• Molecules and Cells
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• v.45 no.3
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• pp.134-147
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• 2022

The anti-oxidant enzyme heme oxygenase-1 (HO-1) is known to exert anti-inflammatory effects. From a library of pyrazolo[3,4-d]pyrimidines, we identified a novel compound KKC080096 that upregulated HO-1 at the mRNA and protein levels in microglial BV-2 cells. KKC080096 exhibited anti-inflammatory effects via suppressing nitric oxide, interleukin1β (IL-1β), and iNOS production in lipopolysaccharide (LPS)-challenged cells. It inhibited the phosphorylation of IKK and MAP kinases (p38, JNK, ERK), which trigger inflammatory signaling, and whose activities are inhibited by HO-1. Further, KKC080096 upregulated anti-inflammatory marker (Arg1, YM1, CD206, IL-10, transforming growth factor-β [TGF-β]) expression. In 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridinetreated mice, KKC080096 lowered microglial activation, protected the nigral dopaminergic neurons, and nigral damage-associated motor deficits. Next, we elucidated the mechanisms by which KKC080096 upregulated HO-1. KKC080096 induced the phosphorylation of AMPK and its known upstream kinases LKB1 and CaMKKbeta, and pharmacological inhibition of AMPK activity reduced the effects of KKC080096 on HO-1 expression and LPS-induced NO generation, suggesting that KKC080096-induced HO-1 upregulation involves LKB1/AMPK and CaMKKbeta/AMPK pathway activation. Further, KKC080096 caused an increase in cellular Nrf2 level, bound to Keap1 (Nrf2 inhibitor protein) with high affinity, and blocked Keap1-Nrf2 interaction. This Nrf2 activation resulted in concurrent induction of HO-1 and other Nrf2-targeted antioxidant enzymes in BV-2 and in dopaminergic CATH.a cells. These results indicate that KKC080096 is a potential therapeutic for oxidative stress-and inflammation-related neurodegenerative disorders such as Parkinson's disease.

• Asia-pacific Journal of Multimedia Services Convergent with Art, Humanities, and Sociology
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• v.8 no.7
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• pp.485-496
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• 2018

In this paper, the smoke behavior in an underground station on operation of the fans in the ventiliation of the station was measured by the experimental method when the fire occurred in the underground station platform where the platfrom screen door was installed. The ventilation characteristics were compared when the ventilation system was operated and when the ventilation system was not operated when a fire occurred at the platform where the clean door was closed. To simulate the fire smoke, the smoke generated from the smoke generator was heated using a hot air fan. The transmittance was measured using a smoke density meter to quantitatively measure fire smoke. If the screen door is closed and the ventilation system of the underground station does not work, it is confirmed that if a fire occurs in the platform, smoke accumulates inside the platform, evacuating passengers is very difficult and can lead to a very dangerous situation. On the other hand, under the condition that the ventilation facility of the subway station is operated, the smoke evacuates to the outside through the ventilation facility of the underground station, and airflow is formed in the direction from the waiting room to the waiting area, so that the passenger located on the platform can safely evacuate toward the concourse. In the following paper, we will discuss the concurrent effect of tunnel ventilation through tunnel vent near the platform.

• Exercise Science
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• v.21 no.3
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• pp.373-384
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• 2012

The effects of inspiratory muscle training in conjunction with aerobic exercise on inspiratory muscle strength, pulmonary function, and maximal oxygen uptake(VO₂max) were examined. Twenty four healthy collegiate men were divided into three groups; respiratory muscle training group(RTG; n=8), running exercise group(REG; n=8), and both respiratory muscle training and running group(BTG; n=8). Their pulmonary function, maximal inspiratory pressures(PImax), and VO₂max were assessed before and after intervention. RTG underwent inspiratory muscle training(IMT) with load set to 50 % of PImax, 30 times per session, twice a day, 4 days a week REG ran on a treadmill at 70-75 % of VO₂max for 30 min a day, 4 days a week. BTG participated both IMT and the running exercise. Participant's anthropometric parameters and pulmonary function were not changed. VO₂max increased by 6.1±3.3 %, 5.9±6.6 %, and 10.0±8.3 % in RTG, REG, and BTG, respectively(p< .05), and PImax also increased by 21.7±14.3 %, 19.7±12.0 %, and 27.0±12.1 % in RTG, REG, and BTG, respectively, but no group differences were found. Based on the study, although statistically insignificant, BTG showed the biggest increase of VO₂max and PImax indicating a possible synergic effect of inspiratory muscle training and aerobic exercise on respiratory responses.

• 재활복지
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• v.16 no.3
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• pp.165-192
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• 2012

This study aims to develop a valid self-report scale for the community integration of persons with psychiatric disabilities. To this end, conducted were in-depth interviews with individuals with psychiatric disabilities, consultation with experts, and a survey. First, literature review and the in-depth interview with individuals with psychiatric disabilities were collected questionnaires regarding the community integration of persons with psychiatric disabilities. Second, preliminary research 1 focused on the selection and modification of the items collected in the first research. Final 44 items were selected by the verification of the importance and content-validity of items under the advices of professionals. Lastly, preliminaty research 2 applied cross-validation method to the data from 524 cases in order to verify the factor structure and concept-validity of the items. The result of exploratory factor analysis shows that 5 factor structures are the most appropriate, and the confirmatory factor analysis suggests that the Self-reporting Scale of Community Integration for the person with psychiatric disabilities consists of 27 questionnaires which compose 5sub-concepts such as'psychological integration','physical integration', 'social support', 'social integration', 'independence/self-actualization'. Moreover, this scale was significantly related to the 'Life Satisfaction scale for the person with psychiatric disabilities'. This proved concurrent validity of the scale.

• 한국노년학
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• v.25 no.2
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• pp.245-266
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• 2005

This study examined the relationship between parent-child relationship experiences in childhood and adulthood, and individual development and psychological well-being in mid to later life using structural equation modeling with data from 1,882 parents who have at least one child over 18 years old. Findings indicated that receiving more affectionate parenting in childhood was associated with greater generativity development, more positive parental experiences with one's own children, and better psychological well-being in mid to later adulthood. In addition, the effects of received parenting in childhood on psychological well-being after midlife were partially mediated by parental experiences with adult children and generativity development. These findings suggest that early experiences with parents in childhood continuously influence psychological well-being in adulthood through their impact on concurrent family experiences. However, early influences can be redirected through adult experiences too. These findings have implications for the development of intervention programs aimed at promoting volunteer work for older adults, as well as for practitioners who work with families and individuals who are having problems.

• Korean Journal of Culture and Social Issue
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• v.24 no.3
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• pp.385-410
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• 2018

Materialistic values can be a important variable to understand Koreans' psychological well-being and mental health. This study aimed to validate the Korean version of the Material Values Scale (K-MVS)(Richins & Dawson, 1992). In study 1, we performed confirmatory factor analysis(CFA) to ascertain the three factor model of the original MVS using 417 Korean undergraduate student data(sample 1). The CFA confirmed the three-factor model of the MVS. Yet, three items that yielded low factor loadings in this study as well as in other MVS validation studies were excluded from the final model. In study 2, content, construct, and concurrent validity of the K-MVS were examined with 650 undergraduate student data(Sample 2). We also tested measurement invariance across two groups(i.e., college student group of Sample 2 and employee group of Sample 3). The result revealed that the three-factor model of the K-MVS hold true across the two groups. Lastly test-retest reliability was calculated with 408 female college student data(Sample 4) that filled out K-MVS twice within 6 months. These findings suggest that the K-MVS is a reliable and valid measure for assessing materialistic values in Korea.

• Korean Journal of Culture and Social Issue
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• v.25 no.4
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• pp.353-375
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• 2019

The purpose of this study was to examine the validity and reliability of the Playfulness Scale for Adults. The Korean version of the Playfulness Scale for adults was developed by Proyer, R.T (2017) to measure the playfulness of adults. To validate the OLIW in Korean, item translation, back-translation, item analysis, and exploratory factor analysis (EFA) were conducted with 406 adults in study 1. Of the results obtained from study1, three items and one factor (7 items) were discarded because they turned out to be improper. In addition, 4 factors that were not the same as the original scale were extracted. This was checked by conducting confirmatory factor analysis (CFA) with 336 adults in study 2. CFA supported the 4 factors structure and all 4 factors showed adequate internal consistency. To check the concurrent validity of the Korean adults playfulness scale, correlation analysis with the APS, SMAP, PSYA, and NEO Personality Assessment was conducted. It showed significant positive correlation to APS, SMAP, PSYA, and showed the similar patterns of correlation with the sub factors of NEO Personality Assessment. Adult playfulness is related to the participation frequency of leisure. In conclusion, the Korean version of the playfulness scale for adults is a valid measure of playfulness for adults in Korea. The implications, practical use and suggestions for future study were discussed.

• Journal of Korean Neurosurgical Society
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• v.66 no.6
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• pp.726-734
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• 2023

Objective : Chronic subdural hematoma (CSDH) patients using antithrombotic agents (AT) at high risk for cardiovascular disease are increasing. The authors aimed to analyze the factors influencing outcome by targeting patients using AT and to establish a desirable treatment strategy. Methods : A retrospective analysis was performed on data from 462 patients who underwent burr hole trephination (BHT) surgery for CSDH at five hospitals from March 2010 to June 2021. Outcomes included incidence of postoperative acute bleeding, recurrence rate, and morbidity or mortality rate. Patients were divided into the following four groups based on their history of AT use : no AT. Only antiplatelet agents (AP), only anticoagulants (AC), both of AP and AC. In addition, a concurrent literature review was conducted alongside our cohort study. Results : Of 462 patients, 119 (119/462, 25.76%) were using AT. AP prescription did not significantly delay surgery (p=0.318), but AC prescription led to a significant increase in the time interval from admission to operation (p=0.048). After BHT, AP or AC intake significantly increased the period required for an in-dwelling drain (p=0.026 and p=0.037). The use of AC was significantly related to acute bleeding (p=0.044), while the use of AP was not (p=0.808). Use of AP or AC had no significant effect on CSDH recurrence (p=0.517 and p=1.000) or reoperation (p=0.924 and p=1.000). Morbidity was not statistically correlated with use of either AP or AC (p=0.795 and p=0.557, respectively), and there was no significant correlation with mortality for use of these medications (p=0.470 and p=1.000). Conclusion : Elderly CSDH patients may benefit from maintenance of AT therapy during BHT due to reduced thromboembolic risk. However, the use of AC necessitates individualized due to potential postoperative bleeding. Careful post-operative monitoring could mitigate prognosis and recurrence impacts.

• Journal of Chest Surgery
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• v.57 no.2
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• pp.128-135
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• 2024

Background: This retrospective study aimed to determine the treatment patterns and the surgical and oncologic outcomes after completion lobectomy (CL) in patients with locoregionally recurrent stage I non-small cell lung cancer (NSCLC) who previously underwent sublobar resection. Methods: Data from 36 patients who initially underwent sublobar resection for clinical, pathological stage IA NSCLC and experienced locoregional recurrence between 2008 and 2016 were analyzed. Results: Thirty-six (3.6%) of 1,003 patients who underwent sublobar resection for NSCLC experienced locoregional recurrence. The patients' median age was 66.5 (range, 44-77) years at the initial operation, and 28 (77.8%) patients were men. Six (16.7%) patients underwent segmentectomy and 30 (83.3%) underwent wedge resection as the initial operation. The median follow-up from the initial operation was 56 (range, 9-150) months. Ten (27.8%) patients underwent CL, 22 (61.1%) underwent non-surgical treatments (chemotherapy, radiation, concurrent chemoradiation therapy), and 4 (11.1%) did not receive treatment or were lost to follow-up after recurrence. Patients who underwent CL experienced no significant complications or deaths. The median follow-up time after CL was 64.5 (range, 19-93) months. The 5-year overall survival (OS) and post-recurrence survival (PRS) were higher in the surgical group than in the non-surgical (p<0.001) and no-treatment groups (p<0.001). Conclusion: CL is a technically demanding but safe procedure for locoregionally recurrent stage I NSCLC after sublobar resection. Patients who underwent CL had better OS and PRS than patients who underwent non-surgical treatments or no treatments; however, a larger cohort study and long-term surveillance are necessary.

• Journal of the Korea Institute of Building Construction
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• v.24 no.1
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• pp.97-108
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• 2024

This research delves into the escalating concerns of accidents and fatalities in the construction industry over the recent five-year period, focusing on the development of a Safety Perception Model to augment safety measures. Given the rising percentage of elderly workers and the concurrent drop in productivity within the sector, there is a pronounced need for leveraging Fourth Industrial Revolution technologies to bolster safety protocols. The study comprises an in-depth analysis of statistical data regarding construction-related fatalities, aiming to shed light on prevailing safety challenges. Central to this investigation is the formulation of a Safety Perception Model tailored for small-scale construction projects. This model facilitates the quantification of safety risks by evaluating safety grades across construction sites. Utilizing the DWM1000 module, among an array of wireless communication technologies, the model enables the real-time tracking of worker locations and the assessment of safety levels on-site. Furthermore, the deployment of a safety management system allows for the evaluation of risk levels associated with individual workers. Aggregating these data points, the Safety Climate Index(SCLI) is calculated to depict the daily, weekly, and monthly safety climate of the site, thereby offering insights into the effectiveness of implemented safety measures and identifying areas for continuous improvement. This study is anticipated to significantly contribute to the systematic enhancement of safety and the prevention of accidents on construction sites, fostering an environment of improved productivity and strengthened safety culture through the application of the Safety Perception Model.