• Journal of Pharmaceutical Investigation
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• v.27 no.4
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• pp.303-311
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• 1997

Proliposomal patch of clenbuterol, ${\beta}_2-agonist$ bronchodilator, was prepared and its feasibility as a novel transdermal drug delivery system was examined. Proliposomal granules containing clenbuterol was prepared by a standard method using sorbitol and lecithin with (Rx 2) or without cholesterol (Rx 1). The porous structure of sorbitol in the proliposomes was maintained allowing tree flowability of the granules. Following contact with water, the granules were converted probably to liposomes almost completely within several minutes. It indicates that proliposomes may be hydrated, when they are applied on the skin under occlusive condition in vivo, by the sweat to form liposomes. Clenbuterol release from Rx 1 and Rx 2 proliposomes to pH 7.4 isotonic phospate buffer (PBS) across cellulose membrane (mol. wt. cut-off of 12000-14000) was retarded significantly compared with that from the mixture of clenbuterol powder and blank proliposomes. Interestingly, proliposomes prepared with lecithin and cholesterol (i.e., Rx 2 proliposomes) showed much more retarded release of clenbuterol than proliposomes prepared only with lecithin (i.e.. Rx 1 proliposomes), indicating that clenbuterol release from proliposomes can be controlled by the addition of cholesterol to the proliposomes. Proliposomal patches were prepared using PVC film as an occlusive backing sheet, two sides adhesive tape (urethane, 1.45 mm thickness) as a reservoir for proliposome granules and Millipore MF-membrane (0.45 mm pore size) as a drug release-controlling membrane. Rx 1 or Rx 2 proliposomes containing 4.6 mg of clenbuterol were loaded into the reservoir of the patch. Clenbuterol release from the patches to pH 7.4 PBS was determined using USP paddle (50 rpm)-over-disc release method. Clenbuterol release from the proliposomal patches was much more retarded even than from a matrix type clenbuterol patch (Boehringer Ingelheim ltd). Being consistent with clenbuterol release from the proliposomal granules, the release from the patches was highly dependent on the presence of cholesterol in the proliposomes : Patches containing Rx 2 proliposomes showed several fold slower drug release than patches containing Rx 1 proliposomes. When the patch containing Rx 1 proliposomes was applied on to the back of a hair-removed rat, clenbuterol concentration in the rat blood was maintained during 6-72 hrs. Transdermal absorption of clenbuterol from the patch was accelerated when the patch was prehydrated with 50 ml of pH 7.4 PBS before topical application. Above results indicate that sustained transdermal delivery of clenbuterol is feasible using proliposomal patches if the cholesterol content and pore size of the release rate-controlling membrane of patches, for example, are appropriately controlled.

• Journal of Conservation Science
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• v.32 no.3
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• pp.377-384
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• 2016

There are physical and chemical method for removement of a lacquered layer existing on the surface when gilding an iron Buddha, these caused environmental pollution by surface degradation and is very noxious for conservation scientist's health. Thus, on this study, we conducted a lacquered layer removement experiments using Nd:YAG Laser which is contactless and eco-friendly. Specimens were made by polishing $5{\times}5$ size of iron(99.9%) specimens surfaces evenly and by differing of number of coating of unrefined lacquer, so there were thickness differences of $10{\mu}m$, $20{\mu}m$, and $30{\mu}m$. The laser machine used in this study was Nd:YAG Laser, and we used two wavelength modes; 1064 nm(160~180 mJ) for infrared light region and 532 nm(50~350 mJ) for ultraviolet light region. The experiment done by investigating the transition of specimens' surfaces with laser wavelength, energy, and numbers of investigation. The remain amount of lacquered layer surfaces before/after laser irradiation was investigated by stereoscopic microscope, observation by SEM, Non-contact Surface Roughness Measurement Device, and FT-IR etc. As a result of each analysis, we could verify the thickness of $10{\mu}m$, $20{\mu}m$ of lacquered layer removed without surface degradation when using 1064 nm wavelength with $1.0J/cm^2$ density. We could find out that Nd:YAG Laser is effective for removing remained lacquered layers when gilding an iron Buddha. In the future, when not only the metal has made various studies also wood lacquered furniture or the like, it seems to be utilized to remove the lacquer without surface damage.

• Proceedings of the KSAR Conference
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• 2003.06a
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• pp.27-27
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• 2003

A diversified and concentrative approach of methylation player can be one of the most powerful studies in the understanding of global epigenetic modifications. Previous studies have suggested that DNA methylation contributes to transcriptional silencing through the several DNA methylation-mediated repression systems by hypermethylation, including methyltransferases (DNMTs), DNA methyltransferase association protein 1 (DMAPl), methyl-CpG binding domain (MBD), and histone deacetylases (HDACs). Assembly of these regulatory protein complexes act sequentially, reciprocally, and interdependently on the newly composed DNA strand through S phase. Therefore, these protein complexes have a role in coupling DNA replication to the designed turn-off system in genome. In this study, we attempted to address the role of DNA methylation by the functional analysis of the methyltransferase molecule, we described the involvement of DMAP1 and DNMTs in cell divistion and the effect of their loss. We also described distinct patterns that DMAP1 and DNMTs are spatially reorganized and displaced from condensing chromosomes as cells progress through mitosis in HeLa cell, COS7, and HIH3T3 cell cycle progressions. DNMT1, DNMT3b, and DMAP1 do not stably contact the genetic material during chromosome compaction and repressive expression. These finding show that the loss of activities of DNMTs and DMAP1 occure stage specifically during the cell cycle, may contribute to the integral balance of global DNA methylation. This is consistent with previous studies resulted in decreased histone acetyltransferases and HDACs, and differs from studies resulted in increased histone methyltransferases. Our results suggest that DNA methylation by DNMTs and DMAP1 during mitosis acts to antagonize hypermethylation by which this mark is epigenetical mitotic-specific methylation.

• Journal of Korean Ophthalmic Optics Society
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• v.15 no.3
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• pp.263-268
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• 2010

Purpose: Eye movements and fixation ability are an important procedure to obtain external information and essential means of clear vision. The purpose of this study was to determine the reading performance such as reading time and number of fixations when random text was viewed at varying distances. Methods: Twenty two presbyopes were participated. All subjects were screened for their suitability to participate in the study by clinical examination, and none of the participants had previously worn contact lenses and no previous experience of wearing any types of presbyopic vision correction except single vision. The reading time and number of fixations were recorded using eye tracker while each subjects was waring four vision corrections which included single vision for distance (SV), bifocal spectacle lenses (BIF), progressive addition lenses (PAL), and monovision (MV). The reading material was presented at distance and near distance. Results: Reading time and number of fixations for near stimulus were significantly different among vision correction used in this study (p<0.001). In particular, wearing SV required longer reading time and produced longer fixation duration for near text. However, reading distance text was similarity performed across vision corrections tested and there was no statistical difference found for either reading time and number of fixations. Conclusions: Wearing presbyopic vision correction is advantageous for reading task of near stimuli, but not having near correction such as wearing SV could result in longer reading time and higher number of fixation due to lacks of accommodative ability for near task. For the future studies, it would be interesting to examine the performance of reading both at adapted and unadapted stages as examining only unadapted wearers was limitation of this study.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.2
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• pp.653-659
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• 2018

High-rise buildings and complex facilities are a representative urban system for the masses, and it requires an increasing role of commodity and safety. Smoke and toxic gasses can cause accidents due to fire in these systems. The purpose of this study is to develop a fiber screen material for emergency evacuation passages that can be avoided quickly and safely in cases of disasters. The fiber screen material is applicable to folding devices for emergency evacuation passages. The material is different from general steel material in that it is lightweight with less burden during storage for a long time in a roll form in a folding device. It also has an excellent secondary function in that it is less affected by radiant heat. Three kinds of fiber screen materials were selected that have good flame retardancy and post-processing characteristics. A performance evaluation was performed by a heat shrinkage test, contact heat test, combustibility test, flame retardancy test, tensile strength test, and tear strength test. As a result, the lightweight fabric shows excellent performance through post-processing, and silicone resin coating can secure safety of the pizza by the fiber screen material performance and radiant heat. The optimum post-treatment conditions were evaluated by performing a burning test after coating two kinds of glass fibers and four types of flame-retardant silicone resins with different weight and thickness.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.11
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• pp.711-717
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• 2017

The railway is a public transportation system that provides large-scale passenger transportation and service, whose reliability and safety is the top priority. The wiring of railway vehicles is classified into train control lines (train lines) and communication lines. The train lines are used for input / output signals related to vehicle driving and safety functions, and the communication lines are used for the input / output signals for passenger services such as broadcasting. In order to measure the reliability of railway vehicles, a train line is applied to the input / output interface of the control signals between the electric control devices in the vehicle, and there are many electromechanical devices such as relays and contactors for the control logic. In fact, since the vehicle control circuit is composed of several thousand contacts, it is difficult to check for errors such as contact failure, and it is impossible to check the real-time status, so a lot of manpower and time is required for regular maintenance. Therefore, we analyze the current state of the train line design of the electric equipment used for driving and services in domestic railway cars and propose three wiring reduction methods to improve it. Based on the analysis of domestic electric vehicles, it was confirmed that the wiring reduction effect is 35% or more.

• Journal of Korean Library and Information Science Society
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• v.38 no.2
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• pp.13-30
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• 2007

The purpose of this study was to explore the role orientation that librarians are expected to carry during their career-life. More specifically, this study examined the pattern of librarians subjectivism related to attitude, belief, and confidence. Q questions were made of 36 items, including personal value system and role attitude. P sample included 23 librarians. Data were collected for 8 days (from April 15, 2005 to April 22, 2005). Analyses showed the following results. First, librarians role orientations were classified into 3 types: user-centered orientation, organization-centered orientation, and expertise-centered orientation. (1) The first type librarians were interested in having good relationships with users, while emphasizing the importance of providing good services to the users. (2) The second type of librarians were concerned with social function of the library, while placing highlight on their roles as organizational members. Among them, achievement evaluation was regarded as an important indicator of personal success. They were interested in having stable organizational culture, as well as economic growth of libraries. This orientation was dominant among married members. (3) The third type of librarians focused on librarians role implementation and professional achievement. They showed interest not only in the improvement of librarians creativity and the growth of expertises, but also the expansion of retraining opportunities. This orientation was conspicuous among female librarians. Second, several commonalities and differences were consistently found among librarians. The first type was interested in user-centered orientation(user contact, need satisfaction, self dignity, etc.). The second type was interested in organization-centered orientation(creativity, expertise growth, retraining opportunity, professional achievement. self-respect, etc.).

• Journal of Korean Society of Environmental Engineers
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• v.37 no.11
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• pp.649-655
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• 2015

As a novel water treatment membrane, concept of ceramic-based graphene membrane (CbGM) was suggested, and its mass transport behavior was investigated. The selectivity of CbGM was given by graphene material which is consisting of active layer, only transmitting water, but rejecting salts. Filtration-assisted assembly methods was employed as a facile method to fabricate CbGM. Surface morphology and characteristics of CbGM were analyzed by scanning electron microscopy (SEM) and contact angle. In addition, three different kinds of solutes (i.e., NaCl, $MgCl_2$, $Na_2SO_4$) were tested in batch forward osmosis system to confirm the mass transport behavior. Through surface morphology analysis and mass transport behavior, it was revealed that interlocking between graphene layers is very important, rather than thickness of laminated graphene layers, in terms of selectivity to CbGM. All the anions in each solute showed faster transport than those of cations. In addition, solutes which have high ion valence charge ratio of anion to cation ($Z^-/Z^+$) was easier to be passed through CbGM. It indirectly implied that the surface charge of CbGM appear to be positive. In addition, It showed that surface charge of CbGM has a great role on mass transport, in particular, transport of matter having charges, generally ions.

• Journal of Korean Ophthalmic Optics Society
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• v.18 no.4
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• pp.413-428
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• 2013

Purpose: The purpose of this study was to evaluate students and optometrist opinion of the usefulness of different subjects of optometry curriculum.This date will then be used as base-line data during a process of curriculum development Methods: 292 of ophthalmic optic's students and 123 of optometrists were surveyed in the usefulness of curriculum (five-point scale) followed by statistical analysis of the results. Results: Optometrists gave a higher average score for curriculum usefulness (3.89) than the students (3.71). The subject which showed the highest usefulness for the student was optometry (4.55) but clinical practice was the highest for the optometrist (4.48). There was significant differences (p<.05) on optics, ophthalmology, basic science, optometrist related subject and foreign language but optometry and contact lenses showed high usefulness in common without significant difference. The usefulness of subject for the student showed significant difference according to gender, grade, age, and desired working place and has demonstrated significant difference depend on gender, age, scholarship, total working experience as an optometrist, workplace, and position for optometrists as well. Conclusions: It is necessary to continue research for the development of standard and bench-marked curriculum for ophthalmic optics and also the curriculum, which reflecting the usefulness and needs obtained from ophthalmic optics' students and optometrists need to be developed.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.9 no.4
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• pp.878-885
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• 2008

The FPDs(Flat Panel Displays) such as LCD(Liquid Crystal Display) and PDP(Plasma Display Panel) and OLED(Organic Light Emitting Diode), recently, have been substituted for CRT(Cathode Ray Tube) displays because they have a convex surface, small volume, light weight and lower electric power consumption. The productivity of FPDs is greatly dependent on the area of thin glass panel with 0.6 - 0.8mm thickness because FPDs are manufactured by cutting a large-scaled thin glass panel with patterns to the required product dimensions. So FPD's industries are trying to increase the area of thin glass panel. For example, the thin glass panel size of the 8th generation is 2,200mm in width, 2,600mm in length and 0.7mm in thickness. The air flows both in the thin glass panel and in the porous PE-plate surface were modeled and analyzed, from which a working condition was estimated. The thin glass panel on the porous PE-plate surface with self-lubricating characteristics was investigated and compared with that on the square duct floating bar surface with many holes of 1mm diameter when the thin glass panel contacts the floating bar surface due to malfunction of electric power supply.