• Journal of Korean Society for Atmospheric Environment
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• v.22 no.1
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• pp.117-126
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• 2006

The purpose of this study is to develop a badge-type passive sampler for the measurement of short-term nitrogen dioxide and to evaluate its performance. The principle of the method is a colorimetric reaction of nitrogen dioxide with sulfanilic acid, N-1-naphthylethylendiamine, and phosphoric acid. First, it has been shown that the filter paper should be rinsed with ultrapure water and ultrasound, and then dried in a vacuumed desiccator. The concentration and volume of absorption reagent (triethanolamine) were $20\%$ and 100 ${\mu}L$, respectively. The extraction time was determined as 60 min. Second, duplicate measurements (n= 116) were carried out for evaluating the precision of the passive sampler. The relative error and the correlation coefficient between duplicates are $3.4\pm 3.0\%$ and 0.994, respectively. In addition, the $95\%$ confidence interval of intraclass correlation coefficient and the estimated value are 0.992$\sim$0.996 and 0.994, respectively. Third, a paired t-test was carried out for evaluating the accuracy of the passive sampler (n=40). In the result of the test, the $95\%$ confidence interval of the difference was -1.710 ppb <$\gamma$< 0.788 ppb. Finally, the average concentration of blanks, measurement detection limit, limit of detection, and limit of quantification are $2.4\pm 0.4$ ppb, 104 ppb, 3.8 ppb, and 7.0 ppb, respectively.

• The Journal of the Acoustical Society of Korea
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• v.15 no.1E
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• pp.5-19
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• 1996

This paper proposes a loose part monitoring system (LPMS) design with a signal processing method based on fuzzy logic. Considering fuzzy characteristics of metallic impact waveform due to not only interferences from various types of noises in an operating nuclear power plant but also complex wave propagation paths within a monitored mechanical structure, the proposed LPMS design incorporates the comprehensive relation among impact signal features in the fuzzy rule bases for the purposes of alarm discrimination and impact diagnosis improvement. The impact signal features for the fuzzy rule bases include the rising time, the falling time, and the peak voltage values of the impact signal envelopes. Fuzzy inference results based on the fuzzy membership values of these impact signal features determine the confidence level data for each signal feature. The total integrated confidence level data is used for alarm discrimination and impact diagnosis purposes. Through the perpormance test of the proposed LPMS with mock-up structures and instrumentation facility, test results show that the system is effective in diagnosis of the loose part impact event(i.e., the evaluation of possible impacted area and degree of impact magnitude) as well as in suppressing false alarm generation.

• Biomolecules & Therapeutics
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• v.15 no.3
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• pp.182-186
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• 2007

Cefixime is an orally absorbed cephalosporin with a broad spectrum of activity against Gram-negative bacteria and is highly resistant to beta-lactamase degradation. The purpose of the present study was to evaluate the bioequivalence of two cefixime capsules, Suprax capsule (Dong-A Pharmaceutical Co., reference drug) and Alpha-Cefixime capsule (Alpha Pharmaceutical Co., test drug), according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty-four normal subjects, $23.5{\pm}3.72$ years in age and $68.3{\pm}8.89$ kg in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. There was one week washout period between the doses. After one capsule containing 100 mg of cefixime was orally administered, plasma was taken at predetermined time intervals and the concentrations of cefixime in plasma were determined using HPLC with UV detector. The pharmacokinetic parameters such as $AUC_{t}$, $C_{max}$ and $T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters. The results showed that the differences in $AUC_{t}$, $C_{max}$ and $T_{max}$ between two products were -3.91%, -2.23% and -3.18%, respectively, when calculated against the reference drug. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of $log0.8{\leq}{\delta}{\leq}log1.25$ (e.g., $log0.8786{\leq}{\delta}{\leq}log1.0523$ and $log0.8889{\leq}{\delta}{\leq}log1.0512$ for $AUC_{t}$ and $C_{max}$, respectively). The 90% confidence intervals using untransformed data was within ${\pm}20%$(e.g., $-10.37%{\leq}{\delta}{\leq}6.73%$ for $T_{max}$). All parameters met the criteria of KFDA for bioequivalence, indicating that Alpha-Cefixime capsule (Alpha Pharmaceutical Co.) is bioequivalent to Suprax capsule (Dong-A Pharmaceutical Co.).

• Journal of the Korean Society of Hazard Mitigation
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• v.9 no.6
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• pp.143-151
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• 2009

Extreme hydrologic events cause serious disaster, such as flood and drought. Many researchers have an effort to estimate design rainfalls or discharges. This study evaluated parameter estimation methods to estimate probability rainfalls with low uncertainty which will be used in design rainfalls. This study collected rainfall data from Incheon, Gangnueng, Gwangju, Busan, and Chupungryong gage station, and generated synthetic rainfall data using ARMA model. This study employed the maximum likelihood method and the Bayesian inference method for estimating parameters of the Gumbel and GEV distribution. Using a bootstrap resampling method, this study estimated the confidence intervals of estimated probability rainfalls. Based on the comparison of the confidence intervals, this study recommended a proper parameter estimation method for estimating probability rainfalls which have a low uncertainty.

• Journal of Hospice and Palliative Care
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• v.23 no.1
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• pp.17-26
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• 2020

Purpose: This study was conducted to develop a hospice music therapist training program and to evaluate its effects. Methods: The educational program consisted of training on the theory of hospice and the theory and practice of hospice music therapy. The course lasted for 4 weeks, with 8 hours of training per week, and 33 music therapists completed the course. In order to assess the effectiveness of the course, participants' knowledge and confidence regarding hospice music therapy and readiness for hospice music therapy before and after education were measured. The statistical analysis was done using SPSS version 18.0 and the paired t-test was used to assess the effectiveness of the program. Results: The trainees showed significant improvements in knowledge (P<0.001) and confidence (P<0.001) in all areas of this course, as well as in readiness for hospice music therapy (P<0.001). Participants' satisfaction with the lectures was assessed using a 5-point Likert scale. The average score for all lecture areas exceeded 4 (yes), and the satisfaction level was mostly high. Students were most satisfied with the lectures on music therapy theory, followed in order by those on music therapy practice and hospice theory. Conclusion: This hospice music therapist training program is considered to be suitable because of its positive educational effects and the high satisfaction of participants with the lectures. In order to provide high-quality music therapy services to patients and their families, this training course should be regularly offered to cultivate competent music therapists, and the content of the education should be standardized and applied in various clinical settings.

• The Journal of the Korea Contents Association
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• v.10 no.1
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• pp.334-342
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• 2010

The purpose of this study was to evaluate web-sites related to infant health at day-care centers. A total of 87 web-sites were ultimately selected through Internet search engines, and educare sites. The basis of assessment in which standards and items were amended for the assessment of health information in previously used, and purpose, content, pertinence, accuracy, confidence, utility, authority, interactivity and continuance was assessed. Though the total score were 32 point, mean score was relatively low, 20.39 point. The score of accuracy and authority was relatively low while that of confidence and interactivity was high. As a result, it was revealed that there were no specific infant health related web-site with reliability guaranteed. Therefore, there is a need to develop a web-site providing accurate health information for infant at day-care centers. It is expected that these results can be utilized as a data for developing reliable web-site related infant health.

• Journal of East-West Nursing Research
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• v.19 no.2
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• pp.159-167
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• 2013

Purpose: The purpose of the study is to develop and to evaluate a internet-based social support program for the mothers of congenitally abnormal children. The theoretical basis of the study is the moderating effect model of social support theory (Cobb, 1976). Methods: In first phase, an internet support program was developed according to the practical web development stages proposed by Boling and Frick (2002). In the second phase, the internet support program was provided and evaluated to 18 mothers who reared congenitally abnormal children from March to May 2008. Results: In the first stage, demands of the program were collected from interviews of eighteen mothers of congenitally abnormal children of ages one to three. At the same time, literature review and validity of the contents were also examined. In the second stage, the correspondence of the program contents to the social support needed was also examined. In the third and fourth stages, prototype of the social program was prepared in documents and that of computer program was prepared. In the final stage, an internet-based web site was constructed. The social support provided by the web site were composed of informational support, emotional support and appraisal support including bulletin board system and chatting service. After program development, pre-tests and post-test were performed to investigate the effect of the program on maternal confidence and mood. Data were analyzed using Wilcoxon signed rank test. The analysis showed that maternal confidence of post-test was improved than that of pre-test with statistically meaningful figure (Z=-2.54, p<.05). The positive mood of post-test was also improved than that of pre-test and the result was statistically supported (Z=-2.20, p<.05). Conclusion: It is suggestive that the internet based social support programs is accessible and appropriate service to congenitally abnormal children's mother. It is necessary to develop and use the internet based social support programs in public health system.

• Journal of Wetlands Research
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• v.11 no.1
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• pp.49-64
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• 2009

Rainfall-runoff models are used for efficient management, distribution, planning, and design of water resources in accordance with the process of hydrologic cycle. The models simplify the transition of rainfall to runoff as rainfall through different processes including evaporation, transpiration, interception, and infiltration. As the models simplify complex physical processes, gaps between the models and actual rainfall events exist. For more accurate simulation, appropriate models that suit analysis goals are selected and reliable long-term hydrological data are collected. However, uncertainty is inherent in models. It is therefore necessary to evaluate reliability of simulation results from models. A number of studies have evaluated uncertainty ingrained in rainfall-runoff models. In this paper, Meta-Gaussian method proposed by Montanari and Brath(2004) was used to assess uncertainty of simulation outputs from rainfall-runoff models. The model, which estimates upper and lower bounds of the confidence interval from probabilistic distribution of a model's error, can quantify global uncertainty of hydrological models. In this paper, Meta-Gaussian method was applied to analyze uncertainty of simulated runoff outputs from $Vflo^{TM}$, a physically-based distribution model and HEC-HMS model, a conceptual lumped model.

• Journal of Pharmaceutical Investigation
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• v.28 no.1
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• pp.35-42
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• 1998

A $3{\times}3$ Latin square crossover study for the bioequivalence of three ondansetron formulations was conducted. Test products were $Vominon^{\circledR}$ 8 mg and $Vominon^{\circledR}$ 4 mg tablets and reference product was $Zofran^{\circledR}$ tablet. Twenty one healthy Korean male subjects received each formulation at the ondansetron dose of 8 mg and plasma concentrations of ondansetron were monitored by HPLC for over a period of 12 hr after the oral administration. Statistical procedure for bioequivalence evaluation of AUC {e.g., analysis of variance (ANOVA), multiple comparison and confidence intervals} was carried out. There were no significant differences in AUC among the formulations. The confidence intervals for the AUC of $Vominon^{\circledR}$ 8 mg and $Vominon^{\circledR}$ 4 mg were between -0.24 and 15.54% and between -2.41 and 13.36% respectively, within a range that proposed by the Korea Food and Drug Administration Guidelines for Bioequivalence. These statistical procedure could be standardized and generally applicable for the assessment of bioequivalence for multiple (more than two) formulations.

• Journal of Korean society of Dental Hygiene
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• v.17 no.5
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• pp.899-910
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• 2017

Objectives: This study was conducted to identify the rates of perceived stress of elderly people over 65 years old and to confirm the influence of stress on general health and oral health status. Methods: Using data from the National Health and Nutrition Survey for 2014, 1,472 people over 65 years of age were selected as final subjects. Stress was used as an independent variable and dependent variables were included physical health (perceived health status), mental health (depression), and oral health (perceived oral health status). The following confounding variables were adjusted for the current study: demographic characteristics (gender, age, education level, house income) and health - related characteristics (drinking, smoking, exercise, frequency of tooth brushing, using oral care product, dental exam, comorbidity, restrict activity). Complex sampling analysis was applied and logistic regression was performed to determine the effects of stress on physical health, mental health and oral health status. Odds ratio (OR) and 95% confidence interval (95% Confidence Interval, 95% CI) were calculated. Results: Logistic regression indicated that stress was significantly associated with low physical health (OR=2.18, 95%CI: 1.49-3.20), low mental health (OR=8.68, 95%CI: 4.98-15.11), low oral health (OR=1.53, 95%CI: 1.06-2.21) after adjusting for confounding variables. Conclusions: The perceived stress of the elderly was found to be related to the general health and oral health status. Therefore, it is necessary to evaluate stress as a predictor of health risk for the health promotion of the elderly on multidisciplinary assessment and continuous evaluation. In addition, health support policies should be provided to achieve good health status for elderly.