• 한국체육학회지인문사회과학편
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• 제57권6호
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• pp.263-272
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• 2018

본 연구는 여성노인의 허약 상태에 대한 보행 변동성과 체력의 역할을 검증하고자 하였다. 본 연구 기관의 지역사회에 거주하는 65세 이상 여성노인 168명(나이 75.07±5.40)을 대상으로 인구사회학적 특성, 신체조성, 보행 변인 및 변동성, 체력, 인지기능, 우울상태를 측정하였다. 그리고 Fried et al.(2001)의 허약진단 지표(체중감소, 정서적 고갈, 신체활동, 보행속도, 악력)를 기준으로 정상, 전-허약, 허약으로 구분하였다. 허약 상태 예측을 위한 보행 변인 및 변동성 그리고 체력의 역할을 검정하기 위해 로지스틱 회귀분석을 실시하였다. 그 결과, 나이, 교육수준, 보유한 질병 수, 일상생활수행능력 및 인지기능 점수와 우울점수를 통제 한 후 허약그룹은 정상그룹(OR=1)과 비교하였을 때, 두 다리 지지비율(OR=1.48, 95% CI=0.10-2.21, p=.049) 및 분당 보폭수(OR=2.06, 95%CI=1.20-3.43, p=.009)의 변동성이 통계적으로 높게 나타났으며, 상체근력(OR=0.49, 95%CI=0.31-0.77, p=.002)이 낮은 것으로 나타났다. 결론적으로 본 연구에서 허약의 예측인자로 나타난 두발 지지비율 및 분당 보폭수의 변동성 그리고 상체근력은 허약 상태를 예측하고 평가하는데 중요한 지표로 사용될 수 있을 것으로 판단된다.

• Tuberculosis and Respiratory Diseases
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• 제86권2호
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• pp.133-141
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• 2023

Background: The present study evaluated the association between participation in a rehabilitation program during a hospital stay and 1-year survival of patients requiring at least 21 days of mechanical ventilation (prolonged mechanical ventilation [PMV]) with various respiratory diseases as their main diagnoses that led to mechanical ventilation. Methods: Retrospective data of 105 patients (71.4% male, mean age 70.1±11.3 years) who received PMV in the past 5 years were analyzed. Rehabilitation included physiotherapy, physical rehabilitation, and dysphagia treatment program that was individually provided by physiatrists. Results: The main diagnosis leading to mechanical ventilation was pneumonia (n=101, 96.2%) and the 1-year survival rate was 33.3% (n=35). One-year survivors had lower Acute Physiology and Chronic Health Evaluation (APACHE) II score (20.2±5.8 vs. 24.2±7.5, p=0.006) and Sequential Organ Failure Assessment score (6.7±5.6 vs. 8.5±2.7, p=0.001) on the day of intubation than non-survivors. More survivors participated in a rehabilitation program during their hospital stays (88.6% vs. 57.1%, p=0.001). The rehabilitation program was an independent factor for 1-year survival based on the Cox proportional hazard model (hazard ratio, 3.513; 95% confidence interval, 1.785 to 6.930; p<0.001) in patients with APACHE II scores ≤23 (a cutoff value based on Youden's index). Conclusion: Our study showed that participation in a rehabilitation program during hospital stay was associated with an improvement of 1-year survival of PMV patients who had less severe illness on the day of intubation.

• Safety and Health at Work
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• 제14권2호
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• pp.141-152
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• 2023

Objective: We performed a meta-analysis of epidemiological results for the association between occupational exposure as a firefighter and cancer as part of the broader evidence synthesis work of the IARC Monographs program. Methods: A systematic literature search was conducted to identify cohort studies of firefighters followed for cancer incidence and mortality. Studies were evaluated for the influence of key biases on results. Random-effects meta-analysis models were used to estimate the association between ever-employment and duration of employment as a firefighter and risk of 12 selected cancers. The impact of bias was explored in sensitivity analyses. Results: Among the 16 included cancer incidence studies, the estimated meta-rate ratio, 95% confidence interval (CI), and heterogeneity statistic (I²) for ever-employment as a career firefighter compared mostly to general populations were 1.58 (1.14-2.20, 8%) for mesothelioma, 1.16 (1.08-1.26, 0%) for bladder cancer, 1.21 (1.12-1.32, 81%) for prostate cancer, 1.37 (1.03-1.82, 56%) for testicular cancer, 1.19 (1.07-1.32, 37%) for colon cancer, 1.36 (1.15-1.62, 83%) for melanoma, 1.12 (1.01-1.25, 0%) for non-Hodgkin lymphoma, 1.28 (1.02-1.61, 40%) for thyroid cancer, and 1.09 (0.92-1.29, 55%) for kidney cancer. Ever-employment as a firefighter was not positively associated with lung, nervous system, or stomach cancer. Results for mesothelioma and bladder cancer exhibited low heterogeneity and were largely robust across sensitivity analyses. Conclusions: There is epidemiological evidence to support a causal relationship between occupational exposure as a firefighter and certain cancers. Challenges persist in the body of evidence related to the quality of exposure assessment, confounding, and medical surveillance bias.

• Journal of Gastric Cancer
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• 제23권3호
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• pp.476-486
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• 2023

Purpose: The optimal tumor mutational burden (TMB) value for predicting treatment response to programmed cell death-1 (PD-1) checkpoint inhibitors in advanced gastric cancer (AGC) remains unclear. We aimed to investigate the optimal TMB cutoff value that could predict the efficacy of PD-1 checkpoint inhibitors in AGC. Materials and Methods: Patients with AGC who received pembrolizumab or nivolumab between October 1, 2020, and July 27, 2021, at Samsung Medical Center in Korea were retrospectively analyzed. The TMB levels were measured using a next-generation sequencing assay. Based on receiver operating characteristic curve analysis, the TMB cutoff value was determined. Results: A total 53 patients were analyzed. The TMB cutoff value for predicting the overall response rate (ORR) to PD-1 checkpoint inhibitors was defined as 13.31 mutations per megabase (mt/Mb) with 56% sensitivity and 95% specificity. Based on this definition, 7 (13.2%) patients were TMB-high (TMB-H). The ORR differed between the TMB-low (TMB-L) and TMB-H (8.7% vs. 71.4%, P=0.001). The progression-free survival and overall survival (OS) for 53 patients were 1.93 (95% confidence interval [CI], 1.600-2.268) and 4.26 months (95% CI, 2.992-5.532). The median OS was longer in the TMB-H (20.8 months; 95% CI, 2.292-39.281) than in the TMB-L (3.31 months; 95% CI, 1.604-5.019; P=0.049). Conclusions: The TMB cutoff value for predicting treatment response in AGC patients who received PD-1 checkpoint inhibitor monotherapy as salvage treatment was 13.31 mt/Mb. When applying the programmed death ligand-1 status to TMB-H, patients who would benefit from PD-1 checkpoint inhibitors can be selected.

• Journal of Preventive Medicine and Public Health
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• 제56권4호
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• pp.319-326
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• 2023

Objectives: The coronavirus disease 2019 (COVID-19) pandemic has increased the workload of healthcare workers (HCWs), impacting their health. This study aimed to assess sleep quality using the Pittsburgh Sleep Quality Index (PSQI) and identify factors associated with poor sleep among HCWs in Vietnam during the COVID-19 pandemic. Methods: In this cross-sectional study, 1000 frontline HCWs were recruited from various healthcare facilities in Vietnam between October 2021 and November 2021. Data were collected using a 3-part self-administered questionnaire, which covered demographics, sleep quality, and factors related to poor sleep. Poor sleep quality was defined as a total PSQI score of 5 or higher. Results: Participants' mean age was 33.20±6.81 years (range, 20.0-61.0), and 63.0% were women. The median work experience was 8.54±6.30 years. Approximately 6.3% had chronic comorbidities, such as hypertension and diabetes mellitus. About 59.5% were directly responsible for patient care and treatment, while 7.1% worked in tracing and sampling. A total of 73.8% reported poor sleep quality. Multivariate logistic regression revealed significant associations between poor sleep quality and the presence of chronic comorbidities (odds ratio [OR], 2.34; 95% confidence interval [CI], 1.17 to 5.24), being a frontline HCW directly involved in patient care and treatment (OR, 1.59; 95% CI, 1.16 to 2.16), increased working hours (OR, 1.84; 95% CI,1.37 to 2.48), and a higher frequency of encountering critically ill and dying patients (OR, 1.42; 95% CI, 1.03 to 1.95). Conclusions: The high prevalence of poor sleep among HCWs in Vietnam during the COVID-19 pandemic was similar to that in other countries. Working conditions should be adjusted to improve sleep quality among this population.

• Journal of Gastric Cancer
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• 제23권3호
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• pp.499-508
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• 2023

Purpose: Despite scientific evidence regarding laparoscopic gastrectomy (LG) for advanced gastric cancer treatment, its application in patients receiving neoadjuvant chemotherapy remains uncertain. Materials and Methods: We used the 2019 Korean Gastric Cancer Association nationwide survey database to extract data from 489 patients with primary gastric cancer who received neoadjuvant chemotherapy. After propensity score matching analysis, we compared the surgical outcomes of 97 patients who underwent LG and 97 patients who underwent open gastrectomy (OG). We investigated the risk factors for postoperative complications using multivariate analysis. Results: The operative time was significantly shorter in the OG group. Patients in the LG group had significantly less blood loss than those in the OG group. Hospital stay and overall postoperative complications were similar between the two groups. The incidence of Clavien-Dindo grade ≥3 complications in the LG group was comparable with that in the OG group (1.03% vs. 4.12%, P=0.215). No statistically significant difference was observed in the number of harvested lymph nodes between the two groups (38.60 vs. 35.79, P=0.182). Multivariate analysis identified body mass index (odds ratio [OR], 1.824; 95% confidence interval [CI], 1.029-3.234; P=0.040) and extent of resection (OR, 3.154; 95% CI, 1.084-9.174; P=0.035) as independent risk factors for overall postoperative complications. Conclusions: Using a large nationwide multicenter survey database, we demonstrated that LG and OG had comparable short-term outcomes in patients with gastric cancer who received neoadjuvant chemotherapy.

• Nutrition Research and Practice
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• 제17권4호
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• pp.780-788
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• 2023

BACKGROUND/OBJECTIVES: This study examined the relationship between famine exposure in early life and the risk of type 2 diabetes in adulthood during the 1959-1961 Chinese Famine. SUBJECTS/METHODS: A total of 3,418 individuals aged 35-74 years free of diabetes from two studies in 2006 and 2009 were followed up prospectively in 2009 and 2012, respectively. Famine exposure was classified as unexposed (individuals born in 1962-1978), fetal exposed (individuals born in 1959-1961), child exposed (individuals born in 1949-1958), and adolescent/adult exposed (born in 1931-1948). A logistic regression model was used to assess the relationship between famine exposure and diabetes after adjustment for potential covariates. RESULTS: During a three-year follow-up, the age-adjusted incidence rates of type 2 diabetes were 5.7%, 14.5%, 12.7%, and 17.8% in unexposed, fetal-exposed, child-exposed, and adolescent/adult-exposed groups, respectively (P < 0.01). Relative to the unexposed group, the relative risks (95% confidence interval) for diabetes were 2.15 (1.29-3.60), 1.53 (0.93-2.51), and 1.65 (0.75-3.63) in the fetal-exposed, child-exposed, and adolescent/adult-exposed groups, after controlling for potential covariates. The interactions between famine exposure and obesity, education level, and family history of diabetes were not observed, except for the urbanization type. Individuals living in rural areas with fetal and childhood famine exposure were at a higher risk of type 2 diabetes, with relative risks of 8.79 (1.82-42.54) and 2.33 (1.17-4.65), respectively. CONCLUSIONS: These findings indicate that famine exposure in early life is an independent predictor of type 2 diabetes, particularly in women. Early identification and intervention may help prevent diabetes in later life.

• 분석과학
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• 제22권1호
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• pp.101-108
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• 2009

다케다약품공업주식회사의 "액토스정$^{(R)}$ 30 mg"을 대조약으로 하고 보령제약주식회사의 "염산피오글리타존정 30 mg"을 시험약으로 하여, $2{\times}2$ 교차시험법에 따라 지원자 28 명을 대상으로 생물학적동등성시험을 실시하였다. 이를 위하여 피오글리타존 30 mg을 각 지원자에게 경구 투여한 후, 0-36 시간 동안 채혈한 혈장 시료를 확보하였다. 혈장 중 피오글리타존을 분석하기 위하여, LC-MS/MS 분석법을 확립하였으며 분석결과의 신뢰성을 높이기 위하여 분석법 검증을 수행하였다. 그 결과, 5-2000 ng/mL의 농도범위에서 우수한 직선성을 나타내었으며, 생물학적동등성시험에 이용될 수 있는 충분한 감도와 특이성, 정밀성 및 정확성을 확인하였다. 각 피험자들의 혈중 약물농도 데이터로부터 구한 혈중약물농도-시간곡선하면적($AUC_t$)과 최고혈중농도($C_{max}$) 등의 약물속도론적 파라미터에 대해 통계학적으로 고찰한 결과, 판정기준을 만족 시켰으며, 따라서 두 제제는 생물학적으로 동등한 것으로 평가하였다.

• Journal of Nutrition and Health
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• 제56권3호
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• pp.288-299
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• 2023

본 연구는 COVID-19 유행 동안 대학생의 체중변화를 알아보고 체중증가와 관련된 생활습관 및 식생활 변화를 파악하기 위해 실시되었다. 대학생 270명을 대상으로 2021년 9월 22에서 10월 26일까지 온라인 설문조사를 실시하였다. 체중증가와 일반적 특성, 생활습관 및 식생활 변화와의 관련성이 로지스틱 회귀분석을 통해 평가되었다. 체중이 증가하였다고 응답한 비율은 남성이 42,9%, 여성이 44.7%이었다. 체중이 증가한 주요 이유로는 외부활동 제한으로 활동량 감소, 배달음식이나 인스턴트 위주의 식습관으로 조사되었다. COVID-19 유행 동안 체중증가와 일반적 특성 및 생활습관과의 관련성을 평가한 결과 체중증가는 주관적 건강상태가 나쁜 경우 (OR, 3.97, 95% CI, 1.98-7.96), 저체중 (OR, 0.19, 95% CI, 0.05-0.83)과 유의적 수준에서 관련성이 있었다. 체중증가와 식생활과의 관련성에 대하여 분석한 결과 체중증가가 아침 섭취빈도 증가(OR, 4.44, 95% CI, 1.76-11.21), 간식 섭취빈도 감소 (OR, 0.35, 95% CI, 0.16-0.77), 과일 섭취빈도 감소 (OR, 3.0, 95% CI, 1.32-6.80), 탄산음료 및 가당음료 섭취빈도 증가 (OR, 2.74, 95% CI, 1.26-5.99), 패스트푸드의 섭취빈도 증가 (OR, 2.32, 95% CI, 1.14-4.70)와 유의적 수준에서 관련이 있었다. COVID-19 유행은 체중증가와 생활습관 및 식생활 변화에 영향을 미쳤다. 향후 감염병을 대비하여 좀 더 많은 표본을 대상으로 한 조사결과를 바탕으로 구체적인 건강 및 영양관리 방안이 마련되어야 한다.

• 한국체육학회지인문사회과학편
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• 제57권5호
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• pp.269-279
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• 2018

본 연구의 목적은 한국 암환자들의 근력운동 빈도, 근력, 그리고 건강관련 삶의 질과의 관계를 조사하는 것이다. 이를 위해 2014~2016년 국민건강영양조사 자료를 통합하여, 총 647명의 암환자들의 주당 근력운동 빈도, 악력, 건강관련 삶의 질의 관계를 복합표본 일반선형모형과 로지스틱 회귀분석 방법을 이용하여 분석하였다. 분석결과, 근력운동빈도가 주당 0~1일인 암환자들은 5일 이상인 암환자들에 비해(0.852±0.016 vs. 0.890±0.020 ; p=0.006), 상대 악력이 낮은 암환자들은 높은 그룹에 비해 (0.850±0.018 vs. 0.911±0.016; p<0.001) 건강관련 삶의 질 지수 (EQ-5D index) 가 유의하게 낮게 나타났다. 또한, 주당 근력운동 빈도가 0~1일인 암환자들은 5일 이상인 암환자들에 비해 운동능력에 문제가 생길 확률이 4.07배 (95% CI=1.31-12.63), 상대 악력이 낮은 그룹은 높은 그룹에 비해 운동능력에 문제가 생길 확률이 4.94배 (95% CI=2.14-11.41), 일상생활에서는 5.18배 (95% CI=1.56-17.14), 통증/불편에서는 2.46배 (95% CI=1.33-4.55) 증가했다. 본 연구결과를 통해 암환자들의 근력운동 빈도와 근력이 건강관련 삶의 질과 유의한 관계에 있는 것으로 나타났으며, 꾸준한 근력운동으로 인한 근력향상은 암환자들의 삶의 질 관리에 큰 도움이 될 것으로 사료된다.