• International Journal of Computer Science & Network Security
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• v.23 no.9
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• pp.192-198
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• 2023

Cyberbullying is a growing problem among adolescents and can have serious psychological and emotional consequences for the victims. In recent years, machine learning techniques have emerged as promising approach for detecting instances of cyberbullying in online communication. This research paper focuses on developing a machine learning models that are able to detect cyberbullying including support vector machines, naïve bayes, and random forests. The study uses a dataset of real-world examples of cyberbullying collected from Twitter and extracts features that represents the ideational metafunction, then evaluates the performance of each algorithm before and after considering the theory of systemic functional linguistics in terms of precision, recall, and F1-score. The result indicates that all three algorithms are effective at detecting cyberbullying with 92% for naïve bayes and an accuracy of 93% for both SVM and random forests. However, the study also highlights the challenges of accurately detecting cyberbullying, particularly given the nuanced and context-dependent nature of online communication. This paper concludes by discussing the implications of these findings for future research and the development of practical tool for cyberbullying prevention and intervention.

• Structural Engineering and Mechanics
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• v.87 no.5
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• pp.405-418
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• 2023

This study focused on the effectiveness of seismic isolation technique in case of a reinforced concrete structure with soft story defined as the stiffness irregularity between adjacent stories. In this context, a seismically isolated 3-story reinforced concrete structure was analyzed by gradually increasing the first story height (3.0, 4.5, and 6.0 m). The seismic isolation system of the structure is assumed to be composed of lead rubber bearings (LRB). In the analyses, isolators were modeled by both deteriorating (temperature-dependent analyses) and non-deteriorating (bounding analyses) hysteretic representations. The deterioration in strength of isolator is due to temperature rise in the lead core during cyclic motion. The ground motion pairs used in bi-directional nonlinear dynamic analyses were selected and scaled according to codified procedures. In the analyses, different isolation periods (Tiso) and characteristic strength to weight ratios (Q/W) were considered in order to determine the sensitivity of structural response to the isolator properties. Response quantities under consideration are floor accelerations, and interstory drift ratios. Analyses results are compared for both hysteretic representations of LRBs. Results are also used to assess the significance of the ratio between the horizontal stiffnesses of soft story and isolation system. It is revealed that seismic isolation is a viable method to reduce structural damage in structures with soft story.

• Journal of Forest and Environmental Science
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• v.26 no.2
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• pp.65-73
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• 2010

Biodiversity, referring to the variety and abundance of species, their genetic composition, and the communities, ecosystem, and landscapes, is essential to maintain healthy and productive forests, and to provide useful hedge against the future uncertainties in conditions of the environment and natural resources. To realize the long-term sustainability for forest production of goods and services is dependent upon maintaining and enhancing the biodiversity in the forest ecosystem. Because we can not always recognized which portion of biodiversity is essential to maintain the stability and sustainability of the natural system, conserving biodiversity is even unconditionally important. Even though the activities of forest resource management may have a variety of negative impacts on biodiversity by modification of the natural ecosystem into economically effective artificial ecosystem, forest professionals have been developing intelligent scheme to coexist management and conservation. However, conservation of biodiversity must be a complex problem encircled by ecological, economical, and social considerations. There seems to be no such a simple and easy solution. Strategies for ecologically deliberated forest resource management, which could play an important role to conserve biodiversity, were discussed.

• Molecules and Cells
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• v.46 no.3
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• pp.176-186
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• 2023

The oxidative balance of a cell is maintained by the Kelch-like ECH-associated protein 1 (KEAP1)/nuclear factor erythroid 2-related factor 2 (NRF2) pathway. This cytoprotective pathway detoxifies reactive oxygen species and xenobiotics. The role of the KEAP1/NRF2 pathway as pro-tumorigenic or anti-tumorigenic throughout stages of carcinogenesis (including initiation, promotion, progression, and metastasis) is complex. This mini review focuses on key studies describing how the KEAP1/NRF2 pathway affects cancer at different phases. The data compiled suggest that the roles of KEAP1/NRF2 in cancer are highly dependent on context; specifically, the model used (carcinogen-induced vs genetic), the tumor type, and the stage of cancer. Moreover, emerging data suggests that KEAP1/NRF2 is also important for regulating the tumor microenvironment and how its effects are amplified either by epigenetics or in response to co-occurring mutations. Further elucidation of the complexity of this pathway is needed in order to develop novel pharmacological tools and drugs to improve patient outcomes.

• International conference on construction engineering and project management
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• 2013.01a
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• pp.546-552
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• 2013

The future competitiveness of construction industry is dependent on K-12 students. However, unfavorable images of construction industry have negative influence on K-12 students' decision-making of their career. This negative image makes them not want to find out what actually happens in construction industry. Consequently, it is important to give K-12 students the opportunity to know what construction employees actually do in their job. Studies show that K-12 students who encounter the job early-on are more likely to choose it as their career. In this context, this paper proposes construction educational game in which it can serve as a medium for capturing K-12 students' interest in Construction Management (CM). Based on the literature reviews, challenges of construction educational game for K-12 students which are edutainment, hands-on experience and social interaction, are derived. To address these issues, conceptual model and scenario are designed. Based on designed scenario, prototype of Simulation based Construction Game in Virtual World (SCGVW) is developed in Second Life (SL) and applicability test to K-12 students are implemented. This paper concludes with a discussion of the lessons learned and the future development steps of the construction educational game for K-12 students.

• Asian Journal for Public Opinion Research
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• v.11 no.2
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• pp.163-178
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• 2023

Individuals have been under more stress since the COVID-19 pandemic began than they were before the pandemic. While social support is a known stress buffer among the general population, its impact on stress among vulnerable populations, such as immigrants and those living in rural areas, has received little attention in the context of South Korea. Accordingly, we examined the relationship between different types of social support and COVID-19 stress among young adult immigrants based on where they live (rural vs. urban). We conducted a survey of 300 young adult immigrants aged 25-34 years and analyzed the results. The dependent variable was COVID-19 stress, and the independent variables were four types of social support: emotional, appraisal, instrumental, and informational. We discovered that young adult immigrants in rural areas perceived higher-level social supportin all aspects compared with those in urban areas. Furthermore, social support was not related to COVID-19 stress in urban areas, while appraisal support was positively and informational support was negatively related to COVID-19 stress in rural areas. Our findings suggest that a contextualized understanding of social support is critical to understanding COVID-related stress during the COVID-19 pandemic.

• Korea Trade Review
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• v.45 no.1
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• pp.137-153
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• 2020

On February 14, 2019, the government of Korea formally decided to consider the feasibility of joining the Comprehensive and Progressive Trans-Pacific Partnership (CPTPP) and has since been conducting bilateral consultations with individual member countries. In terms of the impact estimation, the CPTPP is actually a Korea-Japan FTA, and the most sensitive issue in the FTA is the opening of the auto industry market to Japan. Despite these circumstances, previous studies have predicted that the auto industry will be a beneficiary industry when joining the CPTPP. However, the Korean auto industry is opposed to joining the CPTPP. In order to investigate the cause of this discrepancy, this paper examines the problems of previous studies in estimating the impact of joining the CPTPP and found that the preceding study did not consider the industrial characteristics of the auto sector, especially in the context of Japan-Korea trade, and was heavily dependent on the Armington elasticity (structure) in the demand function of the GTAP CGE model. As a result, the domestic auto sector could lower prices and increase exports when joining the CPTPP. This paper attempts to precisely re-estimate the impact of joining the CPTPP on the auto sector in a way that corrects these problems by changing the CGE model and reflecting the major characteristics of the industry, with policy implications for the negotiation of CPTPP accession.

• IMMUNE NETWORK
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• v.23 no.1
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• pp.5.1-5.28
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• 2023

Th cell lineage determination and functional specialization are tightly linked to the activation of lineage-determining transcription factors (TFs) that bind cis-regulatory elements. These lineage-determining TFs act in concert with multiple layers of transcriptional regulators to alter the epigenetic landscape, including DNA methylation, histone modification and threedimensional chromosome architecture, in order to facilitate the specific Th gene expression programs that allow for phenotypic diversification. Accumulating evidence indicates that Th cell differentiation is not as rigid as classically held; rather, extensive phenotypic plasticity is an inherent feature of T cell lineages. Recent studies have begun to uncover the epigenetic programs that mechanistically govern T cell subset specification and immunological memory. Advances in next generation sequencing technologies have allowed global transcriptomic and epigenomic interrogation of CD4+ Th cells that extends previous findings focusing on individual loci. In this review, we provide an overview of recent genome-wide insights into the transcriptional and epigenetic regulation of CD4+ T cell-mediated adaptive immunity and discuss the implications for disease as well as immunotherapies.

• IMMUNE NETWORK
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• v.24 no.1
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• pp.4.1-4.19
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• 2024

TNF, a pleiotropic proinflammatory cytokine, is important for protective immunity and immunopathology during Mycobacterium tuberculosis (Mtb) infection, which causes tuberculosis (TB) in humans. TNF is produced primarily by phagocytes in the lungs during the early stages of Mtb infection and performs diverse physiological and pathological functions by binding to its receptors in a context-dependent manner. TNF is essential for granuloma formation, chronic infection prevention, and macrophage recruitment to and activation at the site of infection. In animal models, TNF, in cooperation with chemokines, contributes to the initiation, maintenance, and clearance of mycobacteria in granulomas. Although anti-TNF therapy is effective against immune diseases such as rheumatoid arthritis, it carries the risk of reactivating TB. Furthermore, TNF-associated inflammation contributes to cachexia in patients with TB. This review focuses on the multifaceted role of TNF in the pathogenesis and prevention of TB and underscores the importance of investigating the functions of TNF and its receptors in the establishment of protective immunity against and in the pathology of TB. Such investigations will facilitate the development of therapeutic strategies that target TNF signaling, which makes beneficial and detrimental contributions to the pathogenesis of TB.

• IMMUNE NETWORK
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• v.20 no.1
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• pp.6.1-6.20
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• 2020

IL-17 is produced by RAR-related orphan receptor gamma t (RORγt)-expressing cells including Th17 cells, subsets of γδT cells and innate lymphoid cells (ILCs). The biological significance of IL-17-producing cells is well-studied in contexts of inflammation, autoimmunity and host defense against infection. While most of available studies in tumor immunity mainly focused on the role of T-bet-expressing cells, including cytotoxic CD8⁺ T cells and NK cells, and their exhaustion status, the role of IL-17-producing cells remains poorly understood. While IL-17-producing T-cells were shown to be anti-tumorigenic in adoptive T-cell therapy settings, mice deficient in type 17 genes suggest a protumorigenic potential of IL-17-producing cells. This review discusses the features of IL-17-producing cells, of both lymphocytic and myeloid origins, as well as their suggested pro- and/or anti-tumorigenic functions in an organ-dependent context. Potential therapeutic approaches targeting these cells in the tumor microenvironment will also be discussed.