• 한국대기환경학회지
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• 제22권1호
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• pp.117-126
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• 2006

The purpose of this study is to develop a badge-type passive sampler for the measurement of short-term nitrogen dioxide and to evaluate its performance. The principle of the method is a colorimetric reaction of nitrogen dioxide with sulfanilic acid, N-1-naphthylethylendiamine, and phosphoric acid. First, it has been shown that the filter paper should be rinsed with ultrapure water and ultrasound, and then dried in a vacuumed desiccator. The concentration and volume of absorption reagent (triethanolamine) were $20\%$ and 100 ${\mu}L$, respectively. The extraction time was determined as 60 min. Second, duplicate measurements (n= 116) were carried out for evaluating the precision of the passive sampler. The relative error and the correlation coefficient between duplicates are $3.4\pm 3.0\%$ and 0.994, respectively. In addition, the $95\%$ confidence interval of intraclass correlation coefficient and the estimated value are 0.992$\sim$0.996 and 0.994, respectively. Third, a paired t-test was carried out for evaluating the accuracy of the passive sampler (n=40). In the result of the test, the $95\%$ confidence interval of the difference was -1.710 ppb <$\gamma$< 0.788 ppb. Finally, the average concentration of blanks, measurement detection limit, limit of detection, and limit of quantification are $2.4\pm 0.4$ ppb, 104 ppb, 3.8 ppb, and 7.0 ppb, respectively.

• The Journal of the Acoustical Society of Korea
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• 제15권1E호
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• pp.5-19
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• 1996

This paper proposes a loose part monitoring system (LPMS) design with a signal processing method based on fuzzy logic. Considering fuzzy characteristics of metallic impact waveform due to not only interferences from various types of noises in an operating nuclear power plant but also complex wave propagation paths within a monitored mechanical structure, the proposed LPMS design incorporates the comprehensive relation among impact signal features in the fuzzy rule bases for the purposes of alarm discrimination and impact diagnosis improvement. The impact signal features for the fuzzy rule bases include the rising time, the falling time, and the peak voltage values of the impact signal envelopes. Fuzzy inference results based on the fuzzy membership values of these impact signal features determine the confidence level data for each signal feature. The total integrated confidence level data is used for alarm discrimination and impact diagnosis purposes. Through the perpormance test of the proposed LPMS with mock-up structures and instrumentation facility, test results show that the system is effective in diagnosis of the loose part impact event(i.e., the evaluation of possible impacted area and degree of impact magnitude) as well as in suppressing false alarm generation.

• Biomolecules & Therapeutics
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• 제15권3호
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• pp.182-186
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• 2007

Cefixime is an orally absorbed cephalosporin with a broad spectrum of activity against Gram-negative bacteria and is highly resistant to beta-lactamase degradation. The purpose of the present study was to evaluate the bioequivalence of two cefixime capsules, Suprax capsule (Dong-A Pharmaceutical Co., reference drug) and Alpha-Cefixime capsule (Alpha Pharmaceutical Co., test drug), according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty-four normal subjects, $23.5{\pm}3.72$ years in age and $68.3{\pm}8.89$ kg in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. There was one week washout period between the doses. After one capsule containing 100 mg of cefixime was orally administered, plasma was taken at predetermined time intervals and the concentrations of cefixime in plasma were determined using HPLC with UV detector. The pharmacokinetic parameters such as $AUC_{t}$, $C_{max}$ and $T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters. The results showed that the differences in $AUC_{t}$, $C_{max}$ and $T_{max}$ between two products were -3.91%, -2.23% and -3.18%, respectively, when calculated against the reference drug. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of $log0.8{\leq}{\delta}{\leq}log1.25$ (e.g., $log0.8786{\leq}{\delta}{\leq}log1.0523$ and $log0.8889{\leq}{\delta}{\leq}log1.0512$ for $AUC_{t}$ and $C_{max}$, respectively). The 90% confidence intervals using untransformed data was within ${\pm}20%$(e.g., $-10.37%{\leq}{\delta}{\leq}6.73%$ for $T_{max}$). All parameters met the criteria of KFDA for bioequivalence, indicating that Alpha-Cefixime capsule (Alpha Pharmaceutical Co.) is bioequivalent to Suprax capsule (Dong-A Pharmaceutical Co.).

• 한국방재학회 논문집
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• 제9권6호
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• pp.143-151
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• 2009

최근의 극한 수문사상은 홍수, 가뭄과 같은 심각한 재해를 발생시킨다. 많은 연구자들은 불확실한 미래의 확률강우량 및 유출량의 예측을 위해 많은 노력을 하고 있다. 본 연구에서는 불확실성이 낮은 확률강우량의 산정을 위하여 매개변수 추정법을 평가하였다. 인천, 강릉, 광주, 부산, 추풍령 관측소를 연구 대상 관측소로 선정하여 자료를 수집하였고, ARMA모형을 이용하여 합성강우자료를 구축하였다. 본 연구에서는 극치강우사상에 적합한 것으로 알려진 Gumbel 분포와 GEV 분포모형에 대한 매개변수를 최우도법과 베이지안 추론방법을 사용하여 추정하였으며, Bootstrap 방법을 이용하여 확률강우량의 신뢰구간 길이를 추정하였다. 매개변수 추정 방법별 산정된 확률강우량의 신뢰구간 길이를 비교함으로서 불확실성이 낮은 확률강우량을 산정할 수 있는 매개변수 추정방법을 선정하였다.

• Journal of Hospice and Palliative Care
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• 제23권1호
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• pp.17-26
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• 2020

Purpose: This study was conducted to develop a hospice music therapist training program and to evaluate its effects. Methods: The educational program consisted of training on the theory of hospice and the theory and practice of hospice music therapy. The course lasted for 4 weeks, with 8 hours of training per week, and 33 music therapists completed the course. In order to assess the effectiveness of the course, participants' knowledge and confidence regarding hospice music therapy and readiness for hospice music therapy before and after education were measured. The statistical analysis was done using SPSS version 18.0 and the paired t-test was used to assess the effectiveness of the program. Results: The trainees showed significant improvements in knowledge (P<0.001) and confidence (P<0.001) in all areas of this course, as well as in readiness for hospice music therapy (P<0.001). Participants' satisfaction with the lectures was assessed using a 5-point Likert scale. The average score for all lecture areas exceeded 4 (yes), and the satisfaction level was mostly high. Students were most satisfied with the lectures on music therapy theory, followed in order by those on music therapy practice and hospice theory. Conclusion: This hospice music therapist training program is considered to be suitable because of its positive educational effects and the high satisfaction of participants with the lectures. In order to provide high-quality music therapy services to patients and their families, this training course should be regularly offered to cultivate competent music therapists, and the content of the education should be standardized and applied in various clinical settings.

• 한국콘텐츠학회논문지
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• 제10권1호
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• pp.334-342
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• 2010

본 연구의 목적은 보육시설 영유아 건강에 관련한 웹사이트를 평가함으로서, 영유아 건강정보가 타당하고 신뢰성 있는가를 분석하는 것이다. 총87개의 관련 사이트를 검색하고, 기존의 도구를 본 연구 목적에 맞게 수정 보완하여 평가한 결과, 32점 만점에 11~29점의 분포를 나타내 전반적으로 낮게 평가되었다. 정확성과 권위성이 가장 낮았고 내용성, 지속성 등도 약 절반가량의 사이트에서만 충족하고 있었다. 이러한 결과로 볼 때 영유아 건강정보를 제공하고 있는 사이트는 내용의 정확성이 매우 부족할 뿐 아니라 영유아 건강관리에 대한 전문성도 매우 미흡한 것으로 보인다. 특히 건강전문가가 없이 영유아를 집단으로 돌보는 보육시설에서는 이러한 건강정보를 이용하기가 한계가 있을 것으로 판단된다. 따라서 보육시설 영유아의 건강관리를 지원하기 위해서는 전문적 건강정보제공이 시급하다. 본 연구 결과는 영유아 건강관리를 지원하기 위한 프로그램 개발에 유용한 기초자료가 될 것으로 사료된다.

• 동서간호학연구지
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• 제19권2호
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• pp.159-167
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• 2013

Purpose: The purpose of the study is to develop and to evaluate a internet-based social support program for the mothers of congenitally abnormal children. The theoretical basis of the study is the moderating effect model of social support theory (Cobb, 1976). Methods: In first phase, an internet support program was developed according to the practical web development stages proposed by Boling and Frick (2002). In the second phase, the internet support program was provided and evaluated to 18 mothers who reared congenitally abnormal children from March to May 2008. Results: In the first stage, demands of the program were collected from interviews of eighteen mothers of congenitally abnormal children of ages one to three. At the same time, literature review and validity of the contents were also examined. In the second stage, the correspondence of the program contents to the social support needed was also examined. In the third and fourth stages, prototype of the social program was prepared in documents and that of computer program was prepared. In the final stage, an internet-based web site was constructed. The social support provided by the web site were composed of informational support, emotional support and appraisal support including bulletin board system and chatting service. After program development, pre-tests and post-test were performed to investigate the effect of the program on maternal confidence and mood. Data were analyzed using Wilcoxon signed rank test. The analysis showed that maternal confidence of post-test was improved than that of pre-test with statistically meaningful figure (Z=-2.54, p<.05). The positive mood of post-test was also improved than that of pre-test and the result was statistically supported (Z=-2.20, p<.05). Conclusion: It is suggestive that the internet based social support programs is accessible and appropriate service to congenitally abnormal children's mother. It is necessary to develop and use the internet based social support programs in public health system.

• 한국습지학회지
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• 제11권1호
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• pp.49-64
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• 2009

홍수나 가뭄 등 극한 사상을 예측하여 재해에 대비하거나 또는 수자원을 효율적으로 관리, 배분하기 위하여 강우-유출 모형이 이용되고 있다. 그러나 많은 수문학자들은 강우-유출 모형이 가질 수밖에 없는 불확실성에 대하여 언급하였다. 실제 유역에 내린 강우는 증발과 증산, 차단, 침투 등 여러 과정을 거쳐 유출로 이어지는데, 모형에서는 이러한 복잡한 물리적 과정을 단순화하여 표현하였으므로 불확실성이 반드시 존재할 수밖에 없는 것이다. 따라서 모형으로부터의 모의 결과를 신뢰할 수 있는지를 정량적으로 판단하는 과정이 이루어져야 한다. 본 논문에서는 현재까지 강우-유출 모형의 불확실성을 평가한 선행 연구 중 Montanari와 Brath(2004)가 제시한 Meta-Gaussian 기법을 이용하여 강우-유출 모형 모의 결과에 대한 불확실성을 검토하였다. 이 기법은 모형 오차의 확률 분포형으로부터 신뢰구간의 상한계와 하한계를 추정하는 방법으로 수문모형의 전역적 불확실성(Global Uncertainty)을 정량화할 수 있다. 본 논문에서는 동일한 강우사상에 대한 물리적 기반의 분포형 모형인 $Vflo^{TM}$ 모형과 개념적 준 분포형 모형인 HEC-HMS 모형으로부터 모의된 유출량을 Meta-Gaussian 기법을 적용하여 불확실성을 분석하였다.

• Journal of Pharmaceutical Investigation
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• 제28권1호
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• pp.35-42
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• 1998

A $3{\times}3$ Latin square crossover study for the bioequivalence of three ondansetron formulations was conducted. Test products were $Vominon^{\circledR}$ 8 mg and $Vominon^{\circledR}$ 4 mg tablets and reference product was $Zofran^{\circledR}$ tablet. Twenty one healthy Korean male subjects received each formulation at the ondansetron dose of 8 mg and plasma concentrations of ondansetron were monitored by HPLC for over a period of 12 hr after the oral administration. Statistical procedure for bioequivalence evaluation of AUC {e.g., analysis of variance (ANOVA), multiple comparison and confidence intervals} was carried out. There were no significant differences in AUC among the formulations. The confidence intervals for the AUC of $Vominon^{\circledR}$ 8 mg and $Vominon^{\circledR}$ 4 mg were between -0.24 and 15.54% and between -2.41 and 13.36% respectively, within a range that proposed by the Korea Food and Drug Administration Guidelines for Bioequivalence. These statistical procedure could be standardized and generally applicable for the assessment of bioequivalence for multiple (more than two) formulations.

• 한국치위생학회지
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• 제17권5호
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• pp.899-910
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• 2017

Objectives: This study was conducted to identify the rates of perceived stress of elderly people over 65 years old and to confirm the influence of stress on general health and oral health status. Methods: Using data from the National Health and Nutrition Survey for 2014, 1,472 people over 65 years of age were selected as final subjects. Stress was used as an independent variable and dependent variables were included physical health (perceived health status), mental health (depression), and oral health (perceived oral health status). The following confounding variables were adjusted for the current study: demographic characteristics (gender, age, education level, house income) and health - related characteristics (drinking, smoking, exercise, frequency of tooth brushing, using oral care product, dental exam, comorbidity, restrict activity). Complex sampling analysis was applied and logistic regression was performed to determine the effects of stress on physical health, mental health and oral health status. Odds ratio (OR) and 95% confidence interval (95% Confidence Interval, 95% CI) were calculated. Results: Logistic regression indicated that stress was significantly associated with low physical health (OR=2.18, 95%CI: 1.49-3.20), low mental health (OR=8.68, 95%CI: 4.98-15.11), low oral health (OR=1.53, 95%CI: 1.06-2.21) after adjusting for confounding variables. Conclusions: The perceived stress of the elderly was found to be related to the general health and oral health status. Therefore, it is necessary to evaluate stress as a predictor of health risk for the health promotion of the elderly on multidisciplinary assessment and continuous evaluation. In addition, health support policies should be provided to achieve good health status for elderly.