• BMB Reports
• /
• 제50권8호
• /
• pp.391-392
• /
• 2017

Overexpression of mammalian 2-Cys peroxiredoxin (Prx) enzymes is observed in most cancer tissues. Nevertheless, their specific roles in colorectal cancer (CRC) progression has yet to be fully elucidated. Here, a novel molecular mechanism by which PrxII/Tankyrase (TNKS) interaction mediates survival of adenomatous polyposis coli (APC)-mutant CRC cells was explored. In mice with an inactivating APC mutation, a model of spontaneous intestinal tumorigenesis, deletion of PrxII reduced intestinal adenomatous polyposis and thereby increased survival. In APC-mutant human CRC cells, PrxII depletion hindered PARP-dependent Axin1 degradation through TNKS inactivation. $H_2O_2-sensitive$ Cys residues in the zinc-binding domain of TNKS1 was found to be crucial for PARsylation activity. Mechanistically, direct binding of PrxII to ARC4/5 domains of TNKS conferred vital redox protection against oxidative inactivation. As a proof-of-concept experiment, a chemical compound targeting PrxII inhibited the growth of tumors xenografted with APC-mutation-positive CRC cells. Collectively, the results provide evidence revealing a novel redox mechanism for regulating TNKS activity such that physical interaction between PrxII and TNKS promoted survival of APC-mutant colorectal cancer cells by PrxII-dependent antioxidant shielding.

• 대한전기학회:학술대회논문집
• /
• 대한전기학회 1994년도 하계학술대회 논문집 A
• /
• pp.110-113
• /
• 1994

In the hazardous areas where explosive substances in the form of gases, vapor or mists exist, electrical apparatus and installations must be of explosion-proof construction to prevent or limit the danger of the ignition of potentially explosive atmosphere. In Korea, six types of protection have been specified in the government regulations at present: flameproof enclosure, pressurization, oil immersion, increased safety, intrinsic safety, and special types. If electrical apparatus are made of explosion-proof construction in a way other than five above-mentioned types, and their performance is tested and approved by the reponsible authorities, they may be categorized as special type apparatus. In this paper, we introduced a special type of explosion-proof electrical apparatus, called non-incendive type, and presented its constructional requirements. We also investigated evaluation methods of non-incendive type apparatus to assure the explosion-proof performance, and proposed a new classification method of hazardous areas using probabilistic concept.

• 한국조경학회지
• /
• 제36권5호
• /
• pp.35-41
• /
• 2008

본 연구에서는 여러 시 군을 걸쳐 형성되는 광역차원의 탐방로 계획을 위한 탐방로의 노선설정시에 고려되어야 할 계획요소를 도출하고자 하였다. 먼저 광역 탐방로의 개념을 고찰하고 광역 탐방로 계획이 먼저 시행된 지역의 사례와 전문가 의견조사를 통하여 환경, 자원, 접근성, 안전성, 노선, 편의시설, 네트워크 형성과 관련하여 13개 계획요소를 도출하였다. 개별 계획요소별 중요도 평가를 위하여 관련 전문가를 대상으로 설문조사를 실시하였으며, 생태민감지역의 보호 및 기존노선의 활동 등이 높이 평가되었다. 본 계획요소는 광역차원에서 노선의 방향과 위치를 결정할 때 판단의 근거로 활용될 수 있을 것이다.

• 경영과학
• /
• 제29권3호
• /
• pp.23-43
• /
• 2012

Enacted for enhancing the competitiveness of the Korean capital market and financial industry, Capital Market Consolidation Act (CMCA) was intended to induce considerable changes such as adopting the concept of financial investment products, regulating financial investment functionally, extending financial investors' business areas and intensifying protection for investors. Employing DEA (Data Envelopment Analysis), this study measures and compares the efficiencies of domestic financial companies between the before and after the enactment of the Consolidation Act. We categorize the financial companies into 4 groups (banks, life insurance companies, property and casualty insurance companies and securities companies) depending on their business types, and evaluate how much and in which direction the Consolidation Act affects the efficiency of each group respectively. The study shows that there is no significant difference between the average efficiency of banks and that of property and casualty insurance companies due to the trade-off between opportunities and threats of the Act. To the contrary, it shows that the respective average efficiencies of life insurance companies and securities companies moved in the opposite directions to a considerable extent. Through empirical tests, we demonstrate the effect of the Act on the efficiency of Korean financial companies, and suggest the countermeasures for each financial group against the Act.

• Elastomers and Composites
• /
• 제46권2호
• /
• pp.94-101
• /
• 2011

종래의 방사선 차단막은 납판이나 납 분말을 과량 배합하여 사용되고 있기 때문에 무거울 뿐만 아니라 인체중독의 위험성이 있다. 또한 작은 핀홀이 존재할 경우 방사선의 직접 투과 위험성이 있는 단점이 있다. 본 특집에서는 최근 선진국을 중심으로 연구가 활발한 다층구조의 고분자 방사선 차단막 기술에 대해 특허분석과 문헌고찰을 중심으로 소개한다. 특히 판상형 나노무기입자를 이용한 방사선 차단 및 내구성 향상에 대한 새로운 개념을 소개한다.

• Journal of Communications and Networks
• /
• 제6권3호
• /
• pp.280-286
• /
• 2004

The widespread use of the Internet and the maturing of digital video technology have led to an increase in various streaming media application. However, new classes of hosts such as mobile devices are gaining popularity, while the transmission became more heterogeneous. Due to the characteristics of mobile networks such as low speed, high error bit rate, etc., the applications over the wireless channel have different needs and limitations from desktop computers. An intermediary between two communicating endpoints to hide the heterogeneous network links is thought as one of the best approaches. In this paper, we adopted the concept of inter-packet gap and the sequence number between continuously received packets as the error discriminator, and designed an adaptive packet sizing mechanism to improve the network efficiency under varying channel conditions. Based on the proposed mechanism, the packetization scheme with error protection is proposed to scalable encoded video delivery. Finally, simulation results reveal that our proposed mechanism can react to the varying BER conditions with better network efficiency and gain the obvious improvement to video quality for stored MPEG-4 FGS video delivery.

• 한국환경복원기술학회지
• /
• 제5권5호
• /
• pp.76-84
• /
• 2002

This report is the summary of case studies about four quarry rehabilitation and restoration works in France and Austria. In Europe, the rehabilitation program should be prepared before quarrying, and this program should be meet with the expectations of stakeholders (owners, neighbors and NGOs), and the requirements of ecological restoration and environmental protection of the government. This program integrates the concept of sustainable development as well as the often exceptional potential for enhancing ecological diversity offered by quarries. Subsequently, the long-term rehabilitation effort is coordinated as closely as possible with quarrying operations, and finally the site is shut down, all measures are taken to ensure the long-term future of the rehabilitated site. The coordinated restoration project applicable to sections where quarrying operations are still in progress confines the working area to keep the visual impact of the quarry to a minimum. The re-established sites offer such great ecological diversity that they were classified as special plant and wildlife ecological zones. Wide range of rehabilitation alternatives offer opportunities to combine environmental preservation goals with social benefits. The actions include agriculture/forestry, recreational/educational developments and other uses.

• 한국신재생에너지학회:학술대회논문집
• /
• 한국신재생에너지학회 2006년도 춘계학술대회
• /
• pp.37-42
• /
• 2006

In this study, $20Nm^3/hr$ scale compact hydrogen generator which can be apply to the hydrogen station was tested for hydrogen station application. $20Nm^3/hr$ scale compact hydrogen generator was developed by upgrading concept of stacking plate reactor from former $20Nm^3/hr$ scale plate hydrogen generator. concepts for improving system efficiency and performance include such as idea of heat recovery from the exhaust, exhaust duct which is especially design for plate type reactor reinforcement of insulation, enlargement of heat exchange area of reactor, introduction of desulphurizer reactor and PROX rector in a compact design, introduction of back fire protection structure of plate burner and so on, We can learn that final prototype of scale-up $20Nm^3/hr$ scale compact hydrogen generator can be operated steadily in 100% road at which over 94% of methane conversion(S/C=3.75) was obtained. In case of making up the weak point, we expect that it is possible to apply to hydrogen station by way of showing an example.

• 대한원격탐사학회지
• /
• 제23권5호
• /
• pp.473-481
• /
• 2007

Joint Forest Management(JFM) is a concept of developing partnerships between fringe forest user groups and the Forest Department(FD) on the basis of mutual trust and jointly defined roles and responsibilities with regard to forest protection and development. In India, JFM was started during 1992 and it was implemented in many states. However success rate of JFM activity was not promising. Though there are many factors attributed to the failures, one of the main factors is the JFM site. This paper deals with the significant ground works to be done before planning for JFM using recent technologies such as remote sensing(RS) and Geographic Information System(GIS). Also it deals with the advantages of weighted overlay analysis in selecting suitable sites for JFM taking into consideration the various criteria. As a result of weighted overlay analysis, there were four types of suitability classes viz., less, moderate, highly and un-suitable. The moderately suitable class occupied maximum area(13209.64 ha) than less and highly suitable classes. If JFM is implemented on the suitability area, then the failure could be avoided in the future.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
• /
• 제4권7호
• /
• pp.75-84
• /
• 1998

Like all other European countries, as a result of gradual industrialization, Germany is just before the start of new social system; the so-called 'aged society'. Over half of the century, Germany focused their welfare system on facilities. However, with the start of the new 'aged society', they introduced a new concept which consists mainly on home care and community care. These new concepts resulted from the general idea that even elderly have the right to live an independent quality life. Therefore, to satisfy the elderly with such life it has been seen as necessary not only to offer them efficient protection but to introduce an economical welfare system and facility scheme. The regional integration plan for welfare is one of the open schemes in which the lifestyle of the elderly are seen as the whole. Participated by several members and specialists of all social standings, necessary facilities are planned. By looking into a project example carried out in Germany, this study is aimed to increase the quality of the elderly welfare system and facility construction plan.