• 대한수학회논문집
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• 제37권4호
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• pp.1025-1039
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• 2022

For given non-negative real numbers 𝛼_k with ∑^m_k=1 𝛼_k = 1 and normalized analytic functions f_k, k = 1, …, m, defined on the open unit disc, let the functions F and Fn be defined by F(z) := ∑^m_k=1 𝛼_kf_k(z), and F_n(z) := n^-1 ∑^n-1_j=0 e^-2j𝜋i/nF(e^2j𝜋i/nz). This paper studies the functions f_k satisfying the subordination zf'_k(z)/F_n(z) ≺ h(z), where the function h is a convex univalent function with positive real part. We also consider the analogues of the classes of starlike functions with respect to symmetric, conjugate, and symmetric conjugate points. Inclusion and convolution results are proved for these and related classes. Our classes generalize several well-known classes and the connections with the previous works are indicated.

• Biotechnology and Bioprocess Engineering:BBE
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• 제6권4호
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• pp.293-300
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• 2001

A polyrotaxane-biotin conjugate was synthesized and its interaction with streptavidin measured using surface plasmon resonance(SPR) detection. A biodegradable polyrotaxane in which ca, 22 molecules of ${\alpha}$-cyclodextrina(${\alpha}$-CDs) were threaded onto a poly(ethylene oxide) chain(M$\sub$n:4,000) capped with benzyloxycarbonyl-L-phenylalanine was conjugated with a biotin hydorazide and 2-aminoethanol after activing the hydroxyl groups of ${\alpha}$-CDs in the polyrotaxane using N, N'-carbonyldiimidazole. The results of the high-resolution $^1$H-nyclear lmagnetic resonance($^1$H-NMR)spectra and gel permeation chromatography of the conjugate showed that ca, 11 biotin molecules were actually introduced to the polyrotaxane scaffold. An SPR analysis showed that the binding curves of the biotin molecules in the conjugate on the streptavidin-deposited surface changed in a concentration dependent manner, indicating that the biotin in the conjugate was ac-tually recognized by streptavidin. The association equilibrium constant(K$\sub$a/) of the interaction be-tween the conjugate and steptavidin tetramer was of the order 10$\^$7/. These results suggest that polyrotaxane is useful for scaffolds as a polymeric ligand in biomedical fields.

• 한국음향학회지
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• 제20권3호
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• pp.8-14
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• 2001

본 논문에서는 부밴드 적응 필터 구조에서 음향 신호에 부가된 잡음을 제거하기 위한 새로운 비용함수와 블록 공액 경사 알고리듬을 제안하였다. 제안한 비용함수를 위하여 부밴드로 나뉘는 신호를 블록으로 구성한 후 각 대역에서의 신호를 하나의 블록으로 조합하였다. 이러한 과정을 통해 제시된 비용함수는 부밴드 적응 필터 구조에서 적응 필터에 대한 2차 형식을 가짐으로서 제안한 알고리듬의 수렴성이 보장되었다. 또한 제안한 비용함수를 최소화하는 알고리듬으로 사용한 부밴드 블록 공액 경사 알고리듬은 전대역 블록 공액 경사 알고리듬에 비해 잡음제거 성능이 뛰어난 것을 컴퓨터 모의 실험으로 확인하였다.

• 대한기계학회논문집
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• 제9권4호
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• pp.430-439
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• 1985

본 연구에서는 유한차분법을 사용하여 지배방정식의 수치해를 구하였으며, 특 히 유체와 고체 사이의 접촉면조건에서 correlation인자를 도입하여 K/$_{s}$/ $K_{f}$ 비가 큰 값에서는 수치해를 얻을 수가 있었다. 그리고 실험에서 여러가지 $K_{s}$/ $K_{f}$값에 대하여 온도를 측정하였으며, 여기서 계산치와 비교하면서 correlation인 자의 신뢰도를 조사하였다. 수평 이중 환상밀폐공간에서 유선 및 등온선을 여러가지 무차원 변수에 대하여 나타내었다. 등가 열전도도(equivalent conductivity)를 정의 하여 도입하고 $K_{s}$/ $K_{f}$값 중간 셸 두께, Prandtl 그리고 Rayleigh수에 대한 영향을 조사하여 이중 밀폐공간에서의 conjugate 자연대류 열전달특성을 연구하였다..였다..

• Journal of Mechanical Science and Technology
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• 제20권10호
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• pp.1741-1752
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• 2006

A combined Streamline Upwind Petrov-Galerkin method (SUPG) and segregated finite element algorithm for solving conjugate heat transfer problems where heat conduction in a solid is coupled with heat convection in viscous fluid flow is presented. The Streamline Upwind Petrov-Galerkin method is used for the analysis of viscous thermal flow in the fluid region, while the analysis of heat conduction in solid region is performed by the Galerkin method. The method uses the three-node triangular element with equal-order interpolation functions for all the variables of the velocity components, the pressure and the temperature. The main advantage of the presented method is to consistently couple heat transfer along the fluid-solid interface. Four test cases, which are the conjugate Couette flow problem in parallel plate channel, the counter-flow in heat exchanger, the conjugate natural convection in a square cavity with a conducting wall, and the conjugate natural convection and conduction from heated cylinder in square cavity, are selected to evaluate efficiency of the presented method.

• Nuclear Engineering and Technology
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• 제55권5호
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• pp.1802-1813
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• 2023

Conjugate heat transfer between liquid metal and solid is a common phenomenon in a liquid-metal-cooled fast reactor's fuel assembly and heat exchanger, dramatically affecting the reactor's safety and economy. Therefore, comprehensively studying the sophisticated conjugate heat transfer in a liquid-metal-cooled fast reactor is profound. However, it has been evidenced that the traditional Simple Gradient Diffusion Hypothesis (SGDH), assuming a constant turbulent Prandtl number (Pr_t,, usually 0.85 - 1.0), is inappropriate in the Computational Fluid Dynamics (CFD) simulations of liquid metal. In recent decades, numerous studies have been performed on the four-equation model, which is expected to improve the precision of liquid metal's CFD simulations but has not been introduced into the conjugate heat transfer calculation between liquid metal and solid. Consequently, a four-equation model, consisting of the Abe k - ε turbulence model and the Manservisi k_𝜃 - ε_𝜃 heat transfer model, is applied to study the conjugate heat transfer concerning liquid metal in the present work. To verify the numerical validity of the four-equation model used in the conjugate heat transfer simulations, we reproduce Johnson's experiments of the liquid lead-bismuth-cooled turbulent pipe flow using the four-equation model and the traditional SGDH model. The simulation results obtained with different models are compared with the available experimental data, revealing that the relative errors of the local Nusselt number and mean heat transfer coefficient obtained with the four-equation model are considerably reduced compared with the SGDH model. Then, the thermal-hydraulic characteristics of liquid metal turbulent pipe flow obtained with the four-equation model are analyzed. Moreover, the impact of the turbulence model used in the four-equation model on overall simulation performance is investigated. At last, the effectiveness of the four-equation model in the CFD simulations of liquid sodium conjugate heat transfer is assessed. This paper mainly proves that it is feasible to use the four-equation model in the study of liquid metal conjugate heat transfer and provides a reference for the research of conjugate heat transfer in a liquid-metal-cooled fast reactor.

• Journal of Pharmaceutical Investigation
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• 제27권1호
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• pp.1-10
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• 1997

For the purpose of improving the chemotherapeutic index of acyclovir(ACV), it was conjugated with asialofetuin(AF), which has been reported to enter into hepatocytes. When $[H^3]$ acyclovir in itself or its conjugate were administered to rats, the latter was taken up more selectively by the liver than any other tissues. The stability of ACVMP-AF conjugate in phosphate buffer (pH 5.0) and rat liver homogenate showed a pseudo-first order profile. ACVMP-AF, however, was relatively stable in pH7.4 phosphate buffer and rat plasma. The conjugate was added to the isolated rat hepatocyte and cellular uptake was monitored by scintillation counting for up to 6 hours at $37^{\circ}C$. Hepatocytes incubated with the conjugate exhibited radioactivities significantly enhanced over control levels dose-dependently, i.e., a 3-40 fold increase in radioactivities was observed over controls at the conjugate concentrations of $0.1-10\;{\mu}g/ml$. The AUQ in the liver, kidney, spleen, intestine and lung was higher in treatment with ACVMP-AF than that in treatment with ACV. In treatment with ACVMP-AF, the weighted-average overall drug targeting efficiency(Te) for the liver was higher than in treatment with ACV(57.00 vs 13.31 %), and the weighted-average tissue exposure(Re) was 5.03 for the liver. These results indicated that ACVMP-AF conjugate was rapidly taken up by hepatocytes and could be an efficient and selective hepatic targeting system.

• Journal of Microbiology and Biotechnology
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• 제29권11호
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• pp.1799-1805
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• 2019

Doxorubicin (DOX) is one of the most effective anticancer agents used for the treatment of multiple cancers; however, its use is limited by its short half-life and adverse drug reactions, especially cardiotoxicity. In this study, we found that the conjugate of DOX with APTA12 (Gemcitabine incorporated G-quadruplex aptamer) was significantly more cancer selective and cytotoxic than DOX. The conjugate had an affinity for nucleolin, with higher uptake and retention into the cancer cells than those of DOX. Further, it was localized to the nucleus, which is the target site of DOX. Owing to its mechanism of action, DOX has the ability to intercalate into the nucleotides thus making it a suitable drug to form a conjugate with cancer selective aptamers such as APTA12. The conjugation can lead to selectively accumulate in the cancer cells thus decreasing its potential nonspecific as well as cardiotoxic side effects. The aim of this study was to prepare a conjugate of DOX with APTA12 and assess the chemotherapeutic properties of the conjugate specific to cancer cells. The DOX-APTA12 conjugate was prepared by incubation and its cytotoxicity in MCF-10A (non-cancerous mammary cells) and MDA-MB-231 (breast cancer cells) was assessed. The results indicate that DOX-APTA12 conjugate is a potential option for chemotherapy especially for nucleolin expressing breast cancer with reduced doxorubicin associated side effects.

• BMB Reports
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• 제48권9호
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• pp.501-506
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• 2015

Based on the potential beneficial effects of growth hormone releasing peptide (GHRP)-6 on muscle functions, a newly synthesized GHRP-6-biotin conjugate was tested on cultured myoblast cells. Increased expression of myogenic marker proteins was observed in GHRP-6-biotin conjugate-treated cells. Additionally, increased expression levels of insulin-like growth factor-1 and collagen type I were observed. Furthermore, GHRP-6-biotin conjugate-treated cells showed increased metabolic activity, as indicated by increased concentrations of energy metabolites, such as ATP and lactate, and increased enzymatic activity of lactate dehydrogenase and creatine kinase. Finally, binding protein analysis suggested few candidate proteins, including desmin, actin, and zinc finger protein 691 as potential targets for GHRP6-biotin conjugate action. These results suggest that the newly synthesized GHRP-6-biotin conjugate has myogenic stimulating activity through, at least in part, by stimulating collagen type I synthesis and several key proteins. Practical applications of the GHRP-6-biotin conjugate could include improving muscle condition. [BMB Reports 2015; 48(9): 501-506]

• 한국의류학회지
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• 제1권1호
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• pp.25-29
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• 1977

The warmth retentivity of natural and syntheic waddings as bedding stuff, and further, the machanism of heat transmission through conduction, radiation and convection were analysed. The materials used were cotton, silk, and wool as natural waddings, and polyamide, polyester, regular acrylic, conjugate acrylic, regular polyprepylene and conjugate polypropylene as synthetic waddings. The results of this study are as follow: 1. The warmth retentivity is highest in silk. Following silk in descending order is cotton, conjugate acrylic, polyester, regular acrylic, wool, polyamide, conjugate polypropylene and regular polypropylene. There is not any significant relationship between warmth retentivity and the conductivity of the fibers. 2. Transmission by radiation through the fiber waddings is highest in conjugate polypropylene. Following conjugate polypropylene in descending order is regular polypropylene. polyester. polyamide, conjugate acrylic, regular acrylic, wool, cotton, and silk. This is seen to be in nearly reversed order to the abovementioned order of warmth retentivity. In this respect, warmth retentivity with loose fibreous material as in the case of bedding stuff is primarily affected by the interceptive function of the fibers in heat radiation. 3. Warmth retentivity becomes lower with increasing air content of the waddings. This is because heat transmission by radiation incrases as air content increases. The air content increase is due to the fact that the air is unable to intercept heat radiation. In addition, heat transmission accelates in proportion to the increase in convection as the air gap enlarges.