• Journal of the Korean Society for Library and Information Science
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• v.48 no.3
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• pp.27-53
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• 2014

It is often said that collections of public library are too poor to meet user demands in terms of quantity as well as quality. It is also criticized that this situation is related to the lack of material budget and non-systematic purchasing process. Situated in such context, this study attempted to investigate current policies and regulations that control the material budget allocation and purchasing process in public libraries, because book purchasing process in public libraries is especially influenced by policies and regulations both in national and regional levels. Policies and regulations affecting material budget allocation and purchasing process were analyzed into 4 elements, namely about (1) financial foundation supporting collection development and material budget allocation, (2) the formation of material budget and discount rates, (3) prescribing characteristics of monographs public libraries purchase, and (4) acquisition process.

• The Journal of Engineering Geology
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• v.24 no.2
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• pp.273-281
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• 2014

In most current seismic design codes, design earthquake ground motions are defined by a reference spectrum, based on bedrock and site amplification factors that quantify the geotechnical dynamic conditions. Earthquake engineering bedrock is the fundamental geotechnical formation where the seismic waves are attenuated without amplification. To better define bedrock in an earthquake engineering context, shear wave velocity ($V_S$ ) data obtained from in-situ seismic tests were examined for several rock strata in Korea; these data were categorized by borehole drilling investigations. The $V_S$ values for most soft rock data in Korea are > 750 m/s, which is the threshold $V_S$ value for identifying engineering bedrock from a strong motion station. Conversely, VS values are < 750 m/s for 60% of $V_S$ data in weathered rock in Korea. Thus, the soft (or harder) rock strata below the weathered rock layer in Korea can be regarded as earthquake engineering bedrock.

• Molecules and Cells
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• v.39 no.5
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• pp.395-402
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• 2016

Identifying Hoxc8 target genes is at the crux of understanding the Hoxc8-mediated regulatory networks underlying its roles during development. However, identification of these genes remains difficult due to intrinsic factors of Hoxc8, such as low DNA binding specificity, context-dependent regulation, and unknown cofactors. Therefore, as an alternative, the present study attempted to test whether the roles of Hoxc8 could be inferred by simply analyzing genes frequently coexpressed with Hoxc8, and whether these genes include putative target genes. Using archived gene expression datasets in which Hoxc8 was differentially expressed, we identified a total of 567 genes that were positively coexpressed with Hoxc8 in at least four out of eight datasets. Among these, 23 genes were coexpressed in six datasets. Gene sets associated with extracellular matrix and cell adhesion were most significantly enriched, followed by gene sets for skeletal system development, morphogenesis, cell motility, and transcriptional regulation. In particular, transcriptional regulators, including paralogs of Hoxc8, known Hox co-factors, and transcriptional remodeling factors were enriched. We randomly selected Adam19, Ptpn13, Prkd1, Tgfbi, and Aldh1a3, and validated their coexpression in mouse embryonic tissues and cell lines following $TGF-{\beta}2$ treatment or ectopic Hoxc8 expression. Except for Aldh1a3, all genes showed concordant expression with that of Hoxc8, suggesting that the coexpressed genes might include direct or indirect target genes. Collectively, we suggest that the coexpressed genes provide a resource for constructing Hoxc8-mediated regulatory networks.

• Korean Journal of Social Welfare
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• v.63 no.3
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• pp.285-307
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• 2011

This study aims to criticize the recent reform of childcare policy since 2008, which goes for marketization, individualization, and familialization, and to search for its alternative. First, this study analyzes the problems of the above three options based on the context of 'free choice', while examining how welfare regimes have dealt with the changes in childcare policy. Second, the study reviews several controversies in the process of policy formation for childcare service, including coverage of service recipient, policy direction, outcome, efficiency, and priority. Third, it proposes an alternative for accomplishing universal childcare service delivery system. Finally, the paper is to point out that the reform of childcare policy of MB government carries fundamental problems of reinforcing class stratification and gender stratification, and thus dose not attain the ultimate goal of childcare policy.

• Molecules and Cells
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• v.38 no.6
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• pp.548-561
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• 2015

By combining conventional single cell analysis with flow cytometry and public database searches with bioinformatics tools, we extended the expression profiling of thymic stromal cotransporter (TSCOT), Slc46A2/Ly110, that was shown to be expressed in bipotent precursor and cortical thymic epithelial cells. Genome scale analysis verified TSCOT expression in thymic tissue- and cell type- specific fashion and is also expressed in some other epithelial tissues including skin and lung. Coexpression profiling with genes, Foxn1 and Hoxa3, revealed the role of TSCOT during the organogenesis. TSCOT expression was detected in all thymic epithelial cells (TECs), but not in the $CD31^+$endothelial cell lineage in fetal thymus. In addition, ABC transporter-dependent side population and Sca-$1^+$ fetal TEC populations both contain TSCOT-expressing cells, indicating TEC stem cells express TSCOT. TSCOT expression was identified as early as in differentiating embryonic stem cells. TSCOT expression is not under the control of Foxn1 since TSCOT is present in the thymic rudiment of nude mice. By searching variations in the expression levels, TSCOT is positively associated with Grhl3 and Irf6. Cytokines such as IL1b, IL22 and IL24 are the potential regulators of the TSCOT expression. Surprisingly, we found TSCOT expression in the lung is diminished in lung cancers, suggesting TSCOT may be involved in the suppression of lung tumor development. Based on these results, a model for TEC differentiation from the stem cells was proposed in context of multiple epithelial organ formation.

• Journal of the Korean Society of Food Science and Nutrition
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• v.23 no.3
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• pp.530-539
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• 1994

All lipoproteins are made up of three major classes of lipids : triglycerides, cholesterol, and phospholipids. Lipoproteins vary in their relative content of these lipids as well as in size and protein content. Human low density lipoprotein (LDL) is a main carrier for cholesterol in the blood stream, and it is well established that cholesterol deposits in the arteries stem primarily from LDL and that increased levels of plasma LDL correlated with in increased risk of atherosclerosis. Various lines of research provide strong evidence that lDL may become oxidized in vivo and that oxidized-LDL is the species involved in the formation of early atherosclerotic lesions. the most crucial findings in this context are the following : (1) Oxidized -LDL has chemotactic properties and if present in the intimal space of the arteries would recruit blood monocytes which then can develop into tissue macrophages ; (2) marcrophages take up oxidized-LDL unregulated to from lipid laden foam cells ; (3) Oxdized-LDLis highly cytotoxic and could be responsible for damage of the endothelial layer and for the destruction of smooth muscle cells.

• Journal of Periodontal and Implant Science
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• v.37 no.3
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• pp.535-542
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• 2007

Background : Repeated dis/re-connection of implant abutment caused bone loss around implant fixtures due to the new formation of biologic width of the mucosal-implant barrier. The aim of this clinical study was to evaluate whether the repeated dis/re-connection of implant abutment cause bone loss clinically and the effect of cleansing methods on a bone loss during the early healing period. Methods : A total 50 implants were installed in 20 patients and repeated dis/re-connection of abutment was performed at the time of surgery and once per week for 12 weeks. 0.9% normal saline solution as group1 and 0.1% chlorhexidine solution as group 2 was used to clean abutments. All patients had radiographs taken at the placement of implant and 4, 8, and 12 weeks postoperatively. The data for bone loss around implant were analyzed. Results: The marginal bone loss at 12 weeks were $1.28{\pm}0.51mm$, $1,32{\pm}0,57mm$ in the mesial and distal sides in group1, $1.94{\pm}0.75mm$, $1.81{\pm}0.84mm$ in group 2, respectively. In view of marginal bone loss, there was not a significant statistical difference between groups. Conclusions : Repeated dis/re-connection of implant abutment may not cause marginal bone loss around implant fixture although limited samples and short-term observation period. In spite of more bone loss in group 2, there was no statistical significant difference between groups. In context of those results, the clinical significance of the repeated dis/re-connection of implant abutment and the cleansing method of abutments is debatable when it comes to marginal bone loss during early healing period.

• Korean Journal of Social Welfare
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• v.64 no.1
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• pp.53-77
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• 2012

The Easterlin Paradox is widely accepted as a pioneer of happiness study in social science disciplines including Economics, Psychology, and Sociology. Moreover, it should be noted, the paradox has abundant implications on many social issues such as 'economic growth or social equity', 'basic income' and so forth. It is in this regard that this paper purports to understand debates around the paradox. For this purpose, the chapter two examines the theoretical perspectives of the Easterlin Paradox, and accordingly the chapter three examines the Easterlin Paradox debates since the early 1990s. In the context of the Easterlin paradox debates, the chapter four scrutinizes the debates around satiation point in income-happiness nexus and duly concludes with some social welfare implications.

• Publications of The Korean Astronomical Society
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• v.32 no.1
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• pp.213-217
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• 2017

The recent updates of the North Ecliptic Pole deep ($0.5deg^2$, NEP-Deep) multi-wavelength survey covering from X-ray to radio-wave is presented. The NEP-Deep provides us with several thousands of $15{\mu}m$ or $18{\mu}m$ selected galaxies, which is the largest sample ever made at these wavelengths. A continuous filter coverage in the mid-infrared wavelength (7, 9, 11, 15, 18, and 24 µm) is unique and vital to diagnose the contributions from starbursts and AGNs in the galaxies out to z=2. The new goal of the project is to resolve the nature of the cosmic star formation history at the violent epoch (e.g. z=1-2), and to find a clue to understand its decline from z=1 to present universe by utilizing the unique power of the multiwavelength survey. The progress in this context is briefly mentioned.

• Journal of Korean Library and Information Science Society
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• v.45 no.3
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• pp.321-348
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• 2014

The purpose of this study is to examine in depth the personal experience of Pre-Service Librarian Teacher during Student Teaching Practice. This helps us understand the overall process and diverse environment of Student Teaching Practice. We conducted in depth interview with participants who had recently experienced. and data analysis was undertaken using the phenomenological method devised by Giorgi. The significance of Pre-service Teacher Librarian experiences during Student Teaching Practice can be summarized in five categories as follows: 'the formation of Pre-service Librarian teacher's awareness about library and librarian through growth process', 'concretization and Strategy Implementation about Career Planning', 'Self-growth Need through experience of student teaching practice', 'Understanding of Organizational Culture Perception of Communication', 'Face reality about library and librarian'. These constituents can be understood in the context of time sequence. The result of this study may contribute for improving the overall environment at Student Teaching Practice.