• Magazine of the Korean Society of Agricultural Engineers
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• v.41 no.6
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• pp.54-63
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• 1999

Considering that rural village had evolved through a long-sustained effort of harmnization with nature, there should be the wisdom not only to reflect the level of rural resident's housing demand, but also to conserve the traditional characteristics of high-valuation in the modern rural housing. In Korea , standard design proposals of rural houses had been made public three times ; in 1972 , 1984 and 1995. so , firstly, this study analysed the inner-space layouts of design proposals mentioned above, from which changes and problems in the past housing design were derived. And also, through, the positive acceptance of residents' opinion living inthe houses built by standard design proposals in 1970 ~1980's, improved design principles and an alternative model were proposed , finally. The inner-space structed of standard design proposals in 1970s was originated from small-scaled and low-priced one, basically under the " open system". In 1980s, the basic design principle changed to the 'closed system' in which the living room being the focus of indoor family life, and , in 1990s, progressively, therural housing developed to the high qualified type by the spatial enlargement and with increased equipements. However, this structural change of rural house brought about the problem of functional separatioon between farming and daily living activities. In details, limited spaces of multipurpose spaces and sanitary facility would be mentioned as problems for improvement. conclusively in this study, newoly arranged "open system" was recommended , as a basic design principle for theinner space structure formation of rural house, which easily links the constituent inner-house spaces to outer one. Based on this principle, the detailed design criterial was proposed as follows ; 1. The living room be directly linked to the front-yard and centrally placed, the addtional space of which could be secured for the special family events by the flexibleuse of its adjacent room or by the housing of male quarters(separated from main building quarter). 2. The kitchen also be directly linked to side-yard and to livng room , for the convenience of farming activities and the shortening of path flow housewife. 3. The expanded toilet-and-bathroom be placed in the directly connected left-hand side to the living room and also be allowed access through multipurpose spaces to out door. 4. The multipurpose spaces be directly connected to the kitchen and the toilet and-bathroom , of which function would be for undressing of working clothes, quickwashing and ordinary working.nd ordinary working.

• Korean Journal of Agricultural and Forest Meteorology
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• v.9 no.2
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• pp.132-139
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• 2007

The Moderate Resolution Imaging Spectroradiometer (MODIS) regularly provides the eight-day gross primary productivity (GPP) at 1 km resolution. In this study, we evaluated the uncertainties of MODIS GPP caused by errors associated with the Data Assimilation Office (DAO) meteorology and a biophysical variable (fraction of absorbed photosynthetically active radiation, FPAR). In order to recalculate the improved GPP estimate, we employed ground weather station data and reconstructed cloud-free FPAR. The official MODIS GPP was evaluated as +17% higher than the improved GPP. The error associated with DAO meteorology was identified as the primary and the error from the cloud-contaminated FPAR as the secondary constituent in the integrative uncertainty. Among various biome types, the highest relative error of the official MODIS GPP to the improved GPP was found in the mixed forest biome with RE of 20% and the smallest errors were shown in crop land cover at 11%. Our results indicated that the uncertainty embedded in the official MODIS GPP product was considerable, indicating that the MODIS GPP needs to be reconstructed with the improved input data of daily surface meteorology and cloud-free FPAR in order to accurately monitor vegetation productivity in Korea.

• The Korean Journal of Physiology and Pharmacology
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• v.19 no.5
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• pp.389-399
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• 2015

Zinc has been considered as a vital constituent of proteins, including enzymes. Mobile reactive zinc ($Zn^{2+}$) is the key form of zinc involved in signal transductions, which are mainly driven by its binding to proteins or the release of zinc from proteins, possibly via a redox switch. There has been growing evidence of zinc's critical role in cell signaling, due to its flexible coordination geometry and rapid shifts in protein conformation to perform biological reactions. The importance and complexity of $Zn^{2+}$ activity has been presumed to parallel the degree of calcium's participation in cellular processes. Whole body and cellular $Zn^{2+}$ levels are largely regulated by metallothioneins (MTs), $Zn^{2+}$ importers (ZIPs), and $Zn^{2+}$ transporters (ZnTs). Numerous proteins involved in signaling pathways, mitochondrial metabolism, and ion channels that play a pivotal role in controlling cardiac contractility are common targets of $Zn^{2+}$. However, these regulatory actions of $Zn^{2+}$ are not limited to the function of the heart, but also extend to numerous other organ systems, such as the central nervous system, immune system, cardiovascular tissue, and secretory glands, such as the pancreas, prostate, and mammary glands. In this review, the regulation of cellular $Zn^{2+}$ levels, $Zn^{2+}$-mediated signal transduction, impacts of $Zn^{2+}$ on ion channels and mitochondrial metabolism, and finally, the implications of $Zn^{2+}$ in health and disease development were outlined to help widen the current understanding of the versatile and complex roles of $Zn^{2+}$.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.35 no.4
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• pp.438-444
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• 2002

The purpose of this study is screening of microfloras involved in hydrolysis of sea tangle (Laminaria japonica) and sea mustard ( Undaria pinnatifida), This is a part of studies on the hydrolysis of seaweed using microorganisms. General process is difficult to extract of the useful constituent parts as intercellular mucilage, storage polysaccharide and mineral from seafood. It was screening to thirty-three microflora samples as destructed of tissue in sea tangle and sea mustard to about two hundred microflora samples from mountain, rice field, dry field, sea, seaside and fish market etc. in the neighborhood of Yeosu. Sufficient results of the naked eye observation were obtained at eight microflora samples as a feces of bull, a decayed pine tree, a soil of dry field, the mud of the banks in a rice Held, the water of a ditch in a rice Held, the weed of the banks in a rice field, the water in a rice field and leaved in the air, And the value of chemical analysis of the sample is much better in comparison with control. Accordingly, the hydrolysis of seaweed using microorganisms in the inside of these microflora samples can possibility.

• Journal of Ginseng Research
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• v.42 no.4
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• pp.401-411
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• 2018

Longevity in medicine can be defined as a long life without mental or physical deficits. This can be prevented by Alzheimer's disease (AD). Current conventional AD treatments only alleviate the symptoms without reversing AD progression. Recent studies demonstrated that Panax ginseng extract improves AD symptoms in patients with AD, and the two main components of ginseng might contribute to AD amelioration. Ginsenosides show various AD-related neuroprotective effects. Gintonin is a newly identified ginseng constituent that contains lysophosphatidic acids and attenuates AD-related brain neuropathies. Ginsenosides decrease amyloid ${\beta}$-protein ($A{\beta}$) formation by inhibiting ${\beta}$- and ${\gamma}$-secretase activity or by activating the nonamyloidogenic pathway, inhibit acetylcholinesterase activity and $A{\beta}$-induced neurotoxicity, and decrease $A{\beta}$-induced production of reactive oxygen species and neuro-inflammatory reactions. Oral administration of ginsenosides increases the expression levels of enzymes involved in acetylcholine synthesis in the brain and alleviates $A{\beta}$-induced cholinergic deficits in AD models. Similarly, gintonin inhibits $A{\beta}$-induced neurotoxicity and activates the nonamyloidogenic pathway to reduce $A{\beta}$ formation and to increase acetylcholine and choline acetyltransferase expression in the brain through lysophosphatidic acid receptors. Oral administration of gintonin attenuates brain amyloid plaque deposits, boosting hippocampal cholinergic systems and neurogenesis, thereby ameliorating learning and memory impairments. It also improves cognitive functions in patients with AD. Ginsenosides and gintonin attenuate AD-related neuropathology through multiple routes. This review focuses research demonstrating that ginseng constituents could be a candidate as an adjuvant for AD treatment. However, clinical investigations including efficacy and tolerability analyses may be necessary for the clinical acceptance of ginseng components in combination with conventional AD drugs.

• Journal of architectural history
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• v.4 no.1
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• pp.43-70
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• 1995

This paper aims to clarify the historical background and the architectural purpose of the buildings in NakSunJae area to the original state. Through the investigation, the clarified facts are as follows. 1. The relation with the buildings for the Crown Prince in the ChangDok Palace By constructing buildings in the NakSunJae area, the spatial conception of the Royal Palace was changed, that is, buildings for the Crown Prince in the ChangDok Palace disappeared and they became to belong to the ChangGyeong Palace. Moreover, by constructing the NakSunJae and its attached buildings, the area for the Crown Prince shifted to use as a private area for the king. 2. The date and the purpose of the construction The NakSunJae area is consisted of three compounds of building: NakSunJae, SukBokHun and SooKangJae. The NakSunJae was constructed for the king HunChong's private occupancy in 1847 and the SukBokHun for a residence of a royal concubine Kim, in 1847. The SooKangJae was originally built in 1785 in the SooKang Palace where the ex-king took up as his residence after abdicate the throne. Later on, it was repaired as the residence of the Queen SoonWon, king HunChong's grandmother, in commemoration for the 60th anniversary of her birth in 1848. 3. Architectural features of the NakSunJae area at the time of construction First, as the NakSunJae area is surrounded by quite high hills in northeast and by low hills in southwest, it is naturally distinguished from its surroundings and gives a cosy feeling. Second, the NakSunJae area shows very untrammeled style of arrangement in general, because it was constructed as a private occupancy for the king. other buildings are arranged in the latticing orderly, nonetheless, they are free by themselves from a strict form and make themselves an area full of variety. Third, the buildings in the NakSunJae area have a characteristic of naivety of common people's houses, because they were not an official but private place for the king, his concubine and his grandmother. Forth, the ornaments in the NakSunJae area are variously, elegantly and harmoniously patterned with the meaning of good luck. Fifth, back garden in the NakSunJae area was made by taking advantage of sloping hills. The back garden is beautifully configurated by arranging various constituent elements of pavilions, tiered flower beds, chimneys, decorated walls, small doors between walls, stoneworks and trees.

• International Journal of Oral Biology
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• v.36 no.3
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• pp.117-122
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• 2011

Endothelial cells are a vital constituent of most mammalian organs and are required to maintain the integrity of these tissues. These cells also play a major role in angiogenesis, inflammatory reactions, and in the regulation of thrombosis. Angiogenesis facilitates pulp formation and produces the vessels which are essential for the maintenance of tooth homeostasis. These vessels can also be used in bone and tissue regeneration, and in surgical procedures to place implants or to remove cancerous tissue. Furthermore, endothelial cell regeneration is the most critical component of the tooth generation process. The aim of the present study was to stimulate endothelial regeneration at a site of acute cyclophosphamide (CP)-induced endothelial injury by treatment with human umbilical cord-derived endothelial/mesenchymal stem cells (hEPCs). We randomly assigned 16 to 20-week-old female NOD/SCID mice into three separate groups, a hEPC ($1{\times}10^5$ cells) transplanted, 300mg/kg CP treated and saline (control) group. The mice were sacrificed on days 5 and 10 and blood was collected via the abdominal aorta for analysis. The alanine transaminase (ALT), aspartate aminotransferase (AST), serum alkaline phosphatase (s-ALP), and albumin (ALB) levels were then evaluated. Tissue sections from the livers and kidneys were stained with hematoxylin and eosin (HE) for microscopic analysis and were subjected to immunohistochemistry to evaluate any changes in the endothelial layer. CP treatment caused a weight reduction after one day. The kidney/body weight ratio increased in the hEPC treated animals compared with the CP only group at 10 days. Moreover, hEPC treatment resulted in reduced s-ALP, AST, ALT levels compared with the CP only group at 10 days. The CP only animals further showed endothelial injuries at five days which were recovered by hEPC treatment at 10 days. The number of CD31-positive cells was increased by hEPC treatment at both 5 and 10 days. In conclusion, the CP-induced disruption of endothelial cells is recovered by hEPC treatment, indicating that hEPC transplantation has potential benefits in the treatment of endothelial damage.

• Journal of the Korean Society of Food Science and Nutrition
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• v.30 no.6
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• pp.1038-1040
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• 2001

This study was conducted to investigate the constituents of pumpkin, to develop of health food using pumpkin. Crude protein contents of skin (19.82%) and fiber (16.43%) were higher than that of flesh. Crude lipids contents of skin (2.84% ) was higher than those of flesh and fiber. Major free sugars in pumpkin were sucrose, fructose and glucose. Total sugar contents in the flesh was higher than that of fiber. This tendency was opposite to reducing sugar contents. Also, free sugar contents in pumpkin were flesh (30.19 mg/100 g), fiber (22.99 mg/100 g) and skin (15.67 mg/100 g), respectively. The total Phenol and carotenoid contents in 100 g of fiber revealed 379.8$\pm$9.76 mg and 43.71$\pm$1.46 mg, corresponding to 47% and 62% of the total phenol and carotenoid contents of pumpkin. Total flavonoid content in 100 g of skin revealed 81.5$\pm$3.56 mg.

• Geotechnical Engineering
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• v.14 no.1
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• pp.109-126
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• 1998

The use of fly ash as a contaminant barrier material was studied. Mixing ratio of fly ash to bentonite to meet the requirements for landfill liners was determined. The hydraulic behavior exhibited by the fly ash-bentonite liner and the effects of CaO were investigated through hydraulic conductivity tests under various conditions and microscopic analyses including XRD, SEM, helium porosimetry, and image analysis. The hydraulic conductivity of compacted fly ash decreased with the addition of bentonite, which was due mainly to the expanding of bentonite and partly to the filling of voids by chemical reaction products among constituents of the artificial liner. Because of insufficient CaO content, and rich in content but low-reactive $SiO_2$ contained in the fly ashes used, pozzolanic reaction and resulting effects in the artificial liner were not significant. The reactions among constituting materials and their resulting effects on hydraulic conductivity were controlled not by the apparent amounts of each constituent, but by reaction activities of the materials in the artificial liner.

• Korean Journal of Environment and Ecology
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• v.31 no.2
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• pp.188-201
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• 2017

Based on a total of 272 vegetation data collected by the ZM school phytosociological study method, the composition and structural characteristics of the forest vegetation in the Sogwang-ri forest genetic resource reservoir located in Uljin-gun, Gyeongsangbuk-do were compared using the table comparison method and the TWINSPAN method, And their ecological characteristics were analyzed. The types of forest vegetation were classified into 7 types, and it was divided into two major groups, 'Slope and Ridge type', which characterized by Quercus mongolica, Pinus densiflora for. erecta, Lespedeza bicolor etc. and 'valley and concave slope', which characterized by Cornus controversa, Fraxinus mandshurica, Morus bombycis, Hydrangea serrata for. acuminata etc. The hierarchy of the vegetation unit was 2 community groups, 4 communities, and 6 subcommunities. The structural characteristics such as the total percent cover, species importance value, species diversity of the constituent species per unit area($/100m^2$) of each type of forest vegetation were also identified. In order to understand the spatial distribution of forest vegetation, 1/5,000 large-scale physiognomic vegetation map was created by the uppermost dominant species. The composition and structural characteristics of Geumgang pine(P. densiflora for. erecta) forest, which is a core community of protected area by natural and anthropogenic influences, appear as a subtype of Quercus mongolica forest, which is a potential natural vegetation, Appropriate maintenance measures seemed urgently needed.