• 한국수정란이식학회:학술대회논문집
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• 한국수정란이식학회 2002년도 국제심포지엄
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• pp.34-36
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• 2002

Epidermal growth factor (EGF) and insulin-like growth factor-I (IGF-I) have been shown to stimulate proliferation and differentiation of various somatic cells, including placental trophoblasts and also to enhance fetal growth and development when maternally administered. Since an increase of the expression of placental EGF and IGF-I receptors in rat, mouse, and human with the gestation advanced, both EGF and IGF-I were considered to play pivotal roles on fetal growth by regulating some function of placental cells. Amino acids are crucial importance for both maternal and fetal requirements of energy source and essential constituent of fetal mass during pregnancy. Impaired fetal and placental uptake of amino acids has been observed in several models of growth retardation in the rat. Amino acid is concentrated in the fetal side through active transport by amino acid transporters and is one of the important metabolic fuels for the fatal growth. Therefore, at first plasma amino acid concentrations in mothers and fetuses were measured as an index of uphill transport across the placenta associated with EGF and IGF-1. The EGF administration at the concentration of 0, 0.1, or 0.2 $\mu\textrm{g}$/g to pregnant rats from day 18 to 21 of gestation apparently increased fetal/maternal ratio of serum proline concentration and also fatal growth in EGF dose-dependent manner. When IGF-I in doses of 0, 1, 2, and 4 $\mu\textrm{g}$/g were administrated, the ratio of leucine, isoleucine, tryptophan, phenylalanine, tyrosine and also fetal growth significantly increased with a dose-dependent manner. These results suggested that EGF and IGF-I enhanced fatal growth by, as one of its possible mechanisms, promoting placental activity to transfer some amino acid supplies from the mother to the fetus in late pregnancy.

• 건축역사연구
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• 제23권5호
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• pp.47-60
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• 2014

Urban-Hanok emerged as a result of urbanization of Hanok in the modern period. In particular, Urban-Hanok has been mass-produced from the early 1920s, when the population is concentrated in cities, until the middle. Large-scale development by the professional developer has been developed in large-scale land rather than individual client because housing shortage was serious problem. 11 Gahoe-dong was made in 1935-36 is representative Urban-hanok area of Bukchon. It was formed through division of large-scale Land in 1930's. In the 1930's, the large-scale development projects of Urban-Hanok was triggered by the two events. One is Land Investigation Project performed by the Japanese government to capitalization of property, another is the pro-japanese bought the large scale-land in Gahoe-dong at bargain price from The Japanese government. Each lot has still a topographical characteristics such as land-dividing quality, the way of development, characteristic quality of urban-tissue. 11 Gahoe-dong, Urban-hanok area was developed two ways. First, development have been adapted to the topography. The lots have reflected topographical conditions such as land cutting area, a retaining wall, land-diving was maintaining the original topography almost. Second, it was street oriented development. The lots have developed sequentially along the street. So, the lots's shape and size is different each. For this reason, this area distribute various type of Hanok.

• 한국지반환경공학회 논문집
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• 제10권7호
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• pp.167-177
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• 2009

본 연구에서는 터널 붕괴붕락의 유형 중 국부 암괴하중에 의한 숏크리트 라이닝의 파괴특성을 유한요소 해석을 통해 고찰하였다. 우선, 기존 터널 라이닝 파괴특성을 보다 체계적으로 파악하기 위하여 암반과 숏크리트체 강성비와 부착강도의 특성에 변화를 주어 총 9가지의 조건을 설정하였다. 각 조건에 대한 블록낙하실험(falling block test)환경에서 수치해석을 수행하여 파괴양상을 고찰해 보고 기존의 이론적 파괴 메카니즘과 비교/평가하여 보았다. 결과적으로, 기존 문헌에서 언급된 4가지 파괴모드(점착파괴(adhesive failure), 직접전단파괴(direct shear failure), 휨인장파괴(flexural failure) 및 휨전단파괴(punching shear failure))가 모두 구현되긴 하였으나, 점착파괴는 항상 타 파괴유형과 동반되어 나타나며, 별도의 파괴유형으로 분류하는 것은 부적절하다고 판단되었다. 또한 기존 관련 연구에서는 터널공학의 주요개념인 아칭효과에 대해 고려치 않고 단순보 개념하에서 라이닝의 파괴특성을 고찰하였으며, 굴착에 의해 부가되는 라이닝의 초기 축력을 고려치 않고 있다. 이에 대해 터널특성에 부합된 경계조건들을 고려하여 신규 라이닝 파괴모드를 재 고찰하였으며, 곡률이 있는 터널 라이닝조건에서는 크게 두 가지 파괴유형으로 분류할 수 있는 것으로 파악되었다.

• Ocean and Polar Research
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• 제34권1호
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• pp.37-51
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• 2012

We investigated the distribution and species composition of zooplankton in relation to hydrographical characteristics in the Korea Strait during the winter (February) and summer (July) of 2009. Satellite images of sea surface temperatures and in situ CTD data showed that the southeastern water zone (St3-5) off Jeju Island was strongly influenced by the Tsushima Current during both the winter and summer, whereas the Changjiang Diluted Water, characterized as water with relatively low salinity, was evident in the coastal waters of Jeju Island during the summer. During winter, zooplankton abundance was significantly higher than in the summer, with dominance by copepods, ostracods, siphonophorans, appendicularians, and nauplii. In both seasons, copepods represented >70% of the total zooplankton population. Calanus sinicus, a large calanoid copepod, was dominant in near the coast, and that may be associated with the intrusion of low salinity water (i.e., the Changjiang Diluted Water) along the coast. The abundance of P. parvus s.l. and A. omorii, known as neritic copepods, was mainly associated with the Korea Southern Coastal Water. Foraminiferans, Ostracods, O. plumifera, and P. aculeatus were concentrated in the southeastern water off Jeju Island during both seasons; showing their association with the Tsushima Current, which is characterized warm, high salinity water. Our results suggest that the distribution, abundance, and species composition of zooplankton are highly influenced by different water masses in the Korea Strait.

• 대한기계학회논문집B
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• 제35권12호
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• pp.1383-1389
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• 2011

본 연구는 태양열 발전에 사용하는 공기식 다채널 체적식 흡수기의 일관성 있는 열전달 해석에 초점을 두고 있다. 이를 위해 흡수 소재 물성과 채널 형상 변화의 영향을 몬테카를로 광선추적법에 기반한 광학 모델과 전도, 대류, 복사를 고려한 1 차원 열전달 모델에 동시에 반영하였다. 광학 모델 결과는 채널 반경 대비 길이의 형상비가 매우 커서 대부분의 태양 에너지는 15 mm 이내의 짧은 길이에서 흡수됨을 증명하고 있다. 복사 열손실 분류를 통해 채널의 낮은 흡수율에서는 방사 손실은 줄지만 반사손실이 증가하여 흡수기 효율이 감소하는 것을 보였다. 큰 채널 반경이나 작은 질량 유량으로 인해 흡수기 평균 온도가 상승할 때, 방사 손실과 반사 손실 모두 증가하지만 방사 손실의 영향이 더 큰 것으로 나타났다.

• 한국실내디자인학회논문집
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• 제22권1호
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• pp.143-153
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• 2013

The purpose of this study is to explore how to make use of the light and expression methods to embody phenomenal space by considering the representation techniques and characteristics of a variety of 'Phenomenal light' in his works focused on the Steven Holl's views that thought the light as object of creating space. The process is summarized as follows: (1) Study on the relationship between light and color, Classify concept and type of phenomenal light by phenomenal color (2) Consider the characteristics and expression methods of the phenomenal light in the Steven Holl's architecture (3) Finally, organize the concepts and representation techniques of phenomenal light, and then present method to embody phenomenal space by light. According to this, the results are as follows: (1) Perceptual color by the light of the sense forms a variety of perception and texture of light and shadow according to the contrast of shades and the change of materiality, thus embodying multisensory space with the light as the medium approach that helps to experience formal and tactile senses. (2) Spatial color by the light of volume distinguishes the flow and movement of sight, and embody inducing space with the light as Atypical activity that forms atmosphere of space through concentrated or overlapped mass of light and darkness. (3) Existential color by the light of the light source visualizes the existence of the uncertain light, and embody the receptive space with the light as emotional communication that forms symbolic and psychological meaning through metaphorical phenomena of colored light.

• Composites Research
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• 제16권3호
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• pp.18-24
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• 2003

샌드위치 구조물들은 적은 무게의 첨가로 높은 강성(stiffness)을 요구하는 조선업에 널리 사용되어져 왔다. 국부하중 조건 하에서 샌드위치 구조물에 대한 디자인 변수들을 고려하는 것은 중요시되어졌다. 이 연구는 샌드위치 보의 강도에 대한 core층의 밀도, core층의 두께 그리고 face층의 두께 비율의 영향을 기술하였다. 이차원 탄성이론에 바탕을 둔 파손 하중은 AS4/3501-6 facing과 polyurethane foam core 샌드위치 보의 3점 굴곡 실험 결과와 잘 일치 하였다. 또한 그러한 파손 하중들은 face층의 비율의 변화와 함께 비교되었다. 파괴 mode들의 교차점으로 결정되어진 최적조건은 강도(strength)와 강성(stiffness)에 대한 샌드위치 빔의 최적 core 밀도의 값이 결정되었다. 추가적으로 강도에 대한 최적조건과 그렇지 못한 샌드위치 보에 대한 face 두께 비율 효과가 하중 길이에 따라 비교되었으며, 강도와 강성이 core/face무게 비율과 항께 검토하였다.

• 대한토목학회논문집
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• 제32권2D호
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• pp.159-166
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• 2012

건설시공현장에서 콘크리트 타설시 거푸집과 동바리 등의 가설 구조물만으로 유동상태의 콘크리트 자중 및 각종 시공하중을 지지한다. 그러나 타설 중 복잡한 동선과 타설 충격, 지반 침하 등으로 가설구조물에 하중집중이 발생할 수 있으며, 집중하중으로 인하여 발생하는 가설구조물의 불안정은 안전사고의 원인이 된다. 따라서 기존의 건설시공 안전관리방법으로 건설시공 안전관리를 하는데 한계가 있으며, 시공 중 콘크리트 타설 및 양생과정에서 가설구조물의 안전성을 높이기 위해서 콘크리트 타설 프로세스를 지속적으로 모니터링할 필요가 있다. 본 연구에서는 건설시공 안전관리를 위한 USN(Ubiquitous Sensor Network) 기반의 실시간 모니터링 시스템을 제시한다. USN 기반의 실시간 모니터링 시스템은 콘크리트 타설시 거푸집 처짐, 동바리의 하중변화 등을 실시간으로 측정하며, 무선으로 데이터를 전송하여 시공현장 상황을 실시간으로 모니터링한다. 가시설 구조물 모형에 대한 실험에서 측정된 데이터를 허용기준치와 비교한 결과 하중초과 및 거푸집의 이상변형 발생 시 경고초치를 통해 작업자의 작업 중단 및 즉각적인 대피, 신속한 사후 대처 등을 알림으로써 시공현장에서 발생 가능한 사고를 미연에 방지할 수 있다는 것을 보여줬다.

• Journal of Applied Biological Chemistry
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• 제60권3호
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• pp.257-263
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• 2017

A cellulolytic strain Y2 was isolated from soil obtained in the Canadian Alpine region. The isolate was identified as Paenibacillus sp. Y2 by 16S rRNA sequencing. When grown in LB medium supplemented with carboxymethyl-cellulose (CMC), CMCase production increased to 122.0% of that observed in LB without CMC. Culture supernatant was concentrated by ultrafiltration and 80% ammonium sulfate precipitates were separated by Hi-Trap Q and CHT-II chromatography. The purified enzyme (EG-PY2) showed a homogeneous single band and the molecular mass was estimated to be 38 kDa by SDS-PAGE. Optimum pH and temperature of the enzyme were 4.5 and $30^{\circ}C$, respectively. The half-life of enzyme activity at 50 was 140.7 min, but the enzyme was drastically inactivated within 5 min at $55^{\circ}C$. The enzyme was highly activated to 135.7 and 126.7% by 5.0 mM of $Cu^{2+}$ or $Mg^{2+}$ ions, respectively, and moderately activated by $Ba^{2+}$ and $Ca^{2+}$ ions, whereas it was inhibited to 76.8% by $Fe^{2+}$, and to ${\leq}50%$ by $Mn^{2+}$, $Co^{2+}$, $Zn^{2+}$, and EDTA. The enzyme was activated to 211.5% in the presence of 0.5 M of NaCl and greatly tolerant to 3.15M of NaCl. The enzyme showed 2.98 times higher ${\beta}$-glucanase activity than CMCase activity. Based on these results, it can be concluded that EG-PY2 is an acidophilic, cold-active, and halotolerant endoglucanase. The authors suggest it is considered to be useful for various industrial applications, such as, fruit juice clarification, acidic deinking processes, high-salt food processing, textile and pulp industries, and for biofuel production from seaweeds.

• Food Science and Biotechnology
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• 제18권1호
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• pp.223-227
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• 2009

The fruits of Cornus kousa Burg. were extracted with 80% aqueous methanol (MeOH) and the concentrated extract was partitioned with ethyl acetate (EtOAc), n-butanol (n-BuOH), and $H_2O$. From the EtOAc traction, 5 triterpenoids were isolated through repeated silica gel ($SiO_2$), octadecyl silica gel (ODS), and Sephadex LH-20 column chromatography (c.c.). These compounds were determined to be ursolic acid (1), corosolic acid (2), taraxasterol (3), betulinic acid (4), and betulinic aldehyde (5) on the basis of their spectroscopic data including electronic ionization mass spectrometry, ultraviolet spectroscopy, infrared spectroscopy, and nuclear magnetic resonance. This is the first reported isolation of these compounds from this plant. Also, compounds 1, 3, 4, and 5 show a relatively high inhibitory activity against human acyl-CoA: cholesterol acyltransferase-1 (hACAT-1) with inhibition values of $52.8{\pm}0.7$, $91.1{\pm}0.4$, $93.0{\pm}0.7$, and $96.2{\pm}0.2%$ at a concentration of $100{\mu}M$, respectively.