• Preventive Nutrition and Food Science
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• 제18권3호
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• pp.169-174
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• 2013

The acute and subacute hypoglycemic and antihyperglycemic effects of drinkable ripe onion juice (Commercial product name is "Black Onion Extract") were investigated in normal and streptozotocin-induced diabetic rats. For tests of acute and subacute hypoglycemic effects, ripe onion juice (5 and 15 mL/kg b.w.) was administered by oral gavage to normal Sprague Dawley rats and measurements of fasting glucose levels and oral glucose tolerance tests were performed. Tolbutamide was used as a reference drug at a single oral dose of 250 mg/kg b.w. To test anti-hyperglycemic activity, the ripe onion juice was administered to streptozotocin-induced diabetic rats by oral gavage at single dose of 15 mL/kg b.w. per day for 7 consecutive days. Oral administration of the ripe onion juice at either dosed level of 5 or 15 mL/kg b.w. showed no remarkable acute hypoglycemic effect in normal rats. The two dosed levels caused a relatively small reduction, only 18% and 12% (5 and 15 mL/kg b.w., respectively) decrease in glucose levels at 2 h after glucose loading in normal rats. However, at 3 h after glucose loading, blood glucose levels in the ripe onion juice-dosed rats were decreased to the corresponding blood glucose level in tolbutamide-dosed rats. Although showing weak hypoglycemic potential compared to that of tolbutamide, oral administration of ripe onion juice (15 mL/kg b.w.) for a short period (8 days) resulted in a slight reduction in the blood glucose levels that had elevated in Streptozotocin-induced diabetic rats. In conclusion, these results suggest that the commercial product "Black Onion Extract" may possess antihyperglycemic potential in diabetes.

• 대한기계학회논문집A
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• 제41권8호
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• pp.745-750
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• 2017

본 연구에서는 두께 $12{\mu}m$의 구리박막에 대한 인장시험을 수행하였으며, 변위 측정은 디지털이미지를 기반으로 한 디지털이미지상관법을 이용하였다. 일반적인 디지털이미지상관법에서 시험편 표면의 큰변형으로 인해 변형률계산에 큰 오차가 발생하는 문제점을 개선하여, 시험편 전영역에 걸쳐 정밀하게 변형률을 계산할 수 있었으며 직접 시험편의 표면에서 변형률을 정확하게 측정할 수 있었다. 계산된 시험편 표면의 변형률 분포는 일반적인 벌크소재의 시험편에서와는 달리 전체적으로 균일하지가 않고 그 변화폭이 매우 크며, 항복응력이하의 탄성범위에 있는 경우에도 변형률분포는 균일하지 않다. 이것은 구리박막의 전해증착 제조공정에서 발생한 시험편의 거칠기가 비교적 큰 영향을 준 것으로 판단된다.

• Clinics in Shoulder and Elbow
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• 제25권1호
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• pp.57-64
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• 2022

Background: There are various conservative treatment options for lateral epicondylitis (LE). The aim is to evaluate pain, daily functioning, and complications after ultrasound-standardized autologous blood injections in patients with LE. Methods: For this prospective cohort study, consecutive patients (>18 years) diagnosed with LE were included. Autologous blood was injected using a medical device containing an injection disposable with 12 small needles (Instant Tennis Elbow Cure [ITEC]) device. Patient-Rated Tennis Elbow Evaluation (PRTEE), subjective elbow score (SES), palpation and provocation pain, satisfaction, and complications of treatment were measured at baseline and two months after treatment. Paired t-tests and Fisher's exact tests were used for calculating the difference between pre- and post-treatment outcomes. Results: Fifty-five elbows were analyzed. Mean time between pre- and post-treatment was 11.1 weeks (standard deviation [SD], 8.9 weeks). The mean PRTEE score decreased from 68.2 (SD, 15.7) before surgery to 53.2 (SD, 25.9; p<0.001) after. The mean SES improved from 36.9 (SD, 20.8) to 51.7 (SD, 27.4; p<0.001). Despite this improvement, only 44.7% of patients showed relevant clinical improvement in PRTEE, and 37.3% showed significant clinical improvement based on SES. Four patients reported a complication and the injection disposable failed three times. Conclusions: Ultrasound-standardized autologous blood injection using the ITEC device is not an effective tool in reducing symptoms related to LE. This study showed that only half of all patients experienced a positive effect. In this heterogeneous cohort of patients, we showed no added value of ultrasound standardization.

• 운동영양학회지
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• 제23권3호
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• pp.13-21
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• 2019

[Purpose] Chronic stress is a precipitating factor for depression, whereas exercise is beneficial for both the mood and cognitive process. The current study demonstrates the anti-depressive effects of regular exercise and the mechanisms linked to hippocampal neurogenesis. [Methods] Mice were subjected to 14 consecutive days of restraint, followed by 3 weeks of treadmill running, and were then subjected to behavioral tests that included the forced swimming and Y-maze tests. Protein levels were assessed using western blot analysis and newborn cells were detected using 5-bromo-2'-deoxyuridine (BrdU). [Results] Three weeks of treadmill running ameliorated the behavioral depression caused by 14 days of continuous restraint stress. The exercise regimen enhanced BrdU-labeled cells and class III β-tubulin levels in the hippocampal dentate gyrus, as well as those of thioredoxin-1 (TRX-1) and synaptosomal β2-adrenergic receptors (β2-AR) under stress. In vitro experiments involving treatment with recombinant human TRX-1 (rhTRX-1) augmented the levels of phospho-extracellular signal-regulated kinases 1 and 2 (ERK1/2), nuclear β-catenin, and proliferating cell nuclear antigens, which were previously inhibited by U0216 and FH535 (inhibitors of ERK1/2 and β-catenin/T cell factor-mediated transcription, respectively). The hippocampal neurogenesis elicited by a 7-day exercise regimen was abolished by a selective inhibitor of β2-AR, butoxamine. [Conclusion] These results suggest that TRX-1-mediated hippocampal neurogenesis by β2-AR function is a potential mechanism underlying the psychotropic effect of exercise.

• 대한약리학회지
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• 제10권2호
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• pp.25-29
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• 1974

The present clinical trial was performed to evaluate the anthelminthic effect and tolerance of Oxantel pamoate, a new antiwhipworm agent, in the treatment of T. trichiurus infection. Oxantel pamoate oral suspension was administered as a sing1e dose of 10 mg per kg. body weight to a total of 46 T. trichiurus infected cases selected out of 64 positives, by examining 89 fecal specimens collected from the soldiers and in-patients of xx Armed Forces General Hospital. For the evaluation, the negative conversion rate (cure rate) and the egg reduction rate were assessed 22 days after the treatment. The result obtained were as follows: 1. The prevalence rate of T. trichiurus infection in this study was 71.9%, while the mean E.P.G. of 46 treated cases was 126. 2. The egg negative conversion rate was 91.3%, and 98.4% of egg reduction rate was obtained. 3. From the observation of 107 worms expelled during 3 consecutive days after the treatment, it was known that sex ratio of male and female was about 1 : 2 and that average worm burden per capita was 2.3. 4. In all treated cases, the medication was readily accepted and well tolerated. On the hemograms, urinalysis and liver function tests, no significant differences were noted before and after the drug administration. There was also no detectable objective and subjective side effect.

• 한국통신학회논문지
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• 제24권6B호
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• pp.1191-1202
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• 1999

본 논문에서는 간단히 한국통신학회본 논문에서는 웨이브렛 영역에서의 질감 유사성을 특징으로 사용함으로써 프레임간의 급격한 밝기변화에 강건한 특성을 가지는 툴게이트 과금을 위한 차량검지 및 차종분류 알고리듬을 제안하였다. 질감의 유사성을 나타내는 특징으로는 웨이브렛 변환된 입력영상과 배경영상 간의 국부상관계수를 이용하였다. 기존의 차량검지에서 사용되었던 특징인 차영상에 대한 분산과 비교하여 제안된 특징의 유용성을 정상적으로 분석하였으며, 실제 테스트 영상에 대하여 차량과 그림자가 관측되거나 관측되지 않는 도로와의 구분 용이성 정도를 측정함으로써 제안된 특징의 우수성을 보인다. 현장 테스트에 대한 실험 결과는 제안된 차량검지 및 차종분류 알고리듬이 센서의 특성과 그림자의 발생에 의한 프레임 간의 급격한 밝기 변화와 같은 상황하에서도 매우 안정적이며 우수한 성능을 보이는 것을 확인할 수 있다.

• Nutrition Research and Practice
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• 제5권3호
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• pp.230-235
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• 2011

Insomnia has become a major public health issue in recent times. Although quality of sleep is affected by environmental, psychophysiological, and pharmacological factors, diet and nutrient intake also contribute to sleep problems. This study investigated the association between nutrient intake and co-morbid symptoms associated with sleep status among selected adults. Subjects in this study included 87 men and women aged 21-45 years. Presence of insomnia was assessed using the Insomnia Screening Questionnaire, and dietary intake was measured over three consecutive days by dietary survey. Descriptive analysis, ANOVA, and Chi-Square tests were performed to compute and interpret the data. Approximately 60% of the participants were insomniacs. People with insomnia consumed significantly lesser quantities of nutrients as compared to normal sleepers. Differences in intakes of energy, carbohydrates, folic acid, and $B_{12}$ were highly significant (P < 0.002). Further, intakes of protein, fat, and thiamine were significantly different (P < 0.021) between insomniacs and normal sleepers. The nutrient intake pattern of the insomniacs with co-morbid symptoms was quite different from that of the normal sleepers. Based on these results, it is probable that there is an association between nutrition deficiency, co-morbid symptoms, and sleep status. More studies are required to confirm these results.

• Asian-Australasian Journal of Animal Sciences
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• 제18권9호
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• pp.1231-1236
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• 2005

Genetic parameters for first lactation milk production based on test day (TD) records of 56319 Iranian Holstein cows from 655 herds that first calved between 1991 and 2001 were estimated with restricted maximum likelihood method under an Animal model. Traits analyzed were milk yield and milk fat percentage. Heritability for TD records were highest in second half of the lactation, ranging from 0.11 to 0.19 for milk yield and 0.038 to 0.094 for milk fat percentage respectively. Estimates for lactation records for these traits were 0.24 and 0.26 respectively. Genetic correlations between individual TD records were high for consecutive TD records (>0.9) and decreased as the interval between tests increased. Estimates of genetic correlations of TD yield with corresponding lactation yield were highest (0.78 to 0.86) for mid-lactation (TD3 to TD8). Phenotypic correlations were lower than corresponding genetic correlations, but both followed the same pattern. For milk fat percentage no clear pattern was found. Results of this study suggested that TD yields especially in mid-lactation may be used for genetic evaluation instead of 305-day yield.

• The Journal of Korean Physical Therapy
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• 제29권3호
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• pp.142-144
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• 2017

Purpose: Few studies have addressed the effect of diurnal circadian rhythms on postural stability, and thus the aim of the present study was to examine circadian effects on static and dynamic postural stability in young adults. Methods: Twenty-four subjects (9 men, 11 women: age=$22.20{\pm}1.77$, height=$167.20{\pm}10.47$, weight=$59.85{\pm}10.66$) from a university community volunteered for this study. Static and dynamic balance testing, which recorded using a Good Balance system (Good Balance, Metitur Ltd, Finland) was conducted at 9:00, 13:00, and 17:00 hours on two consecutive days, and the sequencing of static and dynamic balance tests were randomized. Results were analyzed using the non-parametric one-way repeated Friedman test in SPSS version 18.0 (SPSS Inc., Chicago, IL, USA), and variable found to be significant were subjected to Wilcoxon post hoc testing. Results: Static and dynamic balance showed significant difference at the three times assessments (test at 9:00, 13:00, and 17:00) during circadian. In the post hoc test of static (anteroposterior distance, mediolateral distance and COP (center of pressure) velocity) and dynamic balance (performance time), 13:00 was the longer and faster than 9:00. Conclusion: These results indicated that control of postural balance is influenced by diurnal circadian rhythms, and confirm that control of postural balance is more effective and better performance in the 09:00 hours than 13:00 hours or 17:00 hours.

• 상하수도학회지
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• 제22권4호
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• pp.405-409
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• 2008

This technical paper is proposing a sound concept in the application of the rehabilitation method of the water supply steel pipe in the large diameter ranged from 1,800mm to 3,500mm. There were conducted the experimental tests for the specimens as well as the real steel pipe of diameter 2,200mm. The water pressure ejected from nozzle tip should be at least 2,500bar to have the satisfied surface profiles required in the design criterion. The most difficult thing is to keep the water pressure at the nozzle tip as 2,500bar during the consecutive work in the interval of the work site more than 1km. It is found that the method suggested in this study is adequate method to meet the specified design criteria. The results of this study provide the useful information how to setup the equipments for the successful work. This method also provides not only the omission of the blasting process but also the effect of the budget reduction.