cluster M3 in the year of 1953. BSs are now known to be present in diverse stellar environments including open clusters, globular clusters, dwarf galaxies, and even the field populations of the Milky Way. This makes them a very useful tool in a wide range of astrophysical applications: Particularly BSs are considered to have a crucial role in the evolution of stellar clusters because they affect on the dynamics, the binary population, and the history of the stellar evolution of the cluster they belong to. Here we report a part of the preliminary results from our ongoing research on the BSs in the two metal-poor globular clusters (GCs) in the Large Magellanic Cloud (LMC), Hodge 11 and NGC1466. Using the high precision multi-band images obtained with the Advanced Camera for Survey (ACS) onboard the Hubble Space Telescope (HST), we extract time-series photometry to search for the signal of periodic variations in the luminosity of the BSs. Our preliminary results confirm that several BSs are intrinsic "short period (0.05 < P < 0.25 days)" variable stars with either pulsating or eclipsing types. We will discuss our investigation on the properties of those variable BS candidates in the context of the formation channels of these exotic main sequence stars, and their roles in the dynamical evolution of the host star clusters.

• International Journal of Computer Science & Network Security
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• v.23 no.6
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• pp.162-168
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• 2023

This article presents an examination of the major cognitive-semantic theories in linguistics (Langacker, Lakoff, Fillmore, Croft). The CST's foundations are discussed concerning the educational policy changes, which are necessary to improve the linguistic disciplines in the changing context of higher education, as well as the empowerment and development of the industry. It is relevant in the light of the linguistic specialists' quality training and the development of effective methods of language learning. Consideration of the theories content, tools, and methods of language teaching, which are an important component of quality teaching and the formation of a set of knowledge and skills of students of linguistic specialties, remains crucial. This study aims to establish the main theoretical positions and directions of cognitive-semantic theory in linguistics, determine the usefulness of teaching the basics of cognitive linguistics, the feasibility of using methods of cognitive-semantic nature in the learning process. During the research, the methods of linguistic description and observation, analysis, and synthesis were applied. The result of the study is to establish the need to study basic linguistic theories, as well as general theoretical precepts of cognitive linguistics, which remains one of the effective directions in the postmodern mainstream. It also clarifies the place of the main cognitive-semantic theories in the teaching linguistics' practice of the XXI century.

• The Journal of the Convergence on Culture Technology
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• v.9 no.3
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• pp.683-688
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• 2023

Content featuring next-generation weapons is continuously appearing in games and virtual reality. In the context of story development, the traces of a target's bullet marks are observed differently according to the unique characteristics of the rifle and bullet. Additionally, there is an example of using forensic ballistics to investigate crime by examining the traces of bullets. Understanding the relationship between the ballistic coefficient and cavity by ballistics is crucial during this process. This paper proposes a physics-based cavity simulation using the modified Bresenham's line algorithm, which can enhance realism in games and virtual reality. This simulation accurately models the trajectory of bullets and cavity formation upon impact, creating a more realistic representation of how bullets interact with materials. Overall, physics-based simulations can greatly enhance the realism and immersion of games and virtual reality experiences and can have applications in forensic investigations.

• Journal of The Geomorphological Association of Korea
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• v.27 no.4
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• pp.13-28
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• 2020

In this study, the distribution and topographic development of marine terraces, UHS (Upper Higher Surface) and HHS (High Higher Surface) at Yeondae-san area, Gampo-eup were discussed. We critically examined on the substance of the Yeongdong-myeon (a low-lying erosion surface) in the east coast of Korea. In study area, UHS including UHS-246m, UHS-241m, UHS-235m, UHS-220m, UHS-210m and UHS-220 is found on the highest altitude among the marine terraces in Korea. The existence of UHS requires new interpretation on topographical surface like Yeongdong-myeon, which has been commonly accepted as a theory in the society of Korean Geography. Since UHS is distributed continuously ascending on the altitude of HHS, the period of formation should be understood in the same context. And UHS of paleo-shoreline 246m has been estimated to be formed about 1.5 million years ago.

• Educational Technology International
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• v.20 no.2
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• pp.195-221
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• 2019

This study explored middle and high school students' learning experiences using e-textbooks in online learning courses. Data were collected from in-depth interviews. The interviewees for this study were 19 students who enrolled voluntarily in an online mathematics and science inquiry program, actively participated in the online learning. The students generally have high academic achievement and motivation for learning in science and mathematics. Data were analyzed based on a grounded theory approach. As a result, the characteristics of the online learning environment using e-textbooks were conceptualized via three different categories including temporal, spatial, and technical. Such characteristics of the learning environment were able to provoke self-directed learning, extended learning, interactive learning, in-depth learning, improved ICT literacy, and formation of positive emotions and learning habits. Most of the learners showed positive feedback towards the use of e-textbooks, while some mentioned the technical limitations compared to conventional paper-based learning. This study suggested that e-textbooks are likely to induce positive experiences for learners in the context of online learning, so it is necessary to design contents that utilize various functions and advantages of electronic teaching materials in order to use e-textbooks effectively.

• BMB Reports
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• v.56 no.11
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• pp.575-583
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• 2023

Mitochondria, fundamental cellular organelles that govern energy metabolism, hold a pivotal role in cellular vitality. While consuming dioxygen to produce adenosine triphosphate (ATP), the electron transfer process within mitochondria can engender the formation of reactive oxygen species that exert dual roles in endothelial homeostatic signaling and oxidative stress. In the context of the intricate electron transfer process, several metal ions that include copper, iron, zinc, and manganese serve as crucial cofactors in mitochondrial metalloenzymes to mediate the synthesis of ATP and antioxidant defense. In this mini review, we provide a comprehensive understanding of the coordination chemistry of mitochondrial cuproenzymes. In detail, cytochrome c oxidase (CcO) reduces dioxygen to water coupled with proton pumping to generate an electrochemical gradient, while superoxide dismutase 1 (SOD1) functions in detoxifying superoxide into hydrogen peroxide. With an emphasis on the catalytic reactions of the copper metalloenzymes and insights into their ligand environment, we also outline the metalation process of these enzymes throughout the copper trafficking system. The impairment of copper homeostasis can trigger mitochondrial dysfunction, and potentially lead to the development of copper-related disorders. We describe the current knowledge regarding copper-mediated toxicity mechanisms, thereby shedding light on prospective therapeutic strategies for pathologies intertwined with copper dyshomeostasis.