• 대한수의학회지
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• 제37권4호
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• pp.855-862
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• 1997

Ivermectin is a synthetic derivative of the naturally occurring avermectin $B_{1a}$ (22, 23-dihydroavermectin $B_{1a}$) and $B_{1b}$ (22, 23-dihydroavermectin $B_{1b}$), It is widely used as antiparasitic and pesticidal agents because of its remarkably potent and broad spectrum of antiparasitic activity. Although the drug has shown excellent anthelmintic effects, development of toxicosis in some animals such as the Collie species of dog is well documented. However, no studies have been reported on the toxic effects of the drug in Korean native animals such as the Jindo dog. The toxic effect of ivermectin was evaluated in 25 Jindo dogs divided into five groups which were orally administered with ivermectin at dosage levels of $200{\mu}g/kg$, $300{\mu}g/kg$, $600{\mu}g/kg$ and $2,500{\mu}g/kg$ of body weight, respectively. Toxic signs were not observed in the groups receiving $200{\mu}g/kg$ and $300{\mu}g/kg$ B.W. ivermectin. One dog developed mild clinical signs of toxicosis in the group receiving $600{\mu}g/kg$ dosage of ivermectin. In the group with $2,500{\mu}g/kg$ dosage, all dogs developed mild (salivation, drooling, vomiting, mydriasis, and/or confusion) and/or moderate (ataxia and tremors) clinical signs of toxicosis. Hematologic changes were not observed in the groups receiving $200{\mu}g/kg$, $300{\mu}g/kg$ and $600{\mu}g/kg$ B.W. ivermectin. In the groups receiving $2,500{\mu}g/kg$ B.W., total erythrocyte counts, total and differential leukocyte counts and hemoglobin levels were not affected by drug. Aspartate aminotransferase levels were increased after administration of ivermectin, while serum cholesterol and blood glucose levels were decreased.

• 한국환경보건학회지
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• 제43권3호
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• pp.202-213
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• 2017

Objectives: HRA (Health Risk Assessment) is an important tool for measuring the health impacts of air pollution. HRA is already being used widely as an important reference for crafting air pollution policies. However, the absence of a domestic CRF (Concentration Response Function) standard, which is a main component for HRA, could cause confusion amongst policy-makers. The purpose of this study is to tabulate a domestic CRF standard for a PM (Particulate Matter)-related HRA. Methods: This study suggested a domestic CRF standard for HRA thorough a literature review. The literature review for meta-analysis was limited to the English language for epidemiological studies published from January 1980 to March 2016. This meta-analysis was conducted by assuming both fixed- and random-effects of CRF. In addition, studies that reported HRA of air pollution for WHO (World Health Organization), the EC (European Commission), and the EPA (Environmental Protection Agency) were reviewed to compare the CRFs of South Korea to the recommended CRFs of WHO, the EC, or the EPA. Additionally, a domestic CRF standard was supplemented by these. Results: Nineteen studies were selected for the CRF for South Korea. Fifty-three CRFs were derived for meta-analysis. CRFs with a standard for PM-related HRA were divided according to the following four criteria: air pollution, exposure characteristics, type of health impact, and age group. Finally, a domestic CRF standard was created comprised of 21 CRFs. Among these, six CRFs were derived from the results of foreign HRA studies. Conclusions: This study is important in that a domestic CRF standard is first suggested. In addition, this study suggests a further area of study for using HRA as a policy tool and a direction of epidemiological study.

• 가족자원경영과 정책
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• 제17권3호
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• pp.125-144
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• 2013

This aim in this study is to investigate the meaning of case management and management in general from the case manger's perspective, as well as case mangers' abilities and networks. We also propose a development direction for the establishment of a local integrated family-centered community management system. Regarding the collection of qualitative data, focus group interviews (FGIs) were conducted with 11 case managers from social welfare organizations in the city of C. The interviews consisted of open-ended questions in the following four categories: understanding of case management, case managers' abilities, case management environments, and local community networks. According to the interview analysis, a total of 16 subcategories in 9 categories and 4 domains have been identified. Due to the ambiguity regarding the concept of case management, case management was completely dependent upon individual case managers' abilities. In particular, family-centered case management was found to exist in several organizations in the same region. In terms of case management environments, the following problems have been observed: absence of related departments and staff, confusion regarding performance evaluation standards, limitations in sharing information among organizations, limitations in resource exploration and management, redundant support, and an uncomfortable relationship between the private and public sector. Horizontal exchange and cooperation among organizations are essential to establish and facilitate a local community network. After all, to establish a local family-centered community case management system, the roles of a Healthy Families Center and a Multi-cultural Family Support Center as parts of a family-centered transfer system should be fully emphasized in local society, and the performance of family-centered case management should be developed.

• 산업융합연구
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• 제20권4호
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• pp.57-69
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• 2022

본 연구는 COVID-19 상황에서 기본간호학 실습 교과목의 블렌디드 러닝 수업에 대한 경험을 이해하고자 시도된 질적연구이다. 간호대학생 18명이 참여한 본 연구는 포커스그룹 인터뷰를 통해 자료수집을 진행하였으며, 블렌디드 러닝 수업의 운영은 홀수주차는 비대면 온라인 학습, 짝수주차는 대면실습 방식으로 구성하여 14주차 까지 진행 되었고, 수집된 자료는 내용분석 방법을 활용하여 분석되었다. 분석결과 총 250개의 진술이 유의미하게 추출되었고, 8개의 하위범주와 4개의 상위범주, 2개의 주제로 분석되었다. 도출된 4개의 상위범주는 '갑작스러운 수업방식 변경에 대한 부적응', '학습 능률 저하와 수업의 혼돈', '온라인 수업에 대한 양가감정', '새로운 학습법에 대한 긍정적인 경험' 으로 진술되었다. 본 연구는 온택트 시대 간호대학생을 위한 기본간호학 실습 블렌디드 러닝수업에 관련한 유용한 정보를 제공함으로써 블렌디드 러닝 수업 운영 프로그램 개발, 다양한 실습교과목 적용을 위한 기초자료를 제공할 수 있을 것이다.

• 산업과 과학
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• 제1권2호
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• pp.9-16
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• 2022

본 연구는 이완음악감상이 입원한 정신질환자의 기분상태 및 자율신경계 즉 심박동수에 미치는 영향을 파악하고자 실험군 17명, 대조군 17명을 대상으로 시행한 무작위 대조군 전후설계이다. 수집된 자료는 SPSS V15.0으로 분석하였다. 기분상태와 자율신경계 즉 심박동수는 두 집단 간에 통계적으로 유의한 차이가 있어 이완음악감상의 효과를 객관적으로 검증하였다(<.05). 기분상태의 하위 영역 중 분노(>.39)와 혼돈(>.33)을 제외한 긴장(<.00), 우울(<.00), 활력(<.03), 피로(<.01)에서 유의한 차이가 있는 것으로 나타나 입원한 정신질환자에게 적용할 수 있는 효과적인 중재방법임을 입증하였다. 향후 장기적인 중재 연구개발 및 적용과 개인의 선호음악을 이용하여 기분변화와 자율신경계에 효과연구를 제언하고자 한다.

• 아태비즈니스연구
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• 제15권1호
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• pp.289-304
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• 2024

Purpose - Focusing on the FGI research method, the current status and issues of barrier-free tourism in Gangwon State were identified, and specific activation plans were derived Design/methodology/approach - This study conducted in-depth interviews with 20 experts related to the tourism industry. The issues, current status, and activation plan of barrier-free tourism in Gangwon State recognized by experts in tourism policy, tourism administration, tourism management, and tourism service industry were derived. Findings - First, the tendency of businesses to be promoted based on the non-disabled by not recognizing the weak as the main tourism demand group, second, confusion caused by the unification of terms related to barrier-free tourism, third, lack of finding tourism constraints subdivided according to the type and degree of disability, fourth, tourism information and evaluation indicators provided by prioritizing the convenience of suppliers rather than consumers, and fifth, the nature of the project focused on improving access to physical infrastructure. Subsequently, the results of the analysis of the plan to revitalize the barrier-free tourism industry in Gangwon State were as follows. First, education and programs to improve disability awareness appropriate to local conditions were activated, second, related information was unified and project sustainability was improved by creating a control tower for the barrier-free tourism industry at the provincial level, third, to overcome the employment crisis based on finding locally tailored jobs related to tourism care professionals, and fourth, to continuously secure quantitative and qualitative data and establish utilization plans. Research implications or Originality - First, it presents theoretical implications for related fields by providing issues and activation measures related to barrier-free tourism from the perspective of experts who are still lacking in research in academia. The practical implications are that based on the opinions of experts working in the tourism field, more specific issues of the barrier-free tourism industry in the province were presented, and policy and practical solutions were presented accordingly, suggesting realistic alternatives that can be carried out in the actual field.

• 인지과학
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• 제19권2호
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• pp.163-175
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• 2008

한국에 거주하는 일본인 12명을 대상으로 한국어 초성 자음에 대한 지각적 혼동을 조사하여 그들이 한국어 자음을 지각할 때 사용하는 심리적 차원과 특질들을 추출하였다. 개음절들은 비소음(no noise) 조건과 소음 조건에서 제시되고 참여자들은 그 정체를 파악하였다. 실험 결과로 자음들 간의 혼동 행렬(confusion matrix)을 구성하였고 이 행렬 자료로 가산 군집 분석, 개별차이 척도법 및 정보 전달율을 계산했다. 가산 군집 분석 결과, 비소음 조건에서 일본인들은 '다 타'를 가장 유사한 소리로 지각했으며, '가 카', '자 차 짜', '타 따', '파 빠', '사 싸' 순으로 지각적 군집을 형성하였다. 소음 조건에서는 '가 다 바', '마 바', '차 카 타 파' 등 10개의 군집이 추출되었는데, 이 군집들은 같은 청취 조건에서 '싸 짜', '다 자', '파 하' 등 발성 유형(공명, 이완, 기식, 긴장)이 같고 조음 방법이 다른 음소들을 유사한 소리로 지각한 한국인의 군집들과 큰 차이를 보였다. 개별차이 척도법을 적용한 결과, 소음 조건에서 공명음을 포함한 이완음과 나머지 음소를 구분하는 차원(이완성 차원), 기식성의 정도와 관련된 차원(기식성 차원) 및 조음 위치(설정음과 주변음)와 관련된 차원(설정성 차원)을 찾았다. 한국인이 보인 기식성과 긴장성 차원은 이원적인 값을 갖고 있었으나 일본인이 보인 차원은 연속적인 값을 가지는 것으로 드러났다. 정보 전달율을 분석한 결과, 일본인은 한국인에 비해 기식성과 긴장성의 후두 자질은 잘 지각하지 못하지만 순음성과 설정성의 조음 위치 자질은 더 잘 지각하였다. 본 연구의 결과들은 각 언어의 음소 범주를 구성하는 기저 표상의 구조적 차이로 다루는 접근의 중요성을 시사한다.

• 정신신체의학
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• 제22권2호
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• pp.87-92
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• 2014

연구목적 본 연구에서는 섬망의 오진과 관련된 임상적 특징 및 임상의를 오진으로 유도할 수 있는 증상적 특징들을 알아보고자 한다. 방 법 일 대학병원에 입원하여 정신과에 협의진료 의뢰된 환자 중, 정신건강의학과 전문의에 의해 섬망으로 진단된 256명을 대상으로 후향적으로 의무기록을 조사하였다. 협진요청서에 명시된 사유를 검토하여, 의뢰의사의 진단이 섬망인 경우 진단일치군으로 섬망이 아닌 경우 진단불일치군으로 구분하였다. 결 과 69명(27%)이 진단불일치군으로, 섬망이 아닌 다른 진단으로 협진이 의뢰되었다. 진단불일치군에서 항정신병약물의 사용, 기질성 정신질환의 과거력이 많았다. Delirium rating scale-Revised-98(DRS-R-98) 중 증상의 변동 항목의 점수가 진단일치군에서 더 높았다. 로지스틱 회귀분석결과 질환의 낮은 심각도, 항정신병약물 사용력, 적은 증상의 변동이 임상의가 섬망 외에 다른 진단을 고려하는 예측인자였다. 결 론 본 연구에서 항정신병약물을 복용중인 경우, 섬망증상의 변동이 적은 경우 오진의 위험이 높았다. 지연된 섬망의 진단과 치료는 환자의 예후에 부정적인 영향을 미칠 수 있으므로 주의 깊은 임상적 관심이 필요하다.

• 한국지역사회생활과학회지
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• 제17권4호
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• pp.81-95
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• 2006

This study was made to find out how stress affect on nutrition status of the college freshmen who were experiencing physical growth and development as well as drastic emotional change. 400 male and female freshmen in 4 year colleges were surveyed respectively through the health check-up procedure for college entrance in February, In order to find out the stress in each group frustration, deprivation, lack of self efficacy, type A behavior and anxiety response were surveyed through 10 questions with total 40 points by assigning 4 points for each question. Diet Status was expressed by DDS (Dietary Diversity Score by 5 food groups) and DVS(Dietary Variety Score). 24-hrs recall method was used to find out the quantity of daily nutrient of EAR(estimated adquacy ratio) by KDRIs(Korean Dietary Recommended Intakes). Nutrition level was analyzed by Can-Pro for professionals (Korea Nutrition Association). And for the quality intake, percentage was calculated and MAR(Mean Adequacy Ratio) were produced. Highest point was obtained in the stress of anxiety with the total 40 score of 30.20, and the scores were 29.79, 28.67, and 28.39 for deprivation, type A behavior and frustration respectively. There was no difference of blood components in accordance with stress type. Stress type was divided into less sensitive group and highly sensitive one and the relationship with the blood nutrient status was observed. The difference of blood component and blood pressure in sensitive and highly sensitive groups was observed in deprivation and anxiety. The index of blood pressure(p<0.05), hemoglobin(p<0.01), HDL-cholesterol(p<0.05), and Fe(p<0.05) was high in the deprivation of sensitive group. Blood pressure and hemoglobin was high in type A of sensitive group(p<0.05). And the contents of blood triglyceride was high in the anxiety of sensitive group(p<0.001) The result of nutrition intake analysis according to stress type showed that there was low intake for energy, riboflavin, and niacin. When the degree of deprivation was high there was a lack of riboflavin intake and there was no significant difference of nutrition intake in lack of self efficacy, type A behavior and anxiety response. Thus, it is necessary for colleges to educate the students to maintain mental stability through various programs and activities after catching a kind and extent of the stress college students we meeting with like the confusion of value system, open heterosexual relationship, and the employment difficulties linked with political uncertainty and economic recession.

• 대한예방한의학회지
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• 제8권1호
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• pp.59-74
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• 2004

We have conducted questionnaire and measured serum liver function tests on 153 patients whom have received a treatment at a local Oriental medicine clinic in Seoul from Sept. 1, 2002 to Dec. 31, 2002. Patients were categorized into the groups of control(10), decoction group(41), herbal group(5), western medicine group(45), and the group taking both herbal and western medicines(55) concurrently or separately. This study was conducted to investigate how these treatment methods can affect the liver functions. Following results were obtained : 1) Most of the research subjects were male(l03 individuals) living in large urban area, with drinking habit, highly educated, and with normal marriage. For the treatment history, 45 individuals received western medicine treatment(28.85%), 46 with Oriental medicine (29.49%), and 55 patients(35.26%) experienced both forms of treatment. 2) Measuring SD of serum liver functions for all the research subjects, T-protein was 6.95(0.73)g/dl, 4.07(0.51)g／dl for albumin, 0.44(0.19)mg／dl for T-bilirubin, 23.18(18.68)U／L for ALT, 27.42(27.43)U／L for AST, and 22l.27(64.58)mg／dl for LDH. 3) Among the research subjects with the liver functions outside of normal range were 0.64% for T-protein, 3.21% for T-bilirubin and ALT, 36.62% for AST, 0.64% for LDH, and none for Albumin. 4) Confusion variables which may affect the liver functions such as age, smoking, drinking, occupation, and residence were eliminated in calculation and no significant differences were witnessed between the control and experiment groups. 5) In measuring affects of treatment duration on the liver functions, no statistical significances were shown in multiple regression's ,${\beta}$(SE) values. 6) The values of odd ratio in the experiment groups compared to the control were in the range of $0.26(0.22){\sim}0.62(1.23)$. but T-bilirubin of the group receiving both Oriental and western medicine was 1.47(1.90) which showed statistical increase(p<0.001). 7) Factors affecting the liver functions are drinking volume per round duration of alcohol intake, western medicine treatment, gender, and age difference caused significant influences. 8) 57 individuals with serum liver functions out of normal range were mostly male, living in large urban area, median age of 38.89, with normal marriage, highly educated drinking less than once a week with less than 2 bottles per round, and with prior treatment in either western or Oriental medicine. Summarizing above results, we can carefully deduce that taking herbal medicine (both decoction and pills) or western medicine doesn't cause much affect in the liver functions. But taking two forms of medication simultaneously or altering dosage affect significant increase in the T-bilirubin level, thus one needs to take precaution when taking both. Further research is needed in this field to verify this evidence.